Zobrazeno 1 - 2
of 2
pro vyhledávání: '"Duncan Allardyce"'
Publikováno v:
RSC Medicinal Chemistry. 14:573-582
A new class of competitive proteasome inhibitors was identified from screening of the ZINC library of natural products. Structure–activity studies highlighted the importance of hydrophobic interactions in enhanced binding affinity.
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::c5466b0845c246df241e052104d16c02
https://doi.org/10.1039/d2md00404f
https://doi.org/10.1039/d2md00404f
Publikováno v:
Chemical Biology & Drug Design.
Inhibitors of the proteasome have found broad therapeutic applications; however, they show severe toxicity due to the abundance of proteasomes in healthy cells. In contrast, inhibitors of the immunoproteasome, which is upregulated during disease stat
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::1a03730f3de63ab1ac603e5ab2fff2e1
https://doi.org/10.1111/cbdd.13539
https://doi.org/10.1111/cbdd.13539