Výsledky vyhledávání - "Duncan Allardyce"

Identification of a new class of proteasome inhibitors based on a naphthyl–azotricyclic-urea–phenyl scaffold

Autor: Duncan Allardyce, Priscilla Adu Mantey, Monika Szalecka, Robert Nkwo, Eriketi Z. Loizidou

Publikováno v: RSC Medicinal Chemistry. 14:573-582

A new class of competitive proteasome inhibitors was identified from screening of the ZINC library of natural products. Structure–activity studies highlighted the importance of hydrophobic interactions in enhanced binding affinity.

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_________::c5466b0845c246df241e052104d16c02
https://doi.org/10.1039/d2md00404f

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Argyrin B, a non‐competitive inhibitor of the human immunoproteasome exhibiting preference for β1i

Autor: Celia M. Bell, Eriketi Z. Loizidou, Duncan Allardyce

Publikováno v: Chemical Biology & Drug Design.

Inhibitors of the proteasome have found broad therapeutic applications; however, they show severe toxicity due to the abundance of proteasomes in healthy cells. In contrast, inhibitors of the immunoproteasome, which is upregulated during disease stat

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::1a03730f3de63ab1ac603e5ab2fff2e1
https://doi.org/10.1111/cbdd.13539

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Periodical

Data on Medicinal Chemistry Reported by Researchers at Middlesex University (Identification of a New Class of Proteasome Inhibitors Based On a Naphthyl-azotricyclic-urea-phenyl Scaffold).

Publikováno v: Genomics & Genetics Weekly; 3/31/2023, p293-293, 1p

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