A randomized, open-label study to investigate the effect of belimumab on pneumococcal vaccination in patients with active, autoantibody-positive systemic lupus erythematosus

Autor: David M. Roth, Duncan A. Gordon, W. Winn Chatham, J Fettiplace, A Chadha, Damon Bass, C Kleoudis

Publikováno v: Lupus

Objective Intravenous belimumab 10 mg/kg is approved as an add-on therapy in patients with active, autoantibody-positive systemic lupus erythematosus. This study aimed to assess the impact of belimumab on immune response to pneumococcal vaccination i

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::f504dd4055f7898a8656ff99b494978a
https://doi.org/10.1177/0961203317703495

Long-term organ damage accrual and safety in patients with SLE treated with belimumab plus standard of care

Autor: Duncan A. Gordon, R. van Vollenhoven, M Oldham, Benjamin Wilson, David M. Roth, Murray B. Urowitz, Cynthia Aranow, C. Molta, J Fettiplace, Ian N. Bruce

Publikováno v: Bruce, I N, Urowitz, M B, van Vollenhoven, R, Aranow, C, Fettiplace, J, Oldham, M, Wilson, B, Molta, C T, Roth, D A & Gordon, D 2016, ' Long-term organ damage accrual and safety in patients with SLE treated with belimumab plus standard of care ', Lupus, vol. 25, no. 7, pp. 699-709 . https://doi.org/10.1177/0961203315625119
Lupus, 25(7), 699-709. SAGE Publications Ltd
Lupus

Objective To examine long-term organ damage and safety following treatment with belimumab plus standard of care (SoC) in patients with systemic lupus erythematosus (SLE). Methods Pooled data were examined from two ongoing open-label studies that enro

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::d66961338c1724f2f89526cdac69d975
https://research.vumc.nl/en/publications/f4224f85-5998-40a7-94bb-690e2c81cc92

Solution structure of a C-terminal coiled-coil domain from bovine IF1: the inhibitor protein of F1 ATPase1 1Edited by M. F. Summers

Autor: Ji-Chun Yang, David Neuhaus, Duncan J. Gordon-Smith, Hortense Videler, John E. Walker, Rodrigo J. Carbajo, Michael J. Runswick

Publikováno v: Journal of Molecular Biology. 308:325-339

Bovine IF1 is a basic, 84 amino acid residue protein that inhibits the hydrolytic action of the F1F0 ATP synthase in mitochondria under anaerobic conditions. Its oligomerization state is dependent on pH. At a pH value below 6.5 it forms an active dim

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_________::778029da98616146c4c2dc27452aa661
https://doi.org/10.1006/jmbi.2001.4570

In memoriam - Hugh A. Smythe, 1927-2012

Autor: Frederick Wolfe, Duncan A. Gordon, Charles H. Goldsmith, Murray B. Urowitz

Publikováno v: The Journal of rheumatology. 40(4)

Murray B. Urowitz Dr. Hugh Arthur Smythe died peacefully at his home in Toronto, Canada, on Sunday, October 14, 2012, at age 85, with his family around him: his beloved wife of 62 years, Bernice, his children Richard (Barb), Anne (Bob), and Conn (Chr

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::874aa9f568165c48f78e97950b5350df
https://pubmed.ncbi.nlm.nih.gov/23547251

LB0001 Efficacy and Safety of Subcutaneous Belimumab plus Standard Care in Patients with Systemic Lupus Erythematosus (SLE) with Low Complement and Positive Anti-DSDNA

Autor: Masato Okada, Anne E. Hammer, Andreas Schwarting, J. Groark, Duncan A. Gordon, William Stohl, R. van Vollenhoven, N.L. Fox, Damon Bass, David M. Roth, Morton Scheinberg, Andrea Doria

Publikováno v: Annals of the Rheumatic Diseases. 75:70.3-71

Background In post hoc analyses of the BLISS trials, patients with SLE with positive anti-dsDNA and low complement (C3/C4) had a greater response to intravenous belimumab (BEL) compared with patients without these characteristics. 1 Objectives To ass

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_________::31959c913e5e053701f37217c2ea7d67
https://doi.org/10.1136/annrheumdis-2016-eular.6236