Zobrazeno 1 - 10 of 18 pro vyhledávání: '"Duncan, Humphries"'
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An Inhaled Galectin-3 Inhibitor in COVID-19 Pneumonitis (DEFINE):A Phase Ib/IIa Randomised Controlled Trial
Autor: Erin E, Gaughan, Tom M, Quinn, Andrew, Mills, Annya M, Bruce, Jean, Antonelli, Alison, MacKinnon, Vassilios, Aslanis, Feng, Li, Richard, O'Connor, Cecilia, Boz, Ross, Mills, Philip, Emanuel, Matthew, Burgess, Giulia, Rinaldi, Asta, Valanciute, Bethany, Mills, Emma, Scholefield, Gareth, Hardisty, Emily, Gwyer Findlay, Richard A, Parker, John, Norrie, James W, Dear, Ahsan R, Akram, Oliver, Koch, Kate, Templeton, David H, Dockrell, Timothy S, Walsh, Stephen, Partridge, Duncan, Humphries, Jie, Wang-Jairaj, Robert J, Slack, Hans, Schambye, De, Phung, Lise, Gravelle, Bertil, Lindmark, Manu, Shankar-Hari, Nikhil, Hirani, Tariq, Sethi, Kevin, Dhaliwal
Publikováno v: Gaughan, E E, Quinn, T M, Mills, A, Bruce, A M, Antonelli, J, Mackinnon, A, Aslanis, V, Li, F, O'connor, R, Boz, C, Mills, R, Emanuel, P, Burgess, M, Rinaldi, G, Valanciute, A, Mills, B, Scholefield, E, Hardisty, G, Gwyer Findlay, E, Parker, R A, Norrie, J, Dear, J W, Akram, A R, Koch, O, Templeton, K, Dockrell, D H, Walsh, T S, Partridge, S, Humphries, D, Wang-jairaj, J, Slack, R J, Schambye, H, Phung, D, Gravelle, L, Lindmark, B, Shankar-Hari, M, Hirani, N, Sethi, T & Dhaliwal, K 2022, ' An Inhaled Galectin-3 Inhibitor in COVID-19 Pneumonitis (DEFINE) : A Phase Ib/IIa Randomised Controlled Trial ', American Journal of Respiratory and Critical Care Medicine . https://doi.org/10.1164/rccm.202203-0477OC
Rationale: High circulating galectin-3 is associated with poor outcomes in patients with COVID-19. We hypothesised that GB0139, a potent inhaled thiodigalactoside galectin-3 inhibitor with anti-inflammatory and antifibrotic actions, would be safely a
Externí odkaz: https://explore.openaire.eu/search/publication?articleId=pmid_dedup__::4cbdceb9f003b857818278fa3a4d79ec
https://www.pure.ed.ac.uk/ws/files/298426001/rccm.202203_0477oc_1_.pdf
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4
Pulmonary-Resident Memory Lymphocytes: Pivotal Orchestrators of Local Immunity Against Respiratory Infections
Autor: Vincent Pavot, Kevin Dhaliwal, Duncan Humphries, Richard A. O’Connor, Daniel Larocque, Martine Chabaud-Riou
Publikováno v: Frontiers in Immunology, Vol 12 (2021)
Frontiers in Immunology
Humphries, D C, O’connor, R A, Larocque, D, Chabaud-riou, M, Dhaliwal, K & Pavot, V 2021, ' Pulmonary-Resident Memory Lymphocytes: Pivotal Orchestrators of Local Immunity Against Respiratory Infections ', Frontiers in Immunology, vol. 12 . https://doi.org/10.3389/fimmu.2021.738955
There is increasing evidence that lung-resident memory T and B cells play a critical role in protecting against respiratory reinfection. With a unique transcriptional and phenotypic profile, resident memory lymphocytes are maintained in a quiescent s
Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::905ccca739e486f62c3094aa3fc0e358
https://doi.org/10.3389/fimmu.2021.738955
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5
Cellular senescence inhibits renal regeneration after injury in mice, with senolytic treatment promoting repair
Autor: Anette Melk, David P. Baird, Sarah A. Neely, Paul Krimpenfort, Sofia Ferreira-Gonzalez, Jeremy Hughes, Marie-Helena Docherty, Duncan Humphries, Roland Schmitt, Katie J. Mylonas, David A. Ferenbach, Eoin O'Sullivan, Stuart J. Forbes
Publikováno v: Mylonas, K J, O'Sullivan, E, Humphries, D, Baird, D, Docherty, M-H, Neely, S, Krimpenfort, P, Melk, A, Schmitt, R, Ferreira-Gonzalez, S, Forbes, S J, Hughes, J & Ferenbach, D A 2021, ' Cellular senescence inhibits renal regeneration after injury in mice, with senolytic treatment promoting repair ', Science Translational Medicine . https://doi.org/10.1126/scitranslmed.abb0203
The ability of the kidney to regenerate successfully after injury is lost with advancing age, chronic kidney disease and after irradiation. The factors responsible for this reduced regenerative capacity remain incompletely understood, with increasing
Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::9c6807ac36b7eef2036175beb443aad0
https://www.pure.ed.ac.uk/ws/files/211798980/Full_manuscript_as_pdf.pdf
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6
Hypoxia drives murine neutrophil protein scavenging to maintain central carbon metabolism
Autor: Andrew J. M. Howden, Sarah R. Walmsley, Alex von Kriegsheim, Jens L. Hukelmann, Eilise M. Ryan, Rebecca S. Dickinson, Fiona Murphy, Gio Rodriguez Blanco, Bart Ghesquière, Patrícia Coelho, Doreen A. Cantrell, Emily R. Watts, Pranvera Sadiku, Robert Grecian, Ananda S. Mirchandani, Wesley Vermaelen, Tyler Morrison, Duncan Humphries, Tracie Plant, Moira K. B. Whyte, Andrew J. Finch
Publikováno v: Watts, E R, Howden, A J M, Morrison, T, Sadiku, P, Hukelmann, J L, Von Kriegsheim, A, Ghesquière, B, Murphy, F, Mirchandani, A S, Humphries, D C, Grecian, R, Ryan, E M, Coelho, P, Rodriguez-blanco, G, Plant, T M, Dickinson, R S, Finch, A J, Vermaelen, W, Cantrell, D A, Whyte, M K B & Walmsley, S R 2021, ' Hypoxia drives murine neutrophil protein scavenging to maintain central carbon metabolism ', Journal of Clinical Investigation . https://doi.org/10.1172/JCI134073
Limiting dysfunctional neutrophilic inflammation while preserving effective immunity requires a better understanding of the processes that dictate neutrophil function in the tissues. Quantitative mass-spectrometry identified how inflammatory murine n
Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::58a5393e0379a24b90ce692f5f16f351
https://hdl.handle.net/20.500.11820/6ee67df8-79e3-477f-a412-02d6f22765b7
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7
Activated neutrophil fluorescent imaging technique for human lungs
Autor: Thane A. Campbell, James W. Dear, Annya Bruce, Bethany Mills, Tashfeen Walton, Emma Scholefield, Adam Marshall, Neil Q. McDonald, Thomas H. Craven, Timothy S. Walsh, Duncan Humphries, Ahsan R. Akram, Kevin Dhaliwal, David E. Newby, Christopher Haslett, Joanne Mair, Adam T. Hill
Publikováno v: Craven, T H, Walton, T, Akram, A R, Scholefield, E, Mcdonald, N, Marshall, A D L, Humphries, D C, Mills, B, Campbell, T A, Bruce, A, Mair, J, Dear, J W, Newby, D E, Hill, A T, Walsh, T S, Haslett, C & Dhaliwal, K 2021, ' Activated neutrophil fluorescent imaging technique for human lungs ', Scientific Reports, vol. 11, no. 1 . https://doi.org/10.1038/s41598-020-80083-w
Scientific Reports
Scientific Reports, Vol 11, Iss 1, Pp 1-15 (2021)
Neutrophil activation is an integral process to acute inflammation and is associated with adverse clinical sequelae. Identification of neutrophil activation in real time in the lungs of patients may permit biological stratification of patients in oth
Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::856a21122b702775030cfd15054a6b98
https://www.pure.ed.ac.uk/ws/files/191779842/s41598_020_80083_w_1_.pdf
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9
Kidney Single-Cell Atlas Reveals Myeloid Heterogeneity in Progression and Regression of Kidney Disease
Autor: Cécile Bénézech, Carolynn Cairns, Oliver Teenan, Katie Connor, James O’sullivan, Angela Salzano, David A. Ferenbach, Kevin Stewart, Eoin O'Sullivan, Neil C. Henderson, Peng Ding, Riinu Pius, Jeremy Hughes, Tamir Chandra, Laura Denby, Duncan Humphries, Prakash Ramachandran, Bryan R. Conway, Daniel J. Simpson
Publikováno v: J Am Soc Nephrol
Conway, B R, O Sullivan, E, Cairns, C, O'Sullivan, J, Simpson, D, Salzano, A, Connor, K, Ding, P, Humphries, D, Stewart, K, Teenan, O, Pius, R, Henderson, N C, Benezech, C, Ramachandran, P, Ferenbach, D A, Hughes, J, Chandra, T & Denby, L 2020, ' Kidney single-cell atlas reveals myeloid heterogeneity in progression and regression of kidney disease ', Journal of the American Society of Nephrology, vol. 31, no. 12, pp. 2833–2854 . https://doi.org/10.1681/ASN.2020060806
Background Little is known about the roles of myeloid cell subsets in kidney injury and in the limited ability of the organ to repair itself. Characterizing these cells based only on surface markers using flow cytometry might not provide a full pheno
Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::f8c985622a807b7b39dbcfe20eb66ca7
https://pubmed.ncbi.nlm.nih.gov/32978267
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10
Semaphorin 3F signaling actively retains neutrophils at sites of inflammation
Autor: Ailiang Zhang, Fiona Murphy, S Eamsamarng, Jenna L. Cash, Andrew J.W. Furley, Freek van Eeden, Tracie Plant, Moira K. B. Whyte, Emily R. Watts, Tyler Morrison, Leila Reyes, Felix Ellett, Jessie-May Morgan, Philip M. Elks, Patrícia Coelho, Stephen A. Renshaw, Ximena L. Raffo-Iraolagoitia, Ananda S. Mirchandani, Duncan Humphries, Manuel A. Sanchez-Garcia, Leo M. Carlin, Sarah R. Walmsley, Catherine A. Loynes
Publikováno v: The Journal of Clinical Investigation
Plant, T, Eamsamarng, S, Sanchez-Garcia, M A, Reyes, L, Renshaw, S A, Coelho, P, Mirchandani, A S, Morgan, J-M, Ellett, F E, Morrison, T, Humphries, D, Watts, E R, Murphy, F, Raffo-Iraolagoitia, X L, Zhang, A, Cash, J L, Loynes, C, Elks, P M, Van Eeden, F, Carlin, L M, Furley, A J W, Whyte, M K B & Walmsley, S R 2020, ' Semaphorin 3F signaling actively retains neutrophils at sites of inflammation ', Journal of Clinical Investigation, vol. 130, no. 6, pp. 3221-3237 . https://doi.org/10.1172/JCI130834
Neutrophilic inflammation is central to disease pathogenesis, for example, in chronic obstructive pulmonary disease, yet the mechanisms that retain neutrophils within tissues remain poorly understood. With emerging evidence that axon guidance factors
Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::4963bd1f4fcfae952a20c7a3ca638346
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