Brain injury in COVID-19 is associated with dysregulated innate and adaptive immune responses

Autor: Needham, EJ, Ren, AL, Digby, RJ, Norton, EJ, Ebrahimi, S, Outtrim, JG, Chatfield, DA, Manktelow, AE, Leibowitz, MM, Newcombe, VFJ, Doffinger, R, Barcenas-Morales, G, Fonseca, C, Taussig, MJ, Burnstein, RM, Samanta, RJ, Dunai, C, Sithole, N, Ashton, NJ, Zetterberg, H, Gisslén, M, Edén, A, Marklund, E, Openshaw, PJM, Dunning, J, Griffiths, MJ, Cavanagh, J, Breen, G, Irani, SR, Elmer, A, Kingston, N, Summers, C, Bradley, JR, Taams, LS, Michael, BD, Bullmore, ET, Smith, KGC, Lyons, PA, Coles, AJ, Menon, DK, Cambridge NeuroCOVID Group the CITIID-NIHR COVID-19 BioResource Collaboration and Cambridge NIHR Clinical Research Facility

Publikováno v: Needham, E J, Ren, A L, Digby, R J, Norton, E J, Ebrahimi, S, Outtrim, J G, Chatfield, D A, Manktelow, A E, Leibowitz, M M, Newcombe, V F J, Doffinger, R, Barcenas-Morales, G, Fonseca, C, Taussig, M J, Burnstein, R M, Samanta, R J, Dunai, C, Sithole, N, Ashton, N J, Zetterberg, H, Gisslén, M, Edén, A, Marklund, E, Openshaw, P J M, Dunning, J, Griffiths, M J, Cavanagh, J, Breen, G, Irani, S R, Elmer, A, Kingston, N, Summers, C, Bradley, J R, Taams, L S, Michael, B D, Bullmore, E T, Smith, K G C, Lyons, P A, Coles, A J & Menon, D K 2022, ' Brain injury in COVID-19 is associated with dysregulated innate and adaptive immune responses ', Brain research, pp. awac321 . https://doi.org/10.1093/brain/awac321

COVID-19 is associated with neurological complications including stroke, delirium and encephalitis. Furthermore, a post-viral syndrome dominated by neuropsychiatric symptoms is common, and is seemingly unrelated to COVID-19 severity. The true frequen

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https://doi.org/10.1093/brain/awac321

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Brain Injury in COVID-19 is Associated with Autoinflammation and Autoimmunity

Autor: Needham, EJ, Ren, AL, Digby, RJ, Outtrim, JG, Chatfield, DA, Manktelow, AE, Newcombe, VFJ, Doffinger, R, Barcenas-Morales, G, Fonseca, C, Taussig, MJ, Burnstein, RM, Dunai, C, Sithole, N, Ashton, NJ, Zetterberg, H, Gisslen, M, Edén, A, Marklund, E, Griffiths, MJ, Cavanagh, J, Breen, G, Irani, Elmer, A, Kingston, N, Bradley, Taams, LS, Michael, BD, Bullmore, ET, Smith, KGC, Lyons, PA, Coles, AJC, Menon, DK, Group, The Cambridge NeuroCOVID, BioResource, The NIHR COVID-19, Cambridge NIHR Clinical Research Facility

COVID-19 has been associated with many neurological complications including stroke, delirium and encephalitis. Furthermore, many individuals experience a protracted post-viral syndrome which is dominated by neuropsychiatric symptoms, and is seemingly

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https://www.repository.cam.ac.uk/handle/1810/343727

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Paradoxical effects of obesity on T cell function during tumor progression and PD-1 checkpoint blockade

Autor: Wang, Z, Aguilar, EG, Luna, JI, Dunai, C, Khuat, LT, Le, CT, Mirsoian, A, Minnar, CM, Stoffel, KM, Sturgill, IR, Grossenbacher, SK, Withers, SS, Rebhun, RB, Hartigan-O’Connor, DJ, Méndez-Lagares, G, Tarantal, AF, Isseroff, RR, Griffith, TS, Schalper, KA, Merleev, A, Saha, A, Maverakis, E, Kelly, K, Aljumaily, R, Ibrahimi, S, Mukherjee, S, Machiorlatti, M, Vesely, SK, Longo, DL, Blazar, BR, Canter, RJ, Murphy, WJ, Monjazeb, AM

Publikováno v: Nature medicine, vol 25, iss 1
Hepatobiliary Surg Nutr
Wang, Z; Aguilar, EG; Luna, JI; Dunai, C; Khuat, LT; Le, CT; et al.(2018). Paradoxical effects of obesity on T cell function during tumor progression and PD-1 checkpoint blockade. Nature Medicine. doi: 10.1038/s41591-018-0221-5. UC Davis: Retrieved from: http://www.escholarship.org/uc/item/14v385n0

© 2018, The Author(s), under exclusive licence to Springer Nature America, Inc. The recent successes of immunotherapy have shifted the paradigm in cancer treatment, but because only a percentage of patients are responsive to immunotherapy, it is imp

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https://escholarship.org/uc/item/14v385n0