A proteomic approach based on peptide affinity chromatography, 2-dimensional electrophoresis and mass spectrometry to identify multiprotein complexes interacting with membrane-bound receptors

Autor: Bécamel Carine, Galéotti Nathalie, Poncet Joël, Jouin Patrick, Dumuis Aline, Bockaert Joël, Marin Philippe

Publikováno v: Biological Procedures Online, Vol 4, Iss 1, Pp 94-104 (2002)

There is accumulating evidence that membrane-bound receptors interact with many intracellular proteins. Multiprotein complexes associated with ionotropic receptors have been extensively characterized, but the identification of proteins interacting wi

Externí odkaz: https://doaj.org/article/c2fc27455c7f4abbb0afb3d196d84cf0

Les récepteurs 5-HT4 : 20 ans déjà ! / Les récepteurs sérotoninergiques 5-HT4

Autor: Bockaert, Joël, Claeysen, Sylvie, Compan, Valerie, Dumuis, Aline

Publikováno v: Sérotonine-Aspects biologiques et cliniques
Sérotonine-Aspects biologiques et cliniques, 2012, 978-2-257-20509-4

International audience

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=dedup_wf_001::562632fa94bdce63c8f42a6b46c9f693
https://hal.science/hal-01667922

G Protein Activation by Serotonin Type 4 Receptor Dimers: evidence that turning on two protomers is more efficient

Autor: Pellissier, Lucie P., Barthet, Gaël, Gaven, Florence, Cassier, Elisabeth, Trinquet, Eric, Pin, Jean-Philippe, Marin, Philippe, Dumuis, Aline, Bockaert, Joël, Banères, Jean-Louis, Claeysen, Sylvie

Publikováno v: Journal of Biological Chemistry
Journal of Biological Chemistry, American Society for Biochemistry and Molecular Biology, 2011, 286 (12), pp.9985-9997. ⟨10.1074/jbc.M110.201939⟩

International audience; The discovery that class C G protein-coupled receptors (GPCRs) function as obligatory dimeric entities has generated major interest in GPCR oligomerization. Oligomerization now appears to be a common feature among all GPCR cla

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=pmid_dedup__::abb90800eb47747a24ac2178da4242a3
https://hal.archives-ouvertes.fr/hal-02482879

Uncoupling and endocytosis of 5-hydroxytryptamine 4 receptors. Distinct molecular events with different GRK2 requirements

Autor: Barthet, Gaël, Gaven, Florence, Framery, Bérénice, Shinjo, Katsuhiro, Nakamura, Takaaki, Claeysen, Sylvie, Bockaert, Joël, Dumuis, Aline

Publikováno v: Journal of Biological Chemistry
Journal of Biological Chemistry, American Society for Biochemistry and Molecular Biology, 2005, 280 (30), pp.27924-34. ⟨10.1074/jbc.M502272200⟩
Journal of Biological Chemistry, 2005, 280 (30), pp.27924-34. ⟨10.1074/jbc.M502272200⟩

The 5-hydroxytryptamine type 4 receptors (5-HT4Rs) are involved in memory, cognition, feeding, respiratory control, and gastrointestinal motility through activation of a G(s)/cAMP pathway. We have shown that 5-HT4R undergoes rapid and profound homolo

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=pmid_dedup__::c9aaa4d5c92fe38b327a589ad9363f9b
https://www.hal.inserm.fr/inserm-00092206

SL65.0155: a novel 5-HT4 receptor partial agonist with potent cognition enhancing properties

Autor: Moser, Paul, Bergis, Olivier, Jegham, Samir, Lochead, Alistair, DUCONSEILLE, ELEE, Terranova, Jean-Paul, Caille, Dominique, Magnon, Martine, Robineau, Pascale, Lezoualc' h, Frank, Berque- Bestel, Isabelle, Gastineau, Monique, Sicsic, Sames, Fischmeister, Rodolphe, Langlois, Michel, Dumuis, Aline, Bockaert, Joël, George, Pascal, Soubrié, Philippe, Scatton, Bernard

Publikováno v: Journal of Pharmacology and Experimental Therapeutics
Journal of Pharmacology and Experimental Therapeutics, American Society for Pharmacology and Experimental Therapeutics, 2002, 302 (2), pp.731-741. ⟨10.1124/jpet.102.034249⟩

International audience

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=dedup_wf_001::69d7da7c1aa67cbe3a1203528654b761
https://hal.archives-ouvertes.fr/hal-03161682/document