Constitutive loss of kynurenine-3-monooxygenase changes circulating kynurenine metabolites without affecting systemic energy metabolism.

Autor: Dumont KD; Molecular and Cellular Exercise Physiology, Department of Physiology and Pharmacology, Karolinska Institutet, Stockholm, Sweden., Jannig PR; Molecular and Cellular Exercise Physiology, Department of Physiology and Pharmacology, Karolinska Institutet, Stockholm, Sweden., Porsmyr-Palmertz M; Molecular and Cellular Exercise Physiology, Department of Physiology and Pharmacology, Karolinska Institutet, Stockholm, Sweden., Ruas JL; Molecular and Cellular Exercise Physiology, Department of Physiology and Pharmacology, Karolinska Institutet, Stockholm, Sweden.; Department of Pharmacology and Stanley and Judith Frankel Institute for Heart & Brain Health, University of Michigan Medical School, Ann Arbor, Michigan, United States.

Publikováno v: American journal of physiology. Endocrinology and metabolism [Am J Physiol Endocrinol Metab] 2025 Feb 01; Vol. 328 (2), pp. E274-E285. Date of Electronic Publication: 2025 Jan 13.

Zfp697 is an RNA-binding protein that regulates skeletal muscle inflammation and remodeling.

Autor: Correia JC; Molecular and Cellular Exercise Physiology, Department of Physiology and Pharmacology, Biomedicum, Karolinska Institutet, Stockholm SE-171 77, Sweden., Jannig PR; Molecular and Cellular Exercise Physiology, Department of Physiology and Pharmacology, Biomedicum, Karolinska Institutet, Stockholm SE-171 77, Sweden., Gosztyla ML; Department of Cellular and Molecular Medicine, University of California, San Diego, La Jolla, CA 92093.; Sanford Stem Cell Institute Innovation Center and Stem Cell Program, University of California San Diego, La Jolla, CA 92093.; Center for RNA Technologies and Therapeutics, University of California San Diego, La Jolla, CA 92093., Cervenka I; Molecular and Cellular Exercise Physiology, Department of Physiology and Pharmacology, Biomedicum, Karolinska Institutet, Stockholm SE-171 77, Sweden., Ducommun S; Molecular and Cellular Exercise Physiology, Department of Physiology and Pharmacology, Biomedicum, Karolinska Institutet, Stockholm SE-171 77, Sweden., Præstholm SM; Molecular and Cellular Exercise Physiology, Department of Physiology and Pharmacology, Biomedicum, Karolinska Institutet, Stockholm SE-171 77, Sweden., Dias JM; Nanomedicine and Spatial Biology, Department of Physiology and Pharmacology, Biomedicum, Karolinska, Stockholm SE-171 77, Sweden.; Department of Cell and Molecular Biology, Biomedicum, Karolinska Institutet, Stockholm SE-171 77, Sweden., Dumont KD; Molecular and Cellular Exercise Physiology, Department of Physiology and Pharmacology, Biomedicum, Karolinska Institutet, Stockholm SE-171 77, Sweden., Liu Z; Molecular Muscle Physiology and Pathophysiology, Department of Physiology and Pharmacology, Biomedicum, Karolinska Institutet, Stockholm SE-171 77, Sweden., Liang Q; Department of Cellular and Molecular Medicine, University of California, San Diego, La Jolla, CA 92093.; Center for RNA Technologies and Therapeutics, University of California San Diego, La Jolla, CA 92093.; Department of Chemistry and Biochemistry, University of California San Diego, La Jolla, CA 92093., Edsgärd D; Science for Life Laboratory, Department of Gene Technology, School of Engineering Sciences in Biotechnology, Chemistry and Health, KTH Royal Institute of Technology, Stockholm SE-100 44, Sweden., Emanuelsson O; Science for Life Laboratory, Department of Gene Technology, School of Engineering Sciences in Biotechnology, Chemistry and Health, KTH Royal Institute of Technology, Stockholm SE-100 44, Sweden., Gregorevic P; Centre for Muscle Research, Department of Anatomy and Physiology, School of Biomedical Sciences, The University of Melbourne, Parkville, VIC 3010, Australia., Westerblad H; Muscle Physiology, Department of Physiology and Pharmacology, Biomedicum, Karolinska Institutet, Stockholm SE-171 77, Sweden., Venckunas T; Institute of Sports Science and Innovations, Lithuanian Sports University, Kaunas 44221, Lithuania., Brazaitis M; Institute of Sports Science and Innovations, Lithuanian Sports University, Kaunas 44221, Lithuania., Kamandulis S; Institute of Sports Science and Innovations, Lithuanian Sports University, Kaunas 44221, Lithuania., Lanner JT; Molecular Muscle Physiology and Pathophysiology, Department of Physiology and Pharmacology, Biomedicum, Karolinska Institutet, Stockholm SE-171 77, Sweden., Teixeira AI; Nanomedicine and Spatial Biology, Department of Physiology and Pharmacology, Biomedicum, Karolinska, Stockholm SE-171 77, Sweden., Yeo GW; Department of Cellular and Molecular Medicine, University of California, San Diego, La Jolla, CA 92093.; Sanford Stem Cell Institute Innovation Center and Stem Cell Program, University of California San Diego, La Jolla, CA 92093.; Center for RNA Technologies and Therapeutics, University of California San Diego, La Jolla, CA 92093., Ruas JL; Molecular and Cellular Exercise Physiology, Department of Physiology and Pharmacology, Biomedicum, Karolinska Institutet, Stockholm SE-171 77, Sweden.; Department of Pharmacology and Stanley & Judith Frankel Institute for Heart & Brain Health, University of Michigan Medical School, Ann Arbor, MI 48109.

Publikováno v: Proceedings of the National Academy of Sciences of the United States of America [Proc Natl Acad Sci U S A] 2024 Aug 20; Vol. 121 (34), pp. e2319724121. Date of Electronic Publication: 2024 Aug 14.