Zobrazeno 1 - 10
of 19
pro vyhledávání: '"Duluxan Sritharan"'
Autor:
Ryan McNulty, Duluxan Sritharan, Seong Ho Pahng, Jeffrey P. Meisch, Shichen Liu, Melanie A. Brennan, Gerda Saxer, Sahand Hormoz, Adam Z. Rosenthal
Publikováno v:
Nature Microbiology. 8:934-945
Clonal bacterial populations rely on transcriptional variation across individual cells to produce specialized states that increase fitness. Understanding all cell states requires studying isogenic bacterial populations at the single-cell level. Here
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::8b7790a2f011c9822423c53a375f96e3
https://doi.org/10.1038/s41564-023-01348-4
https://doi.org/10.1038/s41564-023-01348-4
Publikováno v:
Proceedings of the National Academy of Sciences of the United States of America
Significance High-dimensional datasets are becoming increasingly prevalent in many scientific fields. A universal theme connecting these high-dimensional datasets is the ansatz that data points are constrained to lie on nonlinear low-dimensional mani
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::da5e461ad892a8d347c3def84086faf3
https://pubmed.ncbi.nlm.nih.gov/34272279
https://pubmed.ncbi.nlm.nih.gov/34272279
Autor:
Duluxan Sritharan, Daniel Jacobson, Albert C. Pan, Konstantin Yatsenko, Thomas M. Weinreich, David E. Shaw
Publikováno v:
Proceedings of the National Academy of Sciences of the United States of America
Significance Most proteins associate with other proteins to function, forming complexes that are central to almost all physiological processes. Determining the structures of these complexes and understanding how they associate are problems of fundame
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::7a0da1d4aeea97813a93921e5dc4448c
https://doi.org/10.1073/pnas.1815431116
https://doi.org/10.1073/pnas.1815431116
Clonal bacterial populations rely on transcriptional variation to differentiate into specialized cell states that increase the community’s fitness. Such heterogeneous gene expression is implicated in many fundamental microbial processes including s
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::f340fd12ed111508b02a6c05fd47e78e
https://doi.org/10.21203/rs.3.rs-322406/v1
https://doi.org/10.21203/rs.3.rs-322406/v1
Clonal bacterial populations rely on transcriptional variation to differentiate into specialized cell states that increase the community’s fitness. Such heterogeneous gene expression is implicated in many fundamental microbial processes including s
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::352d998c43fc55dc040dce8f738414b2
https://doi.org/10.1101/2021.03.10.434868
https://doi.org/10.1101/2021.03.10.434868
Autor:
Wei Chien Yuan, Yuko Fujiwara, Sahand Hormoz, Fernando G. Osorio, Stuart H. Orkin, Duluxan Sritharan, Sachin Patel, Priscilla Cheung, Fernando D. Camargo, Sarah Bowling, Alejo E. Rodriguez-Fraticelli, Bin E. Li, Maximilian Nguyen
Publikováno v:
Cell
Summary Tracing the lineage history of cells is key to answering diverse and fundamental questions in biology. Coupling of cell ancestry information with other molecular readouts represents an important goal in the field. Here, we describe the CRISPR
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::02ac1838e5a16acfca9b017f1b0ebafd
https://doi.org/10.1016/j.cell.2020.06.018
https://doi.org/10.1016/j.cell.2020.06.018
Autor:
Yuko Fujiwara, Alejo E. Rodriguez-Fraticelli, Fernando D. Camargo, Fernando G. Osorio, Stuart H. Orkin, Bin E. Li, Maximilian Nguyen, Sahand Hormoz, Duluxan Sritharan, Sachin Patel, Sarah Bowling, Priscilla Cheung
Tracing the lineage history of cells is key to answering diverse and fundamental questions in biology. Particularly in the context of stem cell biology, analysis of single cell lineages in their native state has elucidated novel fates and highlighted
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::066044fbdce4086f21eb58ad83e63c4b
Autor:
Sridevi V. Sarma, Duluxan Sritharan
Publikováno v:
IFAC Proceedings Volumes. 47:7505-7510
Networks consist of interacting components that often function together to achieve a particular goal. For example, in the human cortex, populations of neurons in different layers continuously communicate and encode information about the subject's env
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::ba595ffb09114859991ece7b9d978fa9
https://doi.org/10.3182/20140824-6-za-1003.00313
https://doi.org/10.3182/20140824-6-za-1003.00313
Autor:
Albert C. Pan, Daniel Jacobson, Thomas M. Weinreich, David E. Shaw, Duluxan Sritharan, Konstantin Yatsenko
Publikováno v:
Biophysical Journal. 114:557a
Despite the biological importance of protein-protein complexes, determining their structures and association mechanisms remains an outstanding challenge. Here, we report the results of atomic-level simulations in which we observed five protein-protei
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::4a3c2492a32bd87a1ee2f9bec2c42ae9
https://doi.org/10.1016/j.bpj.2017.11.3045
https://doi.org/10.1016/j.bpj.2017.11.3045
Publikováno v:
Frontiers in Neuroscience, Vol 9 (2015)
Frontiers in Neuroscience
Frontiers in Neuroscience
It has recently been proposed that the epileptic cortex is fragile in the sense that seizures manifest through small perturbations in the synaptic connections that render the entire cortical network unstable. Closed-loop therapy could therefore entai
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::0f2de7d195c4b2780601b585a75542b6
https://doi.org/10.3389/fnins.2015.00058
https://doi.org/10.3389/fnins.2015.00058