Zobrazeno 1 - 10
of 18
pro vyhledávání: '"Dulcie Lai"'
Publikováno v:
Harm Reduction Journal, Vol 16, Iss 1, Pp 1-7 (2019)
Abstract Purpose The availability of take home naloxone (THN) was increased for Canadians in 2016, including access to kits via pharmacies. Unlike typical over-the-counter (OTC) and prescription drugs, THN kits may be stored in non-standard condition
Externí odkaz:
https://doaj.org/article/02b8904dd4244bfa89047297bf705e85
Autor:
Marianne T Hopkins, Aaron M Khalid, Pei-Chun Chang, Karen C Vanderhoek, Dulcie Lai, Meghan D Doerr, Susan J Lolle
Publikováno v:
F1000Research, Vol 2 (2013)
Concern over the tremendous loss of genetic diversity among many of our most important crops has prompted major efforts to preserve seed stocks derived from cultivated species and their wild relatives. Arabidopsis thaliana propagates mainly by self-f
Externí odkaz:
https://doaj.org/article/6f77c648b58d4f428a7aebaabc52dbad
Autor:
Dulcie Lai, Meethila Gade, Edward Yang, Hyun Yong Koh, Jinfeng Lu, Nicole M Walley, Anne F Buckley, Tristan T Sands, Cigdem I Akman, Mohamad A Mikati, Guy M McKhann, James E Goldman, Peter Canoll, Allyson L Alexander, Kristen L Park, Gretchen K Von Allmen, Olga Rodziyevska, Meenakshi B Bhattacharjee, Hart G W Lidov, Hannes Vogel, Gerald A Grant, Brenda E Porter, Annapurna H Poduri, Peter B Crino, Erin L Heinzen
Publikováno v:
Brain
Post-zygotically acquired genetic variants, or somatic variants, that arise during cortical development have emerged as important causes of focal epilepsies, particularly those due to malformations of cortical development. Pathogenic somatic variants
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::b668f913d3777727e5607d37b9cf55d9
https://doi.org/10.1093/brain/awac117
https://doi.org/10.1093/brain/awac117
Autor:
Sattar Khoshkhoo, Yilan Wang, Yasmine Chahine, E. Zeynep Erson-Omay, Stephanie Robert, Emre Kiziltug, Eyiyemisi C. Damisah, Carol Nelson-Williams, Guangya Zhu, Wenna Kong, August Yue Huang, Edward Stronge, H. Westley Phillips, Brian H. Chhouk, Sara Bizzotto, Ming Hui Chen, Thiuni N. Adikari, Zimeng Ye, Tom Witkowski, Dulcie Lai, Nadine Lee, Julie Lokan, Ingrid E. Scheffer, Samuel F. Berkovic, Shozeb Haider, Michael S. Hildebrand, Edward Yang, Murat Gunel, Richard P. Lifton, R Mark Richardson, Ingmar Blümcke, Sanda Alexandrescu, Anita Huttner, Erin L. Heinzen, Jidong Zhu, Annapurna Poduri, Nihal DeLanerolle, Dennis D. Spencer, Eunjung Alice Lee, Christopher A. Walsh, Kristopher T. Kahle
ImportanceMesial temporal lobe epilepsy (MTLE) is the most common focal epilepsy subtype and is often refractory to anti-seizure medications. While most MTLE patients do not have pathogenic germline genetic variants, the contribution of post-zygotic
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::ecb85c906360f137538ac9a7adb0c28c
https://doi.org/10.1101/2022.12.23.22283854
https://doi.org/10.1101/2022.12.23.22283854
Autor:
Dulcie Lai, Meethila Gade, Edward Yang, Hyun Yong Koh, Nicole M. Walley, Anne F. Buckley, Tristan T. Sands, Cigdem I. Akman, Mohamad A. Mikati, Guy M. McKhann, James E. Goldman, Peter D. Canoll, Allyson L. Alexander, Kristen L. Park, Gretchen K. Von Allmen, Meenakshi B. Bhattacharjee, Hart G.W. Lidov, Hannes Vogel, Gerald A. Grant, Brenda E. Porter, Annapurna H. Poduri, Peter B. Crino, Erin L. Heinzen
Post-zygotically acquired genetic variants, or somatic variants, that arise during cortical development have emerged as important causes of focal epilepsies, particularly those due to malformations of cortical development. Pathogenic somatic variants
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::09d54f1a7b8a5e34586ff4179cebf388
https://doi.org/10.1101/2021.12.22.21267563
https://doi.org/10.1101/2021.12.22.21267563
Publikováno v:
Cellular Signalling. 52:12-22
WW domain-containing transcriptional regulator 1 (TAZ) is a transcriptional co-activator and effector of the Hippo signaling pathway. In certain breast cancer subtypes, Hippo signaling is dysregulated leading to activation of TAZ and altered expressi
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::a8126fa9f41d642220fccaa52c03562a
https://doi.org/10.1016/j.cellsig.2018.08.012
https://doi.org/10.1016/j.cellsig.2018.08.012
Publikováno v:
Harm Reduction Journal
Harm Reduction Journal, Vol 16, Iss 1, Pp 1-7 (2019)
Harm Reduction Journal, Vol 16, Iss 1, Pp 1-7 (2019)
Purpose The availability of take home naloxone (THN) was increased for Canadians in 2016, including access to kits via pharmacies. Unlike typical over-the-counter (OTC) and prescription drugs, THN kits may be stored in non-standard conditions, includ
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::b80fe4b4ebfc6fa90bd1ea1e9b3b49c2
https://doi.org/10.1186/s12954-019-0288-4
https://doi.org/10.1186/s12954-019-0288-4
Autor:
Xiaolong Yang, Ivette Valencia-Sama, Dulcie Lai, Yawei Hao, Yulei Zhao, Helena J. Janse van Rensburg
Publikováno v:
Journal of Biological Chemistry. 290:16906-16917
Transcriptional co-activator with a PDZ binding domain (TAZ) is a WW domain-containing transcriptional co-activator and a core component of an emerging Hippo signaling pathway that regulates organ size, tumorigenesis, metastasis, and drug resistance.
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::3501bec972182ee411088babb7b3c347
https://doi.org/10.1074/jbc.m115.642363
https://doi.org/10.1074/jbc.m115.642363
Autor:
Xiaolong Yang, Dulcie Lai
Publikováno v:
Cellular Signalling. 25:1720-1728
Since the metastatic progression of cancers is often fatal with limited treatment options, understanding the mechanism of metastasis is imperative for designing novel and targeted therapies. TAZ has been identified as a novel oncogene in both breast
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::10330a1b91ac65f77ba4c7276a5cea07
https://doi.org/10.1016/j.cellsig.2013.05.002
https://doi.org/10.1016/j.cellsig.2013.05.002
Publikováno v:
Cancer Research. 71:2728-2738
Taxol (paclitaxel) resistance represents a major challenge in breast cancer treatment. The TAZ (transcriptional co-activator with PDZ-binding motif) oncogene is a major component of the novel Hippo–LATS signaling pathway and a transcriptional coact
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::79e4dee145dec2a5491fe639c2e0de77
https://doi.org/10.1158/0008-5472.can-10-2711
https://doi.org/10.1158/0008-5472.can-10-2711