Zobrazeno 1 - 10 of 39 pro vyhledávání: '"Dulcie B. Schmidt"'
1
Tyrosine urea muscarinic acetylcholine receptor antagonists: Achiral quaternary ammonium groups
Autor: Peter T. Buckley, James J. Foley, Edward F. Webb, Roderick S. Davis, Dulcie B. Schmidt, Jakob Busch-Petersen, Michael Salmon, Jian Jin, Widdowson Katherine L, Kristen E. Belmonte, Henry M. Sarau, Yonghui Wang, Qi Jin, Palovich Michael R, Ann M. Bullion
Publikováno v: Bioorganic & Medicinal Chemistry Letters. 22:7087-7091
Tyrosine ureas had been identified as potent muscarinic receptor antagonists with promising in vivo activity. Controlling the stereochemistry of the chiral quaternary ammonium center had proved to be a serious issue for this series, however. Herein w
Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::9db888e1ae472f73545015f2383e6264
https://doi.org/10.1016/j.bmcl.2012.09.085
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2
Optimized procedures for producing biologically active chemokines
Autor: John J. Kerrigan, Dulcie B. Schmidt, James J. Foley, Abby J. Sukman, Tia Lewis, Patrick McDevitt, Kathleen T. Gallagher, Kyung O. Johanson, Robert S. Ames, James A. Fornwald, Taylor L. Graham, Matthew C. Burns, Quinn Lu, Xiaoyan Tang, Gerald E. Hunsberger
Publikováno v: Protein Expression and Purification. 65:251-260
We describe here two strategies to produce biologically active chemokines with authentic N-terminal amino acid residues. The first involves producing the target chemokine with an N-terminal 6×His-SUMO tag in Escherichia coli as inclusion bodies. The
Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::951418dee127686dd1f484c032678731
https://doi.org/10.1016/j.pep.2009.01.017
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3
Vasopressin antagonist analogs modified at position 7
Autor: Dulcie B. Schmidt, William F. Huffman, Jeanne McDONALD, F L Stassen, Heidemarie Greene, James S. Stefankiewicz, L Sulat, Michael L. Moore, Daryl Ashton-Shue, Grace Heckman, L. B. Kinter
Publikováno v: International Journal of Peptide and Protein Research. 28:379-385
Vasopressin antagonist analogs having alanine or glycine at position 7 were essentially equipotent with analogs with proline, N-methylalanine or sarcosine at position 7. This demonstrates that the conformational constraint imposed by an N-alkyl resid
Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::719e46358f9622eff3427762033f152f
https://doi.org/10.1111/j.1399-3011.1986.tb03269.x
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4
Camphor sulfonamide derivatives as novel, potent and selective CXCR3 antagonists
Autor: Henry M. Sarau, Feng Wang, Gerald E. Hunsberger, Elizabeth A. Capper-Spudich, Ralph A. Rivero, James J. Foley, Yonghui Wang, Zheng Yang, Laura S. Fisher, Todd L. Graybill, Michael S. McQueney, Jian Jin, Widdowson Katherine L, Zining Wu, Dulcie B. Schmidt, Terence J. Kiesow, Jakob Busch-Petersen
Publikováno v: Bioorganic & Medicinal Chemistry Letters. 19:114-118
A series of N-arylpiperazine camphor sulfonamides was discovered as novel CXCR3 antagonists. The synthesis, structure–activity relationships, and optimization of the initial hit that resulted in the identification of potent and selective CXCR3 anta
Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::ff022de9cf3c289d1a821663993332c2
https://doi.org/10.1016/j.bmcl.2008.11.008
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7
Aminoalkoxybenzyl pyrrolidines as novel human urotensin-II receptor antagonists
Autor: Jian Jin, Widdowson Katherine L, Dashyant Dhanak, Dulcie B. Schmidt, Henry M. Sarau, Nambi Aiyar, Richard M. Keenan, Stephen A. Douglas, Carl D. Bennett, Steven D. Knight, James J. Foley, Ralph A. Rivero, Diane Naselsky, Gregory L. Warren, Bing Wang, Michael L. Moore
Publikováno v: Bioorganic & Medicinal Chemistry Letters. 15:3229-3232
High throughput screening of the corporate compound collection led to the discovery of a novel series of substituted aminoalkoxybenzyl pyrrolidines as human urotensin-II receptor antagonists. The synthesis, initial structure-activity relationships, a
Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::4ae96515c41082ffce2c76c7a5f02392
https://doi.org/10.1016/j.bmcl.2005.04.074
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10
Identification of Potent, Selective Non-peptide CC Chemokine Receptor-3 Antagonist That Inhibits Eotaxin-, Eotaxin-2-, and Monocyte Chemotactic Protein-4-induced Eosinophil Migration
Autor: Widdowson Katherine L, James J. Foley, Judithann M. Lee, James A. Fornwald, Michael G. Darcy, Lisa T. Christmann, George K. Chan, Dulcie B. Schmidt, Christina S. Imburgia, John R. White, Anthony J. Jurewicz, Dashyant Dhanak, Kimberly A. Dede, Henry M. Sarau
Publikováno v: Journal of Biological Chemistry. 275:36626-36631
Eosinophils have been implicated in the pathogenesis of asthma and other allergic diseases. Several CC chemokines including eotaxin (CCL-11), eotaxin-2 (CCL-24), RANTES (CCL-5), and monocyte chemotactic protein-3 (MCP-3, CCL-7) and 4 (MCP-4, CCL-13)
Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::8daa4cc7bb08f9b79d59dfbc2f4db82d
https://doi.org/10.1074/jbc.m006613200
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