Deep learning for Alzheimer's disease: Mapping large-scale histological tau protein for neuroimaging biomarker validation

Autor: Daniela Ushizima, Yuheng Chen, Maryana Alegro, Dulce Ovando, Rana Eser, WingHung Lee, Kinson Poon, Anubhav Shankar, Namrata Kantamneni, Shruti Satrawada, Edson Amaro Junior, Helmut Heinsen, Duygu Tosun, Lea T. Grinberg

Publikováno v: NeuroImage, Vol 248, Iss , Pp 118790- (2022)

Abnormal tau inclusions are hallmarks of Alzheimer's disease and predictors of clinical decline. Several tau PET tracers are available for neurodegenerative disease research, opening avenues for molecular diagnosis in vivo. However, few have been app

Externí odkaz: https://doaj.org/article/20a536662d554a8788d68002459bc1ac

iPSC-Induced Neurons with the V337M MAPT Mutation are Selectively Vulnerable to Caspase-Mediated Cleavage of Tau and Apoptotic Cell Death

Autor: Rakez Kayed, Chao Wang, Celeste M. Karch, Jason E. Gestwicki, Michelle R. Arkin, Panos Theofilas, Lea T. Grinberg, Andrew J. Ambrose, Dulce Ovando Morales, Li Gan, Bruce L. Miller, David Butler, Teddy Yang, Raymond T. Ng, Sally Temple, Shireen Khan, Brian Chin, Cathrine Petersen

Background: Tau post-translational modifications (PTMs) are associated with progressive tau accumulation and neuronal loss in tauopathies, including forms of frontotemporal lobar degeneration (FTLD) and Alzheimer’s disease (AD). Tau proteolysis by

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::404b55427bd86a0ff720adc50282f155
https://doi.org/10.21203/rs.3.rs-300172/v1

Large scale, voxel‐to‐voxel correlation analysis of tau positron emission tomography signal to histological pathology in non‐Alzheimer tauopathies

Autor: Rana Eser, Dulce Ovando Morales, Stefano Colmignoli, Anubhav Shankar, Lea T. Grinberg, Kinsoon Poon, Renaud La Joie, Alex Burr, Gil D. Rabinovici, Maryana Alegro, Wing Hung Lee, Namrata Kantamneni, Bruce L. Miller, Yuheng Chen

Publikováno v: Alzheimer's & Dementia. 16

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_________::0de42a3768ebc1ce058a87bbad7ab8c4
https://doi.org/10.1002/alz.046332

Deep Learning for Alzheimer’s Disease: Mapping Large-scale Histological Tau Protein for Neuroimaging Biomarker Validation

Autor: Dulce Ovando, Daniela Ushizima, Lea T. Grinberg, Duygu Tosun, Rana Eser, Yuheng Chen, Helmut Heinsen, Maryana Alegro

Deposits of abnormal tau protein inclusions in the brain are a pathological hallmark of Alzheimer’s disease (AD), and are the best predictor of neuronal loss and clinical decline, but have been limited to postmortem assessment. Imaging-based biomar

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_________::50a83992c5df3de1e449f670f6529527
https://doi.org/10.1101/698902

Profound degeneration of wake-promoting neurons in Alzheimer’s disease

Autor: Jun Oh, Helmut Heinsen, Jessica Kudlacek, William W. Seeley, Celica Cosme, Christine M. Walsh, Elisa de Paula França Resende, Thomas C. Neylan, Eduardo Joaquim Lopes Alho, Jackson C. Bittencourt, Rana Eser, Dulce Ovando Morales, Salvatore Spina, Bruce L. Miller, Cathrine Petersen, Lea T. Grinberg, Alexander J. Ehrenberg, Sara R. Dunlop, Panos Theofilas

Publikováno v: Repositório Institucional da USP (Biblioteca Digital da Produção Intelectual)
Universidade de São Paulo (USP)
instacron:USP
Alzheimers Dement

Introduction Sleep-wake disturbances are a common and early feature in Alzheimer's disease (AD). The impact of early tau pathology in wake-promoting neurons (WPNs) remains unclear. Methods We performed stereology in postmortem brains from AD individu

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::e55cefe8e63e6ed702b5c50cd3070139