Zobrazeno 1 - 10 of 22 pro vyhledávání: '"Dulce Fontoura"'
1
Akademický článek
Myocardial and anti-inflammatory effects of chronic bosentan therapy in monocrotaline-induced pulmonary hypertension
Autor: Dulce Fontoura, José Oliveira-Pinto, Marta Tavares-Silva, Sara Leite, Francisco Vasques-Nóvoa, Pedro Mendes-Ferreira, André P. Lourenço, Adelino F. Leite-Moreira
Publikováno v: Revista Portuguesa de Cardiologia, Vol 33, Iss 4, Pp 213-222 (2014)
Introduction and Objectives: Endothelin-1 antagonists are increasingly used in the treatment of pulmonary hypertension despite the lack of knowledge of their myocardial and systemic effects. We assessed the right ventricular myocardial and systemic e
Externí odkaz: https://doaj.org/article/76ae2c75c6de4342be666a6501600127
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2
Akademický článek
Characterization of liver changes in ZSF1 rats, an animal model of metabolic syndrome
Autor: Marta Borges-Canha, José Pedro Portela-Cidade, Glória Conceição, Cláudia Sousa-Mendes, Sara Leite, Dulce Fontoura, Daniel Moreira-Gonçalves, Inês Falcão-Pires, André Lourenço, Adelino Leite-Moreira, Pedro Pimentel-Nunes
Publikováno v: Revista Espanola de Enfermedades Digestivas, Vol 109, Iss 7, Pp 491-497
Background: The non-alcoholic fatty liver disease is the hepatic counterpart of the metabolic syndrome. ZSF1 rats are a metabolic syndrome animal model in which liver changes have not been described yet. Aim: The characterization of liver histologica
Externí odkaz: https://doaj.org/article/0359482c0f864cdda21734cac65a4eba
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3
Chronic Sildenafil Therapy in the ZSF1 Obese Rat Model of Metabolic Syndrome and Heart Failure With Preserved Ejection Fraction
Autor: Liliana Moreira-Costa, Francisco Vasques-Nóvoa, Dulce Fontoura, António Angélico-Gonçalves, Rui J Cerqueira, Cláudia Sousa-Mendes, André P. Lourenço, Sara Leite, Adelino F. Leite-Moreira
Publikováno v: Journal of Cardiovascular Pharmacology and Therapeutics. 26:690-701
Although decreased protein kinase G (PKG) activity was proposed as potential therapeutic target in heart failure with preserved ejection fraction (HFpEF), randomized clinical trials (RCTs) with type-5 phosphodiesterase inhibitors (PDE5i) showed neutr
Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::bf77da945caa823e0d43e884069ed2a2
https://doi.org/10.1177/10742484211034253
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5
RF36 | PSUN101 Liver and Adipose Tissue Effects of Triiodothyronine Treatment in an Animal Model of Metabolic Syndrome
Autor: Marta Borges Canha, João Sérgio Neves, Clãudia Sousa-Mendes, Glória Conceição, Ana Rita Leite, von-Hafe Madalena, Catarina Vale, Dulce Fontoura, Daniela Miranda-Silva, Sara Leite, Alexandre Gonçalves, João Almeida-Coelho, Inês Falcão-Pires, Davide Carvalho, Adelino Leite-Moreira, André Lourenço
Publikováno v: Journal of the Endocrine Society. 6:A38-A38
Introduction Metabolic syndrome (MS) associates to obesity and non-alcoholic fatty liver disease (NAFLD). Besides its high and rising prevalence, the therapeutical options are scarce. Studies show that thyroid hormones (TH) may ameliorate hepatic fun
Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_________::8e3f40837e5199ecc07706d419a4becd
https://doi.org/10.1210/jendso/bvac150.078
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6
In vitro model to study the effects of matrix stiffening on Ca2+ handling and myofilament function in isolated adult rat cardiomyocytes
Autor: Elza D. van Deel, Kim Kardux, Inês Falcão-Pires, Dulce Fontoura, Max Goebel, Jolanda van der Velden, Aref Najafi, Erik T. Valent
Publikováno v: The Journal of Physiology. 595:4597-4610
Key points This paper describes a novel model that allows exploration of matrix-induced cardiomyocyte adaptations independent of the passive effect of matrix rigidity on cardiomyocyte function. Detachment of adult cardiomyocytes from the matrix enabl
Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_________::13ebc1b2eff2950ba2a4a90dcaacb6c2
https://doi.org/10.1113/jp274460
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7
Arterial Remodeling and Dysfunction in the ZSF1 Rat Model of Heart Failure With Preserved Ejection Fraction
Autor: Faiez Zannad, André P. Lourenço, Inês Falcão-Pires, Jaime Ibarrola, Adelino F. Leite-Moreira, Amaya Fernández-Celis, Dulce Fontoura, Natalia López-Andrés, Patrick Rossignol, Sara Leite, Rui J Cerqueira, Walter Paulus
Publikováno v: Circulation. Heart failure
Circulation. Heart failure, Lippincott Williams & Wilkins, 2019, 12 (7), ⟨10.1161/CIRCHEARTFAILURE.118.005596⟩
Circulation. Heart failure, Lippincott Williams & Wilkins, 2019, 12 (7), pp.e005596. ⟨10.1161/CIRCHEARTFAILURE.118.005596⟩
Circulation. Heart failure, 12(7):e005596. Lippincott Williams and Wilkins
Leite, S, Cerqueira, R J, Ibarrola, J, Fontoura, D, Fernández-Celis, A, Zannad, F, Falcão-Pires, I, Paulus, W J, Leite-Moreira, A F, Rossignol, P, López-Andrés, N & Lourenço, A P 2019, ' Arterial Remodeling and Dysfunction in the ZSF1 Rat Model of Heart Failure With Preserved Ejection Fraction ', Circulation. Heart failure, vol. 12, no. 7, e005596 . https://doi.org/10.1161/CIRCHEARTFAILURE.118.005596
Background: The interplay between the stiffened heart and vessels has long been viewed as a core mechanism in heart failure with preserved ejection fraction, but the incremental vascular molecular remodeling mechanisms from systemic arterial hyperten
Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::51ad8af7abc1c19ad5181f96c1e75088
https://hal.univ-lorraine.fr/hal-02512483
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8
Early myocardial changes induced by doxorubicin in the nonfailing dilated ventricle
Autor: Dulce Fontoura, Adelino F. Leite-Moreira, Cláudia Sousa-Mendes, Fábio Trindade, Cláudia Moura, Sofia M. Costa, Nazha Hamdani, Daniela Miranda-Silva, Inês Falcão-Pires, Maria J. Mendes, Wolfgang A. Linke, Patrícia Rodrigues, Rui Vitorino, Carla Barros
Publikováno v: American journal of physiology. Heart and circulatory physiology. 316(3)
Several studies have demonstrated that administration of doxorubicin (DOXO) results in cardiotoxicity, which eventually progresses to dilated cardiomyopathy. The present work aimed to evaluate the early myocardial changes of DOXO-induced cardiotoxici
Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::0b3775db6aa86c631d72b65797e5f095
https://pubmed.ncbi.nlm.nih.gov/30525890
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