Role of the epithelial barrier in intestinal fibrosis associated with inflammatory bowel disease: relevance of the epithelial-to mesenchymal transition

Autor: Dulce C. Macias-Ceja, M. Teresa Mendoza-Ballesteros, María Ortega-Albiach, M. Dolores Barrachina, Dolores Ortiz-Masià

Publikováno v: Frontiers in Cell and Developmental Biology, Vol 11 (2023)

In inflammatory bowel disease (IBD), chronic inflammation in the gastrointestinal tract can lead to tissue damage and remodelling, which can ultimately result in fibrosis. Prolonged injury and inflammation can trigger the activation of fibroblasts an

Externí odkaz: https://doaj.org/article/84f1fe7bc75f4e7fbd81ce2727527f54

IFNγ-Treated Macrophages Induce EMT through the WNT Pathway: Relevance in Crohn’s Disease

Autor: Dulce C. Macias-Ceja, Sandra Coll, Cristina Bauset, Marta Seco-Cervera, Laura Gisbert-Ferrándiz, Francisco Navarro, Jesus Cosin-Roger, Sara Calatayud, María D. Barrachina, Dolores Ortiz-Masia

Publikováno v: Biomedicines, Vol 10, Iss 5, p 1093 (2022)

Background: Fibrosis is a common complication of Crohn’s disease (CD) in which macrophages play a central role. Epithelial-mesenchymal transition (EMT) and the WNT pathway have been associated with fibrosis. We aim to analyse the relevance of the t

Externí odkaz: https://doaj.org/article/e012280dc62d4b5899a82b3b91e4f070

Autophagy Stimulation as a Potential Strategy Against Intestinal Fibrosis

Autor: Jesus Cosin-Roger, Francisco Canet, Dulce C. Macias-Ceja, Laura Gisbert-Ferrándiz, Dolores Ortiz-Masiá, Juan V. Esplugues, Rafael Alós, Francisco Navarro, María D. Barrachina, Sara Calatayud

Publikováno v: Cells, Vol 8, Iss 9, p 1078 (2019)

We recently observed reduced autophagy in Crohn’s disease patients and an anti-inflammatory effect of autophagy stimulation in murine colitis, but both anti- and pro-fibrotic effects are associated with autophagy stimulation in different tissues, a

Externí odkaz: https://doaj.org/article/074139a40f7940c183bfa536a41ae251

IFNγ-treated macrophages induce EMT through the WNT pathway: relevance in Crohn´s disease

Autor: Dulce C Macias-Ceja, Sandra Coll, Cristina Bauset, Marta Seco-Cervera, Francisco Navarro, Jesus Cosin-Roger, Sara Calatayud, Maria D Barrachina, Dolores Ortiz-Masia

Supplementary material of the article

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_________::6e05e12909a6230eb07ce2caa5d5ae8b

WNT2b activates epithelial-mesenchymal transition through FZD4: relevance in penetrating Crohns disease

Autor: Jesus Cosin-Roger, Sara Calatayud, Céline Mamie, Dolores Ortiz-Masiá, P Salvador, J. Manyé, L Gisbert-Ferrándiz, Francisco Navarro-Vicente, Dulce C Macias-Ceja, Maria D. Barrachina, Juan V. Esplugues, Michael Scharl, Rafael Alós

Publikováno v: Journal of Crohn's & colitis
r-INCLIVA. Repositorio Institucional de Producción Científica de INCLIVA
instname
JOURNAL OF CROHNS & COLITIS
r-IGTP: Repositorio Institucional de Producción Científica del Instituto de Investigación Germans Trias i Pujol
r-IGTP. Repositorio Institucional de Producción Científica del Instituto de Investigación Germans Trias i Pujol
Universidad de Alicante (UA)
r-FISABIO. Repositorio Institucional de Producción Científica
r-FISABIO: Repositorio Institucional de Producción Científica
Fundación para el Fomento de la Investigación Sanitaria y Biomédica de la Comunitat Valenciana (FISABIO)

Background and Aims Epithelial-mesenchymal transition [EMT] has been related to fibrosis and fistula formation, common complications associated with Crohn´s disease [CD]. The WNT signalling pathway mediates EMT, and specific WNT/FZD interactions hav

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::0a94c73286d7bb4cc08e86d7d292f02d
https://www.fundanet.incliva.es/publicaciones/ProdCientif/PublicacionFrw.aspx?id=3965