Zobrazeno 1 - 5
of 5
pro vyhledávání: '"Dulce C. Guzmán‐Ocampo"'
Publikováno v:
mBio, Vol 14, Iss 6 (2023)
ABSTRACTThe dynamin-like protein DnmA and its receptor FisA are essential for mitochondrial division in the fungus Aspergillus nidulans. Our research has demonstrated that H2O2 triggers significant changes in mitochondrial morphology, including const
Externí odkaz:
https://doaj.org/article/fd27d99f410a4b4682338f66793edd1d
Autor:
Dulce C. Guzmán-Ocampo, Rodrigo Aguayo-Ortiz, José-Luis Velasco-Bolom, Pancham Lal Gupta, Adrian E. Roitberg, Laura Dominguez
Publikováno v:
ACS chemical neuroscience.
γ-Secretase (GS) is an intramembrane aspartyl protease that participates in the sequential cleavage of C99 to generate different isoforms of the amyloid-β (Aβ) peptides that are associated with the development of Alzheimer's disease. Due to its im
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::bcb937aa6e61094989bb50e633ed6f87
https://pubmed.ncbi.nlm.nih.gov/36562727
https://pubmed.ncbi.nlm.nih.gov/36562727
Publikováno v:
ACS Chemical Neuroscience. 12:2765-2775
γ-Secretase (GS) is one of the most attractive molecular targets for the treatment of Alzheimer's disease (AD). Its key role in the final step of amyloid-β peptides generation and its relationship in the cascade of events for disease development ha
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::089e7c1f80c30fc30f072731f829ae0e
https://doi.org/10.1021/acschemneuro.1c00313
https://doi.org/10.1021/acschemneuro.1c00313
Publikováno v:
Biophysical chemistry. 282
Crystallin aggregation in the eye lens is one of the leading causes of cataract formation. The increase in the human γD-crystallin (HγDC) aggregation propensity has been associated with the oligomerization of its partially folded and fully unfolded
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::0624d633580e9d41c04b9ef88707b072
https://pubmed.ncbi.nlm.nih.gov/34999344
https://pubmed.ncbi.nlm.nih.gov/34999344
Publikováno v:
ChemMedChem. 14(10)
DAPT is a potent γ-secretase (GS) inhibitor that blocks the production of short amyloid-β (Aβ) peptides. Aggregation and oligomerization of Aβ peptides have been associated with the development and progression of Alzheimer's disease. A recent cry
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::b6bebff7754df71e07f82eb42bd6cf9f
https://pubmed.ncbi.nlm.nih.gov/30925201
https://pubmed.ncbi.nlm.nih.gov/30925201