Zobrazeno 1 - 10
of 57
pro vyhledávání: '"Dukka B, Kc"'
Autor:
Anthony E. Postiglione, Laquaundra L. Adams, Ese S. Ekhator, Anuoluwapo E. Odelade, Supriya Patwardhan, Meenal Chaudhari, Avery S. Pardue, Anjali Kumari, William A. LeFever, Olivia P. Tornow, Tamer S. Kaoud, Johnathan Neiswinger, Jun Seop Jeong, Derek Parsonage, Kimberly J. Nelson, Dukka B. Kc, Cristina M. Furdui, Heng Zhu, Andrew J. Wommack, Kevin N. Dalby, Ming Dong, Leslie B. Poole, Jeremiah D. Keyes, Robert H. Newman
Publikováno v:
iScience, Vol 26, Iss 10, Pp 107817- (2023)
Summary: Extracellular signal-regulated kinases 1 and 2 (ERK1/2) are dysregulated in many pervasive diseases. Recently, we discovered that ERK1/2 is oxidized by signal-generated hydrogen peroxide in various cell types. Since the putative sites of oxi
Externí odkaz:
https://doaj.org/article/f86f308d6824464da8ac7565dac3a50d
Publikováno v:
Scientific Reports, Vol 13, Iss 1, Pp 1-10 (2023)
Abstract With the technological advancement in recent years and the widespread use of magnetism in every sector of the current technology, a search for a low-cost magnetic material has been more important than ever. The discovery of magnetism in alte
Externí odkaz:
https://doaj.org/article/5bcc573242f2407f8f5c5accd787e5f7
Publikováno v:
BMC Bioinformatics, Vol 24, Iss 1, Pp 1-20 (2023)
Abstract Background Protein S-nitrosylation (SNO) plays a key role in transferring nitric oxide-mediated signals in both animals and plants and has emerged as an important mechanism for regulating protein functions and cell signaling of all main clas
Externí odkaz:
https://doaj.org/article/24358939c36148d098270c815601afab
Publikováno v:
Scientific Reports, Vol 12, Iss 1, Pp 1-13 (2022)
Abstract Protein succinylation is an important post-translational modification (PTM) responsible for many vital metabolic activities in cells, including cellular respiration, regulation, and repair. Here, we present a novel approach that combines fea
Externí odkaz:
https://doaj.org/article/05ba5159bed749beae6d1133d9a0744b
Publikováno v:
Scientific Reports, Vol 12, Iss 1, Pp 1-9 (2022)
Abstract In classical machine learning, regressors are trained without attempting to gain insight into the mechanism connecting inputs and outputs. Natural sciences, however, are interested in finding a robust interpretable function for the target ph
Externí odkaz:
https://doaj.org/article/9d497d01f018470c9496c874a3d35cdd
Autor:
Niraj Thapa, Meenal Chaudhari, Anthony A. Iannetta, Clarence White, Kaushik Roy, Robert H. Newman, Leslie M. Hicks, Dukka B. KC
Publikováno v:
Scientific Reports, Vol 11, Iss 1, Pp 1-12 (2021)
Abstract Protein phosphorylation, which is one of the most important post-translational modifications (PTMs), is involved in regulating myriad cellular processes. Herein, we present a novel deep learning based approach for organism-specific protein p
Externí odkaz:
https://doaj.org/article/763a7ff34700418ebf40a11c4465bd6e
Publikováno v:
Sensors, Vol 23, Iss 8, p 3983 (2023)
Older adults are more vulnerable to falling due to normal changes due to aging, and their falls are a serious medical risk with high healthcare and societal costs. However, there is a lack of automatic fall detection systems for older adults. This pa
Externí odkaz:
https://doaj.org/article/ddc3b8ca62784d6ba96cccf0bb0f7c2d
Autor:
Niraj Thapa, Meenal Chaudhari, Sean McManus, Kaushik Roy, Robert H. Newman, Hiroto Saigo, Dukka B. KC
Publikováno v:
BMC Bioinformatics, Vol 21, Iss S3, Pp 1-10 (2020)
Abstract Background Protein succinylation has recently emerged as an important and common post-translation modification (PTM) that occurs on lysine residues. Succinylation is notable both in its size (e.g., at 100 Da, it is one of the larger chemical
Externí odkaz:
https://doaj.org/article/4917ff7995944b89bb81b388a0ebb863
Autor:
Niraj Thapa, Meenal Chaudhari, Sean McManus, Kaushik Roy, Robert H. Newman, Hiroto Saigo, Dukka B. KC
Publikováno v:
BMC Bioinformatics, Vol 23, Iss 1, Pp 1-2 (2022)
Externí odkaz:
https://doaj.org/article/bfff90fc476949559138d89a3f3ba307
Autor:
Meenal Chaudhari, Niraj Thapa, Hamid Ismail, Sandhya Chopade, Doina Caragea, Maja Köhn, Robert H. Newman, Dukka B. KC
Publikováno v:
Frontiers in Cell and Developmental Biology, Vol 9 (2021)
Phosphorylation, which is mediated by protein kinases and opposed by protein phosphatases, is an important post-translational modification that regulates many cellular processes, including cellular metabolism, cell migration, and cell division. Due t
Externí odkaz:
https://doaj.org/article/4eebbf72686d46dfbd129369cb4b0c41