Výsledky vyhledávání - "Dukhanina Ea"

Thapsigargin, Inhibitor of Sarco-Endoplasmic Ca2+-ATPase, Effectively Suppresses the Expression of S100A4 Protein in Human Breast Cancer Cell Line

Autor: T. N. Portseva, E V Pankratova, B. M. Lyanova, Dukhanina Ea, Yu. V. Ilyin, A. P. Kotnova, A G Stepchenko, Sofia G. Georgieva

Publikováno v: Doklady Biochemistry and Biophysics. 486:181-183

Thapsigargin, the SERCA ATPase inhibitor, effectively suppresses the expression of metastasis marker S100A4 in breast cancer cells MDA-MB231. It has been demonstrated that transcription of the S100A4 gene is controlled by Ca 2+ -signaling pathways. I

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_________::e846d6f1a4f82a718d4660045eb7a3c7
https://doi.org/10.1134/s1607672919030050

Zobrazit plný text záznamu

The Expression Level of S100A4 Protein Affects the Migration Activity of Breast Cancer Cells

Autor: T. N. Portseva, Sofia G. Georgieva, E V Pankratova, A. P. Kotnova, Dukhanina Ea

Publikováno v: Doklady Biochemistry and Biophysics. 485:104-106

Reduced expression of S100A4 protein metastasis marker in tripletnegative breast cancer cells (BC) MDA MB 231 leads to a decrease in the migratory ability of cells and increases the sensitivity of modified cells to docetaxel therapy. Cells capable of

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::81551313bb6ec90f126862bdc3b955ba
https://doi.org/10.1134/s1607672919020030

Zobrazit plný text záznamu

Oct-1 modifies S100A4 exchange between intra- and extracellular compartments in Namalwa cells and increases their sensitivity to glucocorticoids

Autor: Natalia V. Soshnikova, A. S. Dukhanin, T. N. Portseva, A G Stepchenko, Sofia G. Georgieva, E V Pankratova, Dukhanina Ea

Publikováno v: Cell Cycle. 15:1471-1478

S100A4, a small intra- and extracellular Ca(2+)-binding protein, is involved in tumor progression and metastasis with S100A4 level shown to be correlated with tumor cells metastatic potential. Simultaneously, Octamer transcription factor 1 (Oct-1) re

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::ddfd44873a3f19c66d2bd0eae56e3583
https://doi.org/10.1080/15384101.2016.1175260

Zobrazit plný text záznamu

The role of S100A4 protein in anticancer cytotoxicity: its presence is required on the surface of CD4+CD25+PGRPs+S100A4+ lymphocyte and undesirable on the surface of target cells

Autor: A. S. Dukhanin, Sofia G. Georgieva, Dukhanina Ea, T. I. Luk’yanova

S100A4 is a Ca2+-binding protein that performs an important role in metastasis. It is also known for its antitumor functions. S100A4 is expressed by a specialized subset of CD4+CD25+ lymphocytes and is present on those cell's membranes along with pep

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::cf87ba11fd8dd7033bdffa87fecf3171
https://europepmc.org/articles/PMC5927690/

Zobrazit plný text záznamu

Combined Action of PGRPs-Hsp70 Cytotoxic Complex with Paclitaxel Improves Outcomes of Melanoma Treatment in Mice

Autor: Sofia G. Georgieva, T. I. Luk’yanova, A. S. Dukhanin, Dukhanina Ea

Publikováno v: Bulletin of experimental biology and medicine. 164(5)

We studied the effect of PGRPs-Hsp70 cytotoxic complex that is analogous to natural complex secreted by cytotoxic lymphocytes and the antitumor drug paclitaxel on the development of M3 melanoma in DBA mice. Significant inhibition of tumor growth was

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::1a15a554325b0f007daa1dbe97823327
https://pubmed.ncbi.nlm.nih.gov/29577187

Zobrazit plný text záznamu

The Heat Shock-binding Protein (HspBP1) Protects Cells against the Cytotoxic Action of the Tag7-Hsp70 Complex

Autor: Vince Guerriero, Deborah A. Raynes, E. A. Romanova, Olga D. Kabanova, Nikolai V. Gnuchev, Georgii P. Georgiev, Denis V. Yashin, Alexsander G. Tonevitskii, Dukhanina Ea, Tamara I. Lukyanova, Lidia P. Sashchenko

Publikováno v: Journal of Biological Chemistry. 286:10258-10264

Heat shock-binding protein HspBP1 is a member of the Hsp70 co-chaperone family. The interaction between HspBP1 and the ATPase domain of the major heat shock protein Hsp70 up-regulates nucleotide exchange and reduces the affinity between Hsp70 and the

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::d34d9bf3af80d090291d0e0b7a6e6c9d
https://doi.org/10.1074/jbc.m110.163436

Zobrazit plný text záznamu

Cytotoxic T lymphocytes carrying a pattern recognition protein Tag7 can detect evasive, HLA-negative but Hsp70-exposing tumor cells, thereby ensuring FasL/Fas-mediated contact killing

Autor: Lidia P. Sashchenko, Olga D. Kabanova, Georgii P. Georgiev, E. A. Romanova, Alexander V. Galkin, Dukhanina Ea, Yury V. Shatalov, Nikolai V. Gnuchev, S. V. Khaidukov, Tamara I. Lukyanova, Denis V. Yashin

Publikováno v: Blood. 110:1997-2004

Within the broad problem of host immune surveillance versus tumor immune evasion, a most intriguing question is how the cellular immunity can cope with cancerous cells that have gotten rid of the classical antigen-presenting machinery. One such optio

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::aae897af8b1b1f365f83f456a0dc416e
https://doi.org/10.1182/blood-2006-12-064444

Zobrazit plný text záznamu

A new role for PGRP-S (Tag7) in immune defense: lymphocyte migration is induced by a chemoattractant complex of Tag7 with Mts1

Autor: Denis V. Yashin, T. I. Luk’yanova, Dukhanina Ea, E. A. Romanova, Lidia P. Sashchenko, Georgii P. Georgiev, Vince Guerriero, N. V. Gnuchev

Publikováno v: Cell cycle (Georgetown, Tex.). 14(22)

PGRP-S (Tag7) is an innate immunity protein involved in the antimicrobial defense systems, both in insects and in mammals. We have previously shown that Tag7 specifically interacts with several proteins, including Hsp70 and the calcium binding protei

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::0bbb21d66d6c2f69cf905172c4fdb455
https://pubmed.ncbi.nlm.nih.gov/26654597

Zobrazit plný text záznamu

Tag7 (PGLYRP1) in Complex with Hsp70 Induces Alternative Cytotoxic Processes in Tumor Cells via TNFR1 Receptor

Autor: Dukhanina Ea, Alexander G. Tonevitsky, Anton A. Sheludchenkov, Nikolai V. Gnuchev, E. A. Romanova, Georgii P. Georgiev, Olga K. Ivanova, Natalia V. Soshnikova, Lidia P. Sashchenko, Denis V. Yashin, Alexander G. Gabibov

Publikováno v: The Journal of biological chemistry. 290(35)

Tag7 (also known as peptidoglycan recognition protein PGRP-S, PGLYRP1), an innate immunity protein, interacts with Hsp70 to form a stable Tag7-Hsp70 complex with cytotoxic activity against some tumor cell lines. In this study, we have analyzed the pr

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::b0bccc152bf0d37636cb20be23153ef7
https://pubmed.ncbi.nlm.nih.gov/26183779

Zobrazit plný text záznamu

Nonlymphoid cultured cells possess a system controlling cellular compatibility

Autor: E. S. Ioudinkova, Nikolai V. Gnuchev, Olga V. Iarovaia, Olga D. Kabanova, Dukhanina Ea, Tamara I. Lukianova, Sergey V. Razin, Lidia P. Sashchenko

Publikováno v: Journal of Cellular Biochemistry. 78:186-196

We show that various nonlymphoid cultured cells can activate the production of cytotoxic factors in response to direct contact with cells of a different kind. Accumulation of cytotoxic factors in the medium was detected 1 h after contact of K562 and

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_________::403e90fa9f259c2ff0882a60940f4578
https://doi.org/10.1002/(sici)1097-4644(20000801)78:2<186::aid-jcb2>3.0.co

Zobrazit plný text záznamu

Vyhledávací nástroje:

Upřesnit hledání