Zobrazeno 1 - 10
of 15
pro vyhledávání: '"Duke Virca"'
Autor:
Viktor Magdolen, Valérie Gratio, Mekdes Debela, Dalila Darmoul, Josefine Maier, G. Duke Virca, Nathalie Beaufort, Nicolai Grebenchtchikov, Lina Seiz
Publikováno v:
The American Journal of Pathology. 176:1452-1461
Certain serine proteases are considered to be signaling molecules that act through protease-activated receptors (PARs). Our recent studies have implicated PAR1 and PAR4 (thrombin receptors) and PAR2 (trypsin receptor) in human colon cancer growth. He
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::76585fe62974b1ec5a165a2cf0be6faf
https://doi.org/10.2353/ajpath.2010.090523
https://doi.org/10.2353/ajpath.2010.090523
Autor:
John R. Doedens, Beverly J Castner, Guixian Jin, Susan W. Sunnarborg, Roy A. Black, R. Cowling, Jennifer L. Slack, Richard S. Johnson, Keith Charrier, Ray Paxton, Duke Virca, David C. Lee, Lin Guo, Alison Wallace, Jacques J. Peschon, Rajeev M Mahimkar, June R. Eisenman
Publikováno v:
Biochemical Society Symposia. 70:39-52
Tumour necrosis factor α (TNFα)-converting enzyme (TACE/ADAM-17, where ADAM stands for a disintegrin and metalloproteinase) releases from the cell surface the extracellular domains of TNF and several other proteins. Previous studies have found that
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::f9727d6426c1d576731fc2cee98f33d8
https://doi.org/10.1042/bss0700039
https://doi.org/10.1042/bss0700039
Autor:
J.Greg Murison, Annjanette S. Warren, Timothy A. Bird, Jonathan M.J. Derry, Keith Charrier, Moira Glaccum, Pamela M. Holland, Suzanne Kanaly, Jacques J. Peschon, Cynthia R. Willis, G. Duke Virca
Publikováno v:
Current Biology. 12(16):1424-1428
The epidermis is a stratified, continually renewing epithelium dependent on a balance among cell proliferation, differentiation, and death for homeostasis. In normal epidermis, a mitotically active basal layer gives rise to terminally differentiating
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::ec8fa09bb2a7b4f62e905e680dcb88dc
Autor:
G. Duke Virca, Dalila Darmoul, Hyunjae Chung, Valérie Gratio, Mahmoud Saifeddine, Magda Hamza, Morley D. Hollenberg, Katerina Oikonomopoulou, Eleftherios P. Diamandis
Publikováno v:
Biological chemistry. 393(5)
We hypothesized that kallikrein-related peptidase 14 (KLK14) is produced by colonic tumors and can promote tumorigenesis by activating proteinase-activated receptors (PARs). We found that KLK14 is expressed in human colon adenocarcinoma cells but not
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::6edf53da75406d49cd96b460a25b1cb5
https://pubmed.ncbi.nlm.nih.gov/22505523
https://pubmed.ncbi.nlm.nih.gov/22505523
Autor:
Eleftherios P. Diamandis, G. Duke Virca, Francine Walker, Morley D. Hollenberg, Céline Loriot, Katerina Oikonomopoulou, Valérie Gratio, Dalila Darmoul
Publikováno v:
The American journal of pathology. 179(5)
Serine proteinases participate in tumor growth and invasion by cleaving and activating proteinase-activated receptors (PARs). Recent studies have implicated PAR-1 and PAR-4 (activated by thrombin) and PAR-2 (activated by trypsin but not by thrombin)
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::a30405179003dea57709039979626124
https://pubmed.ncbi.nlm.nih.gov/21907696
https://pubmed.ncbi.nlm.nih.gov/21907696
Autor:
Ann Stiko, Fred D. Lott, Duke Virca, Kelly R. Pitts, Christopher F. Toombs, Bernard Buetow, Ping Guo
Publikováno v:
Journal of pharmacological and toxicological methods. 55(2)
Introduction Methods to determine infarct size following ischemia-reperfusion injury include gross staining with triphenyltetrazolium chloride (TTC) and perfusion of colored dyes to demarcate the non-ischemic zone. Infarcted tissue (INF) can typicall
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::169d80664ba74a0fdc0e7ae4727224f6
https://pubmed.ncbi.nlm.nih.gov/16931060
https://pubmed.ncbi.nlm.nih.gov/16931060
Publikováno v:
The Journal of biological chemistry. 279(14)
Interleukin 1 (IL-1) plays a prominent role in immune and inflammatory reactions. Our understanding of the IL-1 family has recently expanded to include six novel members named IL-1F5 to IL-1F10. Recently, it was reported that IL-1F9 activated NF-kapp
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::312133e6287faac5953062e5627f2d90
https://pubmed.ncbi.nlm.nih.gov/14734551
https://pubmed.ncbi.nlm.nih.gov/14734551
Autor:
Della Friend, John E. Sims, Heather Moore, Roberta Hanna, Hongbo Chen, G. Duke Virca, Dirk E. Smith, Ann M. Farese, Thomas J. MacVittie
Publikováno v:
Immunity. 18(1)
Regulation of the activity of the proinflammatory cytokine IL-1 is complex, involving transcriptional and translational control, precursor processing, a receptor antagonist (IL-1ra), and a decoy receptor. Here we report that the soluble form of the I
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::96a2c4cb196d9f1d02fe6bfdca699f01
https://pubmed.ncbi.nlm.nih.gov/12530978
https://pubmed.ncbi.nlm.nih.gov/12530978
Autor:
Pamela M. Holland, Charles Rauch, John E. Sims, Kirsten E. Garka, G. Duke Virca, Richard S. Johnson, Alison Milne, Timothy A. Bird, Cynthia R. Willis
Publikováno v:
The Journal of biological chemistry. 277(18)
We describe the isolation, cloning, and characterization of human Nek8, a new mammalian NIMA-related kinase, and its candidate substrate Bicd2. Nek8 was isolated as a beta-casein kinase activity in rabbit lung and has an N-terminal catalytic domain h
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::230ac998a53dc06d5d71ecc6d19ce858
https://pubmed.ncbi.nlm.nih.gov/11864968
https://pubmed.ncbi.nlm.nih.gov/11864968
Publikováno v:
The Journal of biological chemistry. 272(51)
In fibroblasts and hepatoma cells, interleukin-1 (IL-1) treatment results in the rapid nuclear accumulation of the transcription factor NF-kappaB, present largely as p65 (RelA)/p50 heterodimers. It is well established that this process is dependent i
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::d99e74e2199bf25fb324de8b714bdb40
https://pubmed.ncbi.nlm.nih.gov/9405476
https://pubmed.ncbi.nlm.nih.gov/9405476