Extending the performance of FcRn and FcγRIIIa affinity liquid chromatography for protein biopharmaceuticals.

Autor: Bouvarel T; School of Pharmaceutical Sciences, University of Geneva, CMU - Rue Michel Servet 1, 1211 Geneva 4, Switzerland; Institute of Pharmaceutical Sciences of Western Switzerland, University of Geneva, CMU - Rue Michel Servet 1, 1211 Geneva 4, Switzerland., Duivelshof BL; School of Pharmaceutical Sciences, University of Geneva, CMU - Rue Michel Servet 1, 1211 Geneva 4, Switzerland; Institute of Pharmaceutical Sciences of Western Switzerland, University of Geneva, CMU - Rue Michel Servet 1, 1211 Geneva 4, Switzerland., Camperi J; Protein Analytical Chemistry, Genentech, 1 DNA Way, South San Francisco, CA, 94080, USA., Schlothauer T; Large Molecule Research, Roche Innovation Center Munich, Nonnenwald 2, D-82377 Penzberg, Germany., Knaupp A; Large Molecule Research, Roche Innovation Center Munich, Nonnenwald 2, D-82377 Penzberg, Germany., Stella C; Protein Analytical Chemistry, Genentech, 1 DNA Way, South San Francisco, CA, 94080, USA., Guillarme D; School of Pharmaceutical Sciences, University of Geneva, CMU - Rue Michel Servet 1, 1211 Geneva 4, Switzerland; Institute of Pharmaceutical Sciences of Western Switzerland, University of Geneva, CMU - Rue Michel Servet 1, 1211 Geneva 4, Switzerland. Electronic address: davy.guillarme@unige.ch.

Publikováno v: Journal of chromatography. A [J Chromatogr A] 2022 Oct 25; Vol. 1682, pp. 463518. Date of Electronic Publication: 2022 Sep 17.

Quantitative N- Glycan Profiling of Therapeutic Monoclonal Antibodies Performed by Middle-Up Level HILIC-HRMS Analysis.

Autor: Duivelshof BL; Institute of Pharmaceutical Sciences of Western Switzerland (ISPSO), University of Geneva, CMU-Rue Michel-Servet 1, 1211 Geneva, Switzerland.; School of Pharmaceutical Sciences, University of Geneva, CMU-Rue Michel-Servet 1, 1211 Geneva, Switzerland., Denorme S; Research Institute for Chromatography (RIC), President Kennedypark 26, 8500 Kortrijk, Belgium., Sandra K; Research Institute for Chromatography (RIC), President Kennedypark 26, 8500 Kortrijk, Belgium., Liu X; Waters Corporation, 34 Maple Street, Milford, MA 01757-3696, USA., Beck A; IRPF-Centre d'Immunologie Pierre-Fabre (CIPF), 5 Avenue Napoléon III, 60497 Saint-Julien-en-Genevois, France., Lauber MA; Waters Corporation, 34 Maple Street, Milford, MA 01757-3696, USA., Guillarme D; Institute of Pharmaceutical Sciences of Western Switzerland (ISPSO), University of Geneva, CMU-Rue Michel-Servet 1, 1211 Geneva, Switzerland.; School of Pharmaceutical Sciences, University of Geneva, CMU-Rue Michel-Servet 1, 1211 Geneva, Switzerland., D'Atri V; Institute of Pharmaceutical Sciences of Western Switzerland (ISPSO), University of Geneva, CMU-Rue Michel-Servet 1, 1211 Geneva, Switzerland.; School of Pharmaceutical Sciences, University of Geneva, CMU-Rue Michel-Servet 1, 1211 Geneva, Switzerland.

Publikováno v: Pharmaceutics [Pharmaceutics] 2021 Oct 20; Vol. 13 (11). Date of Electronic Publication: 2021 Oct 20.

Isolation and Identification of Isocoumarin Derivatives With Specific Inhibitory Activity Against Wnt Pathway and Metabolome Characterization of Lasiodiplodia venezuelensis .

Autor: Pellissier L; School of Pharmaceutical Sciences, University of Geneva, CMU, Geneva, Switzerland.; Institute of Pharmaceutical Sciences of Western Switzerland, University of Geneva, CMU, Geneva, Switzerland., Koval A; Department of Cell Physiology and Metabolism, Translational Research Centre in Oncohaematology, Faculty of Medicine, University of Geneva, CMU, Geneva, Switzerland., Marcourt L; School of Pharmaceutical Sciences, University of Geneva, CMU, Geneva, Switzerland.; Institute of Pharmaceutical Sciences of Western Switzerland, University of Geneva, CMU, Geneva, Switzerland., Ferreira Queiroz E; School of Pharmaceutical Sciences, University of Geneva, CMU, Geneva, Switzerland.; Institute of Pharmaceutical Sciences of Western Switzerland, University of Geneva, CMU, Geneva, Switzerland., Lecoultre N; Mycology Group, Research Department Plant Protection, Agroscope, Nyon, Switzerland., Leoni S; Microbiology Unit, Department of Botany and Plant Biology, University of Geneva, Geneva, Switzerland., Quiros-Guerrero LM; School of Pharmaceutical Sciences, University of Geneva, CMU, Geneva, Switzerland.; Institute of Pharmaceutical Sciences of Western Switzerland, University of Geneva, CMU, Geneva, Switzerland., Barthélémy M; Université Paris-Saclay, CNRS, Institut de Chimie des Substances Naturelles, Gif-sur-Yvette, France., Duivelshof BL; School of Pharmaceutical Sciences, University of Geneva, CMU, Geneva, Switzerland.; Institute of Pharmaceutical Sciences of Western Switzerland, University of Geneva, CMU, Geneva, Switzerland., Guillarme D; School of Pharmaceutical Sciences, University of Geneva, CMU, Geneva, Switzerland.; Institute of Pharmaceutical Sciences of Western Switzerland, University of Geneva, CMU, Geneva, Switzerland., Tardy S; School of Pharmaceutical Sciences, University of Geneva, CMU, Geneva, Switzerland.; Institute of Pharmaceutical Sciences of Western Switzerland, University of Geneva, CMU, Geneva, Switzerland., Eparvier V; Université Paris-Saclay, CNRS, Institut de Chimie des Substances Naturelles, Gif-sur-Yvette, France., Perron K; Institute of Pharmaceutical Sciences of Western Switzerland, University of Geneva, CMU, Geneva, Switzerland.; Microbiology Unit, Department of Botany and Plant Biology, University of Geneva, Geneva, Switzerland., Chave J; CNRS, Biological Diversity and Evolution (UMR 5174), Toulouse, France., Stien D; Sorbonne Université, CNRS, Laboratoire de Biodiversité et Biotechnologie Microbiennes, LBBM, Observatoire Océanologique, Banyuls-Sur-Mer, France., Gindro K; Mycology Group, Research Department Plant Protection, Agroscope, Nyon, Switzerland., Katanaev V; Department of Cell Physiology and Metabolism, Translational Research Centre in Oncohaematology, Faculty of Medicine, University of Geneva, CMU, Geneva, Switzerland.; School of Biomedicine, Far Eastern Federal University, Vladivostok, Russia., Wolfender JL; School of Pharmaceutical Sciences, University of Geneva, CMU, Geneva, Switzerland.; Institute of Pharmaceutical Sciences of Western Switzerland, University of Geneva, CMU, Geneva, Switzerland.

Publikováno v: Frontiers in chemistry [Front Chem] 2021 Aug 12; Vol. 9, pp. 664489. Date of Electronic Publication: 2021 Aug 12 (Print Publication: 2021).

Alternative mobile phase additives for the characterization of protein biopharmaceuticals in liquid chromatography - Mass spectrometry.

Autor: Lardeux H; Institute of Pharmaceutical Sciences of Western Switzerland (ISPSO), University of Geneva, CMU-Rue Michel Servet 1, 1211, Geneva 4, Switzerland; School of Pharmaceutical Sciences, University of Geneva, CMU-Rue Michel Servet 1, 1211, Geneva 4, Switzerland., Duivelshof BL; Institute of Pharmaceutical Sciences of Western Switzerland (ISPSO), University of Geneva, CMU-Rue Michel Servet 1, 1211, Geneva 4, Switzerland; School of Pharmaceutical Sciences, University of Geneva, CMU-Rue Michel Servet 1, 1211, Geneva 4, Switzerland., Colas O; IRPF - Centre D'Immunologie Pierre-Fabre (CIPF), 5 Avenue Napoléon III, BP 60497, Saint-Julien-en-Genevois, France., Beck A; IRPF - Centre D'Immunologie Pierre-Fabre (CIPF), 5 Avenue Napoléon III, BP 60497, Saint-Julien-en-Genevois, France., McCalley DV; Centre for Research in Biosciences, University of the West of England, Frenchay, Bristol, BS16 1QY, UK., Guillarme D; Institute of Pharmaceutical Sciences of Western Switzerland (ISPSO), University of Geneva, CMU-Rue Michel Servet 1, 1211, Geneva 4, Switzerland; School of Pharmaceutical Sciences, University of Geneva, CMU-Rue Michel Servet 1, 1211, Geneva 4, Switzerland., D'Atri V; Institute of Pharmaceutical Sciences of Western Switzerland (ISPSO), University of Geneva, CMU-Rue Michel Servet 1, 1211, Geneva 4, Switzerland; School of Pharmaceutical Sciences, University of Geneva, CMU-Rue Michel Servet 1, 1211, Geneva 4, Switzerland. Electronic address: valentina.datri@unige.ch.

Publikováno v: Analytica chimica acta [Anal Chim Acta] 2021 Apr 29; Vol. 1156, pp. 338347. Date of Electronic Publication: 2021 Feb 24.

Glycan-Mediated Technology for Obtaining Homogeneous Site-Specific Conjugated Antibody-Drug Conjugates: Synthesis and Analytical Characterization by Using Complementary Middle-up LC/HRMS Analysis.

Autor: Duivelshof BL; Institute of Pharmaceutical Sciences of Western Switzerland, University of Geneva, CMU-Rue Michel Servet 1, 1211 Geneva 4, Switzerland., Deslignière E; Laboratoire de Spectrométrie de Masse BioOrganique, IPHC UMR 7178, Université de Strasbourg, CNRS, Strasbourg, France., Hernandez-Alba O; Laboratoire de Spectrométrie de Masse BioOrganique, IPHC UMR 7178, Université de Strasbourg, CNRS, Strasbourg, France., Ehkirch A; Laboratoire de Spectrométrie de Masse BioOrganique, IPHC UMR 7178, Université de Strasbourg, CNRS, Strasbourg, France., Toftevall H; Genovis AB, Box 790, SE-220 07 Lund, Sweden., Sjögren J; Genovis AB, Box 790, SE-220 07 Lund, Sweden., Cianferani S; Laboratoire de Spectrométrie de Masse BioOrganique, IPHC UMR 7178, Université de Strasbourg, CNRS, Strasbourg, France., Beck A; IRPF - Centre d'Immunologie Pierre-Fabre (CIPF), 5 Avenue Napoléon III, BP 60497 Saint-Julien-en-Genevois, France., Guillarme D; Institute of Pharmaceutical Sciences of Western Switzerland, University of Geneva, CMU-Rue Michel Servet 1, 1211 Geneva 4, Switzerland., D'Atri V; Institute of Pharmaceutical Sciences of Western Switzerland, University of Geneva, CMU-Rue Michel Servet 1, 1211 Geneva 4, Switzerland.

Publikováno v: Analytical chemistry [Anal Chem] 2020 Jun 16; Vol. 92 (12), pp. 8170-8177. Date of Electronic Publication: 2020 May 29.