Proposal for individualized dosing of eculizumab in atypical haemolytic uraemic syndrome: patient friendly and cost-effective

Autor: Avest, M. ter, Bouwmeester, R.N., Duineveld, C., Wijnsma, K.L., Volokhina, E.B., Heuvel, L.P.W.J. van den, Burger, D.M., Wetzels, J.F.M., Adang, E.M.M., Kar, N.C.A.J. van de, Heine, R. ter

Publikováno v: Nephrology, Dialysis, Transplantation, 38, 362-371
Nephrology, Dialysis, Transplantation, 38, 2, pp. 362-371

Contains fulltext : 291080.pdf (Publisher’s version ) (Open Access) BACKGROUND: Eculizumab is a lifesaving yet expensive drug for atypical haemolytic uraemic syndrome (aHUS). Current guidelines advise a fixed-dosing schedule, which can be suboptima

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=dedup_wf_001::53f952ce6676fb536d59421892a392d4
http://hdl.handle.net/2066/291080

Early eculizumab withdrawal in patients with atypical hemolytic uremic syndrome in native kidneys is safe and cost-effective

Autor: Bouwmeester, R.N., Duineveld, C., Wijnsma, K.L., Bemelman, F.J., Heijden, J.W. van der, Wijk, J.A.E. van, Bouts, A.H.M., Wetering, J. van de, Dorresteijn, E., Berger, S.P., Gracchi, V., Zuilen, A.D. van, Keijzer-Veen, M.G., Vries, A.P.J. de, Rooij, R.W.G. van, Engels, F.A.P.T., Altena, W., Wildt, R. de, Kempen, E. van, Adang, E.M., Avest, M. ter, Heine, R. ter, Volokhina, E.B., Heuvel, L.P.W.J. van den, Wetzels, J.F.M., Kar, N.C.A.J. van de

Publikováno v: Bouwmeester, R N, Duineveld, C, Wijnsma, K L, Bemelman, F J, van der Heijden, J W, van Wijk, J A E, Bouts, A H M, van de Wetering, J, Dorresteijn, E, Berger, S P, Gracchi, V, van Zuilen, A D, Keijzer-Veen, M G, de Vries, A P J, van Rooij, R W G, Engels, F A P T, Altena, W, de Wildt, R, van Kempen, E, Adang, E M, ter Avest, M, ter Heine, R, Volokhina, E B, van den Heuvel, L P W J, Wetzels, J F M & van de Kar, N C A J 2022, ' Early Eculizumab Withdrawal in Patients With Atypical Hemolytic Uremic Syndrome in Native Kidneys Is Safe and Cost-Effective : Results of the CUREiHUS Study ', Kidney International Reports, vol. 8, no. 1, pp. 91-102 . https://doi.org/10.1016/j.ekir.2022.10.013
Kidney International Reports, 8(1), 91-102. Elsevier Inc.
Kidney International Reports, 8, 1, pp. 91-102
Kidney International Reports, 8(1), 91-102. Elsevier Science
Kidney International Reports, 8(1), 91-102. ELSEVIER SCIENCE INC
Kidney International Reports, 8, 91-102
Kidney International Reports. Elsevier Inc.

Introduction: The introduction of eculizumab has improved the outcome in patients with atypical hemo-lytic uremic syndrome (aHUS). The optimal treatment strategy is debated. Here, we report the results of the CUREiHUS study, a 4-year prospective, obs

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::da7d699e40d5937c24775971a41a47d3
https://hdl.handle.net/1887/3563249

Eculizumab in atypical hemolytic uremic syndrome: strategies toward restrictive use

Autor: Wijnsma, K.L., Duineveld, C., Wetzels, J.F.M., Kar, N.C. van de

Publikováno v: Pediatric Nephrology, 34, 741-742
Pediatric Nephrology, 34, 4, pp. 741-742

Contains fulltext : 202652-corr.pdf (Publisher’s version ) (Open Access) Contains fulltext : 202652.pdf (Publisher’s version ) (Open Access) The original version of this article unfortunately contained two mistakes. The presentation of Table 1 an

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=dedup_wf_001::1d15e8f0a6d633ea73d4316f67bf1896
http://hdl.handle.net/2066/202652

Comparison of experimental designs combining process and mixture variables: Part I. Design construction and theoretical evaluation

Autor: Duineveld, C A A, Smilde, A K, Doornbos, D A

Publikováno v: Chemometrics and Intelligent Laboratory Systems, 19(3), 295-308. ELSEVIER SCIENCE BV

The combination of process variables and mixture variables in experimental design is a problem which has not yet been solved. It is examined here whether a set of designs can be found which can be used for a series of models of reasonable complexity.

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=narcis______::539415d45de8b90b935d17fa1e369f3d
https://research.rug.nl/en/publications/bb9f3129-8837-426e-aa93-f02793cc97c9

COMPARISON OF EXPERIMENTAL-DESIGNS COMBINING PROCESS AND MIXTURE VARIABLES .1. DESIGN CONSTRUCTION AND THEORETICAL EVALUATION

Autor: DUINEVELD, C. A. A., Smilde, A. K., Doornbos, D. A.

Publikováno v: CHEMOMETRICS AND INTELLIGENT LABORATORY SYSTEMS, 19(3), 295-308. Elsevier

The combination of process variables and mixture variables in experimental design is a problem which has not yet been solved. It is examined here whether a set of designs can be found which can be used for a series of models of reasonable complexity.

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=narcis______::b884faad87fd64465bb078228e247192
https://pure.amc.nl/en/publications/comparison-of-experimentaldesigns-combining-process-and-mixture-variables-1-design-construction-and-theoretical-evaluation(e5f328a4-871f-4bfc-a263-f3ccb029754d).html