Carbon source availability drives nutrient utilization in CD8+ T cells

Autor: Kaymak, Irem, Luda, Katarzyna M., Duimstra, Lauren R., Ma, Eric H., Longo, Joseph, Dahabieh, Michael S., Faubert, Brandon, Oswald, Brandon M., Watson, McLane J., Kitchen-Goosen, Susan M., DeCamp, Lisa M., Compton, Shelby E., Fu, Zhen, DeBerardinis, Ralph J., Williams, Kelsey S., Sheldon, Ryan D., Jones, Russell G.

Publikováno v: In Cell Metabolism 6 September 2022 34(9):1298-1311

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Homozygosity analysis in a Turkish dementia cohort

Autor: Dehghani, Nadia, Guven, Gamze, Samancı, Bedia, Gurvit, Hakan, Bras, Jose, Guerreiro, Rita, Beckwell, Jane, Duimstra, Lauren, Gibbons, Elizabeth, Kun-Rodrigues, Celia, Lisboa, Catarina, Hanagasi, Hasmet, Lohmann, Ebba, Bilgiç, Başar

Publikováno v: Alzheimer's and dementia 17(S3), e054052 (2021). doi:10.1002/alz.054052

BackgroundDiseases caused by homozygous variants are more prevalent in consanguineous populations where regions of homozygosity (ROHs) spanning the genome are extended. The same diseases are comparatively rarer in outbred populations, and thus identi

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=od_____10678::a043cd8c58ecaf5d23016f459d05dfe9
https://pub.dzne.de/record/163686

¹³ C metabolite tracing reveals glutamine and acetate as critical in vivo fuels for CD8 T cells.

Autor: Ma EH; Department of Metabolism and Nutritional Programming, Van Andel Institute, Grand Rapids, MI, USA., Dahabieh MS; Department of Metabolism and Nutritional Programming, Van Andel Institute, Grand Rapids, MI, USA., DeCamp LM; Department of Metabolism and Nutritional Programming, Van Andel Institute, Grand Rapids, MI, USA.; Metabolism and Nutrition (MeNu) Program, Van Andel Institute, Grand Rapids, MI, USA., Kaymak I; Department of Metabolism and Nutritional Programming, Van Andel Institute, Grand Rapids, MI, USA., Kitchen-Goosen SM; Department of Metabolism and Nutritional Programming, Van Andel Institute, Grand Rapids, MI, USA.; Metabolism and Nutrition (MeNu) Program, Van Andel Institute, Grand Rapids, MI, USA., Oswald BM; Department of Metabolism and Nutritional Programming, Van Andel Institute, Grand Rapids, MI, USA., Longo J; Department of Metabolism and Nutritional Programming, Van Andel Institute, Grand Rapids, MI, USA., Roy DG; Centre de Recherche du Centre Hospitalier de l'Université de Montréal, Montréal, QC, Canada.; Département de Microbiologie, Infectiologie et Immunologie, Université de Montréal, Montréal, QC, Canada., Verway MJ; Goodman Cancer Institute, Faculty of Medicine, McGill University, Montréal, QC, Canada., Johnson RM; Gilead Sciences Inc., Foster City, CA, USA., Samborska B; Goodman Cancer Institute, Faculty of Medicine, McGill University, Montréal, QC, Canada., Duimstra LR; Department of Metabolism and Nutritional Programming, Van Andel Institute, Grand Rapids, MI, USA., Scullion CA; Department of Metabolism and Nutritional Programming, Van Andel Institute, Grand Rapids, MI, USA., Steadman M; Agios Pharmaceuticals, Cambridge, MA, USA., Vos M; Department of Metabolism and Nutritional Programming, Van Andel Institute, Grand Rapids, MI, USA.; Metabolism and Nutrition (MeNu) Program, Van Andel Institute, Grand Rapids, MI, USA., Roddy TP; Agios Pharmaceuticals, Cambridge, MA, USA., Krawczyk CM; Department of Metabolism and Nutritional Programming, Van Andel Institute, Grand Rapids, MI, USA.; Metabolism and Nutrition (MeNu) Program, Van Andel Institute, Grand Rapids, MI, USA., Williams KS; Department of Metabolism and Nutritional Programming, Van Andel Institute, Grand Rapids, MI, USA.; Metabolism and Nutrition (MeNu) Program, Van Andel Institute, Grand Rapids, MI, USA., Sheldon RD; Department of Metabolism and Nutritional Programming, Van Andel Institute, Grand Rapids, MI, USA.; Metabolism and Nutrition (MeNu) Program, Van Andel Institute, Grand Rapids, MI, USA.; Mass Spectrometry Core, Van Andel Institute, Grand Rapids, MI, USA., Jones RG; Department of Metabolism and Nutritional Programming, Van Andel Institute, Grand Rapids, MI, USA.; Metabolism and Nutrition (MeNu) Program, Van Andel Institute, Grand Rapids, MI, USA.

Publikováno v: Science advances [Sci Adv] 2024 May 31; Vol. 10 (22), pp. eadj1431. Date of Electronic Publication: 2024 May 29.