Zobrazeno 1 - 10
of 49
pro vyhledávání: '"Duhl, David"'
Autor:
Duhl, David M., Boyce, Rustum S.
Publikováno v:
In Annual Reports in Medicinal Chemistry 2003 38:239-248
Publikováno v:
In Annual Reports in Medicinal Chemistry 2003 38:193-202
Autor:
Chiu, Choi-Ying, Leng, Song, Martin, Kathleen A., Kim, Esther, Gorman, Susan, Duhl, David M.J.
Publikováno v:
In Genomics 1 October 1999 61(1):66-73
Autor:
Gorman, Susan W., Haider, Neena B. 1, Grieshammer, Uta, Swiderski, Ruth E., Kim, Esther, Welch, Juliet W., Searby, Charles, Leng, Song, Carmi, Rivka, Sheffield, Val C., Duhl, David M.
Publikováno v:
In Genomics 15 July 1999 59(2):150-160
Autor:
Tomotsune, Daihachiro, Takihara, Yoshihiro, Berger, Joel, Duhl, David, Joo, Sunghae, Kyba, Michael, Shirai, Manabu, Ohta, Hideaki, Matsuda, Yoichi, Honda, Barry M., Simon, Jeffrey, Shimada, Kazunori, Brock, Hugh W., Randazzo, Filippo
Publikováno v:
In Differentiation 1999 65(4):229-239
Autor:
Nathan Brammeier, Walter Annette O, Duhl David, Dirksen E. Bussiere, Paul A. Barsanti, Weibo Wang, Zhi-Jie Ni, Eric J. Martin
Publikováno v:
Bioorganic & Medicinal Chemistry Letters. 20:157-160
A series of tetrahydro-beta-carbolines were identified by HTS as inhibitors of the kinesin Eg5. Molecular modeling and medicinal chemistry techniques were employed to explore the SAR for this series with a focus of removing potential metabolic liabil
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::e5ee7399667fa862020291f65163ea75
https://doi.org/10.1016/j.bmcl.2009.11.012
https://doi.org/10.1016/j.bmcl.2009.11.012
Autor:
Nancy Pryer, Daniel Menezes, Zhenhai Gao, Pietro Taverna, Duhl David, Michael Rugaard Jensen, Guoying Karen Yu, Darrin Stuart, William R. Sellers, Timothy D. Machajewski, Tinya Abrams
Publikováno v:
Molecular cancer therapeutics. 11(3)
A novel oral Hsp90 inhibitor, NVP-HSP990, has been developed and characterized in vitro and in vivo. In vitro, NVP-HSP990 exhibits single digit nanomolar IC50 values on three of the Hsp90 isoforms (Hsp90α, Hsp90β, and GRP94) and 320 nanomolar IC50
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::8214a913c0efedb5cd892c968aaff718
https://pubmed.ncbi.nlm.nih.gov/22246440
https://pubmed.ncbi.nlm.nih.gov/22246440
Autor:
Barsanti, Paul A., Wang, Weibo, Ni, Zhi-Jie, Duhl, David, Brammeier, Nathan, Martin, Eric, Bussiere, Dirksen, Walter, Annette O.
Publikováno v:
In Bioorganic & Medicinal Chemistry Letters 2010 20(1):157-160
Publisher Summary This chapter discusses the role of purine-binding enzymes as cancer targets. It also provides an overview of kinesin spindle protein (KSP), a member of kinesin superfamily of MT motors, which convert the energy released from ATP hyd
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::719b6afc4ea8c6043e410463b405e139
https://doi.org/10.1016/s0065-7743(03)38021-2
https://doi.org/10.1016/s0065-7743(03)38021-2
Autor:
Rustum S. Boyce, Duhl David
Publisher Summary This chapter presents an overview of obesity therapeutics. When measured by body mass index (BMI), a BMI of 30 is the threshold for obesity. Obesity is mischaracterized as a cosmetic or life style issue, when in reality it is a deva
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::fc6baedb4ff00d3375e9fa0423d0fd05
https://doi.org/10.1016/s0065-7743(03)38025-x
https://doi.org/10.1016/s0065-7743(03)38025-x