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Akademický článek

Caspase cleavage of RIPK3 after Asp ³³³ is dispensable for mouse embryogenesis.

Autor: Newton K; Department of Physiological Chemistry, Genentech, 1 DNA Way, South San Francisco, CA, 94080, USA. knewton@gene.com., Wickliffe KE; Department of Physiological Chemistry, Genentech, 1 DNA Way, South San Francisco, CA, 94080, USA., Maltzman A; Department of Physiological Chemistry, Genentech, 1 DNA Way, South San Francisco, CA, 94080, USA., Dugger DL; Department of Physiological Chemistry, Genentech, 1 DNA Way, South San Francisco, CA, 94080, USA., Webster JD; Department of Pathology, Genentech, 1 DNA Way, South San Francisco, CA, 94080, USA., Guo H; Department of Microbiology and Immunology, LSU Health Shreveport, Shreveport, LA, 71103, USA., Dixit VM; Department of Physiological Chemistry, Genentech, 1 DNA Way, South San Francisco, CA, 94080, USA. dixit@gene.com.

Publikováno v: Cell death and differentiation [Cell Death Differ] 2024 Feb; Vol. 31 (2), pp. 254-262. Date of Electronic Publication: 2024 Jan 08.

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Akademický článek

Impaired RIPK1 ubiquitination sensitizes mice to TNF toxicity and inflammatory cell death.

Autor: Kist M; Departments of Early Discovery Biochemistry, Genentech, 1 DNA Way, South San Francisco, CA, 94080, USA., Kőműves LG; Pathology, Genentech, 1 DNA Way, South San Francisco, CA, 94080, USA., Goncharov T; Departments of Early Discovery Biochemistry, Genentech, 1 DNA Way, South San Francisco, CA, 94080, USA., Dugger DL; Physiological Chemistry, Genentech, 1 DNA Way, South San Francisco, CA, 94080, USA., Yu C; Molecular Biology, Genentech, 1 DNA Way, South San Francisco, CA, 94080, USA., Roose-Girma M; Molecular Biology, Genentech, 1 DNA Way, South San Francisco, CA, 94080, USA., Newton K; Physiological Chemistry, Genentech, 1 DNA Way, South San Francisco, CA, 94080, USA., Webster JD; Pathology, Genentech, 1 DNA Way, South San Francisco, CA, 94080, USA., Vucic D; Departments of Early Discovery Biochemistry, Genentech, 1 DNA Way, South San Francisco, CA, 94080, USA. domagoj@gene.com.

Publikováno v: Cell death and differentiation [Cell Death Differ] 2021 Mar; Vol. 28 (3), pp. 985-1000. Date of Electronic Publication: 2020 Sep 30.

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Akademický článek

Ubiquitin Ligase COP1 Suppresses Neuroinflammation by Degrading c/EBPβ in Microglia.

Autor: Ndoja A; Department of Physiological Chemistry, Genentech, South San Francisco, CA 94080, USA., Reja R; Department of Bioinformatics and Computational Biology, Genentech, South San Francisco, CA 94080, USA., Lee SH; Department of Neuroscience, Genentech, South San Francisco, CA 94080, USA., Webster JD; Department of Pathology, Genentech, South San Francisco, CA 94080, USA., Ngu H; Department of Pathology, Genentech, South San Francisco, CA 94080, USA., Rose CM; Department of Microchemistry, Proteomics, Lipidomics and Next Generation Sequencing, Genentech, South San Francisco, CA 94080, USA., Kirkpatrick DS; Department of Microchemistry, Proteomics, Lipidomics and Next Generation Sequencing, Genentech, South San Francisco, CA 94080, USA., Modrusan Z; Department of Microchemistry, Proteomics, Lipidomics and Next Generation Sequencing, Genentech, South San Francisco, CA 94080, USA., Chen YJ; Department of Microchemistry, Proteomics, Lipidomics and Next Generation Sequencing, Genentech, South San Francisco, CA 94080, USA., Dugger DL; Department of Physiological Chemistry, Genentech, South San Francisco, CA 94080, USA., Gandham V; Department of Biomedical Imaging, Genentech, South San Francisco, CA 94080, USA., Xie L; Department of Biomedical Imaging, Genentech, South San Francisco, CA 94080, USA., Newton K; Department of Physiological Chemistry, Genentech, South San Francisco, CA 94080, USA. Electronic address: knewton@gene.com., Dixit VM; Department of Physiological Chemistry, Genentech, South San Francisco, CA 94080, USA. Electronic address: dixit@gene.com.

Publikováno v: Cell [Cell] 2020 Sep 03; Vol. 182 (5), pp. 1156-1169.e12. Date of Electronic Publication: 2020 Aug 13.

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Akademický článek

RIP1 inhibition blocks inflammatory diseases but not tumor growth or metastases.

Autor: Patel S; Department of Discovery Chemistry, Genentech, 1 DNA Way, South San Francisco, CA, 94080, USA. patel.snahel@gene.com., Webster JD; Department of Pathology, Genentech, 1 DNA Way, South San Francisco, CA, 94080, USA., Varfolomeev E; Department of Early Discovery Biochemistry, Genentech, 1 DNA Way, South San Francisco, CA, 94080, USA., Kwon YC; Department of Translational Immunology, Genentech, 1 DNA Way, South San Francisco, CA, 94080, USA., Cheng JH; Department of Molecular Oncology, Genentech, 1 DNA Way, South San Francisco, CA, 94080, USA., Zhang J; Department of Translational Immunology, Genentech, 1 DNA Way, South San Francisco, CA, 94080, USA., Dugger DL; Department of Physiological Chemistry, Genentech, 1 DNA Way, South San Francisco, CA, 94080, USA., Wickliffe KE; Department of Physiological Chemistry, Genentech, 1 DNA Way, South San Francisco, CA, 94080, USA., Maltzman A; Department of Physiological Chemistry, Genentech, 1 DNA Way, South San Francisco, CA, 94080, USA., Sujatha-Bhaskar S; Departments of Immunology, Genentech, 1 DNA Way, South San Francisco, CA, 94080, USA., Bir Kohli P; Department of Biochemical and Cellular Pharmacology, Genentech, 1 DNA Way, South San Francisco, CA, 94080, USA.; Gilead, Foster City, CA, 94404, USA., Ramaswamy S; Department of Biochemical and Cellular Pharmacology, Genentech, 1 DNA Way, South San Francisco, CA, 94080, USA., Deshmukh G; Department of Drug Metabolism and Pharmacokinetics, Genentech, 1 DNA Way, South San Francisco, CA, 94080, USA., Liederer BM; Department of Drug Metabolism and Pharmacokinetics, Genentech, 1 DNA Way, South San Francisco, CA, 94080, USA., Fong R; Department of Structural Biology, Genentech, 1 DNA Way, South San Francisco, CA, 94080, USA., Hamilton G; Department of Discovery Chemistry, Genentech, 1 DNA Way, South San Francisco, CA, 94080, USA., Lupardus P; Department of Structural Biology, Genentech, 1 DNA Way, South San Francisco, CA, 94080, USA., Caplazi P; Department of Pathology, Genentech, 1 DNA Way, South San Francisco, CA, 94080, USA., Lee WP; Department of Translational Immunology, Genentech, 1 DNA Way, South San Francisco, CA, 94080, USA., van Lookeren Campagne M; Departments of Immunology, Genentech, 1 DNA Way, South San Francisco, CA, 94080, USA.; Amgen, South San Francisco, CA, 94080, USA., Johnson A; Department of Biochemical and Cellular Pharmacology, Genentech, 1 DNA Way, South San Francisco, CA, 94080, USA., McKenzie BS; Department of Translational Immunology, Genentech, 1 DNA Way, South San Francisco, CA, 94080, USA., Junttila MR; Department of Molecular Oncology, Genentech, 1 DNA Way, South San Francisco, CA, 94080, USA., Newton K; Department of Physiological Chemistry, Genentech, 1 DNA Way, South San Francisco, CA, 94080, USA., Vucic D; Department of Early Discovery Biochemistry, Genentech, 1 DNA Way, South San Francisco, CA, 94080, USA. domagoj@gene.com.

Publikováno v: Cell death and differentiation [Cell Death Differ] 2020 Jan; Vol. 27 (1), pp. 161-175. Date of Electronic Publication: 2019 May 17.

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Akademický článek

Activity of caspase-8 determines plasticity between cell death pathways.

Autor: Newton K; Department of Physiological Chemistry, Genentech, South San Francisco, CA, USA. knewton@gene.com., Wickliffe KE; Department of Physiological Chemistry, Genentech, South San Francisco, CA, USA., Maltzman A; Department of Physiological Chemistry, Genentech, South San Francisco, CA, USA., Dugger DL; Department of Physiological Chemistry, Genentech, South San Francisco, CA, USA., Reja R; Department of Bioinformatics and Computational Biology, Genentech, South San Francisco, CA, USA., Zhang Y; Department of Bioinformatics and Computational Biology, Genentech, South San Francisco, CA, USA., Roose-Girma M; Department of Molecular Biology, Genentech, South San Francisco, CA, USA., Modrusan Z; Department of Molecular Biology, Genentech, South San Francisco, CA, USA., Sagolla MS; Department of Pathology, Genentech, South San Francisco, CA, USA., Webster JD; Department of Pathology, Genentech, South San Francisco, CA, USA., Dixit VM; Department of Physiological Chemistry, Genentech, South San Francisco, CA, USA. dixit@gene.com.

Publikováno v: Nature [Nature] 2019 Nov; Vol. 575 (7784), pp. 679-682. Date of Electronic Publication: 2019 Nov 13.

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Akademický článek

Cleavage of RIPK1 by caspase-8 is crucial for limiting apoptosis and necroptosis.

Autor: Newton K; Department of Physiological Chemistry, Genentech, South San Francisco, CA, USA. knewton@gene.com., Wickliffe KE; Department of Physiological Chemistry, Genentech, South San Francisco, CA, USA., Dugger DL; Department of Physiological Chemistry, Genentech, South San Francisco, CA, USA., Maltzman A; Department of Physiological Chemistry, Genentech, South San Francisco, CA, USA., Roose-Girma M; Department of Molecular Biology, Genentech, South San Francisco, CA, USA., Dohse M; Department of Pathology, Genentech, South San Francisco, CA, USA., Kőműves L; Department of Pathology, Genentech, South San Francisco, CA, USA., Webster JD; Department of Pathology, Genentech, South San Francisco, CA, USA., Dixit VM; Department of Physiological Chemistry, Genentech, South San Francisco, CA, USA. dixit@gene.com.

Publikováno v: Nature [Nature] 2019 Oct; Vol. 574 (7778), pp. 428-431. Date of Electronic Publication: 2019 Sep 11.

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