Action at a distance: mutations of peripheral residues transform rapid reversible inhibitors to slow, tight binders of cyclooxygenase-2.

Autor: Blobaum AL; From the A. B. Hancock, Jr. Memorial Laboratory for Cancer Research, Departments of Biochemistry, Chemistry, and Pharmacology, Vanderbilt Institute of Chemical Biology, Center in Molecular Toxicology, Vanderbilt-Ingram Cancer Center, Vanderbilt University School of Medicine, Nashville Tennessee 37232., Xu S; From the A. B. Hancock, Jr. Memorial Laboratory for Cancer Research, Departments of Biochemistry, Chemistry, and Pharmacology, Vanderbilt Institute of Chemical Biology, Center in Molecular Toxicology, Vanderbilt-Ingram Cancer Center, Vanderbilt University School of Medicine, Nashville Tennessee 37232., Rowlinson SW; From the A. B. Hancock, Jr. Memorial Laboratory for Cancer Research, Departments of Biochemistry, Chemistry, and Pharmacology, Vanderbilt Institute of Chemical Biology, Center in Molecular Toxicology, Vanderbilt-Ingram Cancer Center, Vanderbilt University School of Medicine, Nashville Tennessee 37232., Duggan KC; From the A. B. Hancock, Jr. Memorial Laboratory for Cancer Research, Departments of Biochemistry, Chemistry, and Pharmacology, Vanderbilt Institute of Chemical Biology, Center in Molecular Toxicology, Vanderbilt-Ingram Cancer Center, Vanderbilt University School of Medicine, Nashville Tennessee 37232., Banerjee S; Department of Chemistry and Chemical Biology, Cornell University, Ithaca, New York 14853, and Northeastern Collaborative Access Team, Argonne National Laboratory, Argonne, Illinois 60439., Kudalkar SN; From the A. B. Hancock, Jr. Memorial Laboratory for Cancer Research, Departments of Biochemistry, Chemistry, and Pharmacology, Vanderbilt Institute of Chemical Biology, Center in Molecular Toxicology, Vanderbilt-Ingram Cancer Center, Vanderbilt University School of Medicine, Nashville Tennessee 37232., Birmingham WR; From the A. B. Hancock, Jr. Memorial Laboratory for Cancer Research, Departments of Biochemistry, Chemistry, and Pharmacology, Vanderbilt Institute of Chemical Biology, Center in Molecular Toxicology, Vanderbilt-Ingram Cancer Center, Vanderbilt University School of Medicine, Nashville Tennessee 37232., Ghebreselasie K; From the A. B. Hancock, Jr. Memorial Laboratory for Cancer Research, Departments of Biochemistry, Chemistry, and Pharmacology, Vanderbilt Institute of Chemical Biology, Center in Molecular Toxicology, Vanderbilt-Ingram Cancer Center, Vanderbilt University School of Medicine, Nashville Tennessee 37232., Marnett LJ; From the A. B. Hancock, Jr. Memorial Laboratory for Cancer Research, Departments of Biochemistry, Chemistry, and Pharmacology, Vanderbilt Institute of Chemical Biology, Center in Molecular Toxicology, Vanderbilt-Ingram Cancer Center, Vanderbilt University School of Medicine, Nashville Tennessee 37232, larry.marnett@vanderbilt.edu.

Publikováno v: The Journal of biological chemistry [J Biol Chem] 2015 May 15; Vol. 290 (20), pp. 12793-803. Date of Electronic Publication: 2015 Mar 30.

Molecular basis for cyclooxygenase inhibition by the non-steroidal anti-inflammatory drug naproxen.

Autor: Duggan KC; AB Hancock Jr Memorial Laboratory for Cancer Research, Department of Biochemistry, Vanderbilt Institute for Chemical Biology, the Center in Molecular Toxicology, Nashville, Tennessee 37232-0146., Walters MJ, Musee J, Harp JM, Kiefer JR, Oates JA, Marnett LJ

Publikováno v: The Journal of biological chemistry [J Biol Chem] 2010 Nov 05; Vol. 285 (45), pp. 34950-9. Date of Electronic Publication: 2010 Sep 01.

Differential sensitivity and mechanism of inhibition of COX-2 oxygenation of arachidonic acid and 2-arachidonoylglycerol by ibuprofen and mefenamic acid.

Autor: Prusakiewicz JJ; Department of Biochemistry, Vanderbilt University School of Medicine, Nashville, Tennessee 37232-0146, USA., Duggan KC, Rouzer CA, Marnett LJ

Publikováno v: Biochemistry [Biochemistry] 2009 Aug 11; Vol. 48 (31), pp. 7353-5.

EFFECT OF FAT-POOR DIET UPON NEOMYCIN INDUCED MALABSORPTION.

Autor: HAYMAN H, FISHER CJ, DUGGAN KC, RUBERT MW, FALOON WW

Publikováno v: Gastroenterology [Gastroenterology] 1964 Aug; Vol. 47, pp. 161-5.