L-glutamine Improves Skeletal Muscle Cell Differentiation and Prevents Myotube Atrophy After Cytokine (TNF-alpha) Stress Via Reduced p38 MAPK Signal Transduction

Autor: Girven, M, Dugdale, HF, Owens, DJ, Hughes, DC, Stewart, CE, Sharples, AP

Tumour Necrosis Factor‐Alpha (TNF‐α) is chronically elevated in conditions where skeletal muscle loss occurs. As l‐glutamine can dampen the effects of inflamed environments, we investigated the role of l‐glutamine in both differentiating C2C

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=core_ac_uk__::1d2779b26c4008c1036c78b33b8483cd

Aberrant myonuclear domains and impaired myofiber contractility despite marked hypertrophy in MYMK-related, Carey-Fineman-Ziter Syndrome.

Autor: Dugdale HF; School of Sport, Exercise and Health Sciences, Loughborough University, Loughborough, UK.; Centre for Human and Applied Physiological Sciences, School of Basic and Medical Biosciences, Faculty of Life Sciences and Medicine, King's College London, London, UK., Levy Y; Centre for Human and Applied Physiological Sciences, School of Basic and Medical Biosciences, Faculty of Life Sciences and Medicine, King's College London, London, UK., Jungbluth H; Randall Centre for Cell and Molecular Biophysics, Muscle Signalling Section, Faculty of Life Sciences and Medicine (FoLSM), King's College London, London, UK.; Department of Paediatric Neurology, Neuromuscular Service, Evelina Children's Hospital, Guy's and St Thomas' Hospital NHS Foundation Trust, London, UK., Oldfors A; Department of Laboratory Medicine, University of Gothenburg, Gothenburg, Sweden., Ochala J; Department of Biomedical Sciences, Faculty of Health and Medical Sciences, University of Copenhagen, Copenhagen, Denmark. julien.ochala@sund.ku.dk.

Publikováno v: Acta neuropathologica communications [Acta Neuropathol Commun] 2024 May 24; Vol. 12 (1), pp. 80. Date of Electronic Publication: 2024 May 24.

Cardiac and Skeletal Muscle Pathology in the D2/mdx Mouse Model and Caveats Associated with the Quantification of Utrophin.

Autor: Kennedy TL; Department of Physiology, Anatomy and Genetics, University of Oxford, Oxford, UK., Dugdale HF; Centre for Human and Applied Physiological Sciences, School of Basic and Medical Biosciences, Faculty of Life Sciences and Medicine, Guy's Campus, King's College London, London, UK. h.f.dugdale@lboro.ac.uk.; School of Sport, Exercise and Health Sciences, Loughborough University, Loughborough, UK. h.f.dugdale@lboro.ac.uk.

Publikováno v: Methods in molecular biology (Clifton, N.J.) [Methods Mol Biol] 2023; Vol. 2587, pp. 55-66.

NEB mutations disrupt the super-relaxed state of myosin and remodel the muscle metabolic proteome in nemaline myopathy.

Autor: Ranu N; Centre of Human and Applied Physiological Sciences, School of Basic and Medical Biosciences, Faculty of Life Sciences & Medicine, King's College London, London, UK., Laitila J; Department of Biomedical Sciences, University of Copenhagen, Copenhagen, Denmark.; The Folkhälsan Institute of Genetics and Department of Medical and Clinical Genetics, Medicum, Biomedicum Helsinki, University of Helsinki, Helsinki, Finland., Dugdale HF; Centre of Human and Applied Physiological Sciences, School of Basic and Medical Biosciences, Faculty of Life Sciences & Medicine, King's College London, London, UK.; School of Sport, Exercise and Health Sciences, Loughborough University, Loughborough, UK., Mariano J; Department of Biochemistry and Molecular Biology, University of Maryland School of Medicine, Baltimore, USA., Kolb JS; Department of Cellular and Molecular Medicine, University of Arizona, Tucson, USA., Wallgren-Pettersson C; The Folkhälsan Institute of Genetics and Department of Medical and Clinical Genetics, Medicum, Biomedicum Helsinki, University of Helsinki, Helsinki, Finland., Witting N; Copenhagen Neuromuscular Center, Rigshospitalet, University of Copenhagen, Copenhagen, Denmark., Vissing J; Copenhagen Neuromuscular Center, Rigshospitalet, University of Copenhagen, Copenhagen, Denmark., Vilchez JJ; Neuromuscular and Ataxias Research Group, Instituto de Investigación Sanitaria La Fe, Valencia, Spain.; Centro de Investigación Biomédica en Red de Enfermedades Raras (CIBERER) Spain, Valencia, Spain., Fiorillo C; Neuromuscular Disorders Unit, IRCCS Istituto Giannina Gaslini, DINOGMI, University of Genoa, Genoa, Italy., Zanoteli E; Department of Neurology, Faculdade de Medicina (FMUSP), Universidade de São Paulo, São Paulo, Brazil., Auranen M; Clinical Neurosciences, University of Helsinki and Helsinki University Hospital, NeurologyHelsinki, Finland., Jokela M; Neurology, Clinical Medicine, University of Turku, Turku, Finland.; Neurocenter, Turku University Hospital, Turku, Finland.; Neuromuscular Research Center, Department of Neurology, Tampere University and University Hospital, Tampere, Finland., Tasca G; Unità Operativa Complessa di Neurologia, Fondazione Policlinico Universitario 'A. Gemelli', IRCCS, Rome, Italy.; John Walton Muscular Dystrophy Research Centre, Newcastle University and Newcastle Hospitals NHS Foundation Trusts, Newcastle Upon Tyne, UK., Claeys KG; Department of Neurology, University Hospitals Leuven, Leuven, Belgium.; Laboratory for Muscle Diseases and Neuropathies, Department of Neurosciences, KU Leuven, Leuven, Belgium., Voermans NC; Department of Neurology, Donders Institute for Brain, Cognition and Behaviour, Radboud University Medical Center, Nijmegen, The Netherlands., Palmio J; Neuromuscular Research Center, Department of Neurology, Tampere University and University Hospital, Tampere, Finland., Huovinen S; Department of Pathology, Fimlab Laboratories, Tampere University Hospital, Tampere, Finland., Moggio M; Neuromuscular and Rare Diseases Unit, Department of Neuroscience, Fondazione IRCCS Ca' Granda Ospedale Maggiore Policlinico, Milan, Italy., Beck TN; Department of Biomedical Sciences, University of Copenhagen, Copenhagen, Denmark., Kontrogianni-Konstantopoulos A; Department of Biochemistry and Molecular Biology, University of Maryland School of Medicine, Baltimore, USA., Granzier H; Department of Cellular and Molecular Medicine, University of Arizona, Tucson, USA., Ochala J; Department of Biomedical Sciences, University of Copenhagen, Copenhagen, Denmark. julien.ochala@sund.ku.dk.

Publikováno v: Acta neuropathologica communications [Acta Neuropathol Commun] 2022 Dec 17; Vol. 10 (1), pp. 185. Date of Electronic Publication: 2022 Dec 17.

Nuclear numbers in syncytial muscle fibers promote size but limit the development of larger myonuclear domains.

Autor: Cramer AAW; Division of Molecular Cardiovascular Biology, Cincinnati Children's Hospital Medical Center, Cincinnati, OH, 45229, USA., Prasad V; Division of Molecular Cardiovascular Biology, Cincinnati Children's Hospital Medical Center, Cincinnati, OH, 45229, USA., Eftestøl E; Division of Molecular Cardiovascular Biology, Cincinnati Children's Hospital Medical Center, Cincinnati, OH, 45229, USA.; Department of Biosciences, University of Oslo, Oslo, Norway., Song T; Department of Internal Medicine, Division of Cardiovascular Health and Disease, University of Cincinnati College of Medicine, Cincinnati, OH, 45229, USA., Hansson KA; Department of Biosciences, University of Oslo, Oslo, Norway.; Center for Integrative Neuroplasticity (CINPLA), Department of Biosciences, University of Oslo, Oslo, Norway., Dugdale HF; Center of Human and Applied Physiological Sciences, School of Basic and Medical Biosciences, Faculty of Life Sciences & Medicine, King's College London, London, UK., Sadayappan S; Department of Internal Medicine, Division of Cardiovascular Health and Disease, University of Cincinnati College of Medicine, Cincinnati, OH, 45229, USA., Ochala J; Center of Human and Applied Physiological Sciences, School of Basic and Medical Biosciences, Faculty of Life Sciences & Medicine, King's College London, London, UK.; Randall Center for Cell and Molecular Biophysics, School of Basic & Medical Biosciences, Faculty of Life Sciences & Medicine, Guy's Campus, King's College London, London, UK.; Department of Biomedical Sciences, University of Copenhagen, Copenhagen, Denmark., Gundersen K; Department of Biosciences, University of Oslo, Oslo, Norway., Millay DP; Division of Molecular Cardiovascular Biology, Cincinnati Children's Hospital Medical Center, Cincinnati, OH, 45229, USA. douglas.millay@cchmc.org.; Department of Pediatrics, University of Cincinnati College of Medicine, Cincinnati, OH, 45229, USA. douglas.millay@cchmc.org.

Publikováno v: Nature communications [Nat Commun] 2020 Dec 08; Vol. 11 (1), pp. 6287. Date of Electronic Publication: 2020 Dec 08.