A New SARS-CoV-2 Variant Poorly Detected by RT-PCR on Nasopharyngeal Samples, with High Lethality

Autor: Reusse P, C. Grolhier, Pronier C, Guillotel E, Geffroy S, Pierre Tattevin, Mathieu Tourdjman, Anna Zhukova, Baidaluk A, Gagniere B, Valence M, Buzele R, Dominique Costagliola, Gabellec A, Etienne Simon-Loriere, Velmans N, Vatan R, Werf Svd, Droumaguet E, Thibault, Lescure X, Massart N, Dufour Mj, Montagne C, Fillatre P, Merour, Enouf, Sylvie Behillil

Publikováno v: SSRN Electronic Journal.

BackgroundIn early January 2021, an outbreak of nosocomial cases of COVID-19 emerged in Western France, with RT-PCR tests repeatedly negative on nasopharyngeal samples but positive on lower respiratory tract samples. Whole genome sequencing (WGS) rev

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https://doi.org/10.2139/ssrn.3844810

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A new SARS-CoV-2 variant with high lethality poorly detected by RT-PCR on nasopharyngeal samples: an observational study.

Autor: Fillâtre P; Service de Réanimation Polyvalente, CH de Saint-Brieuc, 10 rue Marcel Proust, 22000, Saint-Brieuc, France. Electronic address: pierre.fillatre@armorsante.bzh., Dufour MJ; Service de Biologie Médicale, CH de Lannion, Centre Hospitalier Pierre-le-Damany, 22303, Lannion, France., Behillil S; National Reference Centre for Respiratory Viruses, Molecular Genetics of RNA Viruses, CNRS-UMR 3569, University of Paris, Institut Pasteur, Paris, France., Vatan R; Service de Médecine Interne, CH de Lannion, Centre Hospitalier Pierre-le-Damany, 22303, Lannion, France; Service de Maladies Infectieuses, CH de Saint-Brieuc, 10 rue Marcel Proust, 22000, Saint-Brieuc, France., Reusse P; Service de Gériatrie, CH de Lannion, Centre Hospitalier Pierre-le-Damany, 22303, Lannion, France., Gabellec A; Service de Gériatrie, CH de Lannion, Centre Hospitalier Pierre-le-Damany, 22303, Lannion, France., Velmans N; Service de Médecine Interne, CH de Lannion, Centre Hospitalier Pierre-le-Damany, 22303, Lannion, France., Montagne C; Service d'Imagerie Médicale, CH de Lannion, Centre Hospitalier Pierre-le-Damany, 22303, Lannion, France., Geffroy Du Coudret S; Service de Pneumologie, CH de Lannion, Centre Hospitalier Pierre-le-Damany, 22303, Lannion, France., Droumaguet E; Département d'Informatique Médicale, CH de Lannion, Centre Hospitalier Pierre-le-Damany, 22303, Lannion, France., Merour V; Plateforme de Surveillance Continue, CH de Lannion, Centre Hospitalier Pierre-le-Damany, 22303, Lannion, France., Enouf V; National Reference Centre for Respiratory Viruses, Molecular Genetics of RNA Viruses, CNRS-UMR 3569, University of Paris, Institut Pasteur, Paris, France; Mutualized Platform of Microbiology, Pasteur International Bioresources Network, Institut Pasteur, Paris, France., Buzelé R; Service de Maladies Infectieuses, CH de Saint-Brieuc, 10 rue Marcel Proust, 22000, Saint-Brieuc, France., Valence M; Service de Maladies Infectieuses, CH de Saint-Brieuc, 10 rue Marcel Proust, 22000, Saint-Brieuc, France., Guillotel E; Service de Biologie Médicale, CH de Saint-Brieuc, 10, rue Marcel Proust, 22000, Saint-Brieuc, France., Gagnière B; Santé Publique France, French National Public Health Agency, Cellule Bretagne, Rennes, France., Baidaliuk A; Evolutionary Genomics of RNA Viruses, Institut Pasteur, Paris, France., Zhukova A; Unité Bioinformatique Evolutive & Hub de Bioinformatique et Biostatistique-Département Biologie Computationnelle, USR3756 (C3BI/DBC), Institut Pasteur, Paris, France., Tourdjman M; Santé Publique France, The French Public Health Agency, Saint-Maurice, France., Thibault V; Service de Virologie, CHU de Rennes, 2, rue Henri le Guilloux, 35000, Rennes, France., Grolhier C; Service de Virologie, CHU de Rennes, 2, rue Henri le Guilloux, 35000, Rennes, France., Pronier C; Service de Virologie, CHU de Rennes, 2, rue Henri le Guilloux, 35000, Rennes, France., Lescure FX; Department of Infectious and Tropical Diseases, Assistance Publique-Hôpitaux de Paris, Bichat-Claude Bernard University Hospital, Paris, France; Infections Antimicrobials Modelling Evolution (IAME), UMR 1137, University of Paris, Paris, France., Simon-Loriere E; Evolutionary Genomics of RNA Viruses, Institut Pasteur, Paris, France., Costagliola D; Sorbonne Université, INSERM, Institut Pierre Louis d'Épidémiologie et de Santé Publique (IPLESP), Paris, France., Van Der Werf S; National Reference Centre for Respiratory Viruses, Molecular Genetics of RNA Viruses, CNRS-UMR 3569, University of Paris, Institut Pasteur, Paris, France., Tattevin P; Service de Maladie Infectieuse et de Réanimation Médicale, CHU de Rennes, 2, rue Henri le Guilloux, 35000, Rennes, France., Massart N; Service de Réanimation Polyvalente, CH de Saint-Brieuc, 10 rue Marcel Proust, 22000, Saint-Brieuc, France.

Publikováno v: Clinical microbiology and infection : the official publication of the European Society of Clinical Microbiology and Infectious Diseases [Clin Microbiol Infect] 2022 Feb; Vol. 28 (2), pp. 298.e9-298.e15. Date of Electronic Publication: 2021 Oct 07.