A small molecule interacts with VDAC2 to block mouse BAK-driven apoptosis.

Autor: van Delft MF; Blood Cells and Blood Cancer Division, The Walter and Eliza Hall Institute of Medical Research, Parkville, Victoria, Australia. vandelft@wehi.edu.au.; Department of Medical Biology, The University of Melbourne, Parkville, Victoria, Australia. vandelft@wehi.edu.au., Chappaz S; Department of Medical Biology, The University of Melbourne, Parkville, Victoria, Australia.; ACRF Chemical Biology Division, The Walter and Eliza Hall Institute of Medical Research, Parkville, Victoria, Australia.; Anatomy and Developmental Biology, Monash Biomedicine Discovery Institute, Monash University, Melbourne, Victoria, Australia., Khakham Y; Department of Medical Biology, The University of Melbourne, Parkville, Victoria, Australia.; ACRF Chemical Biology Division, The Walter and Eliza Hall Institute of Medical Research, Parkville, Victoria, Australia., Bui CT; Department of Medical Biology, The University of Melbourne, Parkville, Victoria, Australia.; ACRF Chemical Biology Division, The Walter and Eliza Hall Institute of Medical Research, Parkville, Victoria, Australia., Debrincat MA; Blood Cells and Blood Cancer Division, The Walter and Eliza Hall Institute of Medical Research, Parkville, Victoria, Australia.; Department of Medical Biology, The University of Melbourne, Parkville, Victoria, Australia., Lowes KN; Department of Medical Biology, The University of Melbourne, Parkville, Victoria, Australia.; ACRF Chemical Biology Division, The Walter and Eliza Hall Institute of Medical Research, Parkville, Victoria, Australia.; Advanced Technology and Biology Division, The Walter and Eliza Hall Institute of Medical Research, Parkville, Victoria, Australia., Brouwer JM; Department of Medical Biology, The University of Melbourne, Parkville, Victoria, Australia.; Structural Biology Division, The Walter and Eliza Hall Institute of Medical Research, Parkville, Victoria, Australia., Grohmann C; Department of Medical Biology, The University of Melbourne, Parkville, Victoria, Australia.; ACRF Chemical Biology Division, The Walter and Eliza Hall Institute of Medical Research, Parkville, Victoria, Australia., Sharp PP; Department of Medical Biology, The University of Melbourne, Parkville, Victoria, Australia.; ACRF Chemical Biology Division, The Walter and Eliza Hall Institute of Medical Research, Parkville, Victoria, Australia., Dagley LF; Department of Medical Biology, The University of Melbourne, Parkville, Victoria, Australia.; Advanced Technology and Biology Division, The Walter and Eliza Hall Institute of Medical Research, Parkville, Victoria, Australia., Li L; Department of Medical Biology, The University of Melbourne, Parkville, Victoria, Australia.; ACRF Chemical Biology Division, The Walter and Eliza Hall Institute of Medical Research, Parkville, Victoria, Australia., McArthur K; Department of Medical Biology, The University of Melbourne, Parkville, Victoria, Australia.; ACRF Chemical Biology Division, The Walter and Eliza Hall Institute of Medical Research, Parkville, Victoria, Australia.; Anatomy and Developmental Biology, Monash Biomedicine Discovery Institute, Monash University, Melbourne, Victoria, Australia., Luo MX; Department of Medical Biology, The University of Melbourne, Parkville, Victoria, Australia.; ACRF Chemical Biology Division, The Walter and Eliza Hall Institute of Medical Research, Parkville, Victoria, Australia., Chin HS; Blood Cells and Blood Cancer Division, The Walter and Eliza Hall Institute of Medical Research, Parkville, Victoria, Australia.; Department of Medical Biology, The University of Melbourne, Parkville, Victoria, Australia., Fairlie WD; Department of Medical Biology, The University of Melbourne, Parkville, Victoria, Australia.; Structural Biology Division, The Walter and Eliza Hall Institute of Medical Research, Parkville, Victoria, Australia.; La Trobe Institute for Molecular Science, Latrobe University, Bundoora, Victoria, Australia.; Olivia Newton-John Cancer Research Institute, Heidelberg, Victoria, Australia., Lee EF; Department of Medical Biology, The University of Melbourne, Parkville, Victoria, Australia.; Structural Biology Division, The Walter and Eliza Hall Institute of Medical Research, Parkville, Victoria, Australia.; La Trobe Institute for Molecular Science, Latrobe University, Bundoora, Victoria, Australia.; Olivia Newton-John Cancer Research Institute, Heidelberg, Victoria, Australia., Segal D; Blood Cells and Blood Cancer Division, The Walter and Eliza Hall Institute of Medical Research, Parkville, Victoria, Australia.; Department of Medical Biology, The University of Melbourne, Parkville, Victoria, Australia., Duflocq S; Department of Medical Biology, The University of Melbourne, Parkville, Victoria, Australia.; ACRF Chemical Biology Division, The Walter and Eliza Hall Institute of Medical Research, Parkville, Victoria, Australia., Lessene R; Department of Medical Biology, The University of Melbourne, Parkville, Victoria, Australia.; ACRF Chemical Biology Division, The Walter and Eliza Hall Institute of Medical Research, Parkville, Victoria, Australia., Bernard S; Department of Medical Biology, The University of Melbourne, Parkville, Victoria, Australia.; ACRF Chemical Biology Division, The Walter and Eliza Hall Institute of Medical Research, Parkville, Victoria, Australia., Peilleron L; Department of Medical Biology, The University of Melbourne, Parkville, Victoria, Australia.; ACRF Chemical Biology Division, The Walter and Eliza Hall Institute of Medical Research, Parkville, Victoria, Australia., Nguyen T; Department of Medical Biology, The University of Melbourne, Parkville, Victoria, Australia.; ACRF Chemical Biology Division, The Walter and Eliza Hall Institute of Medical Research, Parkville, Victoria, Australia., Miles C; Department of Medical Biology, The University of Melbourne, Parkville, Victoria, Australia.; Advanced Technology and Biology Division, The Walter and Eliza Hall Institute of Medical Research, Parkville, Victoria, Australia., Wan SS; Department of Medical Biology, The University of Melbourne, Parkville, Victoria, Australia.; Advanced Technology and Biology Division, The Walter and Eliza Hall Institute of Medical Research, Parkville, Victoria, Australia., Lane RM; Department of Medical Biology, The University of Melbourne, Parkville, Victoria, Australia.; ACRF Chemical Biology Division, The Walter and Eliza Hall Institute of Medical Research, Parkville, Victoria, Australia.; Anatomy and Developmental Biology, Monash Biomedicine Discovery Institute, Monash University, Melbourne, Victoria, Australia., Wardak A; Department of Medical Biology, The University of Melbourne, Parkville, Victoria, Australia.; Structural Biology Division, The Walter and Eliza Hall Institute of Medical Research, Parkville, Victoria, Australia., Lackovic K; Department of Medical Biology, The University of Melbourne, Parkville, Victoria, Australia.; Advanced Technology and Biology Division, The Walter and Eliza Hall Institute of Medical Research, Parkville, Victoria, Australia., Colman PM; Department of Medical Biology, The University of Melbourne, Parkville, Victoria, Australia.; Structural Biology Division, The Walter and Eliza Hall Institute of Medical Research, Parkville, Victoria, Australia., Sandow JJ; Department of Medical Biology, The University of Melbourne, Parkville, Victoria, Australia.; Advanced Technology and Biology Division, The Walter and Eliza Hall Institute of Medical Research, Parkville, Victoria, Australia., Webb AI; Department of Medical Biology, The University of Melbourne, Parkville, Victoria, Australia.; Advanced Technology and Biology Division, The Walter and Eliza Hall Institute of Medical Research, Parkville, Victoria, Australia., Czabotar PE; Department of Medical Biology, The University of Melbourne, Parkville, Victoria, Australia.; Structural Biology Division, The Walter and Eliza Hall Institute of Medical Research, Parkville, Victoria, Australia., Dewson G; Department of Medical Biology, The University of Melbourne, Parkville, Victoria, Australia.; Ubiquitin Signalling Division, The Walter and Eliza Hall Institute of Medical Research, Parkville, Victoria, Australia., Watson KG; Department of Medical Biology, The University of Melbourne, Parkville, Victoria, Australia.; ACRF Chemical Biology Division, The Walter and Eliza Hall Institute of Medical Research, Parkville, Victoria, Australia., Huang DCS; Blood Cells and Blood Cancer Division, The Walter and Eliza Hall Institute of Medical Research, Parkville, Victoria, Australia.; Department of Medical Biology, The University of Melbourne, Parkville, Victoria, Australia., Lessene G; Department of Medical Biology, The University of Melbourne, Parkville, Victoria, Australia. glessene@wehi.edu.au.; ACRF Chemical Biology Division, The Walter and Eliza Hall Institute of Medical Research, Parkville, Victoria, Australia. glessene@wehi.edu.au.; Department of Pharmacology and Therapeutics, The University of Melbourne, Parkville, Victoria, Australia. glessene@wehi.edu.au., Kile BT; Department of Medical Biology, The University of Melbourne, Parkville, Victoria, Australia.; ACRF Chemical Biology Division, The Walter and Eliza Hall Institute of Medical Research, Parkville, Victoria, Australia.; Anatomy and Developmental Biology, Monash Biomedicine Discovery Institute, Monash University, Melbourne, Victoria, Australia.

Publikováno v: Nature chemical biology [Nat Chem Biol] 2019 Nov; Vol. 15 (11), pp. 1057-1066. Date of Electronic Publication: 2019 Oct 07.

Small-Molecule Modulators of Mitochondrial Channels as Chemotherapeutic Agents.

Autor: Parrasia, Sofia, Mattarei, Andrea, Furlan, Alberto, Zoratti, Mario, Biasutto, Lucia

Publikováno v: Cellular Physiology & Biochemistry (Cell Physiol Biochem Press GmbH & Co. KG); 2019 Supplement, Vol. 53, p11-43, 33p