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GCAT vertical bar Genomes for life: a prospective cohort study of the genomes of Catalonia

Autor: Obon-Santacana, M, Vilardell, M, Carreras, A, Duran, X, Velasco, J, Galvan-Femenia, I, Alonso, T, Puig, L, Sumoy, L, Duell, EJ, Perucho, M, Moreno, V, de Cid, R

Publikováno v: BMJ Open
r-IIB SANT PAU. Repositorio Institucional de Producción Científica del Instituto de Investigación Biomédica Sant Pau
Universitat Pompeu Fabra
r-IGTP. Repositorio Institucional de Producción Científica del Instituto de Investigación Germans Trias i Pujol
instname

Purpose The prevalence of chronic non-communicable diseases (NCDs) is increasing worldwide. NCDs are the leading cause of both morbidity and mortality, and it is estimated that by 2030, they will be responsible for 80% of deaths across the world. The

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=dedup_wf_001::59bb4f50d9486de0563c3ebc44d1c3ca
https://iibsantpau.fundanetsuite.com/Publicaciones/ProdCientif/PublicacionFrw.aspx?id=14069

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Association between telomere length and risk of cancer and non-neoplastic diseases a mendelian randomization study

Autor: Haycock, PC, Burgess, S, Nounu, A, Zheng, J, Okoli, GN, Bowden, J, Wade, KH, Timpson, NJ, Evans, DM, Willeit, P, Aviv, A, Gaunt, TR, Hemani, G, Mangino, M, Ellis, HP, Kurian, KM, Pooley, KA, Eeles, RA, Lee, JE, Fang, S, Chen, WV, Law, MH, Bowdler, LM, Iles, MM, Yang, Q, Worrall, BB, Markus, HS, Hung, RJ, Amos, CI, Spurdle, AB, Thompson, DJ, O'Mara, TA, Wolpin, B, Amundadottir, L, Stolzenberg-Solomon, R, Trichopoulou, A, Onland-Moret, NC, Lund, E, Duell, EJ, Canzian, F, Severi, G, Overvad, K, Gunter, MJ, Tumino, R, Svenson, U, Van Rij, A, Baas, AF, Bown, MJ, Samani, NJ, Van t'Hof, FNG, Tromp, G, Jones, GT, Kuivaniemi, H, Elmore, JR, Johansson, M, Mckay, J, Scelo, G, Carreras-Torres, R, Gaborieau, V, Brennan, P, Bracci, PM, Neale, RE, Olson, SH, Gallinger, S, Li, D, Petersen, GM, Risch, HA, Klein, AP, Han, J, Abnet, CC, Freedman, ND, Taylor, PR, Maris, JM, Aben, KK, Kiemeney, LA, Vermeulen, SH, Wiencke, JK, Walsh, KM

Publikováno v: Haycock, PC; Burgess, S; Nounu, A; Zheng, J; Okoli, GN; Bowden, J; et al.(2017). Association between telomere length and risk of cancer and non-neoplastic diseases a mendelian randomization study. JAMA Oncology, 3(5), 636-651. doi: 10.1001/jamaoncol.2016.5945. UCLA: Retrieved from: http://www.escholarship.org/uc/item/2ch188qq

Copyright 2017 American Medical Association. All rights reserved. IMPORTANCE: The causal direction and magnitude of the association between telomere length and incidence of cancer and non-neoplastic diseases is uncertain owing to the susceptibility o

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=od_______325::6973e2d71ee69d8464b8c8c54a257675
http://www.escholarship.org/uc/item/2ch188qq

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Functional characterization of a multi-cancer risk locus on chr5p15.33 reveals regulation of TERT by ZNF148

Autor: Fang, J, Jia, J, Makowski, M, Xu, M, Wang, Z, Zhang, T, Hoskins, Jw, Choi, J, Han, Y, Zhang, M, Thomas, J, Kovacs, M, Collins, I, Dzyadyk, M, Thompson, A, O'Neill, M, Das, S, Lan, Q, Koster, R, Solomon, Rs, Kraft, P, Wolpin, Bm, Jansen, Pwtc, Olson, S, Mcglynn, Ka, Kanetsky, Pa, Chatterjee, N, Barrett, Jh, Dunning, Am, Taylor, Jc, Newton Bishop, Ja, Bishop, Dt, Andresson, T, Petersen, Gm, Amos, Ci, Iles, Mm, Nathanson, Kl, Landi, Mt, Vermeulen, M, Brown, Km, Amundadottir, Lt, Canzian, F, Kooperberg, C, Arslan, Aa, Bracci, Pm, Buring, J, Duell, Ej, Gallinger, S, Jacobs, Ej, Kamineni, A, Van Den Eeden, S, Klein, Ap, Kolonel, Ln, Li, D, Olson, Sh, Risch, Ha, Sesso, Hd, Visvanathan, K, Zheng, W, Albanes, D, Austin, Ma, Boutron Ruault, Mc, Bueno de Mesquita, Hb, Cotterchio, M, Gaziano, Jm, Giovannucci, El, Goggins, M, Gross, M, Hassan, M, Helzlsouer, Kj, Holly, Ea, Hunter, Dj, Jenab, M, Kaaks, R, Key, Tj, Khaw, Kt, Krogh, V, Kurtz, Rc, Lacroix, A, Le Marchand, L, Mannisto, S, Patel, Av, Peeters, Phm, Riboli, E, Shu, Xo, Sund, M, Thornquist, M, Tjønneland, A, Tobias, Gs, Trichopoulos, D, Wactawski Wende, J, Yu, H, Yu, K, Zeleniuch Jacquotte, A, Hoover, R, Hartge, P, Fuchs, C, Chanock, Sj, Stevens, V, Caporaso, Ne, Brennan, P, Mckay, J, Wu, X, Hung, Rj, Mclaughlin, Jr, Bickeboller, H, Risch, A, Wichmann, E, Houlston, R, Mann, G, Hopper, J, Aitken, J, Armstrong, B, Giles, G, Holland, E, Kefford, R, Cust, A, Jenkins, M, Schmid, H, Puig, S, Aguilera, P, Badenas, C, Barreiro, A, Carrera, C, Gabriel, D, Xavier, Pg, Iglesias Garcia, P, Malvehy, J, Mila, M, Pigem, R, Potrony, M, Batille, Ja, Marti, Gt, Hayward, N, Martin, N, Montgomery, G, Duffy, D, Whiteman, D, Gregor, Sm, Calista, D, Landi, G, Minghetti, P, Arcangeli, F, Bertazzi, Pa, Ghiorzo, Paola, Bianchi, Giovanna, Pastorino, Lorenza, Bruno, William, Andreotti, Virginia, Queirolo, P, Spagnolo, Francesco, Mackie, R, Lang, J, Gruis, N, van Nieuwpoort, Fa, Out, C, Bergman, W, Kukutsch, N, Bavinck, Jnb, Bakker, B, van der Stoep, N, Ter Huurne, J, van der Rhee, H, Bekkenk, M, Snels, D, van Praag, M, Brochez, L, Gerritsen, R, Crijns, M, Vasen, H, Janssen, B, Ingvar, C, Olsson, H, Jonsson, G, Borg, A, Harbst, K, Nielsen, K, Zander, As, Molvern, A, Helsing, P, Andresen, Pa, Rootwelt, H, Akslen, La, Bressac de Paillerets, B, Demenais, F, Avril, Mf, Chaudru, V, Jeannin, P, Lesueur, F, Maubec, E, Mohamdi, H, Bossard, M, Vaysse, A, Boitier, F, Caron, O, Caux, F, Dalle, S, Dereure, O, Leroux, D, Martin, L, Mateus, C, Robert, C, Stoppa Lyonnet, D, Thomas, L, Wierzbicka, E, Elder, D, Ming, M, Mitra, N, Debniak, T, Lubinski, J, Hocevar, M, Novakovic, S, Peric, B, Skerl, P, Hansson, J, Hoiom, V, Freidman, E, Azizi, E, Baron Epel, O, Scope, A, Pavlotsky, F, Cohen Manheim, I, Laitman, Y, Harland, M, Randerson Moor, J, Laye, J, Davies, J, Nsengimana, J, O'Shea, S, Chan, M, Gascoyne, J, Tucker, Ma, Goldstein, Am, Yang, X. r.

Publikováno v: Nature Communications, 8, 1-15
Nature Communications, 8
Nature Communications, Vol 8, Iss 1, Pp 1-17 (2017)
Nature Communications [E], 8. Nature Publishing Group
Nature Communications
Dipòsit Digital de la UB
Universidad de Barcelona
Nature Communications, 8, pp. 1-15
Nature Communications [E], 8

Genome wide association studies (GWAS) have mapped multiple independent cancer susceptibility loci to chr5p15.33. Here, we show that fine-mapping of pancreatic and testicular cancer GWAS within one of these loci (Region 2 in CLPTM1L) focuses the sign

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::685f0d32afab698c8b9cac1e8f4b2533
http://hdl.handle.net/2066/175467

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Alcohol drinking and endometrial cancer risk in the European Prospective Investigation into Cancer and Nutrition (EPIC) study

Publikováno v: Fedirko, V, Jenab, M, Rinaldi, S, Biessy, C, Allen, N E, Dossus, L, Onland-Moret, N C, Schütze, M, Tjønneland, A, Hansen, L, Overvad, K, Clavel-Chapelon, F, Chabbert-Buffet, N, Kaaks, R, Lukanova, A, Bergmann, M M, Boeing, H, Trichopoulou, A, Oustoglou, E, Barbitsioti, A, Saieva, C, Tagliabue, G, Galasso, R, Tumino, R, Sacerdote, C, Peeters, P H, Bueno-de-Mesquita, H B, Weiderpass, E, Gram, I T, Sanchez, S, Duell, E J, Molina-Montes, E, Arriola, L, Chirlaque, M-D, Ardanaz, E, Manjer, J, Lundin, E, Idahl, A, Khaw, K-T, Romaguera-Bosch, D, Wark, P A, Norat, T & Romieu, I 2013, ' Alcohol drinking and endometrial cancer risk in the European Prospective Investigation into Cancer and Nutrition (EPIC) study ', Annals of Epidemiology, vol. 23, no. 2, pp. 93-8 . https://doi.org/10.1016/j.annepidem.2012.11.009

Purpose: Alcohol intake may adversely affect the concentrations of endogenous sex hormones, and thus increase the risk of endometrial cancer. However, epidemiologic studies have provided conflicting results. Therefore, we investigated the association

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::3ee3d33f9cd9b05df1b32c3b24754fac
https://ora.ox.ac.uk/objects/uuid:c711d4fe-af17-4361-93f4-9b65abf43a14

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Prediagnostic plasma testosterone, sex hormone-binding globulin, IGF-I and hepatocellular carcinoma: etiological factors or risk markers?

Publikováno v: Lukanova, A, Becker, S, Hüsing, A, Schock, H, Fedirko, V, Trepo, E, Trichopoulou, A, Bamia, C, Lagiou, P, Benetou, V, Trichopoulos, D, Nöthlings, U, Tjønneland, A, Overvad, K, Dossus, L, Teucher, B, Boeing, H, Aleksandrova, K, Palli, D, Pala, V, Panico, S, Tumino, R, Ricceri, F, Bueno-de-Mesquita, H B, Siersema, P D, Peeters, P M, Quiros, J R, Duell, E J, Molina-Montes, E, Chirlaque, M-D, Gurrea, A B, Dorronsoro, M, Lindkvist, B, Johansen, D, Werner, M, Sund, M, Khaw, K-T, Wareham, N, Key, T J, Travis, R C, Rinaldi, S, Romieu, I, Gunter, M J, Riboli, E, Jenab, M & Kaaks, R 2014, ' Prediagnostic plasma testosterone, sex hormone binding globulin, IGF-I and hepatocellular carcinoma : Etiological factors or risk markers? ', International Journal of Cancer, vol. 134, no. 1, pp. 164-73 . https://doi.org/10.1002/ijc.28342

Elevated pre-diagnostic testosterone and insulin-like growth factor-I (IGF-I) concentrations have been proposed to increase risk of hepatocellular carcinoma (HCC). However, the metabolism of these hormones is altered as a consequence of liver damage

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=pmid_dedup__::83741cf623a89abf7c260ebe6cfb4e20
http://hdl.handle.net/11588/584936

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