Control of endothelial cell function and arteriogenesis by MEG3:EZH2 epigenetic regulation of integrin expression.

Autor: Dunn-Davies H; Wellcome Centre for Cell Biology, University of Edinburgh, Michael Swann Building Max Born Crescent, King's Buildings, Edinburgh EH9 3BF, UK., Dudnakova T; University/British Heart Foundation Centre for Cardiovascular Science, Queen's Medical Research Institute (QMRI), The University of Edinburgh, 47 Little France Crescent, Edinburgh EH16 4TJ, UK., Nogara A; University/British Heart Foundation Centre for Cardiovascular Science, Queen's Medical Research Institute (QMRI), The University of Edinburgh, 47 Little France Crescent, Edinburgh EH16 4TJ, UK., Rodor J; University/British Heart Foundation Centre for Cardiovascular Science, Queen's Medical Research Institute (QMRI), The University of Edinburgh, 47 Little France Crescent, Edinburgh EH16 4TJ, UK., Thomas AC; Bristol Medical School, Translational Health Sciences, University of Bristol, Research and Teaching Floor Level 7, Queens Building, Bristol Royal Infirmary, Bristol BS2 8HW, UK., Parish E; University/British Heart Foundation Centre for Cardiovascular Science, Queen's Medical Research Institute (QMRI), The University of Edinburgh, 47 Little France Crescent, Edinburgh EH16 4TJ, UK., Gautier P; MRC Human Genetics Unit, MRC Institute of Genetics and Cancer, The University of Edinburgh, Western General Hospital, Crewe Road, Edinburgh EH4 2XU, UK., Meynert A; MRC Human Genetics Unit, MRC Institute of Genetics and Cancer, The University of Edinburgh, Western General Hospital, Crewe Road, Edinburgh EH4 2XU, UK., Ulitsky I; Department of Immunology and Regenerative Biology and Department of Molecular Neuroscience, Weizmann-UK Building rm. 007, Weizmann Institute of Science Rehovot 76100, Israel., Madeddu P; Bristol Medical School, Translational Health Sciences, University of Bristol, Research and Teaching Floor Level 7, Queens Building, Bristol Royal Infirmary, Bristol BS2 8HW, UK., Caporali A; University/British Heart Foundation Centre for Cardiovascular Science, Queen's Medical Research Institute (QMRI), The University of Edinburgh, 47 Little France Crescent, Edinburgh EH16 4TJ, UK., Baker A; University/British Heart Foundation Centre for Cardiovascular Science, Queen's Medical Research Institute (QMRI), The University of Edinburgh, 47 Little France Crescent, Edinburgh EH16 4TJ, UK., Tollervey D; Wellcome Centre for Cell Biology, University of Edinburgh, Michael Swann Building Max Born Crescent, King's Buildings, Edinburgh EH9 3BF, UK., Mitić T; University/British Heart Foundation Centre for Cardiovascular Science, Queen's Medical Research Institute (QMRI), The University of Edinburgh, 47 Little France Crescent, Edinburgh EH16 4TJ, UK.

Publikováno v: Molecular therapy. Nucleic acids [Mol Ther Nucleic Acids] 2024 Apr 06; Vol. 35 (2), pp. 102173. Date of Electronic Publication: 2024 Apr 06 (Print Publication: 2024).

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Transcription factor Wilms' tumor 1 regulates developmental RNAs through 3' UTR interaction

Autor: Bharathavikru, R, Dudnakova, T, Aitken, S, Slight, J, Artibani, M, Hohenstein, P, Tollervey, D, Hastie, N

Publikováno v: Genes & Development. 31(4)

Wilms' tumor 1 (WT1) is essential for the development and homeostasis of multiple mesodermal tissues. Despite evidence for post-transcriptional roles, no endogenous WT1 target RNAs exist. Using RNA immunoprecipitation and UV cross-linking, we show th

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=dedup_wf_001::db4bd76b2d4a2256d185ce17f29ea46a
http://ora.ox.ac.uk/objects/uuid:

MIR503HG Loss Promotes Endothelial-to-Mesenchymal Transition in Vascular Disease.

Autor: Monteiro JP; The Queen's Medical Research Institute, Centre for Cardiovascular Science (J.P.M., J.R., A. Caudrillier, J.P.S., A.-M.S., T.D., A.S., L. Deng, S.-H.C., K.S., A.T., T.M., J.I., P.W.F.H., L. Denby, A. Caporali, A.H.B.), University of Edinburgh, Edinburgh, Scotland., Rodor J; The Queen's Medical Research Institute, Centre for Cardiovascular Science (J.P.M., J.R., A. Caudrillier, J.P.S., A.-M.S., T.D., A.S., L. Deng, S.-H.C., K.S., A.T., T.M., J.I., P.W.F.H., L. Denby, A. Caporali, A.H.B.), University of Edinburgh, Edinburgh, Scotland., Caudrillier A; The Queen's Medical Research Institute, Centre for Cardiovascular Science (J.P.M., J.R., A. Caudrillier, J.P.S., A.-M.S., T.D., A.S., L. Deng, S.-H.C., K.S., A.T., T.M., J.I., P.W.F.H., L. Denby, A. Caporali, A.H.B.), University of Edinburgh, Edinburgh, Scotland., Scanlon JP; The Queen's Medical Research Institute, Centre for Cardiovascular Science (J.P.M., J.R., A. Caudrillier, J.P.S., A.-M.S., T.D., A.S., L. Deng, S.-H.C., K.S., A.T., T.M., J.I., P.W.F.H., L. Denby, A. Caporali, A.H.B.), University of Edinburgh, Edinburgh, Scotland., Spiroski AM; The Queen's Medical Research Institute, Centre for Cardiovascular Science (J.P.M., J.R., A. Caudrillier, J.P.S., A.-M.S., T.D., A.S., L. Deng, S.-H.C., K.S., A.T., T.M., J.I., P.W.F.H., L. Denby, A. Caporali, A.H.B.), University of Edinburgh, Edinburgh, Scotland., Dudnakova T; The Queen's Medical Research Institute, Centre for Cardiovascular Science (J.P.M., J.R., A. Caudrillier, J.P.S., A.-M.S., T.D., A.S., L. Deng, S.-H.C., K.S., A.T., T.M., J.I., P.W.F.H., L. Denby, A. Caporali, A.H.B.), University of Edinburgh, Edinburgh, Scotland., Pflüger-Müller B; Institute for Cardiovascular Physiology, Goethe University, Frankfurt, Germany (B.P.-M., M.S.L., R.P.B.).; German Center of Cardiovascular Research (DZHK), Partner site RheinMain, Frankfurt, Germany (B.P.-M., M.S.L., R.P.B.)., Shmakova A; The Queen's Medical Research Institute, Centre for Cardiovascular Science (J.P.M., J.R., A. Caudrillier, J.P.S., A.-M.S., T.D., A.S., L. Deng, S.-H.C., K.S., A.T., T.M., J.I., P.W.F.H., L. Denby, A. Caporali, A.H.B.), University of Edinburgh, Edinburgh, Scotland., von Kriegsheim A; Edinburgh Cancer Research UK Centre, Institute of Genetics and Molecular Medicine (A.v.K.), University of Edinburgh, Edinburgh, Scotland., Deng L, Taylor RS; The Roslin Institute and Royal (Dick) School of Veterinary Studies (R.S.T.), University of Edinburgh, Edinburgh, Scotland., Wilson-Kanamori JR; The Queen's Medical Research Institute, Centre for Inflammation Research (J.R.W.-K., N.C.H.), University of Edinburgh, Edinburgh, Scotland., Chen SH, Stewart K, Thomson A, Mitić T; The Queen's Medical Research Institute, Centre for Cardiovascular Science (J.P.M., J.R., A. Caudrillier, J.P.S., A.-M.S., T.D., A.S., L. Deng, S.-H.C., K.S., A.T., T.M., J.I., P.W.F.H., L. Denby, A. Caporali, A.H.B.), University of Edinburgh, Edinburgh, Scotland., McClure JD; Institute of Cardiovascular and Medical Sciences, British Heart Foundation (BHF) Glasgow Centre, University of Glasgow, Glasgow, United Kingdom (J.D.M., A.C.B.)., Iynikkel J; The Queen's Medical Research Institute, Centre for Cardiovascular Science (J.P.M., J.R., A. Caudrillier, J.P.S., A.-M.S., T.D., A.S., L. Deng, S.-H.C., K.S., A.T., T.M., J.I., P.W.F.H., L. Denby, A. Caporali, A.H.B.), University of Edinburgh, Edinburgh, Scotland., Hadoke PWF; The Queen's Medical Research Institute, Centre for Cardiovascular Science (J.P.M., J.R., A. Caudrillier, J.P.S., A.-M.S., T.D., A.S., L. Deng, S.-H.C., K.S., A.T., T.M., J.I., P.W.F.H., L. Denby, A. Caporali, A.H.B.), University of Edinburgh, Edinburgh, Scotland., Denby L; The Queen's Medical Research Institute, Centre for Cardiovascular Science (J.P.M., J.R., A. Caudrillier, J.P.S., A.-M.S., T.D., A.S., L. Deng, S.-H.C., K.S., A.T., T.M., J.I., P.W.F.H., L. Denby, A. Caporali, A.H.B.), University of Edinburgh, Edinburgh, Scotland., Bradshaw AC; Institute of Cardiovascular and Medical Sciences, British Heart Foundation (BHF) Glasgow Centre, University of Glasgow, Glasgow, United Kingdom (J.D.M., A.C.B.)., Caruso P; BHF Cambridge (CRE), University of Cambridge, Cambridge, United Kingdom (P.C., N.W.M.)., Morrell NW; BHF Cambridge (CRE), University of Cambridge, Cambridge, United Kingdom (P.C., N.W.M.)., Kovacic JC; The Zena and Michael A. Wiener Cardiovascular Institute, School of Medicine at Mount Sinai, New York, New York (J.C.K.).; Victor Chang Cardiac Research Institute, Darlinghurst, Australia. (J.C.K.)., Ulitsky I; Department of Biological Regulation, Weizmann Institute of Science, Rehovot, Israel (I.U.)., Henderson NC; The Queen's Medical Research Institute, Centre for Inflammation Research (J.R.W.-K., N.C.H.), University of Edinburgh, Edinburgh, Scotland., Caporali A; The Queen's Medical Research Institute, Centre for Cardiovascular Science (J.P.M., J.R., A. Caudrillier, J.P.S., A.-M.S., T.D., A.S., L. Deng, S.-H.C., K.S., A.T., T.M., J.I., P.W.F.H., L. Denby, A. Caporali, A.H.B.), University of Edinburgh, Edinburgh, Scotland., Leisegang MS; Institute for Cardiovascular Physiology, Goethe University, Frankfurt, Germany (B.P.-M., M.S.L., R.P.B.).; German Center of Cardiovascular Research (DZHK), Partner site RheinMain, Frankfurt, Germany (B.P.-M., M.S.L., R.P.B.)., Brandes RP; Institute for Cardiovascular Physiology, Goethe University, Frankfurt, Germany (B.P.-M., M.S.L., R.P.B.).; German Center of Cardiovascular Research (DZHK), Partner site RheinMain, Frankfurt, Germany (B.P.-M., M.S.L., R.P.B.)., Baker AH; The Queen's Medical Research Institute, Centre for Cardiovascular Science (J.P.M., J.R., A. Caudrillier, J.P.S., A.-M.S., T.D., A.S., L. Deng, S.-H.C., K.S., A.T., T.M., J.I., P.W.F.H., L. Denby, A. Caporali, A.H.B.), University of Edinburgh, Edinburgh, Scotland.

Publikováno v: Circulation research [Circ Res] 2021 Apr 16; Vol. 128 (8), pp. 1173-1190. Date of Electronic Publication: 2021 Mar 11.

The roles and mechanisms of miRNA in HBV-HCC carcinogenesis: Why no therapeutic agents after 30 years?

Autor: SARTORIUS, KURT^1,2,3 (AUTHOR) kurt.sartorius@wits.ac.za, SARTORIUS, BENN⁴ (AUTHOR), WINKLER, CHERIE⁵ (AUTHOR), CHUTURGOON, ANIL² (AUTHOR), KRAMVIS, ANNA¹ (AUTHOR), AN, PING⁵ (AUTHOR), ZHANG, WEIGANG⁶ (AUTHOR), LU, YUNJIE^3,6,7 (AUTHOR) yj0001@suda.edu.cn

Publikováno v: Biocell. 2024, Vol. 48 Issue 11, p1543-1567. 25p.