Zobrazeno 1 - 10
of 142
pro vyhledávání: '"Dudley W. Lamming"'
Autor:
Reji Babygirija, Michelle M. Sonsalla, Jericha Mill, Isabella James, Jessica H. Han, Cara L. Green, Mariah F. Calubag, Gina Wade, Anna Tobon, John Michael, Michaela M. Trautman, Ryan Matoska, Chung-Yang Yeh, Isaac Grunow, Heidi H. Pak, Michael J. Rigby, Dominique A. Baldwin, Natalie M. Niemi, John M. Denu, Luigi Puglielli, Judith Simcox, Dudley W. Lamming
Publikováno v:
Nature Communications, Vol 15, Iss 1, Pp 1-20 (2024)
Abstract Dietary protein is a critical regulator of metabolic health and aging. Low protein diets are associated with healthy aging in humans, and dietary protein restriction extends the lifespan and healthspan of mice. In this study, we examined the
Externí odkaz:
https://doaj.org/article/b26c60924d774ad28f4fa4d30134ac5c
Autor:
Heidi H. Pak, Allison N. Grossberg, Rachel R. Sanderfoot, Reji Babygirija, Cara L. Green, Mikaela Koller, Monika Dzieciatkowska, Daniel A. Paredes, Dudley W. Lamming
Publikováno v:
Cell Reports, Vol 43, Iss 9, Pp 114663- (2024)
Summary: Calorie restriction (CR) extends lifespan and healthspan in diverse species. Comparing ad libitum- and CR-fed mice is challenging due to their significantly different feeding patterns, with CR-fed mice consuming their daily meal in 2 h and t
Externí odkaz:
https://doaj.org/article/5fe82deba8cf47e18de23ce721f3e896
Autor:
Christian J. Elliehausen, Rozalyn M. Anderson, Gary M. Diffee, Timothy W. Rhoads, Dudley W. Lamming, Troy A. Hornberger, Adam R. Konopka
Publikováno v:
BMC Biology, Vol 21, Iss 1, Pp 1-15 (2023)
Abstract Physical activity and several pharmacological approaches individually combat age-associated conditions and extend healthy longevity in model systems. It is tantalizing to extrapolate that combining geroprotector drugs with exercise could ext
Externí odkaz:
https://doaj.org/article/ce8d8741c2d444e894d37204ef2479d7
Autor:
Reji Babygirija, Dudley W. Lamming
Publikováno v:
Translational Medicine of Aging, Vol 5, Iss , Pp 17-30 (2021)
As a key macronutrient and source of essential macromolecules, dietary protein plays a significant role in health. For many years, protein-rich diets have been recommended as healthy due to the satiety-inducing and muscle-building effects of protein,
Externí odkaz:
https://doaj.org/article/58e016bcefc8409ebb579d662f84d483
Autor:
Dudley W. Lamming, Christy S. Carter
Publikováno v:
Translational Medicine of Aging, Vol 4, Iss , Pp 55-59 (2020)
The “Aging Science Talks: Science for the Community” daily online seminar series was established in reaction to the cancellation of a myriad of regional, national, and international meetings focused on the biology of aging due to the COVID-19 pan
Externí odkaz:
https://doaj.org/article/b80e3c6709624c7398d471aedca6ed9c
Autor:
Katherine H. Schreiber, Sebastian I. Arriola Apelo, Deyang Yu, Jacqueline A. Brinkman, Michael C. Velarde, Faizan A. Syed, Chen-Yu Liao, Emma L. Baar, Kathryn A. Carbajal, Dawn S. Sherman, Denise Ortiz, Regina Brunauer, Shany E. Yang, Stelios T. Tzannis, Brian K. Kennedy, Dudley W. Lamming
Publikováno v:
Nature Communications, Vol 10, Iss 1, Pp 1-12 (2019)
Rapamycin extends lifespan in model organisms by targeting mTORC1, but exerts off-target side effects via inhibition of mTORC2. Here, the authors report the identification of a selective mTORC1 inhibitor, and show that it inhibits mTORC1 activity bot
Externí odkaz:
https://doaj.org/article/62fe1b728b0148059e306c8857df6c69
Autor:
Marko Knoll, Sally Winther, Anirudh Natarajan, Huan Yang, Mengxi Jiang, Prathapan Thiru, Aliakbar Shahsafaei, Tony E. Chavarria, Dudley W. Lamming, Lei Sun, Jacob B. Hansen, Harvey F. Lodish
Publikováno v:
Nature Communications, Vol 8, Iss 1, Pp 1-11 (2017)
Spleen protein tyrosine kinase (Syk) has so far been mainly studied in haematopoietic and immune cells. Here, the authors show that Syk also has a role in brown adipose tissue, where it regulates the formation of brown adipocytes and their thermogeni
Externí odkaz:
https://doaj.org/article/877a0b3be1764ea4bc9c077a7efffb20
Autor:
Wenyuan G. Zhu, Jamie E. Hibbert, Kuan Hung Lin, Nathaniel D. Steinert, Jake L. Lemens, Kent W. Jorgenson, Sarah M. Newman, Dudley W. Lamming, Troy A. Hornberger
Publikováno v:
Cells, Vol 10, Iss 9, p 2459 (2021)
This study describes a mouse model of progressive resistance exercise that utilizes a full-body/multi-joint exercise (weight pulling) along with a training protocol that mimics a traditional human paradigm (three training sessions per week, ~8–12 r
Externí odkaz:
https://doaj.org/article/a8c60c5da2fe40e0b413a2e752c319a0
Autor:
Dudley W. Lamming, Christy S. Carter
Publikováno v:
Translational Medicine of Aging, Vol 4, Iss , Pp 149-150 (2020)
Externí odkaz:
https://doaj.org/article/572c1bc1f7dd432290473cefe3e0863b
Autor:
Deyang Yu, Jay L. Tomasiewicz, Shany E. Yang, Blake R. Miller, Matthew H. Wakai, Dawn S. Sherman, Nicole E. Cummings, Emma L. Baar, Jacqueline A. Brinkman, Faizan A. Syed, Dudley W. Lamming
Publikováno v:
Cell Reports, Vol 29, Iss 1, Pp 236-248.e3 (2019)
Summary: Calorie restriction (CR) extends the healthspan and lifespan of diverse species. In mammals, a broadly conserved metabolic effect of CR is improved insulin sensitivity, which may mediate the beneficial effects of a CR diet. This model has be
Externí odkaz:
https://doaj.org/article/018f0f4ebaf5459995174a4d5fb9a25d