Zobrazeno 1 - 10
of 10
pro vyhledávání: '"Duco van Dalen"'
Autor:
Ka Ying Sharon Hung, Sven Klumpe, Markus R. Eisele, Suzanne Elsasser, Geng Tian, Shuangwu Sun, Jamie A. Moroco, Tat Cheung Cheng, Tapan Joshi, Timo Seibel, Duco Van Dalen, Xin-Hua Feng, Ying Lu, Huib Ovaa, John R. Engen, Byung-Hoon Lee, Till Rudack, Eri Sakata, Daniel Finley
Publikováno v:
Nature Communications, Vol 13, Iss 1, Pp 1-13 (2022)
The interplay of the proteasome and deubiquitinase Ubp6 is crucial for the degradation of ubiquitylated substrates. Here, the authors provide structural insights into the allosteric mechanism by which the activities of both Ubp6 and the proteasome ar
Externí odkaz:
https://doaj.org/article/0db17aeb4b8c4a309992d0d564111f7b
Autor:
Iris M. Hagemans, Peter J. Wierstra, Kas Steuten, Janneke D. M. Molkenboer-Kuenen, Duco van Dalen, Martin ter Beest, Johan M. S. van der Schoot, Olga Ilina, Martin Gotthardt, Carl G. Figdor, Ferenc A. Scheeren, Sandra Heskamp, Martijn Verdoes
Publikováno v:
Journal of Nanobiotechnology, Vol 20, Iss 1, Pp 1-15 (2022)
Abstract Background While immune checkpoint inhibitors such as anti-PD-L1 antibodies have revolutionized cancer treatment, only subgroups of patients show durable responses. Insight in the relation between clinical response, PD-L1 expression and intr
Externí odkaz:
https://doaj.org/article/bce30ec5271e44dfb6d7dc4a81599ac1
Autor:
Iris M. Hagemans, Peter J. Wierstra, Kas Steuten, Janneke D. M. Molkenboer-Kuenen, Duco van Dalen, Martin ter Beest, Johan M. S. van der Schoot, Olga Ilina, Martin Gotthardt, Carl G. Figdor, Ferenc A. Scheeren, Sandra Heskamp, Martijn Verdoes
Publikováno v:
Journal of Nanobiotechnology, Vol 20, Iss 1, Pp 1-3 (2022)
Externí odkaz:
https://doaj.org/article/145df4837af84e51a6fd6145a71f73f9
Autor:
Marit J. van Elsas, Johan M. S. van der Schoot, Alexander Bartels, Kas Steuten, Duco van Dalen, Zacharias Wijfjes, Carl G. Figdor, Thorbald van Hall, Sjoerd H. van der Burg, Martijn Verdoes, Ferenc A. Scheeren
Publikováno v:
International Journal of Molecular Sciences, Vol 23, Iss 15, p 8707 (2022)
Regulatory T cells (Tregs) are major drivers behind immunosuppressive mechanisms and present a major hurdle for cancer therapy. Tregs are characterized by a high expression of CD25, which is a potentially valuable target for Treg depletion to allevia
Externí odkaz:
https://doaj.org/article/9b99950f014f4b1bb3ab28ac5b6c67cb
Autor:
Robbert Q. Kim, Paul P. Geurink, Monique P. C. Mulder, Alexander Fish, Reggy Ekkebus, Farid El Oualid, Willem J. van Dijk, Duco van Dalen, Huib Ovaa, Hugo van Ingen, Titia K. Sixma
Publikováno v:
Nature Communications, Vol 10, Iss 1, Pp 1-16 (2019)
Deubiquitinating enzymes (DUBs) are critical regulators of cellular processes by removing ubiquitin from specific targets. Here global kinetic modelling reveals the mechanism by which the low intrinsic activity of USP7 is substantially enhanced on a
Externí odkaz:
https://doaj.org/article/822bd4cb8eb04f3199afc82488ed53d3
Autor:
Kimberly M. Bonger, Camille M. Le Gall, Melek Parlak Khalily, Martijn Verdoes, Iván Ramos-Tomillero, Liyan Smeding, Carl G. Figdor, Johan M.S. van der Schoot, Anna Cammarata, Zacharias Wijfjes, Ferenc A. Scheeren, Floris J. van Dalen, Duco van Dalen
Publikováno v:
Bioconjugate Chemistry
Bioconjugate Chemistry, 32(2), 301-310. AMER CHEMICAL SOC
Bioconjugate Chemistry, 32, 2, pp. 301-310
Bioconjugate Chemistry, 32, 301-310
bioRxiv
Bioconjugate Chemistry, 32(2), 301-310. AMER CHEMICAL SOC
Bioconjugate Chemistry, 32, 2, pp. 301-310
Bioconjugate Chemistry, 32, 301-310
bioRxiv
I.AbstractFunctionalized antibodies and antibody fragments have found applications in the fields of biomedical imaging, theragnostics, and antibody-drug conjugates (ADC). Antibody functionalization is classically achieved by coupling payloads onto ly
Autor:
Tat Cheung Cheng, Timo Seibel, Daniel Finley, Suzanne Elsasser, Ka Ying Sharon Hung, Till Rudack, Huib Ovaa, John R. Engen, Ying Lu, Byung-Hoon Lee, Markus R. Eisele, Duco Van Dalen, Shuangwu Sun, Tapan Joshi, Xin-Hua Feng, Jamie A. Moroco, Sven Klumpe, Geng Tian, Eri Sakata
The proteasome is the principal cellular protease, and recognizes target proteins that have been covalently marked by ubiquitin chains. The ubiquitin signal is subject to rapid editing at the proteasome, allowing it to reject substrates based on topo
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::269104d0fcccb9b12b4cd2a402700a07
https://doi.org/10.1101/2021.07.16.452743
https://doi.org/10.1101/2021.07.16.452743
Publikováno v:
ChemBioChem, 20, 62-65
ChemBioChem, 20, 1, pp. 62-65
ChemBioChem, 20(1), 62-65
ChemBioChem, 20, 1, pp. 62-65
ChemBioChem, 20(1), 62-65
The enzyme-mediated construction of poly-ubiquitin (Ub) chains on target proteins leads to a variety of cellular responses and is involved in processes ranging from protein degradation to cell cycle control and immune responses. This complex post-tra
Autor:
Gabriëlle B. A. van Tilburg, Huib Ovaa, Paul R. Elliott, Duco van Dalen, Paul P. Geurink, Jonathan N. Pruneda, Tycho E. T. Mevissen, David Komander, Bianca D. M. van Tol, Paul J. G. Brundel
Publikováno v:
ChemBioChem, 17(9), 816-820
Chembiochem
Chembiochem
Deubiquitinating enzymes (DUBs) are proteases that fulfill crucial roles in the ubiquitin (Ub) system, by deconjugation of Ub from its targets and disassembly of polyUb chains. The specificity of a DUB towards one of the polyUb chain linkages largely
Autor:
Duco van Dalen, Camille M. Le Gall, Tomislav Čaval, Johan M.S. van der Schoot, Anouk M. D. Becker, Michael Valente, J. Armando C. van Bruggen, Ferenc A. Scheeren, Carl G. Figdor, Marieke F. Fransen, Yusuf Dolen, Martijn Verdoes, Iris M. Hagemans, Maaike Nederend, Gestur Vidarsson, Jeanette H. W. Leusen, Albert J. R. Heck, Felix L. Fennemann, Arthur E. H. Bentlage, Melanie Engelfriet, Alper Cevirgel
Publikováno v:
bioRxiv
Hybridoma technology is instrumental for the development of novel antibody therapeutics and diagnostics. Recent preclinical and clinical studies highlight the importance of antibody isotype for therapeutic efficacy. However, since the sequence encodi
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::90310b3ac8f789fea72911dd3d9ee2b0