Zobrazeno 1 - 10
of 25
pro vyhledávání: '"Duco S. Koenis"'
Autor:
Jessica K. Nelson, May Zaw Thin, Theodore Evan, Steven Howell, Mary Wu, Bruna Almeida, Nathalie Legrave, Duco S. Koenis, Gabriela Koifman, Yoichiro Sugimoto, Miriam Llorian Sopena, James MacRae, Emma Nye, Michael Howell, Ambrosius P. Snijders, Andreas Prachalias, Yoh Zen, Debashis Sarker, Axel Behrens
Publikováno v:
Nature Communications, Vol 13, Iss 1, Pp 1-18 (2022)
The biological roles of deubiquitinating enzymes (DUBs) in pancreatic ductal adenocarcinoma (PDAC) are not fully explored. Here the authors perform activity based proteomics with a loss of function genetic screen and identify that USP25 promotes PDAC
Externí odkaz:
https://doaj.org/article/cd8dab384b2a46bf9a9f3d5ce3b2663f
Autor:
Kimberly Pistorius, Lucy Ly, Patricia R. Souza, Esteban A. Gomez, Duco S. Koenis, Ana R. Rodriguez, Julie Foster, Jane Sosabowski, Mark Hopkinson, Vinothini Rajeeve, Bernd W. Spur, Andrew Pitsillides, Costantino Pitzalis, Jesmond Dalli
Publikováno v:
EBioMedicine, Vol 79, Iss , Pp 103974- (2022)
Summary: Background: Rheumatoid arthritis (RA) is a progressive degenerative disorder that leads to joint destruction. Available treatments only target the inflammatory component with minimal impact on joint repair. We recently uncovered a previously
Externí odkaz:
https://doaj.org/article/b2ce0d97eb95459798637594025cd17b
Publikováno v:
Frontiers in Immunology, Vol 12 (2021)
The mechanisms that lead to disease onset and propagation in patients with chronic rhinosinusitis (CRS) are not fully elucidated. Maresins (MaR) are a family of essential fatty acid-derived lipid mediators that play a central role in the regulation o
Externí odkaz:
https://doaj.org/article/c09c7549bf14447faa9c156bd891e99b
Autor:
Kondababu Kurakula, Duco S. Koenis, Mark A. Herzik, Yanyun Liu, John W. Craft, Pieter B. van Loenen, Mariska Vos, M. Khang Tran, Henri H. Versteeg, Marie-José T.H. Goumans, Wolfram Ruf, Carlie J.M. de Vries, Mehmet Şen
Publikováno v:
Haematologica, Vol 103, Iss 6 (2018)
Tissue Factor is a cell-surface glycoprotein expressed in various cells of the vasculature and is the principal regulator of the blood coagulation cascade and hemostasis. Notably, aberrant expression of Tissue Factor is associated with cardiovascular
Externí odkaz:
https://doaj.org/article/f24af6fdbd004558a55a651fb28171cf
Publikováno v:
Biochemical pharmacology. 207
We recently found that the G protein coupled receptor GPR101 mediates the phagocyte-directed pro-resolving activities of RvD5
Publikováno v:
ACS Pharmacol Transl Sci
[Image: see text] Specialized pro-resolving mediators (SPMs) are enzymatically oxygenated derivatives of polyunsaturated fatty acids that function as central immunoregulators in mammals. Among them are resolvins (Rvs) that stimulate the clearance of
Autor:
Kimberly Pistorius, Lucy Ly, Patricia R. Souza, Esteban A. Gomez, Duco S. Koenis, Ana R. Rodriguez, Julie Foster, Jane Sosabowski, Mark Hopkinson, Vinothini Rajeeve, Bernd W. Spur, Andrew Pitsillides, Costantino Pitzalis, Jesmond Dalli
Publikováno v:
EBioMedicine. 79
Rheumatoid arthritis (RA) is a progressive degenerative disorder that leads to joint destruction. Available treatments only target the inflammatory component with minimal impact on joint repair. We recently uncovered a previously unappreciated family
Autor:
Jessica K. Nelson, May Zaw Thin, Theodore Evan, Steven Howell, Mary Wu, Bruna Almeida, Nathalie Legrave, Duco S. Koenis, Gabriela Koifman, Yoichiro Sugimoto, Miriam Llorian Sopena, James MacRae, Emma Nye, Michael Howell, Ambrosius P. Snijders, Andreas Prachalias, Yoh Zen, Debashis Sarker, Axel Behrens
Publikováno v:
Nature communications. 13(1)
Deubiquitylating enzymes (DUBs) play an essential role in targeted protein degradation and represent an emerging therapeutic paradigm in cancer. However, their therapeutic potential in pancreatic ductal adenocarcinoma (PDAC) has not been explored. He
Autor:
Carlie J.M. de Vries, Naomi Graber, Robert Jablonowski, Vivian de Waard, Goran Marinković, Isabel Gonçalves, Stefan Jovinge, Jan Nilsson, Lisa de Camp, Alexandru Schiopu, Duco S. Koenis
Publikováno v:
Circulation research, 127(5), 664-676. Lippincott Williams and Wilkins
Rationale: The alarmin S100A9 has been identified as a potential therapeutic target in myocardial infarction. Short-term S100A9 blockade during the inflammatory phase post-myocardial infarction inhibits systemic and cardiac inflammation and improves
Autor:
Martijn Gloerich, Annett de Haan, Geerten P. van Nieuw Amerongen, Vivian de Waard, Jaap D. van Buul, Lilian Schimmel, Carlie J.M. de Vries, Alexandra Klaus-Bergmann, Kalim Nawaz, Anne Marieke D. Van Stalborch, Duco S. Koenis, Miesje M. van der Stoel, Stephan Huveneers, Erik T. Valent
Publikováno v:
Journal of Cell Science, 133(3):jcs239947. Company of Biologists Ltd
Journal of cell science, 133(3):jcs239947. Company of Biologists Ltd
van der Stoel, M, Schimmel, L, Nawaz, K, van Stalborch, A M, de Haan, A, Klaus-Bergmann, A, Valent, E T, Koenis, D S, van Nieuw Amerongen, G P, de Vries, C J, de Waard, V, Gloerich, M, van Buul, J D & Huveneers, S 2020, ' DLC1 is a direct target of activated YAP/TAZ that drives collective migration and sprouting angiogenesis ', Journal of Cell Science, vol. 133, no. 3, jcs239947 . https://doi.org/10.1242/jcs.239947
Journal of cell science, 133(3):jcs239947. Company of Biologists Ltd
van der Stoel, M, Schimmel, L, Nawaz, K, van Stalborch, A M, de Haan, A, Klaus-Bergmann, A, Valent, E T, Koenis, D S, van Nieuw Amerongen, G P, de Vries, C J, de Waard, V, Gloerich, M, van Buul, J D & Huveneers, S 2020, ' DLC1 is a direct target of activated YAP/TAZ that drives collective migration and sprouting angiogenesis ', Journal of Cell Science, vol. 133, no. 3, jcs239947 . https://doi.org/10.1242/jcs.239947
Endothelial YAP/TAZ (YAP is also known as YAP1, and TAZ as WWTR1) signaling is crucial for sprouting angiogenesis and vascular homeostasis. However, the underlying molecular mechanisms that explain how YAP/TAZ control the vasculature remain unclear.