Intestinal gluconeogenesis controls the neonatal development of hypothalamic feeding circuits

Autor: Judith Estrada-Meza, Jasmine Videlo, Clara Bron, Adeline Duchampt, Cécile Saint-Béat, Mickael Zergane, Marine Silva, Fabienne Rajas, Sebastien G. Bouret, Gilles Mithieux, Amandine Gautier-Stein

Publikováno v: Molecular Metabolism, Vol 89, Iss , Pp 102036- (2024)

Objective: Intestinal gluconeogenesis (IGN) regulates adult energy homeostasis in part by controlling the same hypothalamic targets as leptin. In neonates, leptin exhibits a neonatal surge controlling axonal outgrowth between the different hypothalam

Externí odkaz: https://doaj.org/article/6fba53ffa3c9408fb8d9b3eb50d159e5

A caveolin-1 dependent glucose-6-phosphatase trafficking contributes to hepatic glucose production

Autor: Amandine Gautier-Stein, Julien Chilloux, Maud Soty, Bernard Thorens, Christophe Place, Carine Zitoun, Adeline Duchampt, Lorine Da Costa, Fabienne Rajas, Christophe Lamaze, Gilles Mithieux

Publikováno v: Molecular Metabolism, Vol 70, Iss , Pp 101700- (2023)

Objective: Deregulation of hepatic glucose production is a key driver in the pathogenesis of diabetes, but its short-term regulation is incompletely deciphered. According to textbooks, glucose is produced in the endoplasmic reticulum by glucose-6-pho

Externí odkaz: https://doaj.org/article/060822719bc6463b90d66b9b25ea7f50

Intracellular lipids are an independent cause of liver injury and chronic kidney disease in non alcoholic fatty liver disease-like context

Autor: Monteillet, Laure, Gjorgjieva, Monika, Silva, Marine, Verzieux, Vincent, Imikirene, Linda, Duchampt, Adeline, Guillou, Hervé, Mithieux, Gilles, Rajas, Fabienne

Publikováno v: In Molecular Metabolism October 2018 16:100-115

Intracellular lipids are an independent cause of liver injury and chronic kidney disease in non alcoholic fatty liver disease-like context

Autor: Laure Monteillet, Monika Gjorgjieva, Marine Silva, Vincent Verzieux, Linda Imikirene, Adeline Duchampt, Hervé Guillou, Gilles Mithieux, Fabienne Rajas

Publikováno v: Molecular Metabolism, Vol 16, Iss , Pp 100-115 (2018)

Objective: Ectopic lipid accumulation in the liver and kidneys is a hallmark of metabolic diseases leading to non-alcoholic fatty liver disease (NAFLD) and chronic kidney disease (CKD). Moreover, recent data have highlighted a strong correlation betw

Externí odkaz: https://doaj.org/article/c82df5d1226741bd89455d447bbf9e26

Cellular and metabolic effects of renin-angiotensin system blockade on glycogen storage disease type I nephropathy

Autor: Monteillet, Laure, Labrune, Philippe, Hochuli, Michel, Do Cao, Jeremy, Tortereau, Antonin, Miliano, Alexane Cannella, Ardon-Zitoun, Carine, Duchampt, Adeline, Silva, Marine, Verzieux, Vincent, Mithieux, Gilles, Rajas, Fabienne

Publikováno v: Human Molecular Genetics
Human Molecular Genetics, Oxford University Press (OUP), 2021, pp.ddab297. ⟨10.1093/hmg/ddab297⟩
Monteillet, Laure; Labrune, Philippe; Hochuli, Michel; Do Cao, Jeremy; Tortereau, Antonin; Miliano, Alexane Cannella; Ardon-Zitoun, Carine; Duchampt, Adeline; Silva, Marine; Verzieux, Vincent; Mithieux, Gilles; Rajas, Fabienne (2022). Cellular and metabolic effects of renin-angiotensin system blockade on glycogen storage disease type I nephropathy. Human molecular genetics, 31(6), pp. 914-928. Oxford University Press 10.1093/hmg/ddab297

International audience; Glycogen Storage Disease Type I (GSDI) is an inherited disease caused by glucose-6 phosphatase (G6Pase) deficiency, leading to a loss of endogenous glucose production and severe hypoglycemia. Moreover, most GSDI patients devel

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::17279746c72f4c934767fac1a7fb2156
https://www.hal.inserm.fr/inserm-03412696