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Clinical Associations and Prognostic Value of MRI-Visible Perivascular Spaces in Patients With Ischemic Stroke or TIA: A Pooled Analysis

Autor: Best JG; From the UCL Stroke Research Centre (J.G.B., D.W., D.J.W.) and Neuroradiological Academic Unit (H.R.J.), Department of Brain Repair and Rehabilitation, UCL Queen Square Institute of Neurology, London; Department of Statistical Science (G.A.), University College London, United Kingdom; Stroke Research Centre (H.D.), Department of Neurology, Fujian Medical University Union Hospital, Fuzhou, People's Republic of China; Department of Neurology (K.-J.L.), Korea University Guro Hospital, Seoul; Department of Neurology (J.-S.L.), Asan Medical Center, University of Ulsan College of Medicine, Seoul, Republic of Korea; Division of Neurology, Department of Medicine (K.C.T., G.K.K.L.) and Department of Diagnostic Radiology (H.M.), The University of Hong Kong; Department of Neurology (Y.D.K., J.-H.H.), Yonsei University College of Medicine, Seoul; Department of Neurology (T.-J.S.), Seoul Hospital, Ewha Womans University College of Medicine, Seoul, Republic of Korea; Department of Neurology (D.S.D.), Sisli Hamidiye Etfal Teaching and Research Hospital, University of Health Sciences, Turkey; Department of Radiology (M.N.), Saga University Faculty of Medicine; Division of Neurology (M.Y., H.H.), Department of Internal Medicine, Saga University Faculty of Medicine, Japan; Stroke Center Klinik Hirslanden Zürich (M.K., N.P.); University of Basel (M.K.); Department of Neurology and Stroke Center University Hospital and University of Basel (A.Z.), Switzerland; Centre for Clinical Brain Sciences (R.A.-S.S., F.C., J.M.W.), School of Clinical Sciences, University of Edinburgh; Liverpool Centre for Cardiovascular Science at University of Liverpool (G.Y.H.L.), Liverpool John Moores University and Liverpool Heart & Chest Hospital, United Kingdom; Department of Neurology (L.P., M.B.G., S.J.), Inselspital, Bern University Hospital, Switzerland; Department of Imaging, School of Clinical Sciences at Monash Health (L.-A.S.), Peninsula Clinical School, Peninsula Health (C.C.K.), and Stroke and Ageing Research Group, School of Clinical Sciences at Monash Health (T.G.P.), Monash University, Melbourne, Australia; Department of Neurology (M.B., F.F.), University Hospital of Würzburg, Germany; Department of Imaging and Interventional Radiology (J.A., W.C.) and Division of Neurology, Department of Medicine and Therapeutics (C.C., T.W.L., Y.O.Y.S.), Prince of Wales Hospital, The Chinese University of Hong Kong; Institute of Applied Health Sciences (S.D.J.M.), University of Aberdeen, United Kingdom; Biomedical Imaging Group Rotterdam (F.D.), Department of Radiology and Nuclear Medicine (D.H.K.D.-N.), Erasmus University Medical Centre, Rotterdam, The Netherlands; Departments of Radiology and Nuclear Medicine (M.E.K.) and Neurology (J.S.), CARIM School for Cardiovascular Diseases, Maastricht University Medical Centre; Department of Psychiatry and Neuropsychology (S.K.), School for Mental Health and Neuroscience, Maastricht University, The Netherlands; University of Lille (G.K., R.B.), Inserm, CHU de Lille, Lille Neuroscience & Cognition, France; National Centre for Healthy Ageing (V.K.S.), Peninsula Clinical School, Central Clinical School, Monash University, Melbourne, Australia; Department of Neurology (Y.Y.), Kansai Medical University, Osaka, Japan; Department of Neurology (D.N.O.), Istanbul Arel University, Turkey; and Department of Neurology (H.-J.B.), Seoul National University Bundang Hospital, Seoul National University College of Medicine, Seongnam, Republic of Korea., Ambler G; From the UCL Stroke Research Centre (J.G.B., D.W., D.J.W.) and Neuroradiological Academic Unit (H.R.J.), Department of Brain Repair and Rehabilitation, UCL Queen Square Institute of Neurology, London; Department of Statistical Science (G.A.), University College London, United Kingdom; Stroke Research Centre (H.D.), Department of Neurology, Fujian Medical University Union Hospital, Fuzhou, People's Republic of China; Department of Neurology (K.-J.L.), Korea University Guro Hospital, Seoul; Department of Neurology (J.-S.L.), Asan Medical Center, University of Ulsan College of Medicine, Seoul, Republic of Korea; Division of Neurology, Department of Medicine (K.C.T., G.K.K.L.) and Department of Diagnostic Radiology (H.M.), The University of Hong Kong; Department of Neurology (Y.D.K., J.-H.H.), Yonsei University College of Medicine, Seoul; Department of Neurology (T.-J.S.), Seoul Hospital, Ewha Womans University College of Medicine, Seoul, Republic of Korea; Department of Neurology (D.S.D.), Sisli Hamidiye Etfal Teaching and Research Hospital, University of Health Sciences, Turkey; Department of Radiology (M.N.), Saga University Faculty of Medicine; Division of Neurology (M.Y., H.H.), Department of Internal Medicine, Saga University Faculty of Medicine, Japan; Stroke Center Klinik Hirslanden Zürich (M.K., N.P.); University of Basel (M.K.); Department of Neurology and Stroke Center University Hospital and University of Basel (A.Z.), Switzerland; Centre for Clinical Brain Sciences (R.A.-S.S., F.C., J.M.W.), School of Clinical Sciences, University of Edinburgh; Liverpool Centre for Cardiovascular Science at University of Liverpool (G.Y.H.L.), Liverpool John Moores University and Liverpool Heart & Chest Hospital, United Kingdom; Department of Neurology (L.P., M.B.G., S.J.), Inselspital, Bern University Hospital, Switzerland; Department of Imaging, School of Clinical Sciences at Monash Health (L.-A.S.), Peninsula Clinical School, Peninsula Health (C.C.K.), and Stroke and Ageing Research Group, School of Clinical Sciences at Monash Health (T.G.P.), Monash University, Melbourne, Australia; Department of Neurology (M.B., F.F.), University Hospital of Würzburg, Germany; Department of Imaging and Interventional Radiology (J.A., W.C.) and Division of Neurology, Department of Medicine and Therapeutics (C.C., T.W.L., Y.O.Y.S.), Prince of Wales Hospital, The Chinese University of Hong Kong; Institute of Applied Health Sciences (S.D.J.M.), University of Aberdeen, United Kingdom; Biomedical Imaging Group Rotterdam (F.D.), Department of Radiology and Nuclear Medicine (D.H.K.D.-N.), Erasmus University Medical Centre, Rotterdam, The Netherlands; Departments of Radiology and Nuclear Medicine (M.E.K.) and Neurology (J.S.), CARIM School for Cardiovascular Diseases, Maastricht University Medical Centre; Department of Psychiatry and Neuropsychology (S.K.), School for Mental Health and Neuroscience, Maastricht University, The Netherlands; University of Lille (G.K., R.B.), Inserm, CHU de Lille, Lille Neuroscience & Cognition, France; National Centre for Healthy Ageing (V.K.S.), Peninsula Clinical School, Central Clinical School, Monash University, Melbourne, Australia; Department of Neurology (Y.Y.), Kansai Medical University, Osaka, Japan; Department of Neurology (D.N.O.), Istanbul Arel University, Turkey; and Department of Neurology (H.-J.B.), Seoul National University Bundang Hospital, Seoul National University College of Medicine, Seongnam, Republic of Korea., Wilson D; From the UCL Stroke Research Centre (J.G.B., D.W., D.J.W.) and Neuroradiological Academic Unit (H.R.J.), Department of Brain Repair and Rehabilitation, UCL Queen Square Institute of Neurology, London; Department of Statistical Science (G.A.), University College London, United Kingdom; Stroke Research Centre (H.D.), Department of Neurology, Fujian Medical University Union Hospital, Fuzhou, People's Republic of China; Department of Neurology (K.-J.L.), Korea University Guro Hospital, Seoul; Department of Neurology (J.-S.L.), Asan Medical Center, University of Ulsan College of Medicine, Seoul, Republic of Korea; Division of Neurology, Department of Medicine (K.C.T., G.K.K.L.) and Department of Diagnostic Radiology (H.M.), The University of Hong Kong; Department of Neurology (Y.D.K., J.-H.H.), Yonsei University College of Medicine, Seoul; Department of Neurology (T.-J.S.), Seoul Hospital, Ewha Womans University College of Medicine, Seoul, Republic of Korea; Department of Neurology (D.S.D.), Sisli Hamidiye Etfal Teaching and Research Hospital, University of Health Sciences, Turkey; Department of Radiology (M.N.), Saga University Faculty of Medicine; Division of Neurology (M.Y., H.H.), Department of Internal Medicine, Saga University Faculty of Medicine, Japan; Stroke Center Klinik Hirslanden Zürich (M.K., N.P.); University of Basel (M.K.); Department of Neurology and Stroke Center University Hospital and University of Basel (A.Z.), Switzerland; Centre for Clinical Brain Sciences (R.A.-S.S., F.C., J.M.W.), School of Clinical Sciences, University of Edinburgh; Liverpool Centre for Cardiovascular Science at University of Liverpool (G.Y.H.L.), Liverpool John Moores University and Liverpool Heart & Chest Hospital, United Kingdom; Department of Neurology (L.P., M.B.G., S.J.), Inselspital, Bern University Hospital, Switzerland; Department of Imaging, School of Clinical Sciences at Monash Health (L.-A.S.), Peninsula Clinical School, Peninsula Health (C.C.K.), and Stroke and Ageing Research Group, School of Clinical Sciences at Monash Health (T.G.P.), Monash University, Melbourne, Australia; Department of Neurology (M.B., F.F.), University Hospital of Würzburg, Germany; Department of Imaging and Interventional Radiology (J.A., W.C.) and Division of Neurology, Department of Medicine and Therapeutics (C.C., T.W.L., Y.O.Y.S.), Prince of Wales Hospital, The Chinese University of Hong Kong; Institute of Applied Health Sciences (S.D.J.M.), University of Aberdeen, United Kingdom; Biomedical Imaging Group Rotterdam (F.D.), Department of Radiology and Nuclear Medicine (D.H.K.D.-N.), Erasmus University Medical Centre, Rotterdam, The Netherlands; Departments of Radiology and Nuclear Medicine (M.E.K.) and Neurology (J.S.), CARIM School for Cardiovascular Diseases, Maastricht University Medical Centre; Department of Psychiatry and Neuropsychology (S.K.), School for Mental Health and Neuroscience, Maastricht University, The Netherlands; University of Lille (G.K., R.B.), Inserm, CHU de Lille, Lille Neuroscience & Cognition, France; National Centre for Healthy Ageing (V.K.S.), Peninsula Clinical School, Central Clinical School, Monash University, Melbourne, Australia; Department of Neurology (Y.Y.), Kansai Medical University, Osaka, Japan; Department of Neurology (D.N.O.), Istanbul Arel University, Turkey; and Department of Neurology (H.-J.B.), Seoul National University Bundang Hospital, Seoul National University College of Medicine, Seongnam, Republic of Korea., Du H; From the UCL Stroke Research Centre (J.G.B., D.W., D.J.W.) and Neuroradiological Academic Unit (H.R.J.), Department of Brain Repair and Rehabilitation, UCL Queen Square Institute of Neurology, London; Department of Statistical Science (G.A.), University College London, United Kingdom; Stroke Research Centre (H.D.), Department of Neurology, Fujian Medical University Union Hospital, Fuzhou, People's Republic of China; Department of Neurology (K.-J.L.), Korea University Guro Hospital, Seoul; Department of Neurology (J.-S.L.), Asan Medical Center, University of Ulsan College of Medicine, Seoul, Republic of Korea; Division of Neurology, Department of Medicine (K.C.T., G.K.K.L.) and Department of Diagnostic Radiology (H.M.), The University of Hong Kong; Department of Neurology (Y.D.K., J.-H.H.), Yonsei University College of Medicine, Seoul; Department of Neurology (T.-J.S.), Seoul Hospital, Ewha Womans University College of Medicine, Seoul, Republic of Korea; Department of Neurology (D.S.D.), Sisli Hamidiye Etfal Teaching and Research Hospital, University of Health Sciences, Turkey; Department of Radiology (M.N.), Saga University Faculty of Medicine; Division of Neurology (M.Y., H.H.), Department of Internal Medicine, Saga University Faculty of Medicine, Japan; Stroke Center Klinik Hirslanden Zürich (M.K., N.P.); University of Basel (M.K.); Department of Neurology and Stroke Center University Hospital and University of Basel (A.Z.), Switzerland; Centre for Clinical Brain Sciences (R.A.-S.S., F.C., J.M.W.), School of Clinical Sciences, University of Edinburgh; Liverpool Centre for Cardiovascular Science at University of Liverpool (G.Y.H.L.), Liverpool John Moores University and Liverpool Heart & Chest Hospital, United Kingdom; Department of Neurology (L.P., M.B.G., S.J.), Inselspital, Bern University Hospital, Switzerland; Department of Imaging, School of Clinical Sciences at Monash Health (L.-A.S.), Peninsula Clinical School, Peninsula Health (C.C.K.), and Stroke and Ageing Research Group, School of Clinical Sciences at Monash Health (T.G.P.), Monash University, Melbourne, Australia; Department of Neurology (M.B., F.F.), University Hospital of Würzburg, Germany; Department of Imaging and Interventional Radiology (J.A., W.C.) and Division of Neurology, Department of Medicine and Therapeutics (C.C., T.W.L., Y.O.Y.S.), Prince of Wales Hospital, The Chinese University of Hong Kong; Institute of Applied Health Sciences (S.D.J.M.), University of Aberdeen, United Kingdom; Biomedical Imaging Group Rotterdam (F.D.), Department of Radiology and Nuclear Medicine (D.H.K.D.-N.), Erasmus University Medical Centre, Rotterdam, The Netherlands; Departments of Radiology and Nuclear Medicine (M.E.K.) and Neurology (J.S.), CARIM School for Cardiovascular Diseases, Maastricht University Medical Centre; Department of Psychiatry and Neuropsychology (S.K.), School for Mental Health and Neuroscience, Maastricht University, The Netherlands; University of Lille (G.K., R.B.), Inserm, CHU de Lille, Lille Neuroscience & Cognition, France; National Centre for Healthy Ageing (V.K.S.), Peninsula Clinical School, Central Clinical School, Monash University, Melbourne, Australia; Department of Neurology (Y.Y.), Kansai Medical University, Osaka, Japan; Department of Neurology (D.N.O.), Istanbul Arel University, Turkey; and Department of Neurology (H.-J.B.), Seoul National University Bundang Hospital, Seoul National University College of Medicine, Seongnam, Republic of Korea., Lee KJ; From the UCL Stroke Research Centre (J.G.B., D.W., D.J.W.) and Neuroradiological Academic Unit (H.R.J.), Department of Brain Repair and Rehabilitation, UCL Queen Square Institute of Neurology, London; Department of Statistical Science (G.A.), University College London, United Kingdom; Stroke Research Centre (H.D.), Department of Neurology, Fujian Medical University Union Hospital, Fuzhou, People's Republic of China; Department of Neurology (K.-J.L.), Korea University Guro Hospital, Seoul; Department of Neurology (J.-S.L.), Asan Medical Center, University of Ulsan College of Medicine, Seoul, Republic of Korea; Division of Neurology, Department of Medicine (K.C.T., G.K.K.L.) and Department of Diagnostic Radiology (H.M.), The University of Hong Kong; Department of Neurology (Y.D.K., J.-H.H.), Yonsei University College of Medicine, Seoul; Department of Neurology (T.-J.S.), Seoul Hospital, Ewha Womans University College of Medicine, Seoul, Republic of Korea; Department of Neurology (D.S.D.), Sisli Hamidiye Etfal Teaching and Research Hospital, University of Health Sciences, Turkey; Department of Radiology (M.N.), Saga University Faculty of Medicine; Division of Neurology (M.Y., H.H.), Department of Internal Medicine, Saga University Faculty of Medicine, Japan; Stroke Center Klinik Hirslanden Zürich (M.K., N.P.); University of Basel (M.K.); Department of Neurology and Stroke Center University Hospital and University of Basel (A.Z.), Switzerland; Centre for Clinical Brain Sciences (R.A.-S.S., F.C., J.M.W.), School of Clinical Sciences, University of Edinburgh; Liverpool Centre for Cardiovascular Science at University of Liverpool (G.Y.H.L.), Liverpool John Moores University and Liverpool Heart & Chest Hospital, United Kingdom; Department of Neurology (L.P., M.B.G., S.J.), Inselspital, Bern University Hospital, Switzerland; Department of Imaging, School of Clinical Sciences at Monash Health (L.-A.S.), Peninsula Clinical School, Peninsula Health (C.C.K.), and Stroke and Ageing Research Group, School of Clinical Sciences at Monash Health (T.G.P.), Monash University, Melbourne, Australia; Department of Neurology (M.B., F.F.), University Hospital of Würzburg, Germany; Department of Imaging and Interventional Radiology (J.A., W.C.) and Division of Neurology, Department of Medicine and Therapeutics (C.C., T.W.L., Y.O.Y.S.), Prince of Wales Hospital, The Chinese University of Hong Kong; Institute of Applied Health Sciences (S.D.J.M.), University of Aberdeen, United Kingdom; Biomedical Imaging Group Rotterdam (F.D.), Department of Radiology and Nuclear Medicine (D.H.K.D.-N.), Erasmus University Medical Centre, Rotterdam, The Netherlands; Departments of Radiology and Nuclear Medicine (M.E.K.) and Neurology (J.S.), CARIM School for Cardiovascular Diseases, Maastricht University Medical Centre; Department of Psychiatry and Neuropsychology (S.K.), School for Mental Health and Neuroscience, Maastricht University, The Netherlands; University of Lille (G.K., R.B.), Inserm, CHU de Lille, Lille Neuroscience & Cognition, France; National Centre for Healthy Ageing (V.K.S.), Peninsula Clinical School, Central Clinical School, Monash University, Melbourne, Australia; Department of Neurology (Y.Y.), Kansai Medical University, Osaka, Japan; Department of Neurology (D.N.O.), Istanbul Arel University, Turkey; and Department of Neurology (H.-J.B.), Seoul National University Bundang Hospital, Seoul National University College of Medicine, Seongnam, Republic of Korea., Lim JS; From the UCL Stroke Research Centre (J.G.B., D.W., D.J.W.) and Neuroradiological Academic Unit (H.R.J.), Department of Brain Repair and Rehabilitation, UCL Queen Square Institute of Neurology, London; Department of Statistical Science (G.A.), University College London, United Kingdom; Stroke Research Centre (H.D.), Department of Neurology, Fujian Medical University Union Hospital, Fuzhou, People's Republic of China; Department of Neurology (K.-J.L.), Korea University Guro Hospital, Seoul; Department of Neurology (J.-S.L.), Asan Medical Center, University of Ulsan College of Medicine, Seoul, Republic of Korea; Division of Neurology, Department of Medicine (K.C.T., G.K.K.L.) and Department of Diagnostic Radiology (H.M.), The University of Hong Kong; Department of Neurology (Y.D.K., J.-H.H.), Yonsei University College of Medicine, Seoul; Department of Neurology (T.-J.S.), Seoul Hospital, Ewha Womans University College of Medicine, Seoul, Republic of Korea; Department of Neurology (D.S.D.), Sisli Hamidiye Etfal Teaching and Research Hospital, University of Health Sciences, Turkey; Department of Radiology (M.N.), Saga University Faculty of Medicine; Division of Neurology (M.Y., H.H.), Department of Internal Medicine, Saga University Faculty of Medicine, Japan; Stroke Center Klinik Hirslanden Zürich (M.K., N.P.); University of Basel (M.K.); Department of Neurology and Stroke Center University Hospital and University of Basel (A.Z.), Switzerland; Centre for Clinical Brain Sciences (R.A.-S.S., F.C., J.M.W.), School of Clinical Sciences, University of Edinburgh; Liverpool Centre for Cardiovascular Science at University of Liverpool (G.Y.H.L.), Liverpool John Moores University and Liverpool Heart & Chest Hospital, United Kingdom; Department of Neurology (L.P., M.B.G., S.J.), Inselspital, Bern University Hospital, Switzerland; Department of Imaging, School of Clinical Sciences at Monash Health (L.-A.S.), Peninsula Clinical School, Peninsula Health (C.C.K.), and Stroke and Ageing Research Group, School of Clinical Sciences at Monash Health (T.G.P.), Monash University, Melbourne, Australia; Department of Neurology (M.B., F.F.), University Hospital of Würzburg, Germany; Department of Imaging and Interventional Radiology (J.A., W.C.) and Division of Neurology, Department of Medicine and Therapeutics (C.C., T.W.L., Y.O.Y.S.), Prince of Wales Hospital, The Chinese University of Hong Kong; Institute of Applied Health Sciences (S.D.J.M.), University of Aberdeen, United Kingdom; Biomedical Imaging Group Rotterdam (F.D.), Department of Radiology and Nuclear Medicine (D.H.K.D.-N.), Erasmus University Medical Centre, Rotterdam, The Netherlands; Departments of Radiology and Nuclear Medicine (M.E.K.) and Neurology (J.S.), CARIM School for Cardiovascular Diseases, Maastricht University Medical Centre; Department of Psychiatry and Neuropsychology (S.K.), School for Mental Health and Neuroscience, Maastricht University, The Netherlands; University of Lille (G.K., R.B.), Inserm, CHU de Lille, Lille Neuroscience & Cognition, France; National Centre for Healthy Ageing (V.K.S.), Peninsula Clinical School, Central Clinical School, Monash University, Melbourne, Australia; Department of Neurology (Y.Y.), Kansai Medical University, Osaka, Japan; Department of Neurology (D.N.O.), Istanbul Arel University, Turkey; and Department of Neurology (H.-J.B.), Seoul National University Bundang Hospital, Seoul National University College of Medicine, Seongnam, Republic of Korea., Teo KC; From the UCL Stroke Research Centre (J.G.B., D.W., D.J.W.) and Neuroradiological Academic Unit (H.R.J.), Department of Brain Repair and Rehabilitation, UCL Queen Square Institute of Neurology, London; Department of Statistical Science (G.A.), University College London, United Kingdom; Stroke Research Centre (H.D.), Department of Neurology, Fujian Medical University Union Hospital, Fuzhou, People's Republic of China; Department of Neurology (K.-J.L.), Korea University Guro Hospital, Seoul; Department of Neurology (J.-S.L.), Asan Medical Center, University of Ulsan College of Medicine, Seoul, Republic of Korea; Division of Neurology, Department of Medicine (K.C.T., G.K.K.L.) and Department of Diagnostic Radiology (H.M.), The University of Hong Kong; Department of Neurology (Y.D.K., J.-H.H.), Yonsei University College of Medicine, Seoul; Department of Neurology (T.-J.S.), Seoul Hospital, Ewha Womans University College of Medicine, Seoul, Republic of Korea; Department of Neurology (D.S.D.), Sisli Hamidiye Etfal Teaching and Research Hospital, University of Health Sciences, Turkey; Department of Radiology (M.N.), Saga University Faculty of Medicine; Division of Neurology (M.Y., H.H.), Department of Internal Medicine, Saga University Faculty of Medicine, Japan; Stroke Center Klinik Hirslanden Zürich (M.K., N.P.); University of Basel (M.K.); Department of Neurology and Stroke Center University Hospital and University of Basel (A.Z.), Switzerland; Centre for Clinical Brain Sciences (R.A.-S.S., F.C., J.M.W.), School of Clinical Sciences, University of Edinburgh; Liverpool Centre for Cardiovascular Science at University of Liverpool (G.Y.H.L.), Liverpool John Moores University and Liverpool Heart & Chest Hospital, United Kingdom; Department of Neurology (L.P., M.B.G., S.J.), Inselspital, Bern University Hospital, Switzerland; Department of Imaging, School of Clinical Sciences at Monash Health (L.-A.S.), Peninsula Clinical School, Peninsula Health (C.C.K.), and Stroke and Ageing Research Group, School of Clinical Sciences at Monash Health (T.G.P.), Monash University, Melbourne, Australia; Department of Neurology (M.B., F.F.), University Hospital of Würzburg, Germany; Department of Imaging and Interventional Radiology (J.A., W.C.) and Division of Neurology, Department of Medicine and Therapeutics (C.C., T.W.L., Y.O.Y.S.), Prince of Wales Hospital, The Chinese University of Hong Kong; Institute of Applied Health Sciences (S.D.J.M.), University of Aberdeen, United Kingdom; Biomedical Imaging Group Rotterdam (F.D.), Department of Radiology and Nuclear Medicine (D.H.K.D.-N.), Erasmus University Medical Centre, Rotterdam, The Netherlands; Departments of Radiology and Nuclear Medicine (M.E.K.) and Neurology (J.S.), CARIM School for Cardiovascular Diseases, Maastricht University Medical Centre; Department of Psychiatry and Neuropsychology (S.K.), School for Mental Health and Neuroscience, Maastricht University, The Netherlands; University of Lille (G.K., R.B.), Inserm, CHU de Lille, Lille Neuroscience & Cognition, France; National Centre for Healthy Ageing (V.K.S.), Peninsula Clinical School, Central Clinical School, Monash University, Melbourne, Australia; Department of Neurology (Y.Y.), Kansai Medical University, Osaka, Japan; Department of Neurology (D.N.O.), Istanbul Arel University, Turkey; and Department of Neurology (H.-J.B.), Seoul National University Bundang Hospital, Seoul National University College of Medicine, Seongnam, Republic of Korea., Mak H; From the UCL Stroke Research Centre (J.G.B., D.W., D.J.W.) and Neuroradiological Academic Unit (H.R.J.), Department of Brain Repair and Rehabilitation, UCL Queen Square Institute of Neurology, London; Department of Statistical Science (G.A.), University College London, United Kingdom; Stroke Research Centre (H.D.), Department of Neurology, Fujian Medical University Union Hospital, Fuzhou, People's Republic of China; Department of Neurology (K.-J.L.), Korea University Guro Hospital, Seoul; Department of Neurology (J.-S.L.), Asan Medical Center, University of Ulsan College of Medicine, Seoul, Republic of Korea; Division of Neurology, Department of Medicine (K.C.T., G.K.K.L.) and Department of Diagnostic Radiology (H.M.), The University of Hong Kong; Department of Neurology (Y.D.K., J.-H.H.), Yonsei University College of Medicine, Seoul; Department of Neurology (T.-J.S.), Seoul Hospital, Ewha Womans University College of Medicine, Seoul, Republic of Korea; Department of Neurology (D.S.D.), Sisli Hamidiye Etfal Teaching and Research Hospital, University of Health Sciences, Turkey; Department of Radiology (M.N.), Saga University Faculty of Medicine; Division of Neurology (M.Y., H.H.), Department of Internal Medicine, Saga University Faculty of Medicine, Japan; Stroke Center Klinik Hirslanden Zürich (M.K., N.P.); University of Basel (M.K.); Department of Neurology and Stroke Center University Hospital and University of Basel (A.Z.), Switzerland; Centre for Clinical Brain Sciences (R.A.-S.S., F.C., J.M.W.), School of Clinical Sciences, University of Edinburgh; Liverpool Centre for Cardiovascular Science at University of Liverpool (G.Y.H.L.), Liverpool John Moores University and Liverpool Heart & Chest Hospital, United Kingdom; Department of Neurology (L.P., M.B.G., S.J.), Inselspital, Bern University Hospital, Switzerland; Department of Imaging, School of Clinical Sciences at Monash Health (L.-A.S.), Peninsula Clinical School, Peninsula Health (C.C.K.), and Stroke and Ageing Research Group, School of Clinical Sciences at Monash Health (T.G.P.), Monash University, Melbourne, Australia; Department of Neurology (M.B., F.F.), University Hospital of Würzburg, Germany; Department of Imaging and Interventional Radiology (J.A., W.C.) and Division of Neurology, Department of Medicine and Therapeutics (C.C., T.W.L., Y.O.Y.S.), Prince of Wales Hospital, The Chinese University of Hong Kong; Institute of Applied Health Sciences (S.D.J.M.), University of Aberdeen, United Kingdom; Biomedical Imaging Group Rotterdam (F.D.), Department of Radiology and Nuclear Medicine (D.H.K.D.-N.), Erasmus University Medical Centre, Rotterdam, The Netherlands; Departments of Radiology and Nuclear Medicine (M.E.K.) and Neurology (J.S.), CARIM School for Cardiovascular Diseases, Maastricht University Medical Centre; Department of Psychiatry and Neuropsychology (S.K.), School for Mental Health and Neuroscience, Maastricht University, The Netherlands; University of Lille (G.K., R.B.), Inserm, CHU de Lille, Lille Neuroscience & Cognition, France; National Centre for Healthy Ageing (V.K.S.), Peninsula Clinical School, Central Clinical School, Monash University, Melbourne, Australia; Department of Neurology (Y.Y.), Kansai Medical University, Osaka, Japan; Department of Neurology (D.N.O.), Istanbul Arel University, Turkey; and Department of Neurology (H.-J.B.), Seoul National University Bundang Hospital, Seoul National University College of Medicine, Seongnam, Republic of Korea., Kim YD; From the UCL Stroke Research Centre (J.G.B., D.W., D.J.W.) and Neuroradiological Academic Unit (H.R.J.), Department of Brain Repair and Rehabilitation, UCL Queen Square Institute of Neurology, London; Department of Statistical Science (G.A.), University College London, United Kingdom; Stroke Research Centre (H.D.), Department of Neurology, Fujian Medical University Union Hospital, Fuzhou, People's Republic of China; Department of Neurology (K.-J.L.), Korea University Guro Hospital, Seoul; Department of Neurology (J.-S.L.), Asan Medical Center, University of Ulsan College of Medicine, Seoul, Republic of Korea; Division of Neurology, Department of Medicine (K.C.T., G.K.K.L.) and Department of Diagnostic Radiology (H.M.), The University of Hong Kong; Department of Neurology (Y.D.K., J.-H.H.), Yonsei University College of Medicine, Seoul; Department of Neurology (T.-J.S.), Seoul Hospital, Ewha Womans University College of Medicine, Seoul, Republic of Korea; Department of Neurology (D.S.D.), Sisli Hamidiye Etfal Teaching and Research Hospital, University of Health Sciences, Turkey; Department of Radiology (M.N.), Saga University Faculty of Medicine; Division of Neurology (M.Y., H.H.), Department of Internal Medicine, Saga University Faculty of Medicine, Japan; Stroke Center Klinik Hirslanden Zürich (M.K., N.P.); University of Basel (M.K.); Department of Neurology and Stroke Center University Hospital and University of Basel (A.Z.), Switzerland; Centre for Clinical Brain Sciences (R.A.-S.S., F.C., J.M.W.), School of Clinical Sciences, University of Edinburgh; Liverpool Centre for Cardiovascular Science at University of Liverpool (G.Y.H.L.), Liverpool John Moores University and Liverpool Heart & Chest Hospital, United Kingdom; Department of Neurology (L.P., M.B.G., S.J.), Inselspital, Bern University Hospital, Switzerland; Department of Imaging, School of Clinical Sciences at Monash Health (L.-A.S.), Peninsula Clinical School, Peninsula Health (C.C.K.), and Stroke and Ageing Research Group, School of Clinical Sciences at Monash Health (T.G.P.), Monash University, Melbourne, Australia; Department of Neurology (M.B., F.F.), University Hospital of Würzburg, Germany; Department of Imaging and Interventional Radiology (J.A., W.C.) and Division of Neurology, Department of Medicine and Therapeutics (C.C., T.W.L., Y.O.Y.S.), Prince of Wales Hospital, The Chinese University of Hong Kong; Institute of Applied Health Sciences (S.D.J.M.), University of Aberdeen, United Kingdom; Biomedical Imaging Group Rotterdam (F.D.), Department of Radiology and Nuclear Medicine (D.H.K.D.-N.), Erasmus University Medical Centre, Rotterdam, The Netherlands; Departments of Radiology and Nuclear Medicine (M.E.K.) and Neurology (J.S.), CARIM School for Cardiovascular Diseases, Maastricht University Medical Centre; Department of Psychiatry and Neuropsychology (S.K.), School for Mental Health and Neuroscience, Maastricht University, The Netherlands; University of Lille (G.K., R.B.), Inserm, CHU de Lille, Lille Neuroscience & Cognition, France; National Centre for Healthy Ageing (V.K.S.), Peninsula Clinical School, Central Clinical School, Monash University, Melbourne, Australia; Department of Neurology (Y.Y.), Kansai Medical University, Osaka, Japan; Department of Neurology (D.N.O.), Istanbul Arel University, Turkey; and Department of Neurology (H.-J.B.), Seoul National University Bundang Hospital, Seoul National University College of Medicine, Seongnam, Republic of Korea., Song TJ; From the UCL Stroke Research Centre (J.G.B., D.W., D.J.W.) and Neuroradiological Academic Unit (H.R.J.), Department of Brain Repair and Rehabilitation, UCL Queen Square Institute of Neurology, London; Department of Statistical Science (G.A.), University College London, United Kingdom; Stroke Research Centre (H.D.), Department of Neurology, Fujian Medical University Union Hospital, Fuzhou, People's Republic of China; Department of Neurology (K.-J.L.), Korea University Guro Hospital, Seoul; Department of Neurology (J.-S.L.), Asan Medical Center, University of Ulsan College of Medicine, Seoul, Republic of Korea; Division of Neurology, Department of Medicine (K.C.T., G.K.K.L.) and Department of Diagnostic Radiology (H.M.), The University of Hong Kong; Department of Neurology (Y.D.K., J.-H.H.), Yonsei University College of Medicine, Seoul; Department of Neurology (T.-J.S.), Seoul Hospital, Ewha Womans University College of Medicine, Seoul, Republic of Korea; Department of Neurology (D.S.D.), Sisli Hamidiye Etfal Teaching and Research Hospital, University of Health Sciences, Turkey; Department of Radiology (M.N.), Saga University Faculty of Medicine; Division of Neurology (M.Y., H.H.), Department of Internal Medicine, Saga University Faculty of Medicine, Japan; Stroke Center Klinik Hirslanden Zürich (M.K., N.P.); University of Basel (M.K.); Department of Neurology and Stroke Center University Hospital and University of Basel (A.Z.), Switzerland; Centre for Clinical Brain Sciences (R.A.-S.S., F.C., J.M.W.), School of Clinical Sciences, University of Edinburgh; Liverpool Centre for Cardiovascular Science at University of Liverpool (G.Y.H.L.), Liverpool John Moores University and Liverpool Heart & Chest Hospital, United Kingdom; Department of Neurology (L.P., M.B.G., S.J.), Inselspital, Bern University Hospital, Switzerland; Department of Imaging, School of Clinical Sciences at Monash Health (L.-A.S.), Peninsula Clinical School, Peninsula Health (C.C.K.), and Stroke and Ageing Research Group, School of Clinical Sciences at Monash Health (T.G.P.), Monash University, Melbourne, Australia; Department of Neurology (M.B., F.F.), University Hospital of Würzburg, Germany; Department of Imaging and Interventional Radiology (J.A., W.C.) and Division of Neurology, Department of Medicine and Therapeutics (C.C., T.W.L., Y.O.Y.S.), Prince of Wales Hospital, The Chinese University of Hong Kong; Institute of Applied Health Sciences (S.D.J.M.), University of Aberdeen, United Kingdom; Biomedical Imaging Group Rotterdam (F.D.), Department of Radiology and Nuclear Medicine (D.H.K.D.-N.), Erasmus University Medical Centre, Rotterdam, The Netherlands; Departments of Radiology and Nuclear Medicine (M.E.K.) and Neurology (J.S.), CARIM School for Cardiovascular Diseases, Maastricht University Medical Centre; Department of Psychiatry and Neuropsychology (S.K.), School for Mental Health and Neuroscience, Maastricht University, The Netherlands; University of Lille (G.K., R.B.), Inserm, CHU de Lille, Lille Neuroscience & Cognition, France; National Centre for Healthy Ageing (V.K.S.), Peninsula Clinical School, Central Clinical School, Monash University, Melbourne, Australia; Department of Neurology (Y.Y.), Kansai Medical University, Osaka, Japan; Department of Neurology (D.N.O.), Istanbul Arel University, Turkey; and Department of Neurology (H.-J.B.), Seoul National University Bundang Hospital, Seoul National University College of Medicine, Seongnam, Republic of Korea., Selcuk Demirelli D; From the UCL Stroke Research Centre (J.G.B., D.W., D.J.W.) and Neuroradiological Academic Unit (H.R.J.), Department of Brain Repair and Rehabilitation, UCL Queen Square Institute of Neurology, London; Department of Statistical Science (G.A.), University College London, United Kingdom; Stroke Research Centre (H.D.), Department of Neurology, Fujian Medical University Union Hospital, Fuzhou, People's Republic of China; Department of Neurology (K.-J.L.), Korea University Guro Hospital, Seoul; Department of Neurology (J.-S.L.), Asan Medical Center, University of Ulsan College of Medicine, Seoul, Republic of Korea; Division of Neurology, Department of Medicine (K.C.T., G.K.K.L.) and Department of Diagnostic Radiology (H.M.), The University of Hong Kong; Department of Neurology (Y.D.K., J.-H.H.), Yonsei University College of Medicine, Seoul; Department of Neurology (T.-J.S.), Seoul Hospital, Ewha Womans University College of Medicine, Seoul, Republic of Korea; Department of Neurology (D.S.D.), Sisli Hamidiye Etfal Teaching and Research Hospital, University of Health Sciences, Turkey; Department of Radiology (M.N.), Saga University Faculty of Medicine; Division of Neurology (M.Y., H.H.), Department of Internal Medicine, Saga University Faculty of Medicine, Japan; Stroke Center Klinik Hirslanden Zürich (M.K., N.P.); University of Basel (M.K.); Department of Neurology and Stroke Center University Hospital and University of Basel (A.Z.), Switzerland; Centre for Clinical Brain Sciences (R.A.-S.S., F.C., J.M.W.), School of Clinical Sciences, University of Edinburgh; Liverpool Centre for Cardiovascular Science at University of Liverpool (G.Y.H.L.), Liverpool John Moores University and Liverpool Heart & Chest Hospital, United Kingdom; Department of Neurology (L.P., M.B.G., S.J.), Inselspital, Bern University Hospital, Switzerland; Department of Imaging, School of Clinical Sciences at Monash Health (L.-A.S.), Peninsula Clinical School, Peninsula Health (C.C.K.), and Stroke and Ageing Research Group, School of Clinical Sciences at Monash Health (T.G.P.), Monash University, Melbourne, Australia; Department of Neurology (M.B., F.F.), University Hospital of Würzburg, Germany; Department of Imaging and Interventional Radiology (J.A., W.C.) and Division of Neurology, Department of Medicine and Therapeutics (C.C., T.W.L., Y.O.Y.S.), Prince of Wales Hospital, The Chinese University of Hong Kong; Institute of Applied Health Sciences (S.D.J.M.), University of Aberdeen, United Kingdom; Biomedical Imaging Group Rotterdam (F.D.), Department of Radiology and Nuclear Medicine (D.H.K.D.-N.), Erasmus University Medical Centre, Rotterdam, The Netherlands; Departments of Radiology and Nuclear Medicine (M.E.K.) and Neurology (J.S.), CARIM School for Cardiovascular Diseases, Maastricht University Medical Centre; Department of Psychiatry and Neuropsychology (S.K.), School for Mental Health and Neuroscience, Maastricht University, The Netherlands; University of Lille (G.K., R.B.), Inserm, CHU de Lille, Lille Neuroscience & Cognition, France; National Centre for Healthy Ageing (V.K.S.), Peninsula Clinical School, Central Clinical School, Monash University, Melbourne, Australia; Department of Neurology (Y.Y.), Kansai Medical University, Osaka, Japan; Department of Neurology (D.N.O.), Istanbul Arel University, Turkey; and Department of Neurology (H.-J.B.), Seoul National University Bundang Hospital, Seoul National University College of Medicine, Seongnam, Republic of Korea., Nishihara M; From the UCL Stroke Research Centre (J.G.B., D.W., D.J.W.) and Neuroradiological Academic Unit (H.R.J.), Department of Brain Repair and Rehabilitation, UCL Queen Square Institute of Neurology, London; Department of Statistical Science (G.A.), University College London, United Kingdom; Stroke Research Centre (H.D.), Department of Neurology, Fujian Medical University Union Hospital, Fuzhou, People's Republic of China; Department of Neurology (K.-J.L.), Korea University Guro Hospital, Seoul; Department of Neurology (J.-S.L.), Asan Medical Center, University of Ulsan College of Medicine, Seoul, Republic of Korea; Division of Neurology, Department of Medicine (K.C.T., G.K.K.L.) and Department of Diagnostic Radiology (H.M.), The University of Hong Kong; Department of Neurology (Y.D.K., J.-H.H.), Yonsei University College of Medicine, Seoul; Department of Neurology (T.-J.S.), Seoul Hospital, Ewha Womans University College of Medicine, Seoul, Republic of Korea; Department of Neurology (D.S.D.), Sisli Hamidiye Etfal Teaching and Research Hospital, University of Health Sciences, Turkey; Department of Radiology (M.N.), Saga University Faculty of Medicine; Division of Neurology (M.Y., H.H.), Department of Internal Medicine, Saga University Faculty of Medicine, Japan; Stroke Center Klinik Hirslanden Zürich (M.K., N.P.); University of Basel (M.K.); Department of Neurology and Stroke Center University Hospital and University of Basel (A.Z.), Switzerland; Centre for Clinical Brain Sciences (R.A.-S.S., F.C., J.M.W.), School of Clinical Sciences, University of Edinburgh; Liverpool Centre for Cardiovascular Science at University of Liverpool (G.Y.H.L.), Liverpool John Moores University and Liverpool Heart & Chest Hospital, United Kingdom; Department of Neurology (L.P., M.B.G., S.J.), Inselspital, Bern University Hospital, Switzerland; Department of Imaging, School of Clinical Sciences at Monash Health (L.-A.S.), Peninsula Clinical School, Peninsula Health (C.C.K.), and Stroke and Ageing Research Group, School of Clinical Sciences at Monash Health (T.G.P.), Monash University, Melbourne, Australia; Department of Neurology (M.B., F.F.), University Hospital of Würzburg, Germany; Department of Imaging and Interventional Radiology (J.A., W.C.) and Division of Neurology, Department of Medicine and Therapeutics (C.C., T.W.L., Y.O.Y.S.), Prince of Wales Hospital, The Chinese University of Hong Kong; Institute of Applied Health Sciences (S.D.J.M.), University of Aberdeen, United Kingdom; Biomedical Imaging Group Rotterdam (F.D.), Department of Radiology and Nuclear Medicine (D.H.K.D.-N.), Erasmus University Medical Centre, Rotterdam, The Netherlands; Departments of Radiology and Nuclear Medicine (M.E.K.) and Neurology (J.S.), CARIM School for Cardiovascular Diseases, Maastricht University Medical Centre; Department of Psychiatry and Neuropsychology (S.K.), School for Mental Health and Neuroscience, Maastricht University, The Netherlands; University of Lille (G.K., R.B.), Inserm, CHU de Lille, Lille Neuroscience & Cognition, France; National Centre for Healthy Ageing (V.K.S.), Peninsula Clinical School, Central Clinical School, Monash University, Melbourne, Australia; Department of Neurology (Y.Y.), Kansai Medical University, Osaka, Japan; Department of Neurology (D.N.O.), Istanbul Arel University, Turkey; and Department of Neurology (H.-J.B.), Seoul National University Bundang Hospital, Seoul National University College of Medicine, Seongnam, Republic of Korea., Yoshikawa M; From the UCL Stroke Research Centre (J.G.B., D.W., D.J.W.) and Neuroradiological Academic Unit (H.R.J.), Department of Brain Repair and Rehabilitation, UCL Queen Square Institute of Neurology, London; Department of Statistical Science (G.A.), University College London, United Kingdom; Stroke Research Centre (H.D.), Department of Neurology, Fujian Medical University Union Hospital, Fuzhou, People's Republic of China; Department of Neurology (K.-J.L.), Korea University Guro Hospital, Seoul; Department of Neurology (J.-S.L.), Asan Medical Center, University of Ulsan College of Medicine, Seoul, Republic of Korea; Division of Neurology, Department of Medicine (K.C.T., G.K.K.L.) and Department of Diagnostic Radiology (H.M.), The University of Hong Kong; Department of Neurology (Y.D.K., J.-H.H.), Yonsei University College of Medicine, Seoul; Department of Neurology (T.-J.S.), Seoul Hospital, Ewha Womans University College of Medicine, Seoul, Republic of Korea; Department of Neurology (D.S.D.), Sisli Hamidiye Etfal Teaching and Research Hospital, University of Health Sciences, Turkey; Department of Radiology (M.N.), Saga University Faculty of Medicine; Division of Neurology (M.Y., H.H.), Department of Internal Medicine, Saga University Faculty of Medicine, Japan; Stroke Center Klinik Hirslanden Zürich (M.K., N.P.); University of Basel (M.K.); Department of Neurology and Stroke Center University Hospital and University of Basel (A.Z.), Switzerland; Centre for Clinical Brain Sciences (R.A.-S.S., F.C., J.M.W.), School of Clinical Sciences, University of Edinburgh; Liverpool Centre for Cardiovascular Science at University of Liverpool (G.Y.H.L.), Liverpool John Moores University and Liverpool Heart & Chest Hospital, United Kingdom; Department of Neurology (L.P., M.B.G., S.J.), Inselspital, Bern University Hospital, Switzerland; Department of Imaging, School of Clinical Sciences at Monash Health (L.-A.S.), Peninsula Clinical School, Peninsula Health (C.C.K.), and Stroke and Ageing Research Group, School of Clinical Sciences at Monash Health (T.G.P.), Monash University, Melbourne, Australia; Department of Neurology (M.B., F.F.), University Hospital of Würzburg, Germany; Department of Imaging and Interventional Radiology (J.A., W.C.) and Division of Neurology, Department of Medicine and Therapeutics (C.C., T.W.L., Y.O.Y.S.), Prince of Wales Hospital, The Chinese University of Hong Kong; Institute of Applied Health Sciences (S.D.J.M.), University of Aberdeen, United Kingdom; Biomedical Imaging Group Rotterdam (F.D.), Department of Radiology and Nuclear Medicine (D.H.K.D.-N.), Erasmus University Medical Centre, Rotterdam, The Netherlands; Departments of Radiology and Nuclear Medicine (M.E.K.) and Neurology (J.S.), CARIM School for Cardiovascular Diseases, Maastricht University Medical Centre; Department of Psychiatry and Neuropsychology (S.K.), School for Mental Health and Neuroscience, Maastricht University, The Netherlands; University of Lille (G.K., R.B.), Inserm, CHU de Lille, Lille Neuroscience & Cognition, France; National Centre for Healthy Ageing (V.K.S.), Peninsula Clinical School, Central Clinical School, Monash University, Melbourne, Australia; Department of Neurology (Y.Y.), Kansai Medical University, Osaka, Japan; Department of Neurology (D.N.O.), Istanbul Arel University, Turkey; and Department of Neurology (H.-J.B.), Seoul National University Bundang Hospital, Seoul National University College of Medicine, Seongnam, Republic of Korea., Kubacka M; From the UCL Stroke Research Centre (J.G.B., D.W., D.J.W.) and Neuroradiological Academic Unit (H.R.J.), Department of Brain Repair and Rehabilitation, UCL Queen Square Institute of Neurology, London; Department of Statistical Science (G.A.), University College London, United Kingdom; Stroke Research Centre (H.D.), Department of Neurology, Fujian Medical University Union Hospital, Fuzhou, People's Republic of China; Department of Neurology (K.-J.L.), Korea University Guro Hospital, Seoul; Department of Neurology (J.-S.L.), Asan Medical Center, University of Ulsan College of Medicine, Seoul, Republic of Korea; Division of Neurology, Department of Medicine (K.C.T., G.K.K.L.) and Department of Diagnostic Radiology (H.M.), The University of Hong Kong; Department of Neurology (Y.D.K., J.-H.H.), Yonsei University College of Medicine, Seoul; Department of Neurology (T.-J.S.), Seoul Hospital, Ewha Womans University College of Medicine, Seoul, Republic of Korea; Department of Neurology (D.S.D.), Sisli Hamidiye Etfal Teaching and Research Hospital, University of Health Sciences, Turkey; Department of Radiology (M.N.), Saga University Faculty of Medicine; Division of Neurology (M.Y., H.H.), Department of Internal Medicine, Saga University Faculty of Medicine, Japan; Stroke Center Klinik Hirslanden Zürich (M.K., N.P.); University of Basel (M.K.); Department of Neurology and Stroke Center University Hospital and University of Basel (A.Z.), Switzerland; Centre for Clinical Brain Sciences (R.A.-S.S., F.C., J.M.W.), School of Clinical Sciences, University of Edinburgh; Liverpool Centre for Cardiovascular Science at University of Liverpool (G.Y.H.L.), Liverpool John Moores University and Liverpool Heart & Chest Hospital, United Kingdom; Department of Neurology (L.P., M.B.G., S.J.), Inselspital, Bern University Hospital, Switzerland; Department of Imaging, School of Clinical Sciences at Monash Health (L.-A.S.), Peninsula Clinical School, Peninsula Health (C.C.K.), and Stroke and Ageing Research Group, School of Clinical Sciences at Monash Health (T.G.P.), Monash University, Melbourne, Australia; Department of Neurology (M.B., F.F.), University Hospital of Würzburg, Germany; Department of Imaging and Interventional Radiology (J.A., W.C.) and Division of Neurology, Department of Medicine and Therapeutics (C.C., T.W.L., Y.O.Y.S.), Prince of Wales Hospital, The Chinese University of Hong Kong; Institute of Applied Health Sciences (S.D.J.M.), University of Aberdeen, United Kingdom; Biomedical Imaging Group Rotterdam (F.D.), Department of Radiology and Nuclear Medicine (D.H.K.D.-N.), Erasmus University Medical Centre, Rotterdam, The Netherlands; Departments of Radiology and Nuclear Medicine (M.E.K.) and Neurology (J.S.), CARIM School for Cardiovascular Diseases, Maastricht University Medical Centre; Department of Psychiatry and Neuropsychology (S.K.), School for Mental Health and Neuroscience, Maastricht University, The Netherlands; University of Lille (G.K., R.B.), Inserm, CHU de Lille, Lille Neuroscience & Cognition, France; National Centre for Healthy Ageing (V.K.S.), Peninsula Clinical School, Central Clinical School, Monash University, Melbourne, Australia; Department of Neurology (Y.Y.), Kansai Medical University, Osaka, Japan; Department of Neurology (D.N.O.), Istanbul Arel University, Turkey; and Department of Neurology (H.-J.B.), Seoul National University Bundang Hospital, Seoul National University College of Medicine, Seongnam, Republic of Korea., Zietz A; From the UCL Stroke Research Centre (J.G.B., D.W., D.J.W.) and Neuroradiological Academic Unit (H.R.J.), Department of Brain Repair and Rehabilitation, UCL Queen Square Institute of Neurology, London; Department of Statistical Science (G.A.), University College London, United Kingdom; Stroke Research Centre (H.D.), Department of Neurology, Fujian Medical University Union Hospital, Fuzhou, People's Republic of China; Department of Neurology (K.-J.L.), Korea University Guro Hospital, Seoul; Department of Neurology (J.-S.L.), Asan Medical Center, University of Ulsan College of Medicine, Seoul, Republic of Korea; Division of Neurology, Department of Medicine (K.C.T., G.K.K.L.) and Department of Diagnostic Radiology (H.M.), The University of Hong Kong; Department of Neurology (Y.D.K., J.-H.H.), Yonsei University College of Medicine, Seoul; Department of Neurology (T.-J.S.), Seoul Hospital, Ewha Womans University College of Medicine, Seoul, Republic of Korea; Department of Neurology (D.S.D.), Sisli Hamidiye Etfal Teaching and Research Hospital, University of Health Sciences, Turkey; Department of Radiology (M.N.), Saga University Faculty of Medicine; Division of Neurology (M.Y., H.H.), Department of Internal Medicine, Saga University Faculty of Medicine, Japan; Stroke Center Klinik Hirslanden Zürich (M.K., N.P.); University of Basel (M.K.); Department of Neurology and Stroke Center University Hospital and University of Basel (A.Z.), Switzerland; Centre for Clinical Brain Sciences (R.A.-S.S., F.C., J.M.W.), School of Clinical Sciences, University of Edinburgh; Liverpool Centre for Cardiovascular Science at University of Liverpool (G.Y.H.L.), Liverpool John Moores University and Liverpool Heart & Chest Hospital, United Kingdom; Department of Neurology (L.P., M.B.G., S.J.), Inselspital, Bern University Hospital, Switzerland; Department of Imaging, School of Clinical Sciences at Monash Health (L.-A.S.), Peninsula Clinical School, Peninsula Health (C.C.K.), and Stroke and Ageing Research Group, School of Clinical Sciences at Monash Health (T.G.P.), Monash University, Melbourne, Australia; Department of Neurology (M.B., F.F.), University Hospital of Würzburg, Germany; Department of Imaging and Interventional Radiology (J.A., W.C.) and Division of Neurology, Department of Medicine and Therapeutics (C.C., T.W.L., Y.O.Y.S.), Prince of Wales Hospital, The Chinese University of Hong Kong; Institute of Applied Health Sciences (S.D.J.M.), University of Aberdeen, United Kingdom; Biomedical Imaging Group Rotterdam (F.D.), Department of Radiology and Nuclear Medicine (D.H.K.D.-N.), Erasmus University Medical Centre, Rotterdam, The Netherlands; Departments of Radiology and Nuclear Medicine (M.E.K.) and Neurology (J.S.), CARIM School for Cardiovascular Diseases, Maastricht University Medical Centre; Department of Psychiatry and Neuropsychology (S.K.), School for Mental Health and Neuroscience, Maastricht University, The Netherlands; University of Lille (G.K., R.B.), Inserm, CHU de Lille, Lille Neuroscience & Cognition, France; National Centre for Healthy Ageing (V.K.S.), Peninsula Clinical School, Central Clinical School, Monash University, Melbourne, Australia; Department of Neurology (Y.Y.), Kansai Medical University, Osaka, Japan; Department of Neurology (D.N.O.), Istanbul Arel University, Turkey; and Department of Neurology (H.-J.B.), Seoul National University Bundang Hospital, Seoul National University College of Medicine, Seongnam, Republic of Korea., Al-Shahi Salman R; From the UCL Stroke Research Centre (J.G.B., D.W., D.J.W.) and Neuroradiological Academic Unit (H.R.J.), Department of Brain Repair and Rehabilitation, UCL Queen Square Institute of Neurology, London; Department of Statistical Science (G.A.), University College London, United Kingdom; Stroke Research Centre (H.D.), Department of Neurology, Fujian Medical University Union Hospital, Fuzhou, People's Republic of China; Department of Neurology (K.-J.L.), Korea University Guro Hospital, Seoul; Department of Neurology (J.-S.L.), Asan Medical Center, University of Ulsan College of Medicine, Seoul, Republic of Korea; Division of Neurology, Department of Medicine (K.C.T., G.K.K.L.) and Department of Diagnostic Radiology (H.M.), The University of Hong Kong; Department of Neurology (Y.D.K., J.-H.H.), Yonsei University College of Medicine, Seoul; Department of Neurology (T.-J.S.), Seoul Hospital, Ewha Womans University College of Medicine, Seoul, Republic of Korea; Department of Neurology (D.S.D.), Sisli Hamidiye Etfal Teaching and Research Hospital, University of Health Sciences, Turkey; Department of Radiology (M.N.), Saga University Faculty of Medicine; Division of Neurology (M.Y., H.H.), Department of Internal Medicine, Saga University Faculty of Medicine, Japan; Stroke Center Klinik Hirslanden Zürich (M.K., N.P.); University of Basel (M.K.); Department of Neurology and Stroke Center University Hospital and University of Basel (A.Z.), Switzerland; Centre for Clinical Brain Sciences (R.A.-S.S., F.C., J.M.W.), School of Clinical Sciences, University of Edinburgh; Liverpool Centre for Cardiovascular Science at University of Liverpool (G.Y.H.L.), Liverpool John Moores University and Liverpool Heart & Chest Hospital, United Kingdom; Department of Neurology (L.P., M.B.G., S.J.), Inselspital, Bern University Hospital, Switzerland; Department of Imaging, School of Clinical Sciences at Monash Health (L.-A.S.), Peninsula Clinical School, Peninsula Health (C.C.K.), and Stroke and Ageing Research Group, School of Clinical Sciences at Monash Health (T.G.P.), Monash University, Melbourne, Australia; Department of Neurology (M.B., F.F.), University Hospital of Würzburg, Germany; Department of Imaging and Interventional Radiology (J.A., W.C.) and Division of Neurology, Department of Medicine and Therapeutics (C.C., T.W.L., Y.O.Y.S.), Prince of Wales Hospital, The Chinese University of Hong Kong; Institute of Applied Health Sciences (S.D.J.M.), University of Aberdeen, United Kingdom; Biomedical Imaging Group Rotterdam (F.D.), Department of Radiology and Nuclear Medicine (D.H.K.D.-N.), Erasmus University Medical Centre, Rotterdam, The Netherlands; Departments of Radiology and Nuclear Medicine (M.E.K.) and Neurology (J.S.), CARIM School for Cardiovascular Diseases, Maastricht University Medical Centre; Department of Psychiatry and Neuropsychology (S.K.), School for Mental Health and Neuroscience, Maastricht University, The Netherlands; University of Lille (G.K., R.B.), Inserm, CHU de Lille, Lille Neuroscience & Cognition, France; National Centre for Healthy Ageing (V.K.S.), Peninsula Clinical School, Central Clinical School, Monash University, Melbourne, Australia; Department of Neurology (Y.Y.), Kansai Medical University, Osaka, Japan; Department of Neurology (D.N.O.), Istanbul Arel University, Turkey; and Department of Neurology (H.-J.B.), Seoul National University Bundang Hospital, Seoul National University College of Medicine, Seongnam, Republic of Korea., Jäger HR; From the UCL Stroke Research Centre (J.G.B., D.W., D.J.W.) and Neuroradiological Academic Unit (H.R.J.), Department of Brain Repair and Rehabilitation, UCL Queen Square Institute of Neurology, London; Department of Statistical Science (G.A.), University College London, United Kingdom; Stroke Research Centre (H.D.), Department of Neurology, Fujian Medical University Union Hospital, Fuzhou, People's Republic of China; Department of Neurology (K.-J.L.), Korea University Guro Hospital, Seoul; Department of Neurology (J.-S.L.), Asan Medical Center, University of Ulsan College of Medicine, Seoul, Republic of Korea; Division of Neurology, Department of Medicine (K.C.T., G.K.K.L.) and Department of Diagnostic Radiology (H.M.), The University of Hong Kong; Department of Neurology (Y.D.K., J.-H.H.), Yonsei University College of Medicine, Seoul; Department of Neurology (T.-J.S.), Seoul Hospital, Ewha Womans University College of Medicine, Seoul, Republic of Korea; Department of Neurology (D.S.D.), Sisli Hamidiye Etfal Teaching and Research Hospital, University of Health Sciences, Turkey; Department of Radiology (M.N.), Saga University Faculty of Medicine; Division of Neurology (M.Y., H.H.), Department of Internal Medicine, Saga University Faculty of Medicine, Japan; Stroke Center Klinik Hirslanden Zürich (M.K., N.P.); University of Basel (M.K.); Department of Neurology and Stroke Center University Hospital and University of Basel (A.Z.), Switzerland; Centre for Clinical Brain Sciences (R.A.-S.S., F.C., J.M.W.), School of Clinical Sciences, University of Edinburgh; Liverpool Centre for Cardiovascular Science at University of Liverpool (G.Y.H.L.), Liverpool John Moores University and Liverpool Heart & Chest Hospital, United Kingdom; Department of Neurology (L.P., M.B.G., S.J.), Inselspital, Bern University Hospital, Switzerland; Department of Imaging, School of Clinical Sciences at Monash Health (L.-A.S.), Peninsula Clinical School, Peninsula Health (C.C.K.), and Stroke and Ageing Research Group, School of Clinical Sciences at Monash Health (T.G.P.), Monash University, Melbourne, Australia; Department of Neurology (M.B., F.F.), University Hospital of Würzburg, Germany; Department of Imaging and Interventional Radiology (J.A., W.C.) and Division of Neurology, Department of Medicine and Therapeutics (C.C., T.W.L., Y.O.Y.S.), Prince of Wales Hospital, The Chinese University of Hong Kong; Institute of Applied Health Sciences (S.D.J.M.), University of Aberdeen, United Kingdom; Biomedical Imaging Group Rotterdam (F.D.), Department of Radiology and Nuclear Medicine (D.H.K.D.-N.), Erasmus University Medical Centre, Rotterdam, The Netherlands; Departments of Radiology and Nuclear Medicine (M.E.K.) and Neurology (J.S.), CARIM School for Cardiovascular Diseases, Maastricht University Medical Centre; Department of Psychiatry and Neuropsychology (S.K.), School for Mental Health and Neuroscience, Maastricht University, The Netherlands; University of Lille (G.K., R.B.), Inserm, CHU de Lille, Lille Neuroscience & Cognition, France; National Centre for Healthy Ageing (V.K.S.), Peninsula Clinical School, Central Clinical School, Monash University, Melbourne, Australia; Department of Neurology (Y.Y.), Kansai Medical University, Osaka, Japan; Department of Neurology (D.N.O.), Istanbul Arel University, Turkey; and Department of Neurology (H.-J.B.), Seoul National University Bundang Hospital, Seoul National University College of Medicine, Seongnam, Republic of Korea., Lip GYH; From the UCL Stroke Research Centre (J.G.B., D.W., D.J.W.) and Neuroradiological Academic Unit (H.R.J.), Department of Brain Repair and Rehabilitation, UCL Queen Square Institute of Neurology, London; Department of Statistical Science (G.A.), University College London, United Kingdom; Stroke Research Centre (H.D.), Department of Neurology, Fujian Medical University Union Hospital, Fuzhou, People's Republic of China; Department of Neurology (K.-J.L.), Korea University Guro Hospital, Seoul; Department of Neurology (J.-S.L.), Asan Medical Center, University of Ulsan College of Medicine, Seoul, Republic of Korea; Division of Neurology, Department of Medicine (K.C.T., G.K.K.L.) and Department of Diagnostic Radiology (H.M.), The University of Hong Kong; Department of Neurology (Y.D.K., J.-H.H.), Yonsei University College of Medicine, Seoul; Department of Neurology (T.-J.S.), Seoul Hospital, Ewha Womans University College of Medicine, Seoul, Republic of Korea; Department of Neurology (D.S.D.), Sisli Hamidiye Etfal Teaching and Research Hospital, University of Health Sciences, Turkey; Department of Radiology (M.N.), Saga University Faculty of Medicine; Division of Neurology (M.Y., H.H.), Department of Internal Medicine, Saga University Faculty of Medicine, Japan; Stroke Center Klinik Hirslanden Zürich (M.K., N.P.); University of Basel (M.K.); Department of Neurology and Stroke Center University Hospital and University of Basel (A.Z.), Switzerland; Centre for Clinical Brain Sciences (R.A.-S.S., F.C., J.M.W.), School of Clinical Sciences, University of Edinburgh; Liverpool Centre for Cardiovascular Science at University of Liverpool (G.Y.H.L.), Liverpool John Moores University and Liverpool Heart & Chest Hospital, United Kingdom; Department of Neurology (L.P., M.B.G., S.J.), Inselspital, Bern University Hospital, Switzerland; Department of Imaging, School of Clinical Sciences at Monash Health (L.-A.S.), Peninsula Clinical School, Peninsula Health (C.C.K.), and Stroke and Ageing Research Group, School of Clinical Sciences at Monash Health (T.G.P.), Monash University, Melbourne, Australia; Department of Neurology (M.B., F.F.), University Hospital of Würzburg, Germany; Department of Imaging and Interventional Radiology (J.A., W.C.) and Division of Neurology, Department of Medicine and Therapeutics (C.C., T.W.L., Y.O.Y.S.), Prince of Wales Hospital, The Chinese University of Hong Kong; Institute of Applied Health Sciences (S.D.J.M.), University of Aberdeen, United Kingdom; Biomedical Imaging Group Rotterdam (F.D.), Department of Radiology and Nuclear Medicine (D.H.K.D.-N.), Erasmus University Medical Centre, Rotterdam, The Netherlands; Departments of Radiology and Nuclear Medicine (M.E.K.) and Neurology (J.S.), CARIM School for Cardiovascular Diseases, Maastricht University Medical Centre; Department of Psychiatry and Neuropsychology (S.K.), School for Mental Health and Neuroscience, Maastricht University, The Netherlands; University of Lille (G.K., R.B.), Inserm, CHU de Lille, Lille Neuroscience & Cognition, France; National Centre for Healthy Ageing (V.K.S.), Peninsula Clinical School, Central Clinical School, Monash University, Melbourne, Australia; Department of Neurology (Y.Y.), Kansai Medical University, Osaka, Japan; Department of Neurology (D.N.O.), Istanbul Arel University, Turkey; and Department of Neurology (H.-J.B.), Seoul National University Bundang Hospital, Seoul National University College of Medicine, Seongnam, Republic of Korea., Panos L; From the UCL Stroke Research Centre (J.G.B., D.W., D.J.W.) and Neuroradiological Academic Unit (H.R.J.), Department of Brain Repair and Rehabilitation, UCL Queen Square Institute of Neurology, London; Department of Statistical Science (G.A.), University College London, United Kingdom; Stroke Research Centre (H.D.), Department of Neurology, Fujian Medical University Union Hospital, Fuzhou, People's Republic of China; Department of Neurology (K.-J.L.), Korea University Guro Hospital, Seoul; Department of Neurology (J.-S.L.), Asan Medical Center, University of Ulsan College of Medicine, Seoul, Republic of Korea; Division of Neurology, Department of Medicine (K.C.T., G.K.K.L.) and Department of Diagnostic Radiology (H.M.), The University of Hong Kong; Department of Neurology (Y.D.K., J.-H.H.), Yonsei University College of Medicine, Seoul; Department of Neurology (T.-J.S.), Seoul Hospital, Ewha Womans University College of Medicine, Seoul, Republic of Korea; Department of Neurology (D.S.D.), Sisli Hamidiye Etfal Teaching and Research Hospital, University of Health Sciences, Turkey; Department of Radiology (M.N.), Saga University Faculty of Medicine; Division of Neurology (M.Y., H.H.), Department of Internal Medicine, Saga University Faculty of Medicine, Japan; Stroke Center Klinik Hirslanden Zürich (M.K., N.P.); University of Basel (M.K.); Department of Neurology and Stroke Center University Hospital and University of Basel (A.Z.), Switzerland; Centre for Clinical Brain Sciences (R.A.-S.S., F.C., J.M.W.), School of Clinical Sciences, University of Edinburgh; Liverpool Centre for Cardiovascular Science at University of Liverpool (G.Y.H.L.), Liverpool John Moores University and Liverpool Heart & Chest Hospital, United Kingdom; Department of Neurology (L.P., M.B.G., S.J.), Inselspital, Bern University Hospital, Switzerland; Department of Imaging, School of Clinical Sciences at Monash Health (L.-A.S.), Peninsula Clinical School, Peninsula Health (C.C.K.), and Stroke and Ageing Research Group, School of Clinical Sciences at Monash Health (T.G.P.), Monash University, Melbourne, Australia; Department of Neurology (M.B., F.F.), University Hospital of Würzburg, Germany; Department of Imaging and Interventional Radiology (J.A., W.C.) and Division of Neurology, Department of Medicine and Therapeutics (C.C., T.W.L., Y.O.Y.S.), Prince of Wales Hospital, The Chinese University of Hong Kong; Institute of Applied Health Sciences (S.D.J.M.), University of Aberdeen, United Kingdom; Biomedical Imaging Group Rotterdam (F.D.), Department of Radiology and Nuclear Medicine (D.H.K.D.-N.), Erasmus University Medical Centre, Rotterdam, The Netherlands; Departments of Radiology and Nuclear Medicine (M.E.K.) and Neurology (J.S.), CARIM School for Cardiovascular Diseases, Maastricht University Medical Centre; Department of Psychiatry and Neuropsychology (S.K.), School for Mental Health and Neuroscience, Maastricht University, The Netherlands; University of Lille (G.K., R.B.), Inserm, CHU de Lille, Lille Neuroscience & Cognition, France; National Centre for Healthy Ageing (V.K.S.), Peninsula Clinical School, Central Clinical School, Monash University, Melbourne, Australia; Department of Neurology (Y.Y.), Kansai Medical University, Osaka, Japan; Department of Neurology (D.N.O.), Istanbul Arel University, Turkey; and Department of Neurology (H.-J.B.), Seoul National University Bundang Hospital, Seoul National University College of Medicine, Seongnam, Republic of Korea., Goeldlin MB; From the UCL Stroke Research Centre (J.G.B., D.W., D.J.W.) and Neuroradiological Academic Unit (H.R.J.), Department of Brain Repair and Rehabilitation, UCL Queen Square Institute of Neurology, London; Department of Statistical Science (G.A.), University College London, United Kingdom; Stroke Research Centre (H.D.), Department of Neurology, Fujian Medical University Union Hospital, Fuzhou, People's Republic of China; Department of Neurology (K.-J.L.), Korea University Guro Hospital, Seoul; Department of Neurology (J.-S.L.), Asan Medical Center, University of Ulsan College of Medicine, Seoul, Republic of Korea; Division of Neurology, Department of Medicine (K.C.T., G.K.K.L.) and Department of Diagnostic Radiology (H.M.), The University of Hong Kong; Department of Neurology (Y.D.K., J.-H.H.), Yonsei University College of Medicine, Seoul; Department of Neurology (T.-J.S.), Seoul Hospital, Ewha Womans University College of Medicine, Seoul, Republic of Korea; Department of Neurology (D.S.D.), Sisli Hamidiye Etfal Teaching and Research Hospital, University of Health Sciences, Turkey; Department of Radiology (M.N.), Saga University Faculty of Medicine; Division of Neurology (M.Y., H.H.), Department of Internal Medicine, Saga University Faculty of Medicine, Japan; Stroke Center Klinik Hirslanden Zürich (M.K., N.P.); University of Basel (M.K.); Department of Neurology and Stroke Center University Hospital and University of Basel (A.Z.), Switzerland; Centre for Clinical Brain Sciences (R.A.-S.S., F.C., J.M.W.), School of Clinical Sciences, University of Edinburgh; Liverpool Centre for Cardiovascular Science at University of Liverpool (G.Y.H.L.), Liverpool John Moores University and Liverpool Heart & Chest Hospital, United Kingdom; Department of Neurology (L.P., M.B.G., S.J.), Inselspital, Bern University Hospital, Switzerland; Department of Imaging, School of Clinical Sciences at Monash Health (L.-A.S.), Peninsula Clinical School, Peninsula Health (C.C.K.), and Stroke and Ageing Research Group, School of Clinical Sciences at Monash Health (T.G.P.), Monash University, Melbourne, Australia; Department of Neurology (M.B., F.F.), University Hospital of Würzburg, Germany; Department of Imaging and Interventional Radiology (J.A., W.C.) and Division of Neurology, Department of Medicine and Therapeutics (C.C., T.W.L., Y.O.Y.S.), Prince of Wales Hospital, The Chinese University of Hong Kong; Institute of Applied Health Sciences (S.D.J.M.), University of Aberdeen, United Kingdom; Biomedical Imaging Group Rotterdam (F.D.), Department of Radiology and Nuclear Medicine (D.H.K.D.-N.), Erasmus University Medical Centre, Rotterdam, The Netherlands; Departments of Radiology and Nuclear Medicine (M.E.K.) and Neurology (J.S.), CARIM School for Cardiovascular Diseases, Maastricht University Medical Centre; Department of Psychiatry and Neuropsychology (S.K.), School for Mental Health and Neuroscience, Maastricht University, The Netherlands; University of Lille (G.K., R.B.), Inserm, CHU de Lille, Lille Neuroscience & Cognition, France; National Centre for Healthy Ageing (V.K.S.), Peninsula Clinical School, Central Clinical School, Monash University, Melbourne, Australia; Department of Neurology (Y.Y.), Kansai Medical University, Osaka, Japan; Department of Neurology (D.N.O.), Istanbul Arel University, Turkey; and Department of Neurology (H.-J.B.), Seoul National University Bundang Hospital, Seoul National University College of Medicine, Seongnam, Republic of Korea., Slater LA; From the UCL Stroke Research Centre (J.G.B., D.W., D.J.W.) and Neuroradiological Academic Unit (H.R.J.), Department of Brain Repair and Rehabilitation, UCL Queen Square Institute of Neurology, London; Department of Statistical Science (G.A.), University College London, United Kingdom; Stroke Research Centre (H.D.), Department of Neurology, Fujian Medical University Union Hospital, Fuzhou, People's Republic of China; Department of Neurology (K.-J.L.), Korea University Guro Hospital, Seoul; Department of Neurology (J.-S.L.), Asan Medical Center, University of Ulsan College of Medicine, Seoul, Republic of Korea; Division of Neurology, Department of Medicine (K.C.T., G.K.K.L.) and Department of Diagnostic Radiology (H.M.), The University of Hong Kong; Department of Neurology (Y.D.K., J.-H.H.), Yonsei University College of Medicine, Seoul; Department of Neurology (T.-J.S.), Seoul Hospital, Ewha Womans University College of Medicine, Seoul, Republic of Korea; Department of Neurology (D.S.D.), Sisli Hamidiye Etfal Teaching and Research Hospital, University of Health Sciences, Turkey; Department of Radiology (M.N.), Saga University Faculty of Medicine; Division of Neurology (M.Y., H.H.), Department of Internal Medicine, Saga University Faculty of Medicine, Japan; Stroke Center Klinik Hirslanden Zürich (M.K., N.P.); University of Basel (M.K.); Department of Neurology and Stroke Center University Hospital and University of Basel (A.Z.), Switzerland; Centre for Clinical Brain Sciences (R.A.-S.S., F.C., J.M.W.), School of Clinical Sciences, University of Edinburgh; Liverpool Centre for Cardiovascular Science at University of Liverpool (G.Y.H.L.), Liverpool John Moores University and Liverpool Heart & Chest Hospital, United Kingdom; Department of Neurology (L.P., M.B.G., S.J.), Inselspital, Bern University Hospital, Switzerland; Department of Imaging, School of Clinical Sciences at Monash Health (L.-A.S.), Peninsula Clinical School, Peninsula Health (C.C.K.), and Stroke and Ageing Research Group, School of Clinical Sciences at Monash Health (T.G.P.), Monash University, Melbourne, Australia; Department of Neurology (M.B., F.F.), University Hospital of Würzburg, Germany; Department of Imaging and Interventional Radiology (J.A., W.C.) and Division of Neurology, Department of Medicine and Therapeutics (C.C., T.W.L., Y.O.Y.S.), Prince of Wales Hospital, The Chinese University of Hong Kong; Institute of Applied Health Sciences (S.D.J.M.), University of Aberdeen, United Kingdom; Biomedical Imaging Group Rotterdam (F.D.), Department of Radiology and Nuclear Medicine (D.H.K.D.-N.), Erasmus University Medical Centre, Rotterdam, The Netherlands; Departments of Radiology and Nuclear Medicine (M.E.K.) and Neurology (J.S.), CARIM School for Cardiovascular Diseases, Maastricht University Medical Centre; Department of Psychiatry and Neuropsychology (S.K.), School for Mental Health and Neuroscience, Maastricht University, The Netherlands; University of Lille (G.K., R.B.), Inserm, CHU de Lille, Lille Neuroscience & Cognition, France; National Centre for Healthy Ageing (V.K.S.), Peninsula Clinical School, Central Clinical School, Monash University, Melbourne, Australia; Department of Neurology (Y.Y.), Kansai Medical University, Osaka, Japan; Department of Neurology (D.N.O.), Istanbul Arel University, Turkey; and Department of Neurology (H.-J.B.), Seoul National University Bundang Hospital, Seoul National University College of Medicine, Seongnam, Republic of Korea., Karayiannis CC; From the UCL Stroke Research Centre (J.G.B., D.W., D.J.W.) and Neuroradiological Academic Unit (H.R.J.), Department of Brain Repair and Rehabilitation, UCL Queen Square Institute of Neurology, London; Department of Statistical Science (G.A.), University College London, United Kingdom; Stroke Research Centre (H.D.), Department of Neurology, Fujian Medical University Union Hospital, Fuzhou, People's Republic of China; Department of Neurology (K.-J.L.), Korea University Guro Hospital, Seoul; Department of Neurology (J.-S.L.), Asan Medical Center, University of Ulsan College of Medicine, Seoul, Republic of Korea; Division of Neurology, Department of Medicine (K.C.T., G.K.K.L.) and Department of Diagnostic Radiology (H.M.), The University of Hong Kong; Department of Neurology (Y.D.K., J.-H.H.), Yonsei University College of Medicine, Seoul; Department of Neurology (T.-J.S.), Seoul Hospital, Ewha Womans University College of Medicine, Seoul, Republic of Korea; Department of Neurology (D.S.D.), Sisli Hamidiye Etfal Teaching and Research Hospital, University of Health Sciences, Turkey; Department of Radiology (M.N.), Saga University Faculty of Medicine; Division of Neurology (M.Y., H.H.), Department of Internal Medicine, Saga University Faculty of Medicine, Japan; Stroke Center Klinik Hirslanden Zürich (M.K., N.P.); University of Basel (M.K.); Department of Neurology and Stroke Center University Hospital and University of Basel (A.Z.), Switzerland; Centre for Clinical Brain Sciences (R.A.-S.S., F.C., J.M.W.), School of Clinical Sciences, University of Edinburgh; Liverpool Centre for Cardiovascular Science at University of Liverpool (G.Y.H.L.), Liverpool John Moores University and Liverpool Heart & Chest Hospital, United Kingdom; Department of Neurology (L.P., M.B.G., S.J.), Inselspital, Bern University Hospital, Switzerland; Department of Imaging, School of Clinical Sciences at Monash Health (L.-A.S.), Peninsula Clinical School, Peninsula Health (C.C.K.), and Stroke and Ageing Research Group, School of Clinical Sciences at Monash Health (T.G.P.), Monash University, Melbourne, Australia; Department of Neurology (M.B., F.F.), University Hospital of Würzburg, Germany; Department of Imaging and Interventional Radiology (J.A., W.C.) and Division of Neurology, Department of Medicine and Therapeutics (C.C., T.W.L., Y.O.Y.S.), Prince of Wales Hospital, The Chinese University of Hong Kong; Institute of Applied Health Sciences (S.D.J.M.), University of Aberdeen, United Kingdom; Biomedical Imaging Group Rotterdam (F.D.), Department of Radiology and Nuclear Medicine (D.H.K.D.-N.), Erasmus University Medical Centre, Rotterdam, The Netherlands; Departments of Radiology and Nuclear Medicine (M.E.K.) and Neurology (J.S.), CARIM School for Cardiovascular Diseases, Maastricht University Medical Centre; Department of Psychiatry and Neuropsychology (S.K.), School for Mental Health and Neuroscience, Maastricht University, The Netherlands; University of Lille (G.K., R.B.), Inserm, CHU de Lille, Lille Neuroscience & Cognition, France; National Centre for Healthy Ageing (V.K.S.), Peninsula Clinical School, Central Clinical School, Monash University, Melbourne, Australia; Department of Neurology (Y.Y.), Kansai Medical University, Osaka, Japan; Department of Neurology (D.N.O.), Istanbul Arel University, Turkey; and Department of Neurology (H.-J.B.), Seoul National University Bundang Hospital, Seoul National University College of Medicine, Seongnam, Republic of Korea., Phan TG; From the UCL Stroke Research Centre (J.G.B., D.W., D.J.W.) and Neuroradiological Academic Unit (H.R.J.), Department of Brain Repair and Rehabilitation, UCL Queen Square Institute of Neurology, London; Department of Statistical Science (G.A.), University College London, United Kingdom; Stroke Research Centre (H.D.), Department of Neurology, Fujian Medical University Union Hospital, Fuzhou, People's Republic of China; Department of Neurology (K.-J.L.), Korea University Guro Hospital, Seoul; Department of Neurology (J.-S.L.), Asan Medical Center, University of Ulsan College of Medicine, Seoul, Republic of Korea; Division of Neurology, Department of Medicine (K.C.T., G.K.K.L.) and Department of Diagnostic Radiology (H.M.), The University of Hong Kong; Department of Neurology (Y.D.K., J.-H.H.), Yonsei University College of Medicine, Seoul; Department of Neurology (T.-J.S.), Seoul Hospital, Ewha Womans University College of Medicine, Seoul, Republic of Korea; Department of Neurology (D.S.D.), Sisli Hamidiye Etfal Teaching and Research Hospital, University of Health Sciences, Turkey; Department of Radiology (M.N.), Saga University Faculty of Medicine; Division of Neurology (M.Y., H.H.), Department of Internal Medicine, Saga University Faculty of Medicine, Japan; Stroke Center Klinik Hirslanden Zürich (M.K., N.P.); University of Basel (M.K.); Department of Neurology and Stroke Center University Hospital and University of Basel (A.Z.), Switzerland; Centre for Clinical Brain Sciences (R.A.-S.S., F.C., J.M.W.), School of Clinical Sciences, University of Edinburgh; Liverpool Centre for Cardiovascular Science at University of Liverpool (G.Y.H.L.), Liverpool John Moores University and Liverpool Heart & Chest Hospital, United Kingdom; Department of Neurology (L.P., M.B.G., S.J.), Inselspital, Bern University Hospital, Switzerland; Department of Imaging, School of Clinical Sciences at Monash Health (L.-A.S.), Peninsula Clinical School, Peninsula Health (C.C.K.), and Stroke and Ageing Research Group, School of Clinical Sciences at Monash Health (T.G.P.), Monash University, Melbourne, Australia; Department of Neurology (M.B., F.F.), University Hospital of Würzburg, Germany; Department of Imaging and Interventional Radiology (J.A., W.C.) and Division of Neurology, Department of Medicine and Therapeutics (C.C., T.W.L., Y.O.Y.S.), Prince of Wales Hospital, The Chinese University of Hong Kong; Institute of Applied Health Sciences (S.D.J.M.), University of Aberdeen, United Kingdom; Biomedical Imaging Group Rotterdam (F.D.), Department of Radiology and Nuclear Medicine (D.H.K.D.-N.), Erasmus University Medical Centre, Rotterdam, The Netherlands; Departments of Radiology and Nuclear Medicine (M.E.K.) and Neurology (J.S.), CARIM School for Cardiovascular Diseases, Maastricht University Medical Centre; Department of Psychiatry and Neuropsychology (S.K.), School for Mental Health and Neuroscience, Maastricht University, The Netherlands; University of Lille (G.K., R.B.), Inserm, CHU de Lille, Lille Neuroscience & Cognition, France; National Centre for Healthy Ageing (V.K.S.), Peninsula Clinical School, Central Clinical School, Monash University, Melbourne, Australia; Department of Neurology (Y.Y.), Kansai Medical University, Osaka, Japan; Department of Neurology (D.N.O.), Istanbul Arel University, Turkey; and Department of Neurology (H.-J.B.), Seoul National University Bundang Hospital, Seoul National University College of Medicine, Seongnam, Republic of Korea., Bellut M; From the UCL Stroke Research Centre (J.G.B., D.W., D.J.W.) and Neuroradiological Academic Unit (H.R.J.), Department of Brain Repair and Rehabilitation, UCL Queen Square Institute of Neurology, London; Department of Statistical Science (G.A.), University College London, United Kingdom; Stroke Research Centre (H.D.), Department of Neurology, Fujian Medical University Union Hospital, Fuzhou, People's Republic of China; Department of Neurology (K.-J.L.), Korea University Guro Hospital, Seoul; Department of Neurology (J.-S.L.), Asan Medical Center, University of Ulsan College of Medicine, Seoul, Republic of Korea; Division of Neurology, Department of Medicine (K.C.T., G.K.K.L.) and Department of Diagnostic Radiology (H.M.), The University of Hong Kong; Department of Neurology (Y.D.K., J.-H.H.), Yonsei University College of Medicine, Seoul; Department of Neurology (T.-J.S.), Seoul Hospital, Ewha Womans University College of Medicine, Seoul, Republic of Korea; Department of Neurology (D.S.D.), Sisli Hamidiye Etfal Teaching and Research Hospital, University of Health Sciences, Turkey; Department of Radiology (M.N.), Saga University Faculty of Medicine; Division of Neurology (M.Y., H.H.), Department of Internal Medicine, Saga University Faculty of Medicine, Japan; Stroke Center Klinik Hirslanden Zürich (M.K., N.P.); University of Basel (M.K.); Department of Neurology and Stroke Center University Hospital and University of Basel (A.Z.), Switzerland; Centre for Clinical Brain Sciences (R.A.-S.S., F.C., J.M.W.), School of Clinical Sciences, University of Edinburgh; Liverpool Centre for Cardiovascular Science at University of Liverpool (G.Y.H.L.), Liverpool John Moores University and Liverpool Heart & Chest Hospital, United Kingdom; Department of Neurology (L.P., M.B.G., S.J.), Inselspital, Bern University Hospital, Switzerland; Department of Imaging, School of Clinical Sciences at Monash Health (L.-A.S.), Peninsula Clinical School, Peninsula Health (C.C.K.), and Stroke and Ageing Research Group, School of Clinical Sciences at Monash Health (T.G.P.), Monash University, Melbourne, Australia; Department of Neurology (M.B., F.F.), University Hospital of Würzburg, Germany; Department of Imaging and Interventional Radiology (J.A., W.C.) and Division of Neurology, Department of Medicine and Therapeutics (C.C., T.W.L., Y.O.Y.S.), Prince of Wales Hospital, The Chinese University of Hong Kong; Institute of Applied Health Sciences (S.D.J.M.), University of Aberdeen, United Kingdom; Biomedical Imaging Group Rotterdam (F.D.), Department of Radiology and Nuclear Medicine (D.H.K.D.-N.), Erasmus University Medical Centre, Rotterdam, The Netherlands; Departments of Radiology and Nuclear Medicine (M.E.K.) and Neurology (J.S.), CARIM School for Cardiovascular Diseases, Maastricht University Medical Centre; Department of Psychiatry and Neuropsychology (S.K.), School for Mental Health and Neuroscience, Maastricht University, The Netherlands; University of Lille (G.K., R.B.), Inserm, CHU de Lille, Lille Neuroscience & Cognition, France; National Centre for Healthy Ageing (V.K.S.), Peninsula Clinical School, Central Clinical School, Monash University, Melbourne, Australia; Department of Neurology (Y.Y.), Kansai Medical University, Osaka, Japan; Department of Neurology (D.N.O.), Istanbul Arel University, Turkey; and Department of Neurology (H.-J.B.), Seoul National University Bundang Hospital, Seoul National University College of Medicine, Seongnam, Republic of Korea., Abrigo J; From the UCL Stroke Research Centre (J.G.B., D.W., D.J.W.) and Neuroradiological Academic Unit (H.R.J.), Department of Brain Repair and Rehabilitation, UCL Queen Square Institute of Neurology, London; Department of Statistical Science (G.A.), University College London, United Kingdom; Stroke Research Centre (H.D.), Department of Neurology, Fujian Medical University Union Hospital, Fuzhou, People's Republic of China; Department of Neurology (K.-J.L.), Korea University Guro Hospital, Seoul; Department of Neurology (J.-S.L.), Asan Medical Center, University of Ulsan College of Medicine, Seoul, Republic of Korea; Division of Neurology, Department of Medicine (K.C.T., G.K.K.L.) and Department of Diagnostic Radiology (H.M.), The University of Hong Kong; Department of Neurology (Y.D.K., J.-H.H.), Yonsei University College of Medicine, Seoul; Department of Neurology (T.-J.S.), Seoul Hospital, Ewha Womans University College of Medicine, Seoul, Republic of Korea; Department of Neurology (D.S.D.), Sisli Hamidiye Etfal Teaching and Research Hospital, University of Health Sciences, Turkey; Department of Radiology (M.N.), Saga University Faculty of Medicine; Division of Neurology (M.Y., H.H.), Department of Internal Medicine, Saga University Faculty of Medicine, Japan; Stroke Center Klinik Hirslanden Zürich (M.K., N.P.); University of Basel (M.K.); Department of Neurology and Stroke Center University Hospital and University of Basel (A.Z.), Switzerland; Centre for Clinical Brain Sciences (R.A.-S.S., F.C., J.M.W.), School of Clinical Sciences, University of Edinburgh; Liverpool Centre for Cardiovascular Science at University of Liverpool (G.Y.H.L.), Liverpool John Moores University and Liverpool Heart & Chest Hospital, United Kingdom; Department of Neurology (L.P., M.B.G., S.J.), Inselspital, Bern University Hospital, Switzerland; Department of Imaging, School of Clinical Sciences at Monash Health (L.-A.S.), Peninsula Clinical School, Peninsula Health (C.C.K.), and Stroke and Ageing Research Group, School of Clinical Sciences at Monash Health (T.G.P.), Monash University, Melbourne, Australia; Department of Neurology (M.B., F.F.), University Hospital of Würzburg, Germany; Department of Imaging and Interventional Radiology (J.A., W.C.) and Division of Neurology, Department of Medicine and Therapeutics (C.C., T.W.L., Y.O.Y.S.), Prince of Wales Hospital, The Chinese University of Hong Kong; Institute of Applied Health Sciences (S.D.J.M.), University of Aberdeen, United Kingdom; Biomedical Imaging Group Rotterdam (F.D.), Department of Radiology and Nuclear Medicine (D.H.K.D.-N.), Erasmus University Medical Centre, Rotterdam, The Netherlands; Departments of Radiology and Nuclear Medicine (M.E.K.) and Neurology (J.S.), CARIM School for Cardiovascular Diseases, Maastricht University Medical Centre; Department of Psychiatry and Neuropsychology (S.K.), School for Mental Health and Neuroscience, Maastricht University, The Netherlands; University of Lille (G.K., R.B.), Inserm, CHU de Lille, Lille Neuroscience & Cognition, France; National Centre for Healthy Ageing (V.K.S.), Peninsula Clinical School, Central Clinical School, Monash University, Melbourne, Australia; Department of Neurology (Y.Y.), Kansai Medical University, Osaka, Japan; Department of Neurology (D.N.O.), Istanbul Arel University, Turkey; and Department of Neurology (H.-J.B.), Seoul National University Bundang Hospital, Seoul National University College of Medicine, Seongnam, Republic of Korea., Cheng C; From the UCL Stroke Research Centre (J.G.B., D.W., D.J.W.) and Neuroradiological Academic Unit (H.R.J.), Department of Brain Repair and Rehabilitation, UCL Queen Square Institute of Neurology, London; Department of Statistical Science (G.A.), University College London, United Kingdom; Stroke Research Centre (H.D.), Department of Neurology, Fujian Medical University Union Hospital, Fuzhou, People's Republic of China; Department of Neurology (K.-J.L.), Korea University Guro Hospital, Seoul; Department of Neurology (J.-S.L.), Asan Medical Center, University of Ulsan College of Medicine, Seoul, Republic of Korea; Division of Neurology, Department of Medicine (K.C.T., G.K.K.L.) and Department of Diagnostic Radiology (H.M.), The University of Hong Kong; Department of Neurology (Y.D.K., J.-H.H.), Yonsei University College of Medicine, Seoul; Department of Neurology (T.-J.S.), Seoul Hospital, Ewha Womans University College of Medicine, Seoul, Republic of Korea; Department of Neurology (D.S.D.), Sisli Hamidiye Etfal Teaching and Research Hospital, University of Health Sciences, Turkey; Department of Radiology (M.N.), Saga University Faculty of Medicine; Division of Neurology (M.Y., H.H.), Department of Internal Medicine, Saga University Faculty of Medicine, Japan; Stroke Center Klinik Hirslanden Zürich (M.K., N.P.); University of Basel (M.K.); Department of Neurology and Stroke Center University Hospital and University of Basel (A.Z.), Switzerland; Centre for Clinical Brain Sciences (R.A.-S.S., F.C., J.M.W.), School of Clinical Sciences, University of Edinburgh; Liverpool Centre for Cardiovascular Science at University of Liverpool (G.Y.H.L.), Liverpool John Moores University and Liverpool Heart & Chest Hospital, United Kingdom; Department of Neurology (L.P., M.B.G., S.J.), Inselspital, Bern University Hospital, Switzerland; Department of Imaging, School of Clinical Sciences at Monash Health (L.-A.S.), Peninsula Clinical School, Peninsula Health (C.C.K.), and Stroke and Ageing Research Group, School of Clinical Sciences at Monash Health (T.G.P.), Monash University, Melbourne, Australia; Department of Neurology (M.B., F.F.), University Hospital of Würzburg, Germany; Department of Imaging and Interventional Radiology (J.A., W.C.) and Division of Neurology, Department of Medicine and Therapeutics (C.C., T.W.L., Y.O.Y.S.), Prince of Wales Hospital, The Chinese University of Hong Kong; Institute of Applied Health Sciences (S.D.J.M.), University of Aberdeen, United Kingdom; Biomedical Imaging Group Rotterdam (F.D.), Department of Radiology and Nuclear Medicine (D.H.K.D.-N.), Erasmus University Medical Centre, Rotterdam, The Netherlands; Departments of Radiology and Nuclear Medicine (M.E.K.) and Neurology (J.S.), CARIM School for Cardiovascular Diseases, Maastricht University Medical Centre; Department of Psychiatry and Neuropsychology (S.K.), School for Mental Health and Neuroscience, Maastricht University, The Netherlands; University of Lille (G.K., R.B.), Inserm, CHU de Lille, Lille Neuroscience & Cognition, France; National Centre for Healthy Ageing (V.K.S.), Peninsula Clinical School, Central Clinical School, Monash University, Melbourne, Australia; Department of Neurology (Y.Y.), Kansai Medical University, Osaka, Japan; Department of Neurology (D.N.O.), Istanbul Arel University, Turkey; and Department of Neurology (H.-J.B.), Seoul National University Bundang Hospital, Seoul National University College of Medicine, Seongnam, Republic of Korea., Leung TW; From the UCL Stroke Research Centre (J.G.B., D.W., D.J.W.) and Neuroradiological Academic Unit (H.R.J.), Department of Brain Repair and Rehabilitation, UCL Queen Square Institute of Neurology, London; Department of Statistical Science (G.A.), University College London, United Kingdom; Stroke Research Centre (H.D.), Department of Neurology, Fujian Medical University Union Hospital, Fuzhou, People's Republic of China; Department of Neurology (K.-J.L.), Korea University Guro Hospital, Seoul; Department of Neurology (J.-S.L.), Asan Medical Center, University of Ulsan College of Medicine, Seoul, Republic of Korea; Division of Neurology, Department of Medicine (K.C.T., G.K.K.L.) and Department of Diagnostic Radiology (H.M.), The University of Hong Kong; Department of Neurology (Y.D.K., J.-H.H.), Yonsei University College of Medicine, Seoul; Department of Neurology (T.-J.S.), Seoul Hospital, Ewha Womans University College of Medicine, Seoul, Republic of Korea; Department of Neurology (D.S.D.), Sisli Hamidiye Etfal Teaching and Research Hospital, University of Health Sciences, Turkey; Department of Radiology (M.N.), Saga University Faculty of Medicine; Division of Neurology (M.Y., H.H.), Department of Internal Medicine, Saga University Faculty of Medicine, Japan; Stroke Center Klinik Hirslanden Zürich (M.K., N.P.); University of Basel (M.K.); Department of Neurology and Stroke Center University Hospital and University of Basel (A.Z.), Switzerland; Centre for Clinical Brain Sciences (R.A.-S.S., F.C., J.M.W.), School of Clinical Sciences, University of Edinburgh; Liverpool Centre for Cardiovascular Science at University of Liverpool (G.Y.H.L.), Liverpool John Moores University and Liverpool Heart & Chest Hospital, United Kingdom; Department of Neurology (L.P., M.B.G., S.J.), Inselspital, Bern University Hospital, Switzerland; Department of Imaging, School of Clinical Sciences at Monash Health (L.-A.S.), Peninsula Clinical School, Peninsula Health (C.C.K.), and Stroke and Ageing Research Group, School of Clinical Sciences at Monash Health (T.G.P.), Monash University, Melbourne, Australia; Department of Neurology (M.B., F.F.), University Hospital of Würzburg, Germany; Department of Imaging and Interventional Radiology (J.A., W.C.) and Division of Neurology, Department of Medicine and Therapeutics (C.C., T.W.L., Y.O.Y.S.), Prince of Wales Hospital, The Chinese University of Hong Kong; Institute of Applied Health Sciences (S.D.J.M.), University of Aberdeen, United Kingdom; Biomedical Imaging Group Rotterdam (F.D.), Department of Radiology and Nuclear Medicine (D.H.K.D.-N.), Erasmus University Medical Centre, Rotterdam, The Netherlands; Departments of Radiology and Nuclear Medicine (M.E.K.) and Neurology (J.S.), CARIM School for Cardiovascular Diseases, Maastricht University Medical Centre; Department of Psychiatry and Neuropsychology (S.K.), School for Mental Health and Neuroscience, Maastricht University, The Netherlands; University of Lille (G.K., R.B.), Inserm, CHU de Lille, Lille Neuroscience & Cognition, France; National Centre for Healthy Ageing (V.K.S.), Peninsula Clinical School, Central Clinical School, Monash University, Melbourne, Australia; Department of Neurology (Y.Y.), Kansai Medical University, Osaka, Japan; Department of Neurology (D.N.O.), Istanbul Arel University, Turkey; and Department of Neurology (H.-J.B.), Seoul National University Bundang Hospital, Seoul National University College of Medicine, Seongnam, Republic of Korea., Chu W; From the UCL Stroke Research Centre (J.G.B., D.W., D.J.W.) and Neuroradiological Academic Unit (H.R.J.), Department of Brain Repair and Rehabilitation, UCL Queen Square Institute of Neurology, London; Department of Statistical Science (G.A.), University College London, United Kingdom; Stroke Research Centre (H.D.), Department of Neurology, Fujian Medical University Union Hospital, Fuzhou, People's Republic of China; Department of Neurology (K.-J.L.), Korea University Guro Hospital, Seoul; Department of Neurology (J.-S.L.), Asan Medical Center, University of Ulsan College of Medicine, Seoul, Republic of Korea; Division of Neurology, Department of Medicine (K.C.T., G.K.K.L.) and Department of Diagnostic Radiology (H.M.), The University of Hong Kong; Department of Neurology (Y.D.K., J.-H.H.), Yonsei University College of Medicine, Seoul; Department of Neurology (T.-J.S.), Seoul Hospital, Ewha Womans University College of Medicine, Seoul, Republic of Korea; Department of Neurology (D.S.D.), Sisli Hamidiye Etfal Teaching and Research Hospital, University of Health Sciences, Turkey; Department of Radiology (M.N.), Saga University Faculty of Medicine; Division of Neurology (M.Y., H.H.), Department of Internal Medicine, Saga University Faculty of Medicine, Japan; Stroke Center Klinik Hirslanden Zürich (M.K., N.P.); University of Basel (M.K.); Department of Neurology and Stroke Center University Hospital and University of Basel (A.Z.), Switzerland; Centre for Clinical Brain Sciences (R.A.-S.S., F.C., J.M.W.), School of Clinical Sciences, University of Edinburgh; Liverpool Centre for Cardiovascular Science at University of Liverpool (G.Y.H.L.), Liverpool John Moores University and Liverpool Heart & Chest Hospital, United Kingdom; Department of Neurology (L.P., M.B.G., S.J.), Inselspital, Bern University Hospital, Switzerland; Department of Imaging, School of Clinical Sciences at Monash Health (L.-A.S.), Peninsula Clinical School, Peninsula Health (C.C.K.), and Stroke and Ageing Research Group, School of Clinical Sciences at Monash Health (T.G.P.), Monash University, Melbourne, Australia; Department of Neurology (M.B., F.F.), University Hospital of Würzburg, Germany; Department of Imaging and Interventional Radiology (J.A., W.C.) and Division of Neurology, Department of Medicine and Therapeutics (C.C., T.W.L., Y.O.Y.S.), Prince of Wales Hospital, The Chinese University of Hong Kong; Institute of Applied Health Sciences (S.D.J.M.), University of Aberdeen, United Kingdom; Biomedical Imaging Group Rotterdam (F.D.), Department of Radiology and Nuclear Medicine (D.H.K.D.-N.), Erasmus University Medical Centre, Rotterdam, The Netherlands; Departments of Radiology and Nuclear Medicine (M.E.K.) and Neurology (J.S.), CARIM School for Cardiovascular Diseases, Maastricht University Medical Centre; Department of Psychiatry and Neuropsychology (S.K.), School for Mental Health and Neuroscience, Maastricht University, The Netherlands; University of Lille (G.K., R.B.), Inserm, CHU de Lille, Lille Neuroscience & Cognition, France; National Centre for Healthy Ageing (V.K.S.), Peninsula Clinical School, Central Clinical School, Monash University, Melbourne, Australia; Department of Neurology (Y.Y.), Kansai Medical University, Osaka, Japan; Department of Neurology (D.N.O.), Istanbul Arel University, Turkey; and Department of Neurology (H.-J.B.), Seoul National University Bundang Hospital, Seoul National University College of Medicine, Seongnam, Republic of Korea., Chappell F; From the UCL Stroke Research Centre (J.G.B., D.W., D.J.W.) and Neuroradiological Academic Unit (H.R.J.), Department of Brain Repair and Rehabilitation, UCL Queen Square Institute of Neurology, London; Department of Statistical Science (G.A.), University College London, United Kingdom; Stroke Research Centre (H.D.), Department of Neurology, Fujian Medical University Union Hospital, Fuzhou, People's Republic of China; Department of Neurology (K.-J.L.), Korea University Guro Hospital, Seoul; Department of Neurology (J.-S.L.), Asan Medical Center, University of Ulsan College of Medicine, Seoul, Republic of Korea; Division of Neurology, Department of Medicine (K.C.T., G.K.K.L.) and Department of Diagnostic Radiology (H.M.), The University of Hong Kong; Department of Neurology (Y.D.K., J.-H.H.), Yonsei University College of Medicine, Seoul; Department of Neurology (T.-J.S.), Seoul Hospital, Ewha Womans University College of Medicine, Seoul, Republic of Korea; Department of Neurology (D.S.D.), Sisli Hamidiye Etfal Teaching and Research Hospital, University of Health Sciences, Turkey; Department of Radiology (M.N.), Saga University Faculty of Medicine; Division of Neurology (M.Y., H.H.), Department of Internal Medicine, Saga University Faculty of Medicine, Japan; Stroke Center Klinik Hirslanden Zürich (M.K., N.P.); University of Basel (M.K.); Department of Neurology and Stroke Center University Hospital and University of Basel (A.Z.), Switzerland; Centre for Clinical Brain Sciences (R.A.-S.S., F.C., J.M.W.), School of Clinical Sciences, University of Edinburgh; Liverpool Centre for Cardiovascular Science at University of Liverpool (G.Y.H.L.), Liverpool John Moores University and Liverpool Heart & Chest Hospital, United Kingdom; Department of Neurology (L.P., M.B.G., S.J.), Inselspital, Bern University Hospital, Switzerland; Department of Imaging, School of Clinical Sciences at Monash Health (L.-A.S.), Peninsula Clinical School, Peninsula Health (C.C.K.), and Stroke and Ageing Research Group, School of Clinical Sciences at Monash Health (T.G.P.), Monash University, Melbourne, Australia; Department of Neurology (M.B., F.F.), University Hospital of Würzburg, Germany; Department of Imaging and Interventional Radiology (J.A., W.C.) and Division of Neurology, Department of Medicine and Therapeutics (C.C., T.W.L., Y.O.Y.S.), Prince of Wales Hospital, The Chinese University of Hong Kong; Institute of Applied Health Sciences (S.D.J.M.), University of Aberdeen, United Kingdom; Biomedical Imaging Group Rotterdam (F.D.), Department of Radiology and Nuclear Medicine (D.H.K.D.-N.), Erasmus University Medical Centre, Rotterdam, The Netherlands; Departments of Radiology and Nuclear Medicine (M.E.K.) and Neurology (J.S.), CARIM School for Cardiovascular Diseases, Maastricht University Medical Centre; Department of Psychiatry and Neuropsychology (S.K.), School for Mental Health and Neuroscience, Maastricht University, The Netherlands; University of Lille (G.K., R.B.), Inserm, CHU de Lille, Lille Neuroscience & Cognition, France; National Centre for Healthy Ageing (V.K.S.), Peninsula Clinical School, Central Clinical School, Monash University, Melbourne, Australia; Department of Neurology (Y.Y.), Kansai Medical University, Osaka, Japan; Department of Neurology (D.N.O.), Istanbul Arel University, Turkey; and Department of Neurology (H.-J.B.), Seoul National University Bundang Hospital, Seoul National University College of Medicine, Seongnam, Republic of Korea., Makin SDJ; From the UCL Stroke Research Centre (J.G.B., D.W., D.J.W.) and Neuroradiological Academic Unit (H.R.J.), Department of Brain Repair and Rehabilitation, UCL Queen Square Institute of Neurology, London; Department of Statistical Science (G.A.), University College London, United Kingdom; Stroke Research Centre (H.D.), Department of Neurology, Fujian Medical University Union Hospital, Fuzhou, People's Republic of China; Department of Neurology (K.-J.L.), Korea University Guro Hospital, Seoul; Department of Neurology (J.-S.L.), Asan Medical Center, University of Ulsan College of Medicine, Seoul, Republic of Korea; Division of Neurology, Department of Medicine (K.C.T., G.K.K.L.) and Department of Diagnostic Radiology (H.M.), The University of Hong Kong; Department of Neurology (Y.D.K., J.-H.H.), Yonsei University College of Medicine, Seoul; Department of Neurology (T.-J.S.), Seoul Hospital, Ewha Womans University College of Medicine, Seoul, Republic of Korea; Department of Neurology (D.S.D.), Sisli Hamidiye Etfal Teaching and Research Hospital, University of Health Sciences, Turkey; Department of Radiology (M.N.), Saga University Faculty of Medicine; Division of Neurology (M.Y., H.H.), Department of Internal Medicine, Saga University Faculty of Medicine, Japan; Stroke Center Klinik Hirslanden Zürich (M.K., N.P.); University of Basel (M.K.); Department of Neurology and Stroke Center University Hospital and University of Basel (A.Z.), Switzerland; Centre for Clinical Brain Sciences (R.A.-S.S., F.C., J.M.W.), School of Clinical Sciences, University of Edinburgh; Liverpool Centre for Cardiovascular Science at University of Liverpool (G.Y.H.L.), Liverpool John Moores University and Liverpool Heart & Chest Hospital, United Kingdom; Department of Neurology (L.P., M.B.G., S.J.), Inselspital, Bern University Hospital, Switzerland; Department of Imaging, School of Clinical Sciences at Monash Health (L.-A.S.), Peninsula Clinical School, Peninsula Health (C.C.K.), and Stroke and Ageing Research Group, School of Clinical Sciences at Monash Health (T.G.P.), Monash University, Melbourne, Australia; Department of Neurology (M.B., F.F.), University Hospital of Würzburg, Germany; Department of Imaging and Interventional Radiology (J.A., W.C.) and Division of Neurology, Department of Medicine and Therapeutics (C.C., T.W.L., Y.O.Y.S.), Prince of Wales Hospital, The Chinese University of Hong Kong; Institute of Applied Health Sciences (S.D.J.M.), University of Aberdeen, United Kingdom; Biomedical Imaging Group Rotterdam (F.D.), Department of Radiology and Nuclear Medicine (D.H.K.D.-N.), Erasmus University Medical Centre, Rotterdam, The Netherlands; Departments of Radiology and Nuclear Medicine (M.E.K.) and Neurology (J.S.), CARIM School for Cardiovascular Diseases, Maastricht University Medical Centre; Department of Psychiatry and Neuropsychology (S.K.), School for Mental Health and Neuroscience, Maastricht University, The Netherlands; University of Lille (G.K., R.B.), Inserm, CHU de Lille, Lille Neuroscience & Cognition, France; National Centre for Healthy Ageing (V.K.S.), Peninsula Clinical School, Central Clinical School, Monash University, Melbourne, Australia; Department of Neurology (Y.Y.), Kansai Medical University, Osaka, Japan; Department of Neurology (D.N.O.), Istanbul Arel University, Turkey; and Department of Neurology (H.-J.B.), Seoul National University Bundang Hospital, Seoul National University College of Medicine, Seongnam, Republic of Korea., van Dam-Nolen DHK; From the UCL Stroke Research Centre (J.G.B., D.W., D.J.W.) and Neuroradiological Academic Unit (H.R.J.), Department of Brain Repair and Rehabilitation, UCL Queen Square Institute of Neurology, London; Department of Statistical Science (G.A.), University College London, United Kingdom; Stroke Research Centre (H.D.), Department of Neurology, Fujian Medical University Union Hospital, Fuzhou, People's Republic of China; Department of Neurology (K.-J.L.), Korea University Guro Hospital, Seoul; Department of Neurology (J.-S.L.), Asan Medical Center, University of Ulsan College of Medicine, Seoul, Republic of Korea; Division of Neurology, Department of Medicine (K.C.T., G.K.K.L.) and Department of Diagnostic Radiology (H.M.), The University of Hong Kong; Department of Neurology (Y.D.K., J.-H.H.), Yonsei University College of Medicine, Seoul; Department of Neurology (T.-J.S.), Seoul Hospital, Ewha Womans University College of Medicine, Seoul, Republic of Korea; Department of Neurology (D.S.D.), Sisli Hamidiye Etfal Teaching and Research Hospital, University of Health Sciences, Turkey; Department of Radiology (M.N.), Saga University Faculty of Medicine; Division of Neurology (M.Y., H.H.), Department of Internal Medicine, Saga University Faculty of Medicine, Japan; Stroke Center Klinik Hirslanden Zürich (M.K., N.P.); University of Basel (M.K.); Department of Neurology and Stroke Center University Hospital and University of Basel (A.Z.), Switzerland; Centre for Clinical Brain Sciences (R.A.-S.S., F.C., J.M.W.), School of Clinical Sciences, University of Edinburgh; Liverpool Centre for Cardiovascular Science at University of Liverpool (G.Y.H.L.), Liverpool John Moores University and Liverpool Heart & Chest Hospital, United Kingdom; Department of Neurology (L.P., M.B.G., S.J.), Inselspital, Bern University Hospital, Switzerland; Department of Imaging, School of Clinical Sciences at Monash Health (L.-A.S.), Peninsula Clinical School, Peninsula Health (C.C.K.), and Stroke and Ageing Research Group, School of Clinical Sciences at Monash Health (T.G.P.), Monash University, Melbourne, Australia; Department of Neurology (M.B., F.F.), University Hospital of Würzburg, Germany; Department of Imaging and Interventional Radiology (J.A., W.C.) and Division of Neurology, Department of Medicine and Therapeutics (C.C., T.W.L., Y.O.Y.S.), Prince of Wales Hospital, The Chinese University of Hong Kong; Institute of Applied Health Sciences (S.D.J.M.), University of Aberdeen, United Kingdom; Biomedical Imaging Group Rotterdam (F.D.), Department of Radiology and Nuclear Medicine (D.H.K.D.-N.), Erasmus University Medical Centre, Rotterdam, The Netherlands; Departments of Radiology and Nuclear Medicine (M.E.K.) and Neurology (J.S.), CARIM School for Cardiovascular Diseases, Maastricht University Medical Centre; Department of Psychiatry and Neuropsychology (S.K.), School for Mental Health and Neuroscience, Maastricht University, The Netherlands; University of Lille (G.K., R.B.), Inserm, CHU de Lille, Lille Neuroscience & Cognition, France; National Centre for Healthy Ageing (V.K.S.), Peninsula Clinical School, Central Clinical School, Monash University, Melbourne, Australia; Department of Neurology (Y.Y.), Kansai Medical University, Osaka, Japan; Department of Neurology (D.N.O.), Istanbul Arel University, Turkey; and Department of Neurology (H.-J.B.), Seoul National University Bundang Hospital, Seoul National University College of Medicine, Seongnam, Republic of Korea., Kooi ME; From the UCL Stroke Research Centre (J.G.B., D.W., D.J.W.) and Neuroradiological Academic Unit (H.R.J.), Department of Brain Repair and Rehabilitation, UCL Queen Square Institute of Neurology, London; Department of Statistical Science (G.A.), University College London, United Kingdom; Stroke Research Centre (H.D.), Department of Neurology, Fujian Medical University Union Hospital, Fuzhou, People's Republic of China; Department of Neurology (K.-J.L.), Korea University Guro Hospital, Seoul; Department of Neurology (J.-S.L.), Asan Medical Center, University of Ulsan College of Medicine, Seoul, Republic of Korea; Division of Neurology, Department of Medicine (K.C.T., G.K.K.L.) and Department of Diagnostic Radiology (H.M.), The University of Hong Kong; Department of Neurology (Y.D.K., J.-H.H.), Yonsei University College of Medicine, Seoul; Department of Neurology (T.-J.S.), Seoul Hospital, Ewha Womans University College of Medicine, Seoul, Republic of Korea; Department of Neurology (D.S.D.), Sisli Hamidiye Etfal Teaching and Research Hospital, University of Health Sciences, Turkey; Department of Radiology (M.N.), Saga University Faculty of Medicine; Division of Neurology (M.Y., H.H.), Department of Internal Medicine, Saga University Faculty of Medicine, Japan; Stroke Center Klinik Hirslanden Zürich (M.K., N.P.); University of Basel (M.K.); Department of Neurology and Stroke Center University Hospital and University of Basel (A.Z.), Switzerland; Centre for Clinical Brain Sciences (R.A.-S.S., F.C., J.M.W.), School of Clinical Sciences, University of Edinburgh; Liverpool Centre for Cardiovascular Science at University of Liverpool (G.Y.H.L.), Liverpool John Moores University and Liverpool Heart & Chest Hospital, United Kingdom; Department of Neurology (L.P., M.B.G., S.J.), Inselspital, Bern University Hospital, Switzerland; Department of Imaging, School of Clinical Sciences at Monash Health (L.-A.S.), Peninsula Clinical School, Peninsula Health (C.C.K.), and Stroke and Ageing Research Group, School of Clinical Sciences at Monash Health (T.G.P.), Monash University, Melbourne, Australia; Department of Neurology (M.B., F.F.), University Hospital of Würzburg, Germany; Department of Imaging and Interventional Radiology (J.A., W.C.) and Division of Neurology, Department of Medicine and Therapeutics (C.C., T.W.L., Y.O.Y.S.), Prince of Wales Hospital, The Chinese University of Hong Kong; Institute of Applied Health Sciences (S.D.J.M.), University of Aberdeen, United Kingdom; Biomedical Imaging Group Rotterdam (F.D.), Department of Radiology and Nuclear Medicine (D.H.K.D.-N.), Erasmus University Medical Centre, Rotterdam, The Netherlands; Departments of Radiology and Nuclear Medicine (M.E.K.) and Neurology (J.S.), CARIM School for Cardiovascular Diseases, Maastricht University Medical Centre; Department of Psychiatry and Neuropsychology (S.K.), School for Mental Health and Neuroscience, Maastricht University, The Netherlands; University of Lille (G.K., R.B.), Inserm, CHU de Lille, Lille Neuroscience & Cognition, France; National Centre for Healthy Ageing (V.K.S.), Peninsula Clinical School, Central Clinical School, Monash University, Melbourne, Australia; Department of Neurology (Y.Y.), Kansai Medical University, Osaka, Japan; Department of Neurology (D.N.O.), Istanbul Arel University, Turkey; and Department of Neurology (H.-J.B.), Seoul National University Bundang Hospital, Seoul National University College of Medicine, Seongnam, Republic of Korea., Köhler S; From the UCL Stroke Research Centre (J.G.B., D.W., D.J.W.) and Neuroradiological Academic Unit (H.R.J.), Department of Brain Repair and Rehabilitation, UCL Queen Square Institute of Neurology, London; Department of Statistical Science (G.A.), University College London, United Kingdom; Stroke Research Centre (H.D.), Department of Neurology, Fujian Medical University Union Hospital, Fuzhou, People's Republic of China; Department of Neurology (K.-J.L.), Korea University Guro Hospital, Seoul; Department of Neurology (J.-S.L.), Asan Medical Center, University of Ulsan College of Medicine, Seoul, Republic of Korea; Division of Neurology, Department of Medicine (K.C.T., G.K.K.L.) and Department of Diagnostic Radiology (H.M.), The University of Hong Kong; Department of Neurology (Y.D.K., J.-H.H.), Yonsei University College of Medicine, Seoul; Department of Neurology (T.-J.S.), Seoul Hospital, Ewha Womans University College of Medicine, Seoul, Republic of Korea; Department of Neurology (D.S.D.), Sisli Hamidiye Etfal Teaching and Research Hospital, University of Health Sciences, Turkey; Department of Radiology (M.N.), Saga University Faculty of Medicine; Division of Neurology (M.Y., H.H.), Department of Internal Medicine, Saga University Faculty of Medicine, Japan; Stroke Center Klinik Hirslanden Zürich (M.K., N.P.); University of Basel (M.K.); Department of Neurology and Stroke Center University Hospital and University of Basel (A.Z.), Switzerland; Centre for Clinical Brain Sciences (R.A.-S.S., F.C., J.M.W.), School of Clinical Sciences, University of Edinburgh; Liverpool Centre for Cardiovascular Science at University of Liverpool (G.Y.H.L.), Liverpool John Moores University and Liverpool Heart & Chest Hospital, United Kingdom; Department of Neurology (L.P., M.B.G., S.J.), Inselspital, Bern University Hospital, Switzerland; Department of Imaging, School of Clinical Sciences at Monash Health (L.-A.S.), Peninsula Clinical School, Peninsula Health (C.C.K.), and Stroke and Ageing Research Group, School of Clinical Sciences at Monash Health (T.G.P.), Monash University, Melbourne, Australia; Department of Neurology (M.B., F.F.), University Hospital of Würzburg, Germany; Department of Imaging and Interventional Radiology (J.A., W.C.) and Division of Neurology, Department of Medicine and Therapeutics (C.C., T.W.L., Y.O.Y.S.), Prince of Wales Hospital, The Chinese University of Hong Kong; Institute of Applied Health Sciences (S.D.J.M.), University of Aberdeen, United Kingdom; Biomedical Imaging Group Rotterdam (F.D.), Department of Radiology and Nuclear Medicine (D.H.K.D.-N.), Erasmus University Medical Centre, Rotterdam, The Netherlands; Departments of Radiology and Nuclear Medicine (M.E.K.) and Neurology (J.S.), CARIM School for Cardiovascular Diseases, Maastricht University Medical Centre; Department of Psychiatry and Neuropsychology (S.K.), School for Mental Health and Neuroscience, Maastricht University, The Netherlands; University of Lille (G.K., R.B.), Inserm, CHU de Lille, Lille Neuroscience & Cognition, France; National Centre for Healthy Ageing (V.K.S.), Peninsula Clinical School, Central Clinical School, Monash University, Melbourne, Australia; Department of Neurology (Y.Y.), Kansai Medical University, Osaka, Japan; Department of Neurology (D.N.O.), Istanbul Arel University, Turkey; and Department of Neurology (H.-J.B.), Seoul National University Bundang Hospital, Seoul National University College of Medicine, Seongnam, Republic of Korea., Staals J; From the UCL Stroke Research Centre (J.G.B., D.W., D.J.W.) and Neuroradiological Academic Unit (H.R.J.), Department of Brain Repair and Rehabilitation, UCL Queen Square Institute of Neurology, London; Department of Statistical Science (G.A.), University College London, United Kingdom; Stroke Research Centre (H.D.), Department of Neurology, Fujian Medical University Union Hospital, Fuzhou, People's Republic of China; Department of Neurology (K.-J.L.), Korea University Guro Hospital, Seoul; Department of Neurology (J.-S.L.), Asan Medical Center, University of Ulsan College of Medicine, Seoul, Republic of Korea; Division of Neurology, Department of Medicine (K.C.T., G.K.K.L.) and Department of Diagnostic Radiology (H.M.), The University of Hong Kong; Department of Neurology (Y.D.K., J.-H.H.), Yonsei University College of Medicine, Seoul; Department of Neurology (T.-J.S.), Seoul Hospital, Ewha Womans University College of Medicine, Seoul, Republic of Korea; Department of Neurology (D.S.D.), Sisli Hamidiye Etfal Teaching and Research Hospital, University of Health Sciences, Turkey; Department of Radiology (M.N.), Saga University Faculty of Medicine; Division of Neurology (M.Y., H.H.), Department of Internal Medicine, Saga University Faculty of Medicine, Japan; Stroke Center Klinik Hirslanden Zürich (M.K., N.P.); University of Basel (M.K.); Department of Neurology and Stroke Center University Hospital and University of Basel (A.Z.), Switzerland; Centre for Clinical Brain Sciences (R.A.-S.S., F.C., J.M.W.), School of Clinical Sciences, University of Edinburgh; Liverpool Centre for Cardiovascular Science at University of Liverpool (G.Y.H.L.), Liverpool John Moores University and Liverpool Heart & Chest Hospital, United Kingdom; Department of Neurology (L.P., M.B.G., S.J.), Inselspital, Bern University Hospital, Switzerland; Department of Imaging, School of Clinical Sciences at Monash Health (L.-A.S.), Peninsula Clinical School, Peninsula Health (C.C.K.), and Stroke and Ageing Research Group, School of Clinical Sciences at Monash Health (T.G.P.), Monash University, Melbourne, Australia; Department of Neurology (M.B., F.F.), University Hospital of Würzburg, Germany; Department of Imaging and Interventional Radiology (J.A., W.C.) and Division of Neurology, Department of Medicine and Therapeutics (C.C., T.W.L., Y.O.Y.S.), Prince of Wales Hospital, The Chinese University of Hong Kong; Institute of Applied Health Sciences (S.D.J.M.), University of Aberdeen, United Kingdom; Biomedical Imaging Group Rotterdam (F.D.), Department of Radiology and Nuclear Medicine (D.H.K.D.-N.), Erasmus University Medical Centre, Rotterdam, The Netherlands; Departments of Radiology and Nuclear Medicine (M.E.K.) and Neurology (J.S.), CARIM School for Cardiovascular Diseases, Maastricht University Medical Centre; Department of Psychiatry and Neuropsychology (S.K.), School for Mental Health and Neuroscience, Maastricht University, The Netherlands; University of Lille (G.K., R.B.), Inserm, CHU de Lille, Lille Neuroscience & Cognition, France; National Centre for Healthy Ageing (V.K.S.), Peninsula Clinical School, Central Clinical School, Monash University, Melbourne, Australia; Department of Neurology (Y.Y.), Kansai Medical University, Osaka, Japan; Department of Neurology (D.N.O.), Istanbul Arel University, Turkey; and Department of Neurology (H.-J.B.), Seoul National University Bundang Hospital, Seoul National University College of Medicine, Seongnam, Republic of Korea., Kuchcinski G; From the UCL Stroke Research Centre (J.G.B., D.W., D.J.W.) and Neuroradiological Academic Unit (H.R.J.), Department of Brain Repair and Rehabilitation, UCL Queen Square Institute of Neurology, London; Department of Statistical Science (G.A.), University College London, United Kingdom; Stroke Research Centre (H.D.), Department of Neurology, Fujian Medical University Union Hospital, Fuzhou, People's Republic of China; Department of Neurology (K.-J.L.), Korea University Guro Hospital, Seoul; Department of Neurology (J.-S.L.), Asan Medical Center, University of Ulsan College of Medicine, Seoul, Republic of Korea; Division of Neurology, Department of Medicine (K.C.T., G.K.K.L.) and Department of Diagnostic Radiology (H.M.), The University of Hong Kong; Department of Neurology (Y.D.K., J.-H.H.), Yonsei University College of Medicine, Seoul; Department of Neurology (T.-J.S.), Seoul Hospital, Ewha Womans University College of Medicine, Seoul, Republic of Korea; Department of Neurology (D.S.D.), Sisli Hamidiye Etfal Teaching and Research Hospital, University of Health Sciences, Turkey; Department of Radiology (M.N.), Saga University Faculty of Medicine; Division of Neurology (M.Y., H.H.), Department of Internal Medicine, Saga University Faculty of Medicine, Japan; Stroke Center Klinik Hirslanden Zürich (M.K., N.P.); University of Basel (M.K.); Department of Neurology and Stroke Center University Hospital and University of Basel (A.Z.), Switzerland; Centre for Clinical Brain Sciences (R.A.-S.S., F.C., J.M.W.), School of Clinical Sciences, University of Edinburgh; Liverpool Centre for Cardiovascular Science at University of Liverpool (G.Y.H.L.), Liverpool John Moores University and Liverpool Heart & Chest Hospital, United Kingdom; Department of Neurology (L.P., M.B.G., S.J.), Inselspital, Bern University Hospital, Switzerland; Department of Imaging, School of Clinical Sciences at Monash Health (L.-A.S.), Peninsula Clinical School, Peninsula Health (C.C.K.), and Stroke and Ageing Research Group, School of Clinical Sciences at Monash Health (T.G.P.), Monash University, Melbourne, Australia; Department of Neurology (M.B., F.F.), University Hospital of Würzburg, Germany; Department of Imaging and Interventional Radiology (J.A., W.C.) and Division of Neurology, Department of Medicine and Therapeutics (C.C., T.W.L., Y.O.Y.S.), Prince of Wales Hospital, The Chinese University of Hong Kong; Institute of Applied Health Sciences (S.D.J.M.), University of Aberdeen, United Kingdom; Biomedical Imaging Group Rotterdam (F.D.), Department of Radiology and Nuclear Medicine (D.H.K.D.-N.), Erasmus University Medical Centre, Rotterdam, The Netherlands; Departments of Radiology and Nuclear Medicine (M.E.K.) and Neurology (J.S.), CARIM School for Cardiovascular Diseases, Maastricht University Medical Centre; Department of Psychiatry and Neuropsychology (S.K.), School for Mental Health and Neuroscience, Maastricht University, The Netherlands; University of Lille (G.K., R.B.), Inserm, CHU de Lille, Lille Neuroscience & Cognition, France; National Centre for Healthy Ageing (V.K.S.), Peninsula Clinical School, Central Clinical School, Monash University, Melbourne, Australia; Department of Neurology (Y.Y.), Kansai Medical University, Osaka, Japan; Department of Neurology (D.N.O.), Istanbul Arel University, Turkey; and Department of Neurology (H.-J.B.), Seoul National University Bundang Hospital, Seoul National University College of Medicine, Seongnam, Republic of Korea., Bordet R; From the UCL Stroke Research Centre (J.G.B., D.W., D.J.W.) and Neuroradiological Academic Unit (H.R.J.), Department of Brain Repair and Rehabilitation, UCL Queen Square Institute of Neurology, London; Department of Statistical Science (G.A.), University College London, United Kingdom; Stroke Research Centre (H.D.), Department of Neurology, Fujian Medical University Union Hospital, Fuzhou, People's Republic of China; Department of Neurology (K.-J.L.), Korea University Guro Hospital, Seoul; Department of Neurology (J.-S.L.), Asan Medical Center, University of Ulsan College of Medicine, Seoul, Republic of Korea; Division of Neurology, Department of Medicine (K.C.T., G.K.K.L.) and Department of Diagnostic Radiology (H.M.), The University of Hong Kong; Department of Neurology (Y.D.K., J.-H.H.), Yonsei University College of Medicine, Seoul; Department of Neurology (T.-J.S.), Seoul Hospital, Ewha Womans University College of Medicine, Seoul, Republic of Korea; Department of Neurology (D.S.D.), Sisli Hamidiye Etfal Teaching and Research Hospital, University of Health Sciences, Turkey; Department of Radiology (M.N.), Saga University Faculty of Medicine; Division of Neurology (M.Y., H.H.), Department of Internal Medicine, Saga University Faculty of Medicine, Japan; Stroke Center Klinik Hirslanden Zürich (M.K., N.P.); University of Basel (M.K.); Department of Neurology and Stroke Center University Hospital and University of Basel (A.Z.), Switzerland; Centre for Clinical Brain Sciences (R.A.-S.S., F.C., J.M.W.), School of Clinical Sciences, University of Edinburgh; Liverpool Centre for Cardiovascular Science at University of Liverpool (G.Y.H.L.), Liverpool John Moores University and Liverpool Heart & Chest Hospital, United Kingdom; Department of Neurology (L.P., M.B.G., S.J.), Inselspital, Bern University Hospital, Switzerland; Department of Imaging, School of Clinical Sciences at Monash Health (L.-A.S.), Peninsula Clinical School, Peninsula Health (C.C.K.), and Stroke and Ageing Research Group, School of Clinical Sciences at Monash Health (T.G.P.), Monash University, Melbourne, Australia; Department of Neurology (M.B., F.F.), University Hospital of Würzburg, Germany; Department of Imaging and Interventional Radiology (J.A., W.C.) and Division of Neurology, Department of Medicine and Therapeutics (C.C., T.W.L., Y.O.Y.S.), Prince of Wales Hospital, The Chinese University of Hong Kong; Institute of Applied Health Sciences (S.D.J.M.), University of Aberdeen, United Kingdom; Biomedical Imaging Group Rotterdam (F.D.), Department of Radiology and Nuclear Medicine (D.H.K.D.-N.), Erasmus University Medical Centre, Rotterdam, The Netherlands; Departments of Radiology and Nuclear Medicine (M.E.K.) and Neurology (J.S.), CARIM School for Cardiovascular Diseases, Maastricht University Medical Centre; Department of Psychiatry and Neuropsychology (S.K.), School for Mental Health and Neuroscience, Maastricht University, The Netherlands; University of Lille (G.K., R.B.), Inserm, CHU de Lille, Lille Neuroscience & Cognition, France; National Centre for Healthy Ageing (V.K.S.), Peninsula Clinical School, Central Clinical School, Monash University, Melbourne, Australia; Department of Neurology (Y.Y.), Kansai Medical University, Osaka, Japan; Department of Neurology (D.N.O.), Istanbul Arel University, Turkey; and Department of Neurology (H.-J.B.), Seoul National University Bundang Hospital, Seoul National University College of Medicine, Seongnam, Republic of Korea., Dubost F; From the UCL Stroke Research Centre (J.G.B., D.W., D.J.W.) and Neuroradiological Academic Unit (H.R.J.), Department of Brain Repair and Rehabilitation, UCL Queen Square Institute of Neurology, London; Department of Statistical Science (G.A.), University College London, United Kingdom; Stroke Research Centre (H.D.), Department of Neurology, Fujian Medical University Union Hospital, Fuzhou, People's Republic of China; Department of Neurology (K.-J.L.), Korea University Guro Hospital, Seoul; Department of Neurology (J.-S.L.), Asan Medical Center, University of Ulsan College of Medicine, Seoul, Republic of Korea; Division of Neurology, Department of Medicine (K.C.T., G.K.K.L.) and Department of Diagnostic Radiology (H.M.), The University of Hong Kong; Department of Neurology (Y.D.K., J.-H.H.), Yonsei University College of Medicine, Seoul; Department of Neurology (T.-J.S.), Seoul Hospital, Ewha Womans University College of Medicine, Seoul, Republic of Korea; Department of Neurology (D.S.D.), Sisli Hamidiye Etfal Teaching and Research Hospital, University of Health Sciences, Turkey; Department of Radiology (M.N.), Saga University Faculty of Medicine; Division of Neurology (M.Y., H.H.), Department of Internal Medicine, Saga University Faculty of Medicine, Japan; Stroke Center Klinik Hirslanden Zürich (M.K., N.P.); University of Basel (M.K.); Department of Neurology and Stroke Center University Hospital and University of Basel (A.Z.), Switzerland; Centre for Clinical Brain Sciences (R.A.-S.S., F.C., J.M.W.), School of Clinical Sciences, University of Edinburgh; Liverpool Centre for Cardiovascular Science at University of Liverpool (G.Y.H.L.), Liverpool John Moores University and Liverpool Heart & Chest Hospital, United Kingdom; Department of Neurology (L.P., M.B.G., S.J.), Inselspital, Bern University Hospital, Switzerland; Department of Imaging, School of Clinical Sciences at Monash Health (L.-A.S.), Peninsula Clinical School, Peninsula Health (C.C.K.), and Stroke and Ageing Research Group, School of Clinical Sciences at Monash Health (T.G.P.), Monash University, Melbourne, Australia; Department of Neurology (M.B., F.F.), University Hospital of Würzburg, Germany; Department of Imaging and Interventional Radiology (J.A., W.C.) and Division of Neurology, Department of Medicine and Therapeutics (C.C., T.W.L., Y.O.Y.S.), Prince of Wales Hospital, The Chinese University of Hong Kong; Institute of Applied Health Sciences (S.D.J.M.), University of Aberdeen, United Kingdom; Biomedical Imaging Group Rotterdam (F.D.), Department of Radiology and Nuclear Medicine (D.H.K.D.-N.), Erasmus University Medical Centre, Rotterdam, The Netherlands; Departments of Radiology and Nuclear Medicine (M.E.K.) and Neurology (J.S.), CARIM School for Cardiovascular Diseases, Maastricht University Medical Centre; Department of Psychiatry and Neuropsychology (S.K.), School for Mental Health and Neuroscience, Maastricht University, The Netherlands; University of Lille (G.K., R.B.), Inserm, CHU de Lille, Lille Neuroscience & Cognition, France; National Centre for Healthy Ageing (V.K.S.), Peninsula Clinical School, Central Clinical School, Monash University, Melbourne, Australia; Department of Neurology (Y.Y.), Kansai Medical University, Osaka, Japan; Department of Neurology (D.N.O.), Istanbul Arel University, Turkey; and Department of Neurology (H.-J.B.), Seoul National University Bundang Hospital, Seoul National University College of Medicine, Seongnam, Republic of Korea., Wardlaw JM; From the UCL Stroke Research Centre (J.G.B., D.W., D.J.W.) and Neuroradiological Academic Unit (H.R.J.), Department of Brain Repair and Rehabilitation, UCL Queen Square Institute of Neurology, London; Department of Statistical Science (G.A.), University College London, United Kingdom; Stroke Research Centre (H.D.), Department of Neurology, Fujian Medical University Union Hospital, Fuzhou, People's Republic of China; Department of Neurology (K.-J.L.), Korea University Guro Hospital, Seoul; Department of Neurology (J.-S.L.), Asan Medical Center, University of Ulsan College of Medicine, Seoul, Republic of Korea; Division of Neurology, Department of Medicine (K.C.T., G.K.K.L.) and Department of Diagnostic Radiology (H.M.), The University of Hong Kong; Department of Neurology (Y.D.K., J.-H.H.), Yonsei University College of Medicine, Seoul; Department of Neurology (T.-J.S.), Seoul Hospital, Ewha Womans University College of Medicine, Seoul, Republic of Korea; Department of Neurology (D.S.D.), Sisli Hamidiye Etfal Teaching and Research Hospital, University of Health Sciences, Turkey; Department of Radiology (M.N.), Saga University Faculty of Medicine; Division of Neurology (M.Y., H.H.), Department of Internal Medicine, Saga University Faculty of Medicine, Japan; Stroke Center Klinik Hirslanden Zürich (M.K., N.P.); University of Basel (M.K.); Department of Neurology and Stroke Center University Hospital and University of Basel (A.Z.), Switzerland; Centre for Clinical Brain Sciences (R.A.-S.S., F.C., J.M.W.), School of Clinical Sciences, University of Edinburgh; Liverpool Centre for Cardiovascular Science at University of Liverpool (G.Y.H.L.), Liverpool John Moores University and Liverpool Heart & Chest Hospital, United Kingdom; Department of Neurology (L.P., M.B.G., S.J.), Inselspital, Bern University Hospital, Switzerland; Department of Imaging, School of Clinical Sciences at Monash Health (L.-A.S.), Peninsula Clinical School, Peninsula Health (C.C.K.), and Stroke and Ageing Research Group, School of Clinical Sciences at Monash Health (T.G.P.), Monash University, Melbourne, Australia; Department of Neurology (M.B., F.F.), University Hospital of Würzburg, Germany; Department of Imaging and Interventional Radiology (J.A., W.C.) and Division of Neurology, Department of Medicine and Therapeutics (C.C., T.W.L., Y.O.Y.S.), Prince of Wales Hospital, The Chinese University of Hong Kong; Institute of Applied Health Sciences (S.D.J.M.), University of Aberdeen, United Kingdom; Biomedical Imaging Group Rotterdam (F.D.), Department of Radiology and Nuclear Medicine (D.H.K.D.-N.), Erasmus University Medical Centre, Rotterdam, The Netherlands; Departments of Radiology and Nuclear Medicine (M.E.K.) and Neurology (J.S.), CARIM School for Cardiovascular Diseases, Maastricht University Medical Centre; Department of Psychiatry and Neuropsychology (S.K.), School for Mental Health and Neuroscience, Maastricht University, The Netherlands; University of Lille (G.K., R.B.), Inserm, CHU de Lille, Lille Neuroscience & Cognition, France; National Centre for Healthy Ageing (V.K.S.), Peninsula Clinical School, Central Clinical School, Monash University, Melbourne, Australia; Department of Neurology (Y.Y.), Kansai Medical University, Osaka, Japan; Department of Neurology (D.N.O.), Istanbul Arel University, Turkey; and Department of Neurology (H.-J.B.), Seoul National University Bundang Hospital, Seoul National University College of Medicine, Seongnam, Republic of Korea., Soo YOY; From the UCL Stroke Research Centre (J.G.B., D.W., D.J.W.) and Neuroradiological Academic Unit (H.R.J.), Department of Brain Repair and Rehabilitation, UCL Queen Square Institute of Neurology, London; Department of Statistical Science (G.A.), University College London, United Kingdom; Stroke Research Centre (H.D.), Department of Neurology, Fujian Medical University Union Hospital, Fuzhou, People's Republic of China; Department of Neurology (K.-J.L.), Korea University Guro Hospital, Seoul; Department of Neurology (J.-S.L.), Asan Medical Center, University of Ulsan College of Medicine, Seoul, Republic of Korea; Division of Neurology, Department of Medicine (K.C.T., G.K.K.L.) and Department of Diagnostic Radiology (H.M.), The University of Hong Kong; Department of Neurology (Y.D.K., J.-H.H.), Yonsei University College of Medicine, Seoul; Department of Neurology (T.-J.S.), Seoul Hospital, Ewha Womans University College of Medicine, Seoul, Republic of Korea; Department of Neurology (D.S.D.), Sisli Hamidiye Etfal Teaching and Research Hospital, University of Health Sciences, Turkey; Department of Radiology (M.N.), Saga University Faculty of Medicine; Division of Neurology (M.Y., H.H.), Department of Internal Medicine, Saga University Faculty of Medicine, Japan; Stroke Center Klinik Hirslanden Zürich (M.K., N.P.); University of Basel (M.K.); Department of Neurology and Stroke Center University Hospital and University of Basel (A.Z.), Switzerland; Centre for Clinical Brain Sciences (R.A.-S.S., F.C., J.M.W.), School of Clinical Sciences, University of Edinburgh; Liverpool Centre for Cardiovascular Science at University of Liverpool (G.Y.H.L.), Liverpool John Moores University and Liverpool Heart & Chest Hospital, United Kingdom; Department of Neurology (L.P., M.B.G., S.J.), Inselspital, Bern University Hospital, Switzerland; Department of Imaging, School of Clinical Sciences at Monash Health (L.-A.S.), Peninsula Clinical School, Peninsula Health (C.C.K.), and Stroke and Ageing Research Group, School of Clinical Sciences at Monash Health (T.G.P.), Monash University, Melbourne, Australia; Department of Neurology (M.B., F.F.), University Hospital of Würzburg, Germany; Department of Imaging and Interventional Radiology (J.A., W.C.) and Division of Neurology, Department of Medicine and Therapeutics (C.C., T.W.L., Y.O.Y.S.), Prince of Wales Hospital, The Chinese University of Hong Kong; Institute of Applied Health Sciences (S.D.J.M.), University of Aberdeen, United Kingdom; Biomedical Imaging Group Rotterdam (F.D.), Department of Radiology and Nuclear Medicine (D.H.K.D.-N.), Erasmus University Medical Centre, Rotterdam, The Netherlands; Departments of Radiology and Nuclear Medicine (M.E.K.) and Neurology (J.S.), CARIM School for Cardiovascular Diseases, Maastricht University Medical Centre; Department of Psychiatry and Neuropsychology (S.K.), School for Mental Health and Neuroscience, Maastricht University, The Netherlands; University of Lille (G.K., R.B.), Inserm, CHU de Lille, Lille Neuroscience & Cognition, France; National Centre for Healthy Ageing (V.K.S.), Peninsula Clinical School, Central Clinical School, Monash University, Melbourne, Australia; Department of Neurology (Y.Y.), Kansai Medical University, Osaka, Japan; Department of Neurology (D.N.O.), Istanbul Arel University, Turkey; and Department of Neurology (H.-J.B.), Seoul National University Bundang Hospital, Seoul National University College of Medicine, Seongnam, Republic of Korea., Fluri F; From the UCL Stroke Research Centre (J.G.B., D.W., D.J.W.) and Neuroradiological Academic Unit (H.R.J.), Department of Brain Repair and Rehabilitation, UCL Queen Square Institute of Neurology, London; Department of Statistical Science (G.A.), University College London, United Kingdom; Stroke Research Centre (H.D.), Department of Neurology, Fujian Medical University Union Hospital, Fuzhou, People's Republic of China; Department of Neurology (K.-J.L.), Korea University Guro Hospital, Seoul; Department of Neurology (J.-S.L.), Asan Medical Center, University of Ulsan College of Medicine, Seoul, Republic of Korea; Division of Neurology, Department of Medicine (K.C.T., G.K.K.L.) and Department of Diagnostic Radiology (H.M.), The University of Hong Kong; Department of Neurology (Y.D.K., J.-H.H.), Yonsei University College of Medicine, Seoul; Department of Neurology (T.-J.S.), Seoul Hospital, Ewha Womans University College of Medicine, Seoul, Republic of Korea; Department of Neurology (D.S.D.), Sisli Hamidiye Etfal Teaching and Research Hospital, University of Health Sciences, Turkey; Department of Radiology (M.N.), Saga University Faculty of Medicine; Division of Neurology (M.Y., H.H.), Department of Internal Medicine, Saga University Faculty of Medicine, Japan; Stroke Center Klinik Hirslanden Zürich (M.K., N.P.); University of Basel (M.K.); Department of Neurology and Stroke Center University Hospital and University of Basel (A.Z.), Switzerland; Centre for Clinical Brain Sciences (R.A.-S.S., F.C., J.M.W.), School of Clinical Sciences, University of Edinburgh; Liverpool Centre for Cardiovascular Science at University of Liverpool (G.Y.H.L.), Liverpool John Moores University and Liverpool Heart & Chest Hospital, United Kingdom; Department of Neurology (L.P., M.B.G., S.J.), Inselspital, Bern University Hospital, Switzerland; Department of Imaging, School of Clinical Sciences at Monash Health (L.-A.S.), Peninsula Clinical School, Peninsula Health (C.C.K.), and Stroke and Ageing Research Group, School of Clinical Sciences at Monash Health (T.G.P.), Monash University, Melbourne, Australia; Department of Neurology (M.B., F.F.), University Hospital of Würzburg, Germany; Department of Imaging and Interventional Radiology (J.A., W.C.) and Division of Neurology, Department of Medicine and Therapeutics (C.C., T.W.L., Y.O.Y.S.), Prince of Wales Hospital, The Chinese University of Hong Kong; Institute of Applied Health Sciences (S.D.J.M.), University of Aberdeen, United Kingdom; Biomedical Imaging Group Rotterdam (F.D.), Department of Radiology and Nuclear Medicine (D.H.K.D.-N.), Erasmus University Medical Centre, Rotterdam, The Netherlands; Departments of Radiology and Nuclear Medicine (M.E.K.) and Neurology (J.S.), CARIM School for Cardiovascular Diseases, Maastricht University Medical Centre; Department of Psychiatry and Neuropsychology (S.K.), School for Mental Health and Neuroscience, Maastricht University, The Netherlands; University of Lille (G.K., R.B.), Inserm, CHU de Lille, Lille Neuroscience & Cognition, France; National Centre for Healthy Ageing (V.K.S.), Peninsula Clinical School, Central Clinical School, Monash University, Melbourne, Australia; Department of Neurology (Y.Y.), Kansai Medical University, Osaka, Japan; Department of Neurology (D.N.O.), Istanbul Arel University, Turkey; and Department of Neurology (H.-J.B.), Seoul National University Bundang Hospital, Seoul National University College of Medicine, Seongnam, Republic of Korea., Srikanth VK; From the UCL Stroke Research Centre (J.G.B., D.W., D.J.W.) and Neuroradiological Academic Unit (H.R.J.), Department of Brain Repair and Rehabilitation, UCL Queen Square Institute of Neurology, London; Department of Statistical Science (G.A.), University College London, United Kingdom; Stroke Research Centre (H.D.), Department of Neurology, Fujian Medical University Union Hospital, Fuzhou, People's Republic of China; Department of Neurology (K.-J.L.), Korea University Guro Hospital, Seoul; Department of Neurology (J.-S.L.), Asan Medical Center, University of Ulsan College of Medicine, Seoul, Republic of Korea; Division of Neurology, Department of Medicine (K.C.T., G.K.K.L.) and Department of Diagnostic Radiology (H.M.), The University of Hong Kong; Department of Neurology (Y.D.K., J.-H.H.), Yonsei University College of Medicine, Seoul; Department of Neurology (T.-J.S.), Seoul Hospital, Ewha Womans University College of Medicine, Seoul, Republic of Korea; Department of Neurology (D.S.D.), Sisli Hamidiye Etfal Teaching and Research Hospital, University of Health Sciences, Turkey; Department of Radiology (M.N.), Saga University Faculty of Medicine; Division of Neurology (M.Y., H.H.), Department of Internal Medicine, Saga University Faculty of Medicine, Japan; Stroke Center Klinik Hirslanden Zürich (M.K., N.P.); University of Basel (M.K.); Department of Neurology and Stroke Center University Hospital and University of Basel (A.Z.), Switzerland; Centre for Clinical Brain Sciences (R.A.-S.S., F.C., J.M.W.), School of Clinical Sciences, University of Edinburgh; Liverpool Centre for Cardiovascular Science at University of Liverpool (G.Y.H.L.), Liverpool John Moores University and Liverpool Heart & Chest Hospital, United Kingdom; Department of Neurology (L.P., M.B.G., S.J.), Inselspital, Bern University Hospital, Switzerland; Department of Imaging, School of Clinical Sciences at Monash Health (L.-A.S.), Peninsula Clinical School, Peninsula Health (C.C.K.), and Stroke and Ageing Research Group, School of Clinical Sciences at Monash Health (T.G.P.), Monash University, Melbourne, Australia; Department of Neurology (M.B., F.F.), University Hospital of Würzburg, Germany; Department of Imaging and Interventional Radiology (J.A., W.C.) and Division of Neurology, Department of Medicine and Therapeutics (C.C., T.W.L., Y.O.Y.S.), Prince of Wales Hospital, The Chinese University of Hong Kong; Institute of Applied Health Sciences (S.D.J.M.), University of Aberdeen, United Kingdom; Biomedical Imaging Group Rotterdam (F.D.), Department of Radiology and Nuclear Medicine (D.H.K.D.-N.), Erasmus University Medical Centre, Rotterdam, The Netherlands; Departments of Radiology and Nuclear Medicine (M.E.K.) and Neurology (J.S.), CARIM School for Cardiovascular Diseases, Maastricht University Medical Centre; Department of Psychiatry and Neuropsychology (S.K.), School for Mental Health and Neuroscience, Maastricht University, The Netherlands; University of Lille (G.K., R.B.), Inserm, CHU de Lille, Lille Neuroscience & Cognition, France; National Centre for Healthy Ageing (V.K.S.), Peninsula Clinical School, Central Clinical School, Monash University, Melbourne, Australia; Department of Neurology (Y.Y.), Kansai Medical University, Osaka, Japan; Department of Neurology (D.N.O.), Istanbul Arel University, Turkey; and Department of Neurology (H.-J.B.), Seoul National University Bundang Hospital, Seoul National University College of Medicine, Seongnam, Republic of Korea., Jung S; From the UCL Stroke Research Centre (J.G.B., D.W., D.J.W.) and Neuroradiological Academic Unit (H.R.J.), Department of Brain Repair and Rehabilitation, UCL Queen Square Institute of Neurology, London; Department of Statistical Science (G.A.), University College London, United Kingdom; Stroke Research Centre (H.D.), Department of Neurology, Fujian Medical University Union Hospital, Fuzhou, People's Republic of China; Department of Neurology (K.-J.L.), Korea University Guro Hospital, Seoul; Department of Neurology (J.-S.L.), Asan Medical Center, University of Ulsan College of Medicine, Seoul, Republic of Korea; Division of Neurology, Department of Medicine (K.C.T., G.K.K.L.) and Department of Diagnostic Radiology (H.M.), The University of Hong Kong; Department of Neurology (Y.D.K., J.-H.H.), Yonsei University College of Medicine, Seoul; Department of Neurology (T.-J.S.), Seoul Hospital, Ewha Womans University College of Medicine, Seoul, Republic of Korea; Department of Neurology (D.S.D.), Sisli Hamidiye Etfal Teaching and Research Hospital, University of Health Sciences, Turkey; Department of Radiology (M.N.), Saga University Faculty of Medicine; Division of Neurology (M.Y., H.H.), Department of Internal Medicine, Saga University Faculty of Medicine, Japan; Stroke Center Klinik Hirslanden Zürich (M.K., N.P.); University of Basel (M.K.); Department of Neurology and Stroke Center University Hospital and University of Basel (A.Z.), Switzerland; Centre for Clinical Brain Sciences (R.A.-S.S., F.C., J.M.W.), School of Clinical Sciences, University of Edinburgh; Liverpool Centre for Cardiovascular Science at University of Liverpool (G.Y.H.L.), Liverpool John Moores University and Liverpool Heart & Chest Hospital, United Kingdom; Department of Neurology (L.P., M.B.G., S.J.), Inselspital, Bern University Hospital, Switzerland; Department of Imaging, School of Clinical Sciences at Monash Health (L.-A.S.), Peninsula Clinical School, Peninsula Health (C.C.K.), and Stroke and Ageing Research Group, School of Clinical Sciences at Monash Health (T.G.P.), Monash University, Melbourne, Australia; Department of Neurology (M.B., F.F.), University Hospital of Würzburg, Germany; Department of Imaging and Interventional Radiology (J.A., W.C.) and Division of Neurology, Department of Medicine and Therapeutics (C.C., T.W.L., Y.O.Y.S.), Prince of Wales Hospital, The Chinese University of Hong Kong; Institute of Applied Health Sciences (S.D.J.M.), University of Aberdeen, United Kingdom; Biomedical Imaging Group Rotterdam (F.D.), Department of Radiology and Nuclear Medicine (D.H.K.D.-N.), Erasmus University Medical Centre, Rotterdam, The Netherlands; Departments of Radiology and Nuclear Medicine (M.E.K.) and Neurology (J.S.), CARIM School for Cardiovascular Diseases, Maastricht University Medical Centre; Department of Psychiatry and Neuropsychology (S.K.), School for Mental Health and Neuroscience, Maastricht University, The Netherlands; University of Lille (G.K., R.B.), Inserm, CHU de Lille, Lille Neuroscience & Cognition, France; National Centre for Healthy Ageing (V.K.S.), Peninsula Clinical School, Central Clinical School, Monash University, Melbourne, Australia; Department of Neurology (Y.Y.), Kansai Medical University, Osaka, Japan; Department of Neurology (D.N.O.), Istanbul Arel University, Turkey; and Department of Neurology (H.-J.B.), Seoul National University Bundang Hospital, Seoul National University College of Medicine, Seongnam, Republic of Korea., Peters N; From the UCL Stroke Research Centre (J.G.B., D.W., D.J.W.) and Neuroradiological Academic Unit (H.R.J.), Department of Brain Repair and Rehabilitation, UCL Queen Square Institute of Neurology, London; Department of Statistical Science (G.A.), University College London, United Kingdom; Stroke Research Centre (H.D.), Department of Neurology, Fujian Medical University Union Hospital, Fuzhou, People's Republic of China; Department of Neurology (K.-J.L.), Korea University Guro Hospital, Seoul; Department of Neurology (J.-S.L.), Asan Medical Center, University of Ulsan College of Medicine, Seoul, Republic of Korea; Division of Neurology, Department of Medicine (K.C.T., G.K.K.L.) and Department of Diagnostic Radiology (H.M.), The University of Hong Kong; Department of Neurology (Y.D.K., J.-H.H.), Yonsei University College of Medicine, Seoul; Department of Neurology (T.-J.S.), Seoul Hospital, Ewha Womans University College of Medicine, Seoul, Republic of Korea; Department of Neurology (D.S.D.), Sisli Hamidiye Etfal Teaching and Research Hospital, University of Health Sciences, Turkey; Department of Radiology (M.N.), Saga University Faculty of Medicine; Division of Neurology (M.Y., H.H.), Department of Internal Medicine, Saga University Faculty of Medicine, Japan; Stroke Center Klinik Hirslanden Zürich (M.K., N.P.); University of Basel (M.K.); Department of Neurology and Stroke Center University Hospital and University of Basel (A.Z.), Switzerland; Centre for Clinical Brain Sciences (R.A.-S.S., F.C., J.M.W.), School of Clinical Sciences, University of Edinburgh; Liverpool Centre for Cardiovascular Science at University of Liverpool (G.Y.H.L.), Liverpool John Moores University and Liverpool Heart & Chest Hospital, United Kingdom; Department of Neurology (L.P., M.B.G., S.J.), Inselspital, Bern University Hospital, Switzerland; Department of Imaging, School of Clinical Sciences at Monash Health (L.-A.S.), Peninsula Clinical School, Peninsula Health (C.C.K.), and Stroke and Ageing Research Group, School of Clinical Sciences at Monash Health (T.G.P.), Monash University, Melbourne, Australia; Department of Neurology (M.B., F.F.), University Hospital of Würzburg, Germany; Department of Imaging and Interventional Radiology (J.A., W.C.) and Division of Neurology, Department of Medicine and Therapeutics (C.C., T.W.L., Y.O.Y.S.), Prince of Wales Hospital, The Chinese University of Hong Kong; Institute of Applied Health Sciences (S.D.J.M.), University of Aberdeen, United Kingdom; Biomedical Imaging Group Rotterdam (F.D.), Department of Radiology and Nuclear Medicine (D.H.K.D.-N.), Erasmus University Medical Centre, Rotterdam, The Netherlands; Departments of Radiology and Nuclear Medicine (M.E.K.) and Neurology (J.S.), CARIM School for Cardiovascular Diseases, Maastricht University Medical Centre; Department of Psychiatry and Neuropsychology (S.K.), School for Mental Health and Neuroscience, Maastricht University, The Netherlands; University of Lille (G.K., R.B.), Inserm, CHU de Lille, Lille Neuroscience & Cognition, France; National Centre for Healthy Ageing (V.K.S.), Peninsula Clinical School, Central Clinical School, Monash University, Melbourne, Australia; Department of Neurology (Y.Y.), Kansai Medical University, Osaka, Japan; Department of Neurology (D.N.O.), Istanbul Arel University, Turkey; and Department of Neurology (H.-J.B.), Seoul National University Bundang Hospital, Seoul National University College of Medicine, Seongnam, Republic of Korea., Hara H; From the UCL Stroke Research Centre (J.G.B., D.W., D.J.W.) and Neuroradiological Academic Unit (H.R.J.), Department of Brain Repair and Rehabilitation, UCL Queen Square Institute of Neurology, London; Department of Statistical Science (G.A.), University College London, United Kingdom; Stroke Research Centre (H.D.), Department of Neurology, Fujian Medical University Union Hospital, Fuzhou, People's Republic of China; Department of Neurology (K.-J.L.), Korea University Guro Hospital, Seoul; Department of Neurology (J.-S.L.), Asan Medical Center, University of Ulsan College of Medicine, Seoul, Republic of Korea; Division of Neurology, Department of Medicine (K.C.T., G.K.K.L.) and Department of Diagnostic Radiology (H.M.), The University of Hong Kong; Department of Neurology (Y.D.K., J.-H.H.), Yonsei University College of Medicine, Seoul; Department of Neurology (T.-J.S.), Seoul Hospital, Ewha Womans University College of Medicine, Seoul, Republic of Korea; Department of Neurology (D.S.D.), Sisli Hamidiye Etfal Teaching and Research Hospital, University of Health Sciences, Turkey; Department of Radiology (M.N.), Saga University Faculty of Medicine; Division of Neurology (M.Y., H.H.), Department of Internal Medicine, Saga University Faculty of Medicine, Japan; Stroke Center Klinik Hirslanden Zürich (M.K., N.P.); University of Basel (M.K.); Department of Neurology and Stroke Center University Hospital and University of Basel (A.Z.), Switzerland; Centre for Clinical Brain Sciences (R.A.-S.S., F.C., J.M.W.), School of Clinical Sciences, University of Edinburgh; Liverpool Centre for Cardiovascular Science at University of Liverpool (G.Y.H.L.), Liverpool John Moores University and Liverpool Heart & Chest Hospital, United Kingdom; Department of Neurology (L.P., M.B.G., S.J.), Inselspital, Bern University Hospital, Switzerland; Department of Imaging, School of Clinical Sciences at Monash Health (L.-A.S.), Peninsula Clinical School, Peninsula Health (C.C.K.), and Stroke and Ageing Research Group, School of Clinical Sciences at Monash Health (T.G.P.), Monash University, Melbourne, Australia; Department of Neurology (M.B., F.F.), University Hospital of Würzburg, Germany; Department of Imaging and Interventional Radiology (J.A., W.C.) and Division of Neurology, Department of Medicine and Therapeutics (C.C., T.W.L., Y.O.Y.S.), Prince of Wales Hospital, The Chinese University of Hong Kong; Institute of Applied Health Sciences (S.D.J.M.), University of Aberdeen, United Kingdom; Biomedical Imaging Group Rotterdam (F.D.), Department of Radiology and Nuclear Medicine (D.H.K.D.-N.), Erasmus University Medical Centre, Rotterdam, The Netherlands; Departments of Radiology and Nuclear Medicine (M.E.K.) and Neurology (J.S.), CARIM School for Cardiovascular Diseases, Maastricht University Medical Centre; Department of Psychiatry and Neuropsychology (S.K.), School for Mental Health and Neuroscience, Maastricht University, The Netherlands; University of Lille (G.K., R.B.), Inserm, CHU de Lille, Lille Neuroscience & Cognition, France; National Centre for Healthy Ageing (V.K.S.), Peninsula Clinical School, Central Clinical School, Monash University, Melbourne, Australia; Department of Neurology (Y.Y.), Kansai Medical University, Osaka, Japan; Department of Neurology (D.N.O.), Istanbul Arel University, Turkey; and Department of Neurology (H.-J.B.), Seoul National University Bundang Hospital, Seoul National University College of Medicine, Seongnam, Republic of Korea., Yakushiji Y; From the UCL Stroke Research Centre (J.G.B., D.W., D.J.W.) and Neuroradiological Academic Unit (H.R.J.), Department of Brain Repair and Rehabilitation, UCL Queen Square Institute of Neurology, London; Department of Statistical Science (G.A.), University College London, United Kingdom; Stroke Research Centre (H.D.), Department of Neurology, Fujian Medical University Union Hospital, Fuzhou, People's Republic of China; Department of Neurology (K.-J.L.), Korea University Guro Hospital, Seoul; Department of Neurology (J.-S.L.), Asan Medical Center, University of Ulsan College of Medicine, Seoul, Republic of Korea; Division of Neurology, Department of Medicine (K.C.T., G.K.K.L.) and Department of Diagnostic Radiology (H.M.), The University of Hong Kong; Department of Neurology (Y.D.K., J.-H.H.), Yonsei University College of Medicine, Seoul; Department of Neurology (T.-J.S.), Seoul Hospital, Ewha Womans University College of Medicine, Seoul, Republic of Korea; Department of Neurology (D.S.D.), Sisli Hamidiye Etfal Teaching and Research Hospital, University of Health Sciences, Turkey; Department of Radiology (M.N.), Saga University Faculty of Medicine; Division of Neurology (M.Y., H.H.), Department of Internal Medicine, Saga University Faculty of Medicine, Japan; Stroke Center Klinik Hirslanden Zürich (M.K., N.P.); University of Basel (M.K.); Department of Neurology and Stroke Center University Hospital and University of Basel (A.Z.), Switzerland; Centre for Clinical Brain Sciences (R.A.-S.S., F.C., J.M.W.), School of Clinical Sciences, University of Edinburgh; Liverpool Centre for Cardiovascular Science at University of Liverpool (G.Y.H.L.), Liverpool John Moores University and Liverpool Heart & Chest Hospital, United Kingdom; Department of Neurology (L.P., M.B.G., S.J.), Inselspital, Bern University Hospital, Switzerland; Department of Imaging, School of Clinical Sciences at Monash Health (L.-A.S.), Peninsula Clinical School, Peninsula Health (C.C.K.), and Stroke and Ageing Research Group, School of Clinical Sciences at Monash Health (T.G.P.), Monash University, Melbourne, Australia; Department of Neurology (M.B., F.F.), University Hospital of Würzburg, Germany; Department of Imaging and Interventional Radiology (J.A., W.C.) and Division of Neurology, Department of Medicine and Therapeutics (C.C., T.W.L., Y.O.Y.S.), Prince of Wales Hospital, The Chinese University of Hong Kong; Institute of Applied Health Sciences (S.D.J.M.), University of Aberdeen, United Kingdom; Biomedical Imaging Group Rotterdam (F.D.), Department of Radiology and Nuclear Medicine (D.H.K.D.-N.), Erasmus University Medical Centre, Rotterdam, The Netherlands; Departments of Radiology and Nuclear Medicine (M.E.K.) and Neurology (J.S.), CARIM School for Cardiovascular Diseases, Maastricht University Medical Centre; Department of Psychiatry and Neuropsychology (S.K.), School for Mental Health and Neuroscience, Maastricht University, The Netherlands; University of Lille (G.K., R.B.), Inserm, CHU de Lille, Lille Neuroscience & Cognition, France; National Centre for Healthy Ageing (V.K.S.), Peninsula Clinical School, Central Clinical School, Monash University, Melbourne, Australia; Department of Neurology (Y.Y.), Kansai Medical University, Osaka, Japan; Department of Neurology (D.N.O.), Istanbul Arel University, Turkey; and Department of Neurology (H.-J.B.), Seoul National University Bundang Hospital, Seoul National University College of Medicine, Seongnam, Republic of Korea., Necioglu Orken D; From the UCL Stroke Research Centre (J.G.B., D.W., D.J.W.) and Neuroradiological Academic Unit (H.R.J.), Department of Brain Repair and Rehabilitation, UCL Queen Square Institute of Neurology, London; Department of Statistical Science (G.A.), University College London, United Kingdom; Stroke Research Centre (H.D.), Department of Neurology, Fujian Medical University Union Hospital, Fuzhou, People's Republic of China; Department of Neurology (K.-J.L.), Korea University Guro Hospital, Seoul; Department of Neurology (J.-S.L.), Asan Medical Center, University of Ulsan College of Medicine, Seoul, Republic of Korea; Division of Neurology, Department of Medicine (K.C.T., G.K.K.L.) and Department of Diagnostic Radiology (H.M.), The University of Hong Kong; Department of Neurology (Y.D.K., J.-H.H.), Yonsei University College of Medicine, Seoul; Department of Neurology (T.-J.S.), Seoul Hospital, Ewha Womans University College of Medicine, Seoul, Republic of Korea; Department of Neurology (D.S.D.), Sisli Hamidiye Etfal Teaching and Research Hospital, University of Health Sciences, Turkey; Department of Radiology (M.N.), Saga University Faculty of Medicine; Division of Neurology (M.Y., H.H.), Department of Internal Medicine, Saga University Faculty of Medicine, Japan; Stroke Center Klinik Hirslanden Zürich (M.K., N.P.); University of Basel (M.K.); Department of Neurology and Stroke Center University Hospital and University of Basel (A.Z.), Switzerland; Centre for Clinical Brain Sciences (R.A.-S.S., F.C., J.M.W.), School of Clinical Sciences, University of Edinburgh; Liverpool Centre for Cardiovascular Science at University of Liverpool (G.Y.H.L.), Liverpool John Moores University and Liverpool Heart & Chest Hospital, United Kingdom; Department of Neurology (L.P., M.B.G., S.J.), Inselspital, Bern University Hospital, Switzerland; Department of Imaging, School of Clinical Sciences at Monash Health (L.-A.S.), Peninsula Clinical School, Peninsula Health (C.C.K.), and Stroke and Ageing Research Group, School of Clinical Sciences at Monash Health (T.G.P.), Monash University, Melbourne, Australia; Department of Neurology (M.B., F.F.), University Hospital of Würzburg, Germany; Department of Imaging and Interventional Radiology (J.A., W.C.) and Division of Neurology, Department of Medicine and Therapeutics (C.C., T.W.L., Y.O.Y.S.), Prince of Wales Hospital, The Chinese University of Hong Kong; Institute of Applied Health Sciences (S.D.J.M.), University of Aberdeen, United Kingdom; Biomedical Imaging Group Rotterdam (F.D.), Department of Radiology and Nuclear Medicine (D.H.K.D.-N.), Erasmus University Medical Centre, Rotterdam, The Netherlands; Departments of Radiology and Nuclear Medicine (M.E.K.) and Neurology (J.S.), CARIM School for Cardiovascular Diseases, Maastricht University Medical Centre; Department of Psychiatry and Neuropsychology (S.K.), School for Mental Health and Neuroscience, Maastricht University, The Netherlands; University of Lille (G.K., R.B.), Inserm, CHU de Lille, Lille Neuroscience & Cognition, France; National Centre for Healthy Ageing (V.K.S.), Peninsula Clinical School, Central Clinical School, Monash University, Melbourne, Australia; Department of Neurology (Y.Y.), Kansai Medical University, Osaka, Japan; Department of Neurology (D.N.O.), Istanbul Arel University, Turkey; and Department of Neurology (H.-J.B.), Seoul National University Bundang Hospital, Seoul National University College of Medicine, Seongnam, Republic of Korea., Heo JH; From the UCL Stroke Research Centre (J.G.B., D.W., D.J.W.) and Neuroradiological Academic Unit (H.R.J.), Department of Brain Repair and Rehabilitation, UCL Queen Square Institute of Neurology, London; Department of Statistical Science (G.A.), University College London, United Kingdom; Stroke Research Centre (H.D.), Department of Neurology, Fujian Medical University Union Hospital, Fuzhou, People's Republic of China; Department of Neurology (K.-J.L.), Korea University Guro Hospital, Seoul; Department of Neurology (J.-S.L.), Asan Medical Center, University of Ulsan College of Medicine, Seoul, Republic of Korea; Division of Neurology, Department of Medicine (K.C.T., G.K.K.L.) and Department of Diagnostic Radiology (H.M.), The University of Hong Kong; Department of Neurology (Y.D.K., J.-H.H.), Yonsei University College of Medicine, Seoul; Department of Neurology (T.-J.S.), Seoul Hospital, Ewha Womans University College of Medicine, Seoul, Republic of Korea; Department of Neurology (D.S.D.), Sisli Hamidiye Etfal Teaching and Research Hospital, University of Health Sciences, Turkey; Department of Radiology (M.N.), Saga University Faculty of Medicine; Division of Neurology (M.Y., H.H.), Department of Internal Medicine, Saga University Faculty of Medicine, Japan; Stroke Center Klinik Hirslanden Zürich (M.K., N.P.); University of Basel (M.K.); Department of Neurology and Stroke Center University Hospital and University of Basel (A.Z.), Switzerland; Centre for Clinical Brain Sciences (R.A.-S.S., F.C., J.M.W.), School of Clinical Sciences, University of Edinburgh; Liverpool Centre for Cardiovascular Science at University of Liverpool (G.Y.H.L.), Liverpool John Moores University and Liverpool Heart & Chest Hospital, United Kingdom; Department of Neurology (L.P., M.B.G., S.J.), Inselspital, Bern University Hospital, Switzerland; Department of Imaging, School of Clinical Sciences at Monash Health (L.-A.S.), Peninsula Clinical School, Peninsula Health (C.C.K.), and Stroke and Ageing Research Group, School of Clinical Sciences at Monash Health (T.G.P.), Monash University, Melbourne, Australia; Department of Neurology (M.B., F.F.), University Hospital of Würzburg, Germany; Department of Imaging and Interventional Radiology (J.A., W.C.) and Division of Neurology, Department of Medicine and Therapeutics (C.C., T.W.L., Y.O.Y.S.), Prince of Wales Hospital, The Chinese University of Hong Kong; Institute of Applied Health Sciences (S.D.J.M.), University of Aberdeen, United Kingdom; Biomedical Imaging Group Rotterdam (F.D.), Department of Radiology and Nuclear Medicine (D.H.K.D.-N.), Erasmus University Medical Centre, Rotterdam, The Netherlands; Departments of Radiology and Nuclear Medicine (M.E.K.) and Neurology (J.S.), CARIM School for Cardiovascular Diseases, Maastricht University Medical Centre; Department of Psychiatry and Neuropsychology (S.K.), School for Mental Health and Neuroscience, Maastricht University, The Netherlands; University of Lille (G.K., R.B.), Inserm, CHU de Lille, Lille Neuroscience & Cognition, France; National Centre for Healthy Ageing (V.K.S.), Peninsula Clinical School, Central Clinical School, Monash University, Melbourne, Australia; Department of Neurology (Y.Y.), Kansai Medical University, Osaka, Japan; Department of Neurology (D.N.O.), Istanbul Arel University, Turkey; and Department of Neurology (H.-J.B.), Seoul National University Bundang Hospital, Seoul National University College of Medicine, Seongnam, Republic of Korea., Lau GKK; From the UCL Stroke Research Centre (J.G.B., D.W., D.J.W.) and Neuroradiological Academic Unit (H.R.J.), Department of Brain Repair and Rehabilitation, UCL Queen Square Institute of Neurology, London; Department of Statistical Science (G.A.), University College London, United Kingdom; Stroke Research Centre (H.D.), Department of Neurology, Fujian Medical University Union Hospital, Fuzhou, People's Republic of China; Department of Neurology (K.-J.L.), Korea University Guro Hospital, Seoul; Department of Neurology (J.-S.L.), Asan Medical Center, University of Ulsan College of Medicine, Seoul, Republic of Korea; Division of Neurology, Department of Medicine (K.C.T., G.K.K.L.) and Department of Diagnostic Radiology (H.M.), The University of Hong Kong; Department of Neurology (Y.D.K., J.-H.H.), Yonsei University College of Medicine, Seoul; Department of Neurology (T.-J.S.), Seoul Hospital, Ewha Womans University College of Medicine, Seoul, Republic of Korea; Department of Neurology (D.S.D.), Sisli Hamidiye Etfal Teaching and Research Hospital, University of Health Sciences, Turkey; Department of Radiology (M.N.), Saga University Faculty of Medicine; Division of Neurology (M.Y., H.H.), Department of Internal Medicine, Saga University Faculty of Medicine, Japan; Stroke Center Klinik Hirslanden Zürich (M.K., N.P.); University of Basel (M.K.); Department of Neurology and Stroke Center University Hospital and University of Basel (A.Z.), Switzerland; Centre for Clinical Brain Sciences (R.A.-S.S., F.C., J.M.W.), School of Clinical Sciences, University of Edinburgh; Liverpool Centre for Cardiovascular Science at University of Liverpool (G.Y.H.L.), Liverpool John Moores University and Liverpool Heart & Chest Hospital, United Kingdom; Department of Neurology (L.P., M.B.G., S.J.), Inselspital, Bern University Hospital, Switzerland; Department of Imaging, School of Clinical Sciences at Monash Health (L.-A.S.), Peninsula Clinical School, Peninsula Health (C.C.K.), and Stroke and Ageing Research Group, School of Clinical Sciences at Monash Health (T.G.P.), Monash University, Melbourne, Australia; Department of Neurology (M.B., F.F.), University Hospital of Würzburg, Germany; Department of Imaging and Interventional Radiology (J.A., W.C.) and Division of Neurology, Department of Medicine and Therapeutics (C.C., T.W.L., Y.O.Y.S.), Prince of Wales Hospital, The Chinese University of Hong Kong; Institute of Applied Health Sciences (S.D.J.M.), University of Aberdeen, United Kingdom; Biomedical Imaging Group Rotterdam (F.D.), Department of Radiology and Nuclear Medicine (D.H.K.D.-N.), Erasmus University Medical Centre, Rotterdam, The Netherlands; Departments of Radiology and Nuclear Medicine (M.E.K.) and Neurology (J.S.), CARIM School for Cardiovascular Diseases, Maastricht University Medical Centre; Department of Psychiatry and Neuropsychology (S.K.), School for Mental Health and Neuroscience, Maastricht University, The Netherlands; University of Lille (G.K., R.B.), Inserm, CHU de Lille, Lille Neuroscience & Cognition, France; National Centre for Healthy Ageing (V.K.S.), Peninsula Clinical School, Central Clinical School, Monash University, Melbourne, Australia; Department of Neurology (Y.Y.), Kansai Medical University, Osaka, Japan; Department of Neurology (D.N.O.), Istanbul Arel University, Turkey; and Department of Neurology (H.-J.B.), Seoul National University Bundang Hospital, Seoul National University College of Medicine, Seongnam, Republic of Korea., Bae HJ; From the UCL Stroke Research Centre (J.G.B., D.W., D.J.W.) and Neuroradiological Academic Unit (H.R.J.), Department of Brain Repair and Rehabilitation, UCL Queen Square Institute of Neurology, London; Department of Statistical Science (G.A.), University College London, United Kingdom; Stroke Research Centre (H.D.), Department of Neurology, Fujian Medical University Union Hospital, Fuzhou, People's Republic of China; Department of Neurology (K.-J.L.), Korea University Guro Hospital, Seoul; Department of Neurology (J.-S.L.), Asan Medical Center, University of Ulsan College of Medicine, Seoul, Republic of Korea; Division of Neurology, Department of Medicine (K.C.T., G.K.K.L.) and Department of Diagnostic Radiology (H.M.), The University of Hong Kong; Department of Neurology (Y.D.K., J.-H.H.), Yonsei University College of Medicine, Seoul; Department of Neurology (T.-J.S.), Seoul Hospital, Ewha Womans University College of Medicine, Seoul, Republic of Korea; Department of Neurology (D.S.D.), Sisli Hamidiye Etfal Teaching and Research Hospital, University of Health Sciences, Turkey; Department of Radiology (M.N.), Saga University Faculty of Medicine; Division of Neurology (M.Y., H.H.), Department of Internal Medicine, Saga University Faculty of Medicine, Japan; Stroke Center Klinik Hirslanden Zürich (M.K., N.P.); University of Basel (M.K.); Department of Neurology and Stroke Center University Hospital and University of Basel (A.Z.), Switzerland; Centre for Clinical Brain Sciences (R.A.-S.S., F.C., J.M.W.), School of Clinical Sciences, University of Edinburgh; Liverpool Centre for Cardiovascular Science at University of Liverpool (G.Y.H.L.), Liverpool John Moores University and Liverpool Heart & Chest Hospital, United Kingdom; Department of Neurology (L.P., M.B.G., S.J.), Inselspital, Bern University Hospital, Switzerland; Department of Imaging, School of Clinical Sciences at Monash Health (L.-A.S.), Peninsula Clinical School, Peninsula Health (C.C.K.), and Stroke and Ageing Research Group, School of Clinical Sciences at Monash Health (T.G.P.), Monash University, Melbourne, Australia; Department of Neurology (M.B., F.F.), University Hospital of Würzburg, Germany; Department of Imaging and Interventional Radiology (J.A., W.C.) and Division of Neurology, Department of Medicine and Therapeutics (C.C., T.W.L., Y.O.Y.S.), Prince of Wales Hospital, The Chinese University of Hong Kong; Institute of Applied Health Sciences (S.D.J.M.), University of Aberdeen, United Kingdom; Biomedical Imaging Group Rotterdam (F.D.), Department of Radiology and Nuclear Medicine (D.H.K.D.-N.), Erasmus University Medical Centre, Rotterdam, The Netherlands; Departments of Radiology and Nuclear Medicine (M.E.K.) and Neurology (J.S.), CARIM School for Cardiovascular Diseases, Maastricht University Medical Centre; Department of Psychiatry and Neuropsychology (S.K.), School for Mental Health and Neuroscience, Maastricht University, The Netherlands; University of Lille (G.K., R.B.), Inserm, CHU de Lille, Lille Neuroscience & Cognition, France; National Centre for Healthy Ageing (V.K.S.), Peninsula Clinical School, Central Clinical School, Monash University, Melbourne, Australia; Department of Neurology (Y.Y.), Kansai Medical University, Osaka, Japan; Department of Neurology (D.N.O.), Istanbul Arel University, Turkey; and Department of Neurology (H.-J.B.), Seoul National University Bundang Hospital, Seoul National University College of Medicine, Seongnam, Republic of Korea., Werring DJ; From the UCL Stroke Research Centre (J.G.B., D.W., D.J.W.) and Neuroradiological Academic Unit (H.R.J.), Department of Brain Repair and Rehabilitation, UCL Queen Square Institute of Neurology, London; Department of Statistical Science (G.A.), University College London, United Kingdom; Stroke Research Centre (H.D.), Department of Neurology, Fujian Medical University Union Hospital, Fuzhou, People's Republic of China; Department of Neurology (K.-J.L.), Korea University Guro Hospital, Seoul; Department of Neurology (J.-S.L.), Asan Medical Center, University of Ulsan College of Medicine, Seoul, Republic of Korea; Division of Neurology, Department of Medicine (K.C.T., G.K.K.L.) and Department of Diagnostic Radiology (H.M.), The University of Hong Kong; Department of Neurology (Y.D.K., J.-H.H.), Yonsei University College of Medicine, Seoul; Department of Neurology (T.-J.S.), Seoul Hospital, Ewha Womans University College of Medicine, Seoul, Republic of Korea; Department of Neurology (D.S.D.), Sisli Hamidiye Etfal Teaching and Research Hospital, University of Health Sciences, Turkey; Department of Radiology (M.N.), Saga University Faculty of Medicine; Division of Neurology (M.Y., H.H.), Department of Internal Medicine, Saga University Faculty of Medicine, Japan; Stroke Center Klinik Hirslanden Zürich (M.K., N.P.); University of Basel (M.K.); Department of Neurology and Stroke Center University Hospital and University of Basel (A.Z.), Switzerland; Centre for Clinical Brain Sciences (R.A.-S.S., F.C., J.M.W.), School of Clinical Sciences, University of Edinburgh; Liverpool Centre for Cardiovascular Science at University of Liverpool (G.Y.H.L.), Liverpool John Moores University and Liverpool Heart & Chest Hospital, United Kingdom; Department of Neurology (L.P., M.B.G., S.J.), Inselspital, Bern University Hospital, Switzerland; Department of Imaging, School of Clinical Sciences at Monash Health (L.-A.S.), Peninsula Clinical School, Peninsula Health (C.C.K.), and Stroke and Ageing Research Group, School of Clinical Sciences at Monash Health (T.G.P.), Monash University, Melbourne, Australia; Department of Neurology (M.B., F.F.), University Hospital of Würzburg, Germany; Department of Imaging and Interventional Radiology (J.A., W.C.) and Division of Neurology, Department of Medicine and Therapeutics (C.C., T.W.L., Y.O.Y.S.), Prince of Wales Hospital, The Chinese University of Hong Kong; Institute of Applied Health Sciences (S.D.J.M.), University of Aberdeen, United Kingdom; Biomedical Imaging Group Rotterdam (F.D.), Department of Radiology and Nuclear Medicine (D.H.K.D.-N.), Erasmus University Medical Centre, Rotterdam, The Netherlands; Departments of Radiology and Nuclear Medicine (M.E.K.) and Neurology (J.S.), CARIM School for Cardiovascular Diseases, Maastricht University Medical Centre; Department of Psychiatry and Neuropsychology (S.K.), School for Mental Health and Neuroscience, Maastricht University, The Netherlands; University of Lille (G.K., R.B.), Inserm, CHU de Lille, Lille Neuroscience & Cognition, France; National Centre for Healthy Ageing (V.K.S.), Peninsula Clinical School, Central Clinical School, Monash University, Melbourne, Australia; Department of Neurology (Y.Y.), Kansai Medical University, Osaka, Japan; Department of Neurology (D.N.O.), Istanbul Arel University, Turkey; and Department of Neurology (H.-J.B.), Seoul National University Bundang Hospital, Seoul National University College of Medicine, Seongnam, Republic of Korea.

Publikováno v: Neurology [Neurology] 2024 Jan 09; Vol. 102 (1), pp. e207795. Date of Electronic Publication: 2023 Dec 13.

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Determinants of Perivascular Spaces in the General Population: A Pooled Cohort Analysis of Individual Participant Data.

Autor: Evans TE; From the Departments of Clinical Genetics (T.E.E., M.J.K., H.H.H.A.), Radiology and Nuclear Medicine (T.E.E., F.D., K.M.H.W., P.Y., M.B., H.H.H.A., M.W.V.), Epidemiology (M.J.K., M.A.I., P.Y., M.K.I., M.W.V.), and Neurology (M.K.I.), Erasmus MC, Rotterdam, the Netherlands; Department of Neurology (P.S., P.K., R.S.), Medical University of Graz, Austria; German Center for Neurodegenerative Diseases (DZNE) (K.W., M.H., H.J.G.), Site Rostock/Greifswald; Department of Psychiatry and Psychotherapy (K.W., H.J.G.) and Institute of Diagnostic Radiology and Neuroradiology (S.L.), University Medicine Greifswald, Germany; Department of Pharmacology (S.H., C.C.), National University of Singapore; Memory Aging & Cognition Centre (MACC) (S.H., C.C., M.K.I.), National University Health System, Singapore; Saw Swee Hock School of Public Health (S.H.), National University of Singapore; Department of Biomedical Data Sciences (F.D.), Stanford University, CA; J. Philip Kistler Stroke Research Center (P.Y.), Department of Neurology, Massachusetts General Hospital, Harvard Medical School, Boston; The Machine Learning Section (M.B.), Department of Computer Science, University of Copenhagen, Denmark; Neuroimage Analytics Laboratory (NAL) and the Biggs Institute Neuroimaging Core (BINC) (M.H.), Glenn Biggs Institute for Alzheimer's and Neurodegenerative Diseases, University of Texas Health Science Center San Antonio (UTHSCSA), TX; and Latin American Brain Health (BrainLat) (H.H.H.A.), Universidad Adolfo Ibáñez, Santiago, Chile., Knol MJ; From the Departments of Clinical Genetics (T.E.E., M.J.K., H.H.H.A.), Radiology and Nuclear Medicine (T.E.E., F.D., K.M.H.W., P.Y., M.B., H.H.H.A., M.W.V.), Epidemiology (M.J.K., M.A.I., P.Y., M.K.I., M.W.V.), and Neurology (M.K.I.), Erasmus MC, Rotterdam, the Netherlands; Department of Neurology (P.S., P.K., R.S.), Medical University of Graz, Austria; German Center for Neurodegenerative Diseases (DZNE) (K.W., M.H., H.J.G.), Site Rostock/Greifswald; Department of Psychiatry and Psychotherapy (K.W., H.J.G.) and Institute of Diagnostic Radiology and Neuroradiology (S.L.), University Medicine Greifswald, Germany; Department of Pharmacology (S.H., C.C.), National University of Singapore; Memory Aging & Cognition Centre (MACC) (S.H., C.C., M.K.I.), National University Health System, Singapore; Saw Swee Hock School of Public Health (S.H.), National University of Singapore; Department of Biomedical Data Sciences (F.D.), Stanford University, CA; J. Philip Kistler Stroke Research Center (P.Y.), Department of Neurology, Massachusetts General Hospital, Harvard Medical School, Boston; The Machine Learning Section (M.B.), Department of Computer Science, University of Copenhagen, Denmark; Neuroimage Analytics Laboratory (NAL) and the Biggs Institute Neuroimaging Core (BINC) (M.H.), Glenn Biggs Institute for Alzheimer's and Neurodegenerative Diseases, University of Texas Health Science Center San Antonio (UTHSCSA), TX; and Latin American Brain Health (BrainLat) (H.H.H.A.), Universidad Adolfo Ibáñez, Santiago, Chile., Schwingenschuh P; From the Departments of Clinical Genetics (T.E.E., M.J.K., H.H.H.A.), Radiology and Nuclear Medicine (T.E.E., F.D., K.M.H.W., P.Y., M.B., H.H.H.A., M.W.V.), Epidemiology (M.J.K., M.A.I., P.Y., M.K.I., M.W.V.), and Neurology (M.K.I.), Erasmus MC, Rotterdam, the Netherlands; Department of Neurology (P.S., P.K., R.S.), Medical University of Graz, Austria; German Center for Neurodegenerative Diseases (DZNE) (K.W., M.H., H.J.G.), Site Rostock/Greifswald; Department of Psychiatry and Psychotherapy (K.W., H.J.G.) and Institute of Diagnostic Radiology and Neuroradiology (S.L.), University Medicine Greifswald, Germany; Department of Pharmacology (S.H., C.C.), National University of Singapore; Memory Aging & Cognition Centre (MACC) (S.H., C.C., M.K.I.), National University Health System, Singapore; Saw Swee Hock School of Public Health (S.H.), National University of Singapore; Department of Biomedical Data Sciences (F.D.), Stanford University, CA; J. Philip Kistler Stroke Research Center (P.Y.), Department of Neurology, Massachusetts General Hospital, Harvard Medical School, Boston; The Machine Learning Section (M.B.), Department of Computer Science, University of Copenhagen, Denmark; Neuroimage Analytics Laboratory (NAL) and the Biggs Institute Neuroimaging Core (BINC) (M.H.), Glenn Biggs Institute for Alzheimer's and Neurodegenerative Diseases, University of Texas Health Science Center San Antonio (UTHSCSA), TX; and Latin American Brain Health (BrainLat) (H.H.H.A.), Universidad Adolfo Ibáñez, Santiago, Chile., Wittfeld K; From the Departments of Clinical Genetics (T.E.E., M.J.K., H.H.H.A.), Radiology and Nuclear Medicine (T.E.E., F.D., K.M.H.W., P.Y., M.B., H.H.H.A., M.W.V.), Epidemiology (M.J.K., M.A.I., P.Y., M.K.I., M.W.V.), and Neurology (M.K.I.), Erasmus MC, Rotterdam, the Netherlands; Department of Neurology (P.S., P.K., R.S.), Medical University of Graz, Austria; German Center for Neurodegenerative Diseases (DZNE) (K.W., M.H., H.J.G.), Site Rostock/Greifswald; Department of Psychiatry and Psychotherapy (K.W., H.J.G.) and Institute of Diagnostic Radiology and Neuroradiology (S.L.), University Medicine Greifswald, Germany; Department of Pharmacology (S.H., C.C.), National University of Singapore; Memory Aging & Cognition Centre (MACC) (S.H., C.C., M.K.I.), National University Health System, Singapore; Saw Swee Hock School of Public Health (S.H.), National University of Singapore; Department of Biomedical Data Sciences (F.D.), Stanford University, CA; J. Philip Kistler Stroke Research Center (P.Y.), Department of Neurology, Massachusetts General Hospital, Harvard Medical School, Boston; The Machine Learning Section (M.B.), Department of Computer Science, University of Copenhagen, Denmark; Neuroimage Analytics Laboratory (NAL) and the Biggs Institute Neuroimaging Core (BINC) (M.H.), Glenn Biggs Institute for Alzheimer's and Neurodegenerative Diseases, University of Texas Health Science Center San Antonio (UTHSCSA), TX; and Latin American Brain Health (BrainLat) (H.H.H.A.), Universidad Adolfo Ibáñez, Santiago, Chile., Hilal S; From the Departments of Clinical Genetics (T.E.E., M.J.K., H.H.H.A.), Radiology and Nuclear Medicine (T.E.E., F.D., K.M.H.W., P.Y., M.B., H.H.H.A., M.W.V.), Epidemiology (M.J.K., M.A.I., P.Y., M.K.I., M.W.V.), and Neurology (M.K.I.), Erasmus MC, Rotterdam, the Netherlands; Department of Neurology (P.S., P.K., R.S.), Medical University of Graz, Austria; German Center for Neurodegenerative Diseases (DZNE) (K.W., M.H., H.J.G.), Site Rostock/Greifswald; Department of Psychiatry and Psychotherapy (K.W., H.J.G.) and Institute of Diagnostic Radiology and Neuroradiology (S.L.), University Medicine Greifswald, Germany; Department of Pharmacology (S.H., C.C.), National University of Singapore; Memory Aging & Cognition Centre (MACC) (S.H., C.C., M.K.I.), National University Health System, Singapore; Saw Swee Hock School of Public Health (S.H.), National University of Singapore; Department of Biomedical Data Sciences (F.D.), Stanford University, CA; J. Philip Kistler Stroke Research Center (P.Y.), Department of Neurology, Massachusetts General Hospital, Harvard Medical School, Boston; The Machine Learning Section (M.B.), Department of Computer Science, University of Copenhagen, Denmark; Neuroimage Analytics Laboratory (NAL) and the Biggs Institute Neuroimaging Core (BINC) (M.H.), Glenn Biggs Institute for Alzheimer's and Neurodegenerative Diseases, University of Texas Health Science Center San Antonio (UTHSCSA), TX; and Latin American Brain Health (BrainLat) (H.H.H.A.), Universidad Adolfo Ibáñez, Santiago, Chile., Ikram MA; From the Departments of Clinical Genetics (T.E.E., M.J.K., H.H.H.A.), Radiology and Nuclear Medicine (T.E.E., F.D., K.M.H.W., P.Y., M.B., H.H.H.A., M.W.V.), Epidemiology (M.J.K., M.A.I., P.Y., M.K.I., M.W.V.), and Neurology (M.K.I.), Erasmus MC, Rotterdam, the Netherlands; Department of Neurology (P.S., P.K., R.S.), Medical University of Graz, Austria; German Center for Neurodegenerative Diseases (DZNE) (K.W., M.H., H.J.G.), Site Rostock/Greifswald; Department of Psychiatry and Psychotherapy (K.W., H.J.G.) and Institute of Diagnostic Radiology and Neuroradiology (S.L.), University Medicine Greifswald, Germany; Department of Pharmacology (S.H., C.C.), National University of Singapore; Memory Aging & Cognition Centre (MACC) (S.H., C.C., M.K.I.), National University Health System, Singapore; Saw Swee Hock School of Public Health (S.H.), National University of Singapore; Department of Biomedical Data Sciences (F.D.), Stanford University, CA; J. Philip Kistler Stroke Research Center (P.Y.), Department of Neurology, Massachusetts General Hospital, Harvard Medical School, Boston; The Machine Learning Section (M.B.), Department of Computer Science, University of Copenhagen, Denmark; Neuroimage Analytics Laboratory (NAL) and the Biggs Institute Neuroimaging Core (BINC) (M.H.), Glenn Biggs Institute for Alzheimer's and Neurodegenerative Diseases, University of Texas Health Science Center San Antonio (UTHSCSA), TX; and Latin American Brain Health (BrainLat) (H.H.H.A.), Universidad Adolfo Ibáñez, Santiago, Chile., Dubost F; From the Departments of Clinical Genetics (T.E.E., M.J.K., H.H.H.A.), Radiology and Nuclear Medicine (T.E.E., F.D., K.M.H.W., P.Y., M.B., H.H.H.A., M.W.V.), Epidemiology (M.J.K., M.A.I., P.Y., M.K.I., M.W.V.), and Neurology (M.K.I.), Erasmus MC, Rotterdam, the Netherlands; Department of Neurology (P.S., P.K., R.S.), Medical University of Graz, Austria; German Center for Neurodegenerative Diseases (DZNE) (K.W., M.H., H.J.G.), Site Rostock/Greifswald; Department of Psychiatry and Psychotherapy (K.W., H.J.G.) and Institute of Diagnostic Radiology and Neuroradiology (S.L.), University Medicine Greifswald, Germany; Department of Pharmacology (S.H., C.C.), National University of Singapore; Memory Aging & Cognition Centre (MACC) (S.H., C.C., M.K.I.), National University Health System, Singapore; Saw Swee Hock School of Public Health (S.H.), National University of Singapore; Department of Biomedical Data Sciences (F.D.), Stanford University, CA; J. Philip Kistler Stroke Research Center (P.Y.), Department of Neurology, Massachusetts General Hospital, Harvard Medical School, Boston; The Machine Learning Section (M.B.), Department of Computer Science, University of Copenhagen, Denmark; Neuroimage Analytics Laboratory (NAL) and the Biggs Institute Neuroimaging Core (BINC) (M.H.), Glenn Biggs Institute for Alzheimer's and Neurodegenerative Diseases, University of Texas Health Science Center San Antonio (UTHSCSA), TX; and Latin American Brain Health (BrainLat) (H.H.H.A.), Universidad Adolfo Ibáñez, Santiago, Chile., van Wijnen KMH; From the Departments of Clinical Genetics (T.E.E., M.J.K., H.H.H.A.), Radiology and Nuclear Medicine (T.E.E., F.D., K.M.H.W., P.Y., M.B., H.H.H.A., M.W.V.), Epidemiology (M.J.K., M.A.I., P.Y., M.K.I., M.W.V.), and Neurology (M.K.I.), Erasmus MC, Rotterdam, the Netherlands; Department of Neurology (P.S., P.K., R.S.), Medical University of Graz, Austria; German Center for Neurodegenerative Diseases (DZNE) (K.W., M.H., H.J.G.), Site Rostock/Greifswald; Department of Psychiatry and Psychotherapy (K.W., H.J.G.) and Institute of Diagnostic Radiology and Neuroradiology (S.L.), University Medicine Greifswald, Germany; Department of Pharmacology (S.H., C.C.), National University of Singapore; Memory Aging & Cognition Centre (MACC) (S.H., C.C., M.K.I.), National University Health System, Singapore; Saw Swee Hock School of Public Health (S.H.), National University of Singapore; Department of Biomedical Data Sciences (F.D.), Stanford University, CA; J. Philip Kistler Stroke Research Center (P.Y.), Department of Neurology, Massachusetts General Hospital, Harvard Medical School, Boston; The Machine Learning Section (M.B.), Department of Computer Science, University of Copenhagen, Denmark; Neuroimage Analytics Laboratory (NAL) and the Biggs Institute Neuroimaging Core (BINC) (M.H.), Glenn Biggs Institute for Alzheimer's and Neurodegenerative Diseases, University of Texas Health Science Center San Antonio (UTHSCSA), TX; and Latin American Brain Health (BrainLat) (H.H.H.A.), Universidad Adolfo Ibáñez, Santiago, Chile., Katschnig P; From the Departments of Clinical Genetics (T.E.E., M.J.K., H.H.H.A.), Radiology and Nuclear Medicine (T.E.E., F.D., K.M.H.W., P.Y., M.B., H.H.H.A., M.W.V.), Epidemiology (M.J.K., M.A.I., P.Y., M.K.I., M.W.V.), and Neurology (M.K.I.), Erasmus MC, Rotterdam, the Netherlands; Department of Neurology (P.S., P.K., R.S.), Medical University of Graz, Austria; German Center for Neurodegenerative Diseases (DZNE) (K.W., M.H., H.J.G.), Site Rostock/Greifswald; Department of Psychiatry and Psychotherapy (K.W., H.J.G.) and Institute of Diagnostic Radiology and Neuroradiology (S.L.), University Medicine Greifswald, Germany; Department of Pharmacology (S.H., C.C.), National University of Singapore; Memory Aging & Cognition Centre (MACC) (S.H., C.C., M.K.I.), National University Health System, Singapore; Saw Swee Hock School of Public Health (S.H.), National University of Singapore; Department of Biomedical Data Sciences (F.D.), Stanford University, CA; J. Philip Kistler Stroke Research Center (P.Y.), Department of Neurology, Massachusetts General Hospital, Harvard Medical School, Boston; The Machine Learning Section (M.B.), Department of Computer Science, University of Copenhagen, Denmark; Neuroimage Analytics Laboratory (NAL) and the Biggs Institute Neuroimaging Core (BINC) (M.H.), Glenn Biggs Institute for Alzheimer's and Neurodegenerative Diseases, University of Texas Health Science Center San Antonio (UTHSCSA), TX; and Latin American Brain Health (BrainLat) (H.H.H.A.), Universidad Adolfo Ibáñez, Santiago, Chile., Yilmaz P; From the Departments of Clinical Genetics (T.E.E., M.J.K., H.H.H.A.), Radiology and Nuclear Medicine (T.E.E., F.D., K.M.H.W., P.Y., M.B., H.H.H.A., M.W.V.), Epidemiology (M.J.K., M.A.I., P.Y., M.K.I., M.W.V.), and Neurology (M.K.I.), Erasmus MC, Rotterdam, the Netherlands; Department of Neurology (P.S., P.K., R.S.), Medical University of Graz, Austria; German Center for Neurodegenerative Diseases (DZNE) (K.W., M.H., H.J.G.), Site Rostock/Greifswald; Department of Psychiatry and Psychotherapy (K.W., H.J.G.) and Institute of Diagnostic Radiology and Neuroradiology (S.L.), University Medicine Greifswald, Germany; Department of Pharmacology (S.H., C.C.), National University of Singapore; Memory Aging & Cognition Centre (MACC) (S.H., C.C., M.K.I.), National University Health System, Singapore; Saw Swee Hock School of Public Health (S.H.), National University of Singapore; Department of Biomedical Data Sciences (F.D.), Stanford University, CA; J. Philip Kistler Stroke Research Center (P.Y.), Department of Neurology, Massachusetts General Hospital, Harvard Medical School, Boston; The Machine Learning Section (M.B.), Department of Computer Science, University of Copenhagen, Denmark; Neuroimage Analytics Laboratory (NAL) and the Biggs Institute Neuroimaging Core (BINC) (M.H.), Glenn Biggs Institute for Alzheimer's and Neurodegenerative Diseases, University of Texas Health Science Center San Antonio (UTHSCSA), TX; and Latin American Brain Health (BrainLat) (H.H.H.A.), Universidad Adolfo Ibáñez, Santiago, Chile., de Bruijne M; From the Departments of Clinical Genetics (T.E.E., M.J.K., H.H.H.A.), Radiology and Nuclear Medicine (T.E.E., F.D., K.M.H.W., P.Y., M.B., H.H.H.A., M.W.V.), Epidemiology (M.J.K., M.A.I., P.Y., M.K.I., M.W.V.), and Neurology (M.K.I.), Erasmus MC, Rotterdam, the Netherlands; Department of Neurology (P.S., P.K., R.S.), Medical University of Graz, Austria; German Center for Neurodegenerative Diseases (DZNE) (K.W., M.H., H.J.G.), Site Rostock/Greifswald; Department of Psychiatry and Psychotherapy (K.W., H.J.G.) and Institute of Diagnostic Radiology and Neuroradiology (S.L.), University Medicine Greifswald, Germany; Department of Pharmacology (S.H., C.C.), National University of Singapore; Memory Aging & Cognition Centre (MACC) (S.H., C.C., M.K.I.), National University Health System, Singapore; Saw Swee Hock School of Public Health (S.H.), National University of Singapore; Department of Biomedical Data Sciences (F.D.), Stanford University, CA; J. Philip Kistler Stroke Research Center (P.Y.), Department of Neurology, Massachusetts General Hospital, Harvard Medical School, Boston; The Machine Learning Section (M.B.), Department of Computer Science, University of Copenhagen, Denmark; Neuroimage Analytics Laboratory (NAL) and the Biggs Institute Neuroimaging Core (BINC) (M.H.), Glenn Biggs Institute for Alzheimer's and Neurodegenerative Diseases, University of Texas Health Science Center San Antonio (UTHSCSA), TX; and Latin American Brain Health (BrainLat) (H.H.H.A.), Universidad Adolfo Ibáñez, Santiago, Chile., Habes M; From the Departments of Clinical Genetics (T.E.E., M.J.K., H.H.H.A.), Radiology and Nuclear Medicine (T.E.E., F.D., K.M.H.W., P.Y., M.B., H.H.H.A., M.W.V.), Epidemiology (M.J.K., M.A.I., P.Y., M.K.I., M.W.V.), and Neurology (M.K.I.), Erasmus MC, Rotterdam, the Netherlands; Department of Neurology (P.S., P.K., R.S.), Medical University of Graz, Austria; German Center for Neurodegenerative Diseases (DZNE) (K.W., M.H., H.J.G.), Site Rostock/Greifswald; Department of Psychiatry and Psychotherapy (K.W., H.J.G.) and Institute of Diagnostic Radiology and Neuroradiology (S.L.), University Medicine Greifswald, Germany; Department of Pharmacology (S.H., C.C.), National University of Singapore; Memory Aging & Cognition Centre (MACC) (S.H., C.C., M.K.I.), National University Health System, Singapore; Saw Swee Hock School of Public Health (S.H.), National University of Singapore; Department of Biomedical Data Sciences (F.D.), Stanford University, CA; J. Philip Kistler Stroke Research Center (P.Y.), Department of Neurology, Massachusetts General Hospital, Harvard Medical School, Boston; The Machine Learning Section (M.B.), Department of Computer Science, University of Copenhagen, Denmark; Neuroimage Analytics Laboratory (NAL) and the Biggs Institute Neuroimaging Core (BINC) (M.H.), Glenn Biggs Institute for Alzheimer's and Neurodegenerative Diseases, University of Texas Health Science Center San Antonio (UTHSCSA), TX; and Latin American Brain Health (BrainLat) (H.H.H.A.), Universidad Adolfo Ibáñez, Santiago, Chile., Chen C; From the Departments of Clinical Genetics (T.E.E., M.J.K., H.H.H.A.), Radiology and Nuclear Medicine (T.E.E., F.D., K.M.H.W., P.Y., M.B., H.H.H.A., M.W.V.), Epidemiology (M.J.K., M.A.I., P.Y., M.K.I., M.W.V.), and Neurology (M.K.I.), Erasmus MC, Rotterdam, the Netherlands; Department of Neurology (P.S., P.K., R.S.), Medical University of Graz, Austria; German Center for Neurodegenerative Diseases (DZNE) (K.W., M.H., H.J.G.), Site Rostock/Greifswald; Department of Psychiatry and Psychotherapy (K.W., H.J.G.) and Institute of Diagnostic Radiology and Neuroradiology (S.L.), University Medicine Greifswald, Germany; Department of Pharmacology (S.H., C.C.), National University of Singapore; Memory Aging & Cognition Centre (MACC) (S.H., C.C., M.K.I.), National University Health System, Singapore; Saw Swee Hock School of Public Health (S.H.), National University of Singapore; Department of Biomedical Data Sciences (F.D.), Stanford University, CA; J. Philip Kistler Stroke Research Center (P.Y.), Department of Neurology, Massachusetts General Hospital, Harvard Medical School, Boston; The Machine Learning Section (M.B.), Department of Computer Science, University of Copenhagen, Denmark; Neuroimage Analytics Laboratory (NAL) and the Biggs Institute Neuroimaging Core (BINC) (M.H.), Glenn Biggs Institute for Alzheimer's and Neurodegenerative Diseases, University of Texas Health Science Center San Antonio (UTHSCSA), TX; and Latin American Brain Health (BrainLat) (H.H.H.A.), Universidad Adolfo Ibáñez, Santiago, Chile., Langer S; From the Departments of Clinical Genetics (T.E.E., M.J.K., H.H.H.A.), Radiology and Nuclear Medicine (T.E.E., F.D., K.M.H.W., P.Y., M.B., H.H.H.A., M.W.V.), Epidemiology (M.J.K., M.A.I., P.Y., M.K.I., M.W.V.), and Neurology (M.K.I.), Erasmus MC, Rotterdam, the Netherlands; Department of Neurology (P.S., P.K., R.S.), Medical University of Graz, Austria; German Center for Neurodegenerative Diseases (DZNE) (K.W., M.H., H.J.G.), Site Rostock/Greifswald; Department of Psychiatry and Psychotherapy (K.W., H.J.G.) and Institute of Diagnostic Radiology and Neuroradiology (S.L.), University Medicine Greifswald, Germany; Department of Pharmacology (S.H., C.C.), National University of Singapore; Memory Aging & Cognition Centre (MACC) (S.H., C.C., M.K.I.), National University Health System, Singapore; Saw Swee Hock School of Public Health (S.H.), National University of Singapore; Department of Biomedical Data Sciences (F.D.), Stanford University, CA; J. Philip Kistler Stroke Research Center (P.Y.), Department of Neurology, Massachusetts General Hospital, Harvard Medical School, Boston; The Machine Learning Section (M.B.), Department of Computer Science, University of Copenhagen, Denmark; Neuroimage Analytics Laboratory (NAL) and the Biggs Institute Neuroimaging Core (BINC) (M.H.), Glenn Biggs Institute for Alzheimer's and Neurodegenerative Diseases, University of Texas Health Science Center San Antonio (UTHSCSA), TX; and Latin American Brain Health (BrainLat) (H.H.H.A.), Universidad Adolfo Ibáñez, Santiago, Chile., Völzke H; From the Departments of Clinical Genetics (T.E.E., M.J.K., H.H.H.A.), Radiology and Nuclear Medicine (T.E.E., F.D., K.M.H.W., P.Y., M.B., H.H.H.A., M.W.V.), Epidemiology (M.J.K., M.A.I., P.Y., M.K.I., M.W.V.), and Neurology (M.K.I.), Erasmus MC, Rotterdam, the Netherlands; Department of Neurology (P.S., P.K., R.S.), Medical University of Graz, Austria; German Center for Neurodegenerative Diseases (DZNE) (K.W., M.H., H.J.G.), Site Rostock/Greifswald; Department of Psychiatry and Psychotherapy (K.W., H.J.G.) and Institute of Diagnostic Radiology and Neuroradiology (S.L.), University Medicine Greifswald, Germany; Department of Pharmacology (S.H., C.C.), National University of Singapore; Memory Aging & Cognition Centre (MACC) (S.H., C.C., M.K.I.), National University Health System, Singapore; Saw Swee Hock School of Public Health (S.H.), National University of Singapore; Department of Biomedical Data Sciences (F.D.), Stanford University, CA; J. Philip Kistler Stroke Research Center (P.Y.), Department of Neurology, Massachusetts General Hospital, Harvard Medical School, Boston; The Machine Learning Section (M.B.), Department of Computer Science, University of Copenhagen, Denmark; Neuroimage Analytics Laboratory (NAL) and the Biggs Institute Neuroimaging Core (BINC) (M.H.), Glenn Biggs Institute for Alzheimer's and Neurodegenerative Diseases, University of Texas Health Science Center San Antonio (UTHSCSA), TX; and Latin American Brain Health (BrainLat) (H.H.H.A.), Universidad Adolfo Ibáñez, Santiago, Chile., Ikram MK; From the Departments of Clinical Genetics (T.E.E., M.J.K., H.H.H.A.), Radiology and Nuclear Medicine (T.E.E., F.D., K.M.H.W., P.Y., M.B., H.H.H.A., M.W.V.), Epidemiology (M.J.K., M.A.I., P.Y., M.K.I., M.W.V.), and Neurology (M.K.I.), Erasmus MC, Rotterdam, the Netherlands; Department of Neurology (P.S., P.K., R.S.), Medical University of Graz, Austria; German Center for Neurodegenerative Diseases (DZNE) (K.W., M.H., H.J.G.), Site Rostock/Greifswald; Department of Psychiatry and Psychotherapy (K.W., H.J.G.) and Institute of Diagnostic Radiology and Neuroradiology (S.L.), University Medicine Greifswald, Germany; Department of Pharmacology (S.H., C.C.), National University of Singapore; Memory Aging & Cognition Centre (MACC) (S.H., C.C., M.K.I.), National University Health System, Singapore; Saw Swee Hock School of Public Health (S.H.), National University of Singapore; Department of Biomedical Data Sciences (F.D.), Stanford University, CA; J. Philip Kistler Stroke Research Center (P.Y.), Department of Neurology, Massachusetts General Hospital, Harvard Medical School, Boston; The Machine Learning Section (M.B.), Department of Computer Science, University of Copenhagen, Denmark; Neuroimage Analytics Laboratory (NAL) and the Biggs Institute Neuroimaging Core (BINC) (M.H.), Glenn Biggs Institute for Alzheimer's and Neurodegenerative Diseases, University of Texas Health Science Center San Antonio (UTHSCSA), TX; and Latin American Brain Health (BrainLat) (H.H.H.A.), Universidad Adolfo Ibáñez, Santiago, Chile., Grabe HJ; From the Departments of Clinical Genetics (T.E.E., M.J.K., H.H.H.A.), Radiology and Nuclear Medicine (T.E.E., F.D., K.M.H.W., P.Y., M.B., H.H.H.A., M.W.V.), Epidemiology (M.J.K., M.A.I., P.Y., M.K.I., M.W.V.), and Neurology (M.K.I.), Erasmus MC, Rotterdam, the Netherlands; Department of Neurology (P.S., P.K., R.S.), Medical University of Graz, Austria; German Center for Neurodegenerative Diseases (DZNE) (K.W., M.H., H.J.G.), Site Rostock/Greifswald; Department of Psychiatry and Psychotherapy (K.W., H.J.G.) and Institute of Diagnostic Radiology and Neuroradiology (S.L.), University Medicine Greifswald, Germany; Department of Pharmacology (S.H., C.C.), National University of Singapore; Memory Aging & Cognition Centre (MACC) (S.H., C.C., M.K.I.), National University Health System, Singapore; Saw Swee Hock School of Public Health (S.H.), National University of Singapore; Department of Biomedical Data Sciences (F.D.), Stanford University, CA; J. Philip Kistler Stroke Research Center (P.Y.), Department of Neurology, Massachusetts General Hospital, Harvard Medical School, Boston; The Machine Learning Section (M.B.), Department of Computer Science, University of Copenhagen, Denmark; Neuroimage Analytics Laboratory (NAL) and the Biggs Institute Neuroimaging Core (BINC) (M.H.), Glenn Biggs Institute for Alzheimer's and Neurodegenerative Diseases, University of Texas Health Science Center San Antonio (UTHSCSA), TX; and Latin American Brain Health (BrainLat) (H.H.H.A.), Universidad Adolfo Ibáñez, Santiago, Chile., Schmidt R; From the Departments of Clinical Genetics (T.E.E., M.J.K., H.H.H.A.), Radiology and Nuclear Medicine (T.E.E., F.D., K.M.H.W., P.Y., M.B., H.H.H.A., M.W.V.), Epidemiology (M.J.K., M.A.I., P.Y., M.K.I., M.W.V.), and Neurology (M.K.I.), Erasmus MC, Rotterdam, the Netherlands; Department of Neurology (P.S., P.K., R.S.), Medical University of Graz, Austria; German Center for Neurodegenerative Diseases (DZNE) (K.W., M.H., H.J.G.), Site Rostock/Greifswald; Department of Psychiatry and Psychotherapy (K.W., H.J.G.) and Institute of Diagnostic Radiology and Neuroradiology (S.L.), University Medicine Greifswald, Germany; Department of Pharmacology (S.H., C.C.), National University of Singapore; Memory Aging & Cognition Centre (MACC) (S.H., C.C., M.K.I.), National University Health System, Singapore; Saw Swee Hock School of Public Health (S.H.), National University of Singapore; Department of Biomedical Data Sciences (F.D.), Stanford University, CA; J. Philip Kistler Stroke Research Center (P.Y.), Department of Neurology, Massachusetts General Hospital, Harvard Medical School, Boston; The Machine Learning Section (M.B.), Department of Computer Science, University of Copenhagen, Denmark; Neuroimage Analytics Laboratory (NAL) and the Biggs Institute Neuroimaging Core (BINC) (M.H.), Glenn Biggs Institute for Alzheimer's and Neurodegenerative Diseases, University of Texas Health Science Center San Antonio (UTHSCSA), TX; and Latin American Brain Health (BrainLat) (H.H.H.A.), Universidad Adolfo Ibáñez, Santiago, Chile., Adams HHH; From the Departments of Clinical Genetics (T.E.E., M.J.K., H.H.H.A.), Radiology and Nuclear Medicine (T.E.E., F.D., K.M.H.W., P.Y., M.B., H.H.H.A., M.W.V.), Epidemiology (M.J.K., M.A.I., P.Y., M.K.I., M.W.V.), and Neurology (M.K.I.), Erasmus MC, Rotterdam, the Netherlands; Department of Neurology (P.S., P.K., R.S.), Medical University of Graz, Austria; German Center for Neurodegenerative Diseases (DZNE) (K.W., M.H., H.J.G.), Site Rostock/Greifswald; Department of Psychiatry and Psychotherapy (K.W., H.J.G.) and Institute of Diagnostic Radiology and Neuroradiology (S.L.), University Medicine Greifswald, Germany; Department of Pharmacology (S.H., C.C.), National University of Singapore; Memory Aging & Cognition Centre (MACC) (S.H., C.C., M.K.I.), National University Health System, Singapore; Saw Swee Hock School of Public Health (S.H.), National University of Singapore; Department of Biomedical Data Sciences (F.D.), Stanford University, CA; J. Philip Kistler Stroke Research Center (P.Y.), Department of Neurology, Massachusetts General Hospital, Harvard Medical School, Boston; The Machine Learning Section (M.B.), Department of Computer Science, University of Copenhagen, Denmark; Neuroimage Analytics Laboratory (NAL) and the Biggs Institute Neuroimaging Core (BINC) (M.H.), Glenn Biggs Institute for Alzheimer's and Neurodegenerative Diseases, University of Texas Health Science Center San Antonio (UTHSCSA), TX; and Latin American Brain Health (BrainLat) (H.H.H.A.), Universidad Adolfo Ibáñez, Santiago, Chile. h.adams@erasmusmc.nl., Vernooij MW; From the Departments of Clinical Genetics (T.E.E., M.J.K., H.H.H.A.), Radiology and Nuclear Medicine (T.E.E., F.D., K.M.H.W., P.Y., M.B., H.H.H.A., M.W.V.), Epidemiology (M.J.K., M.A.I., P.Y., M.K.I., M.W.V.), and Neurology (M.K.I.), Erasmus MC, Rotterdam, the Netherlands; Department of Neurology (P.S., P.K., R.S.), Medical University of Graz, Austria; German Center for Neurodegenerative Diseases (DZNE) (K.W., M.H., H.J.G.), Site Rostock/Greifswald; Department of Psychiatry and Psychotherapy (K.W., H.J.G.) and Institute of Diagnostic Radiology and Neuroradiology (S.L.), University Medicine Greifswald, Germany; Department of Pharmacology (S.H., C.C.), National University of Singapore; Memory Aging & Cognition Centre (MACC) (S.H., C.C., M.K.I.), National University Health System, Singapore; Saw Swee Hock School of Public Health (S.H.), National University of Singapore; Department of Biomedical Data Sciences (F.D.), Stanford University, CA; J. Philip Kistler Stroke Research Center (P.Y.), Department of Neurology, Massachusetts General Hospital, Harvard Medical School, Boston; The Machine Learning Section (M.B.), Department of Computer Science, University of Copenhagen, Denmark; Neuroimage Analytics Laboratory (NAL) and the Biggs Institute Neuroimaging Core (BINC) (M.H.), Glenn Biggs Institute for Alzheimer's and Neurodegenerative Diseases, University of Texas Health Science Center San Antonio (UTHSCSA), TX; and Latin American Brain Health (BrainLat) (H.H.H.A.), Universidad Adolfo Ibáñez, Santiago, Chile.

Publikováno v: Neurology [Neurology] 2023 Jan 10; Vol. 100 (2), pp. e107-e122. Date of Electronic Publication: 2022 Oct 17.