5-Alkoxy-1-aryl-3-polyfluoroalkylpyrazoles with Antinociceptive Activity: Partial Agonists of TRPV1 Ion Channels.

Autor: Khudina OG; Ural Branch of the Russian Academy of Sciences, Postovsky Institute of Organic Synthesis, S. Kovalevskoi St., 22, Ekaterinburg, 620108, Russia., Burgart YV; Ural Branch of the Russian Academy of Sciences, Postovsky Institute of Organic Synthesis, S. Kovalevskoi St., 22, Ekaterinburg, 620108, Russia., Malkova NA; Ural Branch of the Russian Academy of Sciences, Postovsky Institute of Organic Synthesis, S. Kovalevskoi St., 22, Ekaterinburg, 620108, Russia., Shchegolkov EV; Ural Branch of the Russian Academy of Sciences, Postovsky Institute of Organic Synthesis, S. Kovalevskoi St., 22, Ekaterinburg, 620108, Russia., Krasnykh OP; Scientific and Educational Center for Applied Chemical-Biological Research, Perm National Research Polytechnic University, Komsomolsky Av., 29, Perm, 614990, Russia., Triandafilova GA; Scientific and Educational Center for Applied Chemical-Biological Research, Perm National Research Polytechnic University, Komsomolsky Av., 29, Perm, 614990, Russia., Malysheva KO; Scientific and Educational Center for Applied Chemical-Biological Research, Perm National Research Polytechnic University, Komsomolsky Av., 29, Perm, 614990, Russia., Solodnikov SY; Scientific and Educational Center for Applied Chemical-Biological Research, Perm National Research Polytechnic University, Komsomolsky Av., 29, Perm, 614990, Russia., Dubodel ES; The Russian Academy of Sciences, Shemyakin-Ovchinnikov Institute of Bioorganic Chemistry, Miklukho-Maklaya St., 16/10, Moscow, 117997, Russia., Korolkova YV; The Russian Academy of Sciences, Shemyakin-Ovchinnikov Institute of Bioorganic Chemistry, Miklukho-Maklaya St., 16/10, Moscow, 117997, Russia., Kozlov SA; The Russian Academy of Sciences, Shemyakin-Ovchinnikov Institute of Bioorganic Chemistry, Miklukho-Maklaya St., 16/10, Moscow, 117997, Russia., Borisevich SS; The Russian Academy of Sciences, Ufa Institute of Chemistry, Octyabrya Av., 71, Ufa, 450078, Russia., Mozhaitsev ES; Siberian Branch of the Russian Academy of Sciences, N. N. Vorozhtsov Novosibirsk Institute of Organic Chemistry, Lavrentiev Av., 9, Novosibirsk, 630090, Russia., Saloutin VI; Ural Branch of the Russian Academy of Sciences, Postovsky Institute of Organic Synthesis, S. Kovalevskoi St., 22, Ekaterinburg, 620108, Russia.

Publikováno v: ChemMedChem [ChemMedChem] 2023 Jun 15; Vol. 18 (12), pp. e202300063. Date of Electronic Publication: 2023 Apr 17.