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of 3
pro vyhledávání: '"Dubhe B. Bulté"'
Autor:
Juan A. Martínez, Dubhe B. Bulté, Martha A. Contreras, Laura A. Palomares, Octavio T. Ramírez
Publikováno v:
Frontiers in Bioengineering and Biotechnology, Vol 8 (2020)
Chinese hamster ovary (CHO) cell culture has a major importance on the production of biopharmaceuticals, including recombinant therapeutic proteins such as monoclonal antibodies (MAb). Mathematical modeling of biological systems can successfully asse
Externí odkaz:
https://doaj.org/article/7d51b82e1c12434dbdb38dc413d1d9fa
Autor:
Johan B. Rojek, Yogesh Basavaraju, Saranya Nallapareddy, Dubhe B. Bulté, Roland Baumgartner, Sanne Schoffelen, Lise M. Grav, Steffen Goletz, Lasse E. Pedersen
Publikováno v:
Rojek, J B, Basavaraju, Y, Nallapareddy, S, Ocaña, D B B, Baumgartner, R, Schoffelen, S, Grav, L M, Goletz, S & Pedersen, L E 2023, ' Expanding the CRISPR toolbox for Chinese hamster ovary cells with comprehensive tools for Mad7 genome editing ', Biotechnology and Bioengineering, vol. 120, no. 6, pp. 1478-1491 . https://doi.org/10.1002/bit.28367
The production of high-value biopharmaceuticals is dominated by mammalian production cells, particularly Chinese Hamster Ovary (CHO) cells, which have been widely used and preferred in manufacturing processes. The discovery of CRISPR-Cas9 significant
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::91caf044e2db16ca0a19316de7c4310b
https://doi.org/10.1002/bit.28367
https://doi.org/10.1002/bit.28367
Autor:
Dubhe B. Bulté, Carolina Gómez Parra, Martha A. Contreras, Octavio T. Ramírez, Lilia G Noriega, Juan A. Martínez, Laura A. Palomares
Publikováno v:
Biotechnology and bioengineeringREFERENCES. 117(9)
Chinese hamster ovary (CHO) cells are characterized by a low glucose catabolic efficiency, resulting in undesirable lactate production. Here, it is hypothesized that such low efficiency is determined by the transport of pyruvate into the mitochondria
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::941c721f8c1666e8adbbf4012a6cfe64
https://pubmed.ncbi.nlm.nih.gov/32436990
https://pubmed.ncbi.nlm.nih.gov/32436990