Zobrazeno 1 - 10
of 20
pro vyhledávání: '"Duane R. Pilch"'
Autor:
Duane R. Pilch, James E. Haber, Robert Shroff, Michael Lichten, William M. Bonner, John H.J. Petrini, Ayelet Arbel-Eden, Grzegorz Ira
Publikováno v:
Current Biology. 14:1703-1711
Background: In response to DNA double-strand breaks (DSBs), eukaryotic cells rapidly phosphorylate histone H2A isoform H2AX at a C-terminal serine (to form γ-H2AX) and accumulate repair proteins at or near DSBs. To date, these events have been defin
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::0a4815482ad8481c07324388b7562e2c
https://doi.org/10.1016/j.cub.2004.09.047
https://doi.org/10.1016/j.cub.2004.09.047
Autor:
Oscar Fernandez-Capetillo, David W. Staudt, André Nussenzweig, Alicia Lee, Arkady Celeste, Michael J. Kruhlak, Robert F. Bonner, Duane R. Pilch, William M. Bonner
Publikováno v:
Nature Cell Biology. 5:675-679
Histone H2AX is rapidly phosphorylated in the chromatin micro-environment surrounding a DNA double-strand break (DSB). Although H2AX deficiency is not detrimental to life, H2AX is required for the accumulation of numerous essential proteins into irra
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::6655f0678aba8fe8bf4e9687d534fb27
https://doi.org/10.1038/ncb1004
https://doi.org/10.1038/ncb1004
Autor:
Duane R. Pilch, Emmy P. Rogakou, Christophe E. Redon, Noel F. Lowndes, Ann Orr, William M. Bonner
Publikováno v:
EMBO reports. 4:678-684
Cells maintain genomic stability by the coordination of DNA-damage repair and cell-cycle checkpoint control. In replicating cells, DNA damage usually activates intra-S-phase checkpoint controls, which are characterized by delayed S-phase progression
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::1b6deb80f453aca28d01a65525c073ea
https://doi.org/10.1038/sj.embor.embor871
https://doi.org/10.1038/sj.embor.embor871
Autor:
Bernardo Reina-San-Martin, Alexandru Olaru, R. Daniel Camerini-Otero, Katia Manova, Duane R. Pilch, Oscar Fernandez-Capetillo, Michel C. Nussenzweig, Michael Eckhaus, Christophe E. Redon, Michael J. Difilippantonio, William M. Bonner, Olga A. Sedelnikova, Hua Tang Chen, Simone Petersen, Ferenc Livak, Vincenzo Coppola, Peter J. Romanienko, Arkady Celeste, Eric Meffre, Lino Tessarollo, André Nussenzweig
Publikováno v:
Science. 296:922-927
Higher order chromatin structure presents a barrier to the recognition and repair of DNA damage. Double-strand breaks (DSBs) induce histone H2AX phosphorylation, which is associated with the recruitment of repair factors to damaged DNA. To help clari
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::57f2042d5fe1071447f4e3a6a6c77cec
https://doi.org/10.1126/science.1069398
https://doi.org/10.1126/science.1069398
Autor:
Olga A. Sedelnikova, Emmy P. Rogakou, Kenneth Newrock, Christophe E. Redon, Duane R. Pilch, William M. Bonner
Publikováno v:
Current Opinion in Genetics & Development. 12:162-169
Two of the nucleosomal histone families, H3 and H2A, have highly conserved variants with specialized functions. Recent studies have begun to elucidate the roles of two of the H2A variants, H2AX and H2AZ. H2AX is phosphorylated on a serine four residu
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::4fab217e96341cc3d5729b8710fff353
https://doi.org/10.1016/s0959-437x(02)00282-4
https://doi.org/10.1016/s0959-437x(02)00282-4
Autor:
Christophe E. Redon, Leif Hanitsch, Patrick C. Wilson, Masamichi Muramatsu, Bernardo Reina-San-Martin, Rafael Casellas, Thomas Ried, Michael J. Difilippantonio, Tasuku Honjo, Hua Tang Chen, Arkady Celeste, William M. Bonner, Simone Petersen, Duane R. Pilch, Michel C. Nussenzweig, André Nussenzweig
Publikováno v:
Nature. 414:660-665
Class switch recombination (CSR) is a region-specific DNA recombination reaction that replaces one immunoglobulin heavy-chain constant region (Ch) gene with another. This enables a single variable (V) region gene to be used in conjunction with differ
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::dd123450b89793fc4b93f8f20ccc2170
https://doi.org/10.1038/414660a
https://doi.org/10.1038/414660a
Publikováno v:
Journal of Biological Chemistry. 273:5858-5868
When mammalian cell cultures or mice are exposed to ionizing radiation in survivable or lethal amounts, novel mass components are found in the histone H2A region of two-dimensional gels. Collectively referred to as gamma, these components are formed
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::64beb1cd3e2af78020bf61ab10f1b940
https://doi.org/10.1074/jbc.273.10.5858
https://doi.org/10.1074/jbc.273.10.5858
Publikováno v:
Nucleic Acids Research. 24:4525-4534
Chimeric genes which contained the mouse U1b snRNA promoter, portions of the histone H2a or globin coding regions and the U1b 3'-end followed by a histone 3'-end were constructed. The distance between the U1 promoter and the U1 3' box was varied betw
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::54729eb2d79aa49538255ffed75d9b43
https://doi.org/10.1093/nar/24.22.4525
https://doi.org/10.1093/nar/24.22.4525
Publikováno v:
Cancer Biology & Therapy. 2:233-235
Laboratory of Molecular Pharmacology; Center for Cancer Research; NationalCancer Institute; National Institutes of Health; Bethesda, Maryland USA*Correspondence to: William M Bonner; NIH/NCI/CCR/LMP; Bldg. 37 Rm. 5050AMSC 4255; 9000 Rockville Pike; B
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::48dfb1141f266c8dc2b6b2eed3014070
https://doi.org/10.4161/cbt.2.3.373
https://doi.org/10.4161/cbt.2.3.373
Autor:
Vessela S. Ivanova, William M. Bonner, Ann Orr, Duane R. Pilch, Christopher L. Hatch, Cecilia Mannironi
Publikováno v:
DNA and Cell Biology. 13:161-170
To help elucidate the factors regulating the expression of histone multigene families in proliferating cells, we asked whether the relative expression of different members of such a family was dependent upon or independent of the type of proliferatin
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::25b3291d7186e16ae8e0df8e854643bd
https://doi.org/10.1089/dna.1994.13.161
https://doi.org/10.1089/dna.1994.13.161