Zobrazeno 1 - 10
of 67
pro vyhledávání: '"Duane L. Venton"'
Autor:
Caleb E. Finch, Kirsten L. Viola, Mary P. Lambert, Lei Chang, Jiaxin Yu, Todd E. Morgan, Brett A. Chromy, Duane L. Venton, William L. Klein, Grant A. Krafft
Publikováno v:
Journal of Neurochemistry. 79:595-605
In recent studies of transgenic models of Alzheimer's disease (AD), it has been reported that antibodies to aged beta amyloid peptide 1-42 (Abeta(1-42)) solutions (mixtures of Abeta monomers, oligomers and amyloid fibrils) cause conspicuous reduction
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::96098a176f10436a2a383b9568dfcf66
https://doi.org/10.1046/j.1471-4159.2001.00592.x
https://doi.org/10.1046/j.1471-4159.2001.00592.x
Publikováno v:
Journal of Medicinal Chemistry. 47:3329-3333
Recent studies have indicated that the most important role of beta-amyloid peptide (Abeta) in the etiology of Alzheimer's disease may not be in plaque formation but in the formation of soluble, metastable Abeta(1-42) neurotoxic intermediates (called
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::557cf294e5609d88f59bbcc1f082ea82
https://doi.org/10.1021/jm034224e
https://doi.org/10.1021/jm034224e
Publikováno v:
Bioorganic & Medicinal Chemistry. 10:3291-3299
Per-6-substituted- and A,C,E(F)-tri-6-substituted-6-deoxy-β-cyclodextrin (β-CD) libraries were generated using solution-phase combinatorial chemistry techniques starting from the corresponding iodo precursors and different combinations of individua
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::b8671abde59b40b57327f8388fe5e512
https://doi.org/10.1016/s0968-0896(02)00205-5
https://doi.org/10.1016/s0968-0896(02)00205-5
Autor:
Charles P. Woodbury, Duane L. Venton
Publikováno v:
Chemometrics and Intelligent Laboratory Systems. 48:131-150
Combinatorial chemistry has taken the pharmaceutical industry by storm, and is now widely applied at the leading edge of the drug discovery process. An approach to quickly survey structural space, combinatorial chemistry has stimulated development of
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::24669c42bce410568117ba71e3addabe
https://doi.org/10.1016/s0169-7439(99)00009-x
https://doi.org/10.1016/s0169-7439(99)00009-x
Publikováno v:
Analytical Biochemistry. 261:164-182
We describe a new method for measuring binding constants, pulsed ultrafiltration. In this technique, a single injection or “pulse” of ligand is passed through a cell containing macromolecules confined by a conventional ultrafiltration membrane. A
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::62ecc3eb53fdd06dc527bc9f7fdcc0dc
https://doi.org/10.1006/abio.1998.2722
https://doi.org/10.1006/abio.1998.2722
Autor:
Duane L. Venton, Yongzhong Zhao, Chao Ran Huang, Dejan Nikolic, RB van Breemen, Charles P. Woodbury
Publikováno v:
Analytical Chemistry. 69:2159-2164
In response to the need for rapid screening of combinatorial libraries to identify new lead compounds during drug discovery, we have developed an on-line combination of ultrafiltration and electrospray mass spectrometry, called pulsed ultrafiltration
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::60af96b551cba0bd668e926a45a2631f
https://doi.org/10.1021/ac970132j
https://doi.org/10.1021/ac970132j
Autor:
Patrick G. Swann, Guy C. Le Breton, Urszula Slomczynska, Anton J. Hopfinger, Minka Urbancic, Archana Desai, Mary M. Frauenhoff, Duane L. Venton, Rose A. Casanova
Publikováno v:
Biopolymers. 40:617-625
We sought to develop a peptide library in solution and dynamically screen this library for peptides that would bind to macromolecules of interest. Peptide diversity was achieved in an initial stock solution of peptides by using proteases under condit
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::5f982e68bb469104bfd61d44a5137284
https://doi.org/10.1002/(sici)1097-0282(1996)40:6<617::aid-bip3>3.0.co
https://doi.org/10.1002/(sici)1097-0282(1996)40:6<617::aid-bip3>3.0.co
Autor:
Eswari Gudipati, Duane L. Venton
Publikováno v:
Biochimica et Biophysica Acta (BBA) - Protein Structure and Molecular Enzymology. 1250:117-125
The present study expands previous work [(1984) Biochim. Biophys. Acta. 797, 343-347] by showing that organo-functionalized polysiloxane copolymers could entrap two of the most frequently immobilized enzymes, i.e. urease and invertase with retention
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::9ba6ad158ee98c6b953ad1bbffecfbb4
https://doi.org/10.1016/0167-4838(95)00079-a
https://doi.org/10.1016/0167-4838(95)00079-a
Autor:
Duane L. Venton, Eswari Gudipati
Publikováno v:
Biochimica et Biophysica Acta (BBA) - Protein Structure and Molecular Enzymology. 1250:126-136
Results presented in the companion paper suggested that the protein itself might be actively involved in the polymerization process while being entrapped in polysiloxane polymers. It was speculated that the organo-functional side chains on the silano
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::24e626df341e3822f403822254ced97b
https://doi.org/10.1016/0167-4838(95)00080-e
https://doi.org/10.1016/0167-4838(95)00080-e
Publikováno v:
European Journal of Medicinal Chemistry. 30:321-326
Summary The title compounds have been synthesized and their in vitro thromboxane A2 (TxA2) receptor antagonist activity evaluated. Both cis and trans isomers (1, 2) were shown to specifically inhibit submaximal human platelet aggregation induced by 2
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::ced1f748ea658e461e3e63d70c149e72
https://doi.org/10.1016/0223-5234(96)88240-7
https://doi.org/10.1016/0223-5234(96)88240-7