Zobrazeno 1 - 10
of 83
pro vyhledávání: '"Duane H. Hamilton"'
Autor:
Sagar R. Shah, Justin M. David, Nathaniel D. Tippens, Ahmed Mohyeldin, Juan C. Martinez-Gutierrez, Sara Ganaha, Paula Schiapparelli, Duane H. Hamilton, Claudia Palena, Andre Levchenko, Alfredo Quiñones-Hinojosa
Publikováno v:
Cell Reports, Vol 21, Iss 2, Pp 495-507 (2017)
Summary: Molecular factors that define stem cell identity have recently emerged as oncogenic drivers. For instance, brachyury, a key developmental transcriptional factor, is also implicated in carcinogenesis, most notably of chordoma, through mechani
Externí odkaz:
https://doaj.org/article/9a097c96397848789a733c1da1ff6a42
Publikováno v:
Frontiers in Oncology, Vol 8 (2018)
The acquisition of mesenchymal features by carcinoma cells is now recognized as a driver of metastasis and tumor resistance to a range of anticancer therapeutics, including chemotherapy, radiation, and certain small-molecule targeted therapies. With
Externí odkaz:
https://doaj.org/article/fff7367ee457439dbb1c9d4081ea0849
Autor:
Renee N Donahue, Jeffrey Schlom, James L Gulley, James W Hodge, Claudia Palena, Duane H Hamilton, Sofia R Gameiro
Publikováno v:
Journal for ImmunoTherapy of Cancer, Vol 12, Iss 7 (2024)
The development of vaccines, especially RNA-based, directed against patient-specific tumor neoepitopes is an active and productive area of cancer immunotherapy. Promising clinical results in melanoma and other solid tumor types are emerging. As with
Externí odkaz:
https://doaj.org/article/a0dfb2ad06104e178521dabe0f22daa7
Autor:
Jeffrey Schlom, Claudia Palena, Kristen Fousek, Duane H Hamilton, Lucas A Horn, Haiyan Qin, Madeline Dahut, Shantel Angstadt
Publikováno v:
Journal for ImmunoTherapy of Cancer, Vol 11, Iss 9 (2023)
Background Enzalutamide, a next-generation antiandrogen agent, is approved for the treatment of metastatic castration-resistant prostate cancer (CRPC). While enzalutamide has been shown to improve time to progression and extend overall survival in me
Externí odkaz:
https://doaj.org/article/aaee34ce72d74349a73d564f6c92a17c
Autor:
James L Gulley, Andrew Nguyen, Shahrooz Rabizadeh, Kayvan Niazi, Duane H Hamilton, Marieke Griffioen, Stephen C Benz, Patricia Spilman, Peter A Fasching, Matthias W Beckmann, Matthias Ruebner, J Zachary Sanborn, Charles J Vaske, Karin L Lee, Anita N. Kremer
Publikováno v:
Journal for ImmunoTherapy of Cancer, Vol 9, Iss 6 (2021)
Background Therapeutic regimens designed to augment the immunological response of a patient with breast cancer (BC) to tumor tissue are critically informed by tumor mutational burden and the antigenicity of expressed neoepitopes. Herein we describe a
Externí odkaz:
https://doaj.org/article/c6c241c5fc884858ab13b1108e690d29
Autor:
Kristen, Fousek, Lucas A, Horn, Haiyan, Qin, Madeline, Dahut, Masafumi, Iida, Dan, Yacubovich, Duane H, Hamilton, Anish, Thomas, Jeffrey, Schlom, Claudia, Palena
Publikováno v:
Journal of Thoracic Oncology. 18:350-368
SCLC is a highly aggressive tumor with a 5-year survival rate of less than 6%. A heterogeneous disease, SCLC is classified into four subtypes that include tumors with neuroendocrine and non-neuroendocrine features. Immune checkpoint blockade has been
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::c21a8f404e2dc557baa1ad56a5650bcc
https://doi.org/10.1016/j.jtho.2022.11.008
https://doi.org/10.1016/j.jtho.2022.11.008
Autor:
S. Elizabeth Franks, Ginette S. Santiago-Sanchez, Kellsye P. Fabian, Kristen Solocinski, Paul L. Chariou, Duane H. Hamilton, Joshua T. Kowalczyk, Michelle R. Padget, Sofia R. Gameiro, Jeffrey Schlom, James W. Hodge
Publikováno v:
Cancer Immunology, Immunotherapy.
There is strong evidence that chemotherapy can induce tumor necrosis which can be exploited for the targeted delivery of immuno-oncology agents into the tumor microenvironment (TME). We hypothesized that docetaxel, a chemotherapeutic agent that induc
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::d29858f0b78507088b0f683a8c29d5cf
https://doi.org/10.1007/s00262-023-03459-7
https://doi.org/10.1007/s00262-023-03459-7
Autor:
Duane H. Hamilton, Jeffrey Schlom, Kayvan Niazi, Patrick Soon-Shiong, Shahrooz Rabizadeh, John H. Lee, Lars Rohlin, Peter Ordentlich, Zhen Su, John Z. Sanborn, Claudia Palena, Sofia R. Gameiro, Andrew Nguyen, Kristin C. Hicks, Stephen C. Benz, Karin L. Lee
Supplementary figures and tables
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::76402d3621e33d3448c35be905e61c29
https://doi.org/10.1158/2326-6066.22542444
https://doi.org/10.1158/2326-6066.22542444
Autor:
Duane H. Hamilton, Jeffrey Schlom, Kayvan Niazi, Patrick Soon-Shiong, Shahrooz Rabizadeh, John H. Lee, Lars Rohlin, Peter Ordentlich, Zhen Su, John Z. Sanborn, Claudia Palena, Sofia R. Gameiro, Andrew Nguyen, Kristin C. Hicks, Stephen C. Benz, Karin L. Lee
Progressive tumor growth is associated with deficits in the immunity generated against tumor antigens. Vaccines targeting tumor neoepitopes have the potential to address qualitative defects; however, additional mechanisms of immune failure may underl
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::3729fdc3b7646646a9bd407d7f4fe26d
https://doi.org/10.1158/2326-6066.c.6549930.v1
https://doi.org/10.1158/2326-6066.c.6549930.v1
Autor:
Claudia Palena, Duane H. Hamilton, Bruce Huang, Romaine I. Fernando, Joseph R. Cohen, Cecilia Larocca
PDF file - 89K, TGF-β1 secretion in LNCap and H520 cells.
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::6baecd56cee11709c81b4bceaed3dacf
https://doi.org/10.1158/1535-7163.22500876
https://doi.org/10.1158/1535-7163.22500876