Zobrazeno 1 - 10
of 15
pro vyhledávání: '"Duane E. Rudisill"'
Autor:
David R. Snead, Yonghong Gan, Thomas Scattolin, Dinesh J. Paymode, Michal Achmatowicz, Duane E. Rudisill, Ephraim S. Vidal, Tawfik Gharbaoui, Phil Roberts, Jianbo Yang, Zhangbing Shi, Wei Liu, Joshua Bolger, Zhen Qiao, Cheng-yi Chen
Publikováno v:
Organic Process Research & Development. 27:530-538
A commercial route to MRTX849 (adagrasib) was developed to support clinical and commercial needs. Yield was improved to 32% over six chemical steps. A doubly regioselective SNAr reduced consumption of an expensive chiral intermediate, reaction optimi
Autor:
Vanasse Benoit J, Loc T. Tran, Juan Gamboa, Xuemin Chen, Timothy A. Ayers, Xiaodong Wu, Nakyen Choy, Rocco Disanto, Duane E. Rudisill, Duc P. Ngo, Ying Jiang, Geoffrey A. D'netto, Gardetto Anthony J, Sithamalli V. Chandramouli, David J. Lythgoe, Frederick Roberts, Narendra Kumar, Matthew R. Powers, Andrew W. Bridge, James H. Peers, Warren Copeland, Clive Pemberton
Publikováno v:
Organic Process Research & Development. 16:484-494
An enantioselective Overman 3,3-sigmatropic rearrangement on a quinuclidine skeleton was developed for the pilot-plant synthesis of a glycine transporter 1 inhibitor. The first stereocenter was produced by a Ru-catalyzed asymmetric transfer hydrogena
Autor:
John J. Shay, Hyacinthe Yarabe, Duane E. Rudisill, Bao-Guo Huang, Clive Pemberton, Matthew R. Powers, Hanna Reda G, Ann Marie Gelormini, Juan A Gamboa, James H. Peers, Kubiak Gregory G
Publikováno v:
Organic Process Research & Development. 15:1040-1045
The development of a scalable process for 3-arylsulfanyl-1H-pyrrolo[3,2-b]pyridine-2-carboxylic acid amides (1), potent casein kinase I inhibitors, is described. The rapid identification of suitabl...
Autor:
Richard H. Heyn, Duane E. Rudisill, Christopher J. Kozak, Kenneth I. Hardcastle, Beverly A. Barnum, Jeffrey W. McMillan, Gregory M. Williams
Publikováno v:
Journal of the American Chemical Society. 112:205-215
Deprotonation of (cycloheptatriene) Fe(CO) 3 gives a deep red nucleophilic anion (C 7 H 7 )Fe(CO) 3 (K + ), Anion reacts with acid chlorides to give (7-exo-acyl-C 7 H 7 ) Fe(CO) 3 complexes, in high yield. The products were characterized by spectrosc
Autor:
John K. Stille, Duane E. Rudisill
Publikováno v:
ChemInform. 21
The palladium(0)-catalyzed cross-coupling reaction of alkynylstannanes with 2-bromoanilines or 2-trifloxyanilines results in the formation of 2-alkynylanilines. The coupling reaction tolerates substituents on the anilines, including ester, ether, chl
Autor:
Kenneth I. Hardcastle, Richard H. Heyn, Duane E. Rudisill, Jeffrey W. McMillan, Beverly A. Barnum, Christopher J. Kozak, Gregory M. Williams
Publikováno v:
ChemInform. 21
Deprotonation of (cycloheptatriene) Fe(CO) 3 gives a deep red nucleophilic anion (C 7 H 7 )Fe(CO) 3 (K + ), Anion reacts with acid chlorides to give (7-exo-acyl-C 7 H 7 ) Fe(CO) 3 complexes, in high yield. The products were characterized by spectrosc
Publikováno v:
Tetrahedron Letters. 29:1509-1512
Hydrozirconation of propargylamine ( 2 ) followed by cleavage with iodine leads to the formation of (E)-vinyl iodide ( 4 ). Palladium catalyzed coupling of 4 and 3,3-dimethylbutynylstannane results in the formation of Terbinafine ( 1a ).
Autor:
Gregory M. Williams, Duane E. Rudisill
Publikováno v:
Inorganic Chemistry. 28:797-800
Publikováno v:
The Journal of Organic Chemistry. 53:1170-1176
Autor:
Duane E. Rudisill, Gregory M Williams
Publikováno v:
Tetrahedron Letters. 27:3465-3468
The anion derived by deprotonating (cycloheptatriene)Fe(CO) 3 reacts with acid chlorides to give exo C-7 substitution. The acyl group is readily isomerized to C-5 on treatment with base. The C-7 acylated products can be deprotonated; the resulting an