Zobrazeno 1 - 10
of 22
pro vyhledávání: '"Duane E, DeMong"'
Autor:
David A. Candito, Vladimir Simov, Anmol Gulati, Solomon Kattar, Ryan W. Chau, Blair T. Lapointe, Joey L. Methot, Duane E. DeMong, Thomas H. Graham, Ravi Kurukulasuriya, Mitchell H. Keylor, Ling Tong, Gregori J. Morriello, John J. Acton, Barbara Pio, Weiguo Liu, Jack D. Scott, Michael J. Ardolino, Theodore A. Martinot, Matthew L. Maddess, Xin Yan, Hakan Gunaydin, Rachel L. Palte, Spencer E. McMinn, Lisa Nogle, Hongshi Yu, Ellen C. Minnihan, Charles A. Lesburg, Ping Liu, Jing Su, Laxminarayan G. Hegde, Lily Y. Moy, Janice D. Woodhouse, Robert Faltus, Tina Xiong, Paul Ciaccio, Jennifer A. Piesvaux, Karin M. Otte, Matthew E. Kennedy, David Jonathan Bennett, Erin F. DiMauro, Matthew J. Fell, Santhosh Neelamkavil, Harold B. Wood, Peter H. Fuller, J. Michael Ellis
Publikováno v:
Journal of Medicinal Chemistry. 65:16801-16817
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::365ba0e1a6a6d085b4344b637344b726
https://doi.org/10.1021/acs.jmedchem.2c01605
https://doi.org/10.1021/acs.jmedchem.2c01605
Autor:
Joel M. Harris, Xiaoping Zhou, John A. Morrow, Sue-Ing Lin, Marco A. S. Baptista, John M. Sanders, Xiaoping Zhang, Hong Mei, Mark W. Embrey, Sylvie M. Sur, Duane E. DeMong, Ravi P. Nargund, Alan Hruza, Heather E. Tiscia, Matthew J. Fell, Zhizhang Yin, Gautam Agnihotri, Honglu Zhang, Thomas J. Greshock, Jack D. Scott, Yinghui Lin, Zhi-Cai Shi, John A. Mccauley, Sarah W. Li, Ronald K. Chang, Mark T. Bilodeau, Michael W. Miller, Reshma Kuvelkar, Andrew Stamford, Marc Poirier, Hong Liu, Megan K. Macala, Kallol Basu, Li Xiao, Lynn A. Hyde, Jonathan T. Kern, Xing Dai, Christian Mirescu, Paul L. Walsh, Matthew E. Kennedy, John J. Renger, Zhiyong Hu, John Columbus, Robert E. Drolet, Eric M. Parker
Publikováno v:
Journal of medicinal chemistry. 60(7)
Leucine-rich repeat kinase 2 (LRRK2) is a large, multidomain protein which contains a kinase domain and GTPase domain among other regions. Individuals possessing gain of function mutations in the kinase domain such as the most prevalent G2019S mutati
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::4d2ca3dd5156b7d725b7ec9d610b7b59
https://pubmed.ncbi.nlm.nih.gov/28245354
https://pubmed.ncbi.nlm.nih.gov/28245354
Autor:
Jean E. Lachowicz, Kung-I Feng, Joyce J. Hwa, Jitendra D. Belani, Michael Wong, Ling Kang, Diane Grotz, Wensheng Yu, Sue-Ing Lin, Yang Cao, Andrew Stamford, Richard A. Morrison, Peishan Lin, Duane E. DeMong, Hongtao Zhang, Peng Dai, Jolicia Gauuan, Christopher Sondey, Joseph A. Kozlowski, He Zhao, Mark Liang, Ying Zhai, Brian J. Lavey, Xing Dai, Aileen Soriano, Tao Meng, Ping Chen, De-Yi Yang, William J. Greenlee, Bradley Prudence K, Kathleen Cox, Bhuneshwari Patel, Paul McNamara, Jesse K. Wong, Michael W. Miller, Guowei Zhou, Teresa Andreani
Publikováno v:
Journal of Medicinal Chemistry. 57:2601-2610
A novel series of spiroimidazolone-based antagonists of the human glucagon receptor (hGCGR) has been developed. Our efforts have led to compound 1, N-((2H-tetrazol-5-yl)methyl)-4-((R)-1-((5r,8R)-8-(tert-butyl)-3-(3,5-dichlorophenyl)-2-oxo-1,4-diazasp
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::1d79521da6469de081b15fb4cf46d71d
https://doi.org/10.1021/jm401858f
https://doi.org/10.1021/jm401858f
Publikováno v:
Organic Letters. 15:2830-2833
A series of 4-arylimidazolones have been accessed via late-stage, palladium-mediated arylation of acetone- and cyclohexanone-derived 4-chloroimidazolones. The 4-chloroimidazolones were prepared via a novel rearrangement of the corresponding imidazolo
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::49611f38a7e9fba53d9087cca2f67ff7
https://doi.org/10.1021/ol401165e
https://doi.org/10.1021/ol401165e
Autor:
Michelle D. Smith, Eric M. Parker, Lynn A. Hyde, Kallol Basu, Hong Mei, J. Michael Ellis, Frederique M. Poulet, Matthew E. Kennedy, Michael W. Miller, Xiaoping Zhou, Duane E. DeMong, Boonlert Cheewatrakoolpong, John A. Morrow, Yinghui Lin, Matthew J. Fell, Zhizhang Yin, Jack D. Scott, Carrie G. Markgraf, Christian Mirescu
Publikováno v:
The Journal of pharmacology and experimental therapeutics. 355(3)
Mutations in the leucine-rich repeat kinase 2 (LRRK2) gene are the most common genetic cause of familial and sporadic Parkinson's disease (PD). That the most prevalent mutation, G2019S, leads to increased kinase activity has led to a concerted effort
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::e2ca92ba39cf6f27ca83cb5f2fa840e4
https://pubmed.ncbi.nlm.nih.gov/26407721
https://pubmed.ncbi.nlm.nih.gov/26407721
Autor:
Duane E. DeMong, Robert M. Williams
Publikováno v:
Tetrahedron Letters. 42:3529-3532
An improved asymmetric synthesis of the guanidine-containing amino acid (2 S ,3 R )-capreomycidine has been achieved in seven steps and 28% overall yield. The key synthetic step involved a Mannich-type reaction between a chiral glycine aluminum enola
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::896331ffab5229c5ac58d183f5542310
https://doi.org/10.1016/s0040-4039(01)00487-7
https://doi.org/10.1016/s0040-4039(01)00487-7
Publikováno v:
ChemInform. 44
A series of 4-arylimidazolones have been accessed via late-stage, palladium-mediated arylation of acetone- and cyclohexanone-derived 4-chloroimidazolones. The 4-chloroimidazolones were prepared via a novel rearrangement of the corresponding imidazolo
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::c2ec0d2abf34da020128e68525c51560
https://doi.org/10.1002/chin.201340123
https://doi.org/10.1002/chin.201340123
Autor:
Duane E. DeMong, Robert M. Williams
Publikováno v:
Tetrahedron Letters. 43:2355-2357
The first asymmetric synthesis of (2S)-, and (2R)-amino-3,3-dimethoxypropanoic acid (α-formylglycine dimethylacetal) has been achieved in two steps and 91% overall yield. The key step involved the quenching of a chiral glycine titanium enolate with
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::aaf06d6ab3177c8af284a3c61a71fce6
https://doi.org/10.1016/s0040-4039(02)00269-1
https://doi.org/10.1016/s0040-4039(02)00269-1
Publikováno v:
Organic Letters. 3:4287-4289
Wittig reaction of (triphenylphosphoranylidene)acetonitrile with the lactone carbonyl of (5R,6S)-4-(benzyloxycarbonyl)-5,6-diphenyl-2,3,5,6-tetrahydro-4H-1,4-oxazin-2-one (3) and subsequent reduction generates morpholinylethylamine dihydrochloride (5
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::ab6581f046c04386e7f0a2cc49a77774
https://doi.org/10.1021/ol016959o
https://doi.org/10.1021/ol016959o
Autor:
Duane E. DeMong, Robert M. Williams
Publikováno v:
Tetrahedron Letters. 42:183-185
Asymmetric syntheses of (2 S ,3 S )- and (2 R ,3 R )-β-hydroxyornithine have been achieved in four steps and 46% overall yield. The key step in this synthesis involved an aldol reaction between a chiral glycine boron enolate and (3-oxo-propyl)-carba
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::0fe92edd51141a7e32253db4af3567ae
https://doi.org/10.1016/s0040-4039(00)01945-6
https://doi.org/10.1016/s0040-4039(00)01945-6