Zobrazeno 1 - 10
of 579
pro vyhledávání: '"Duane D. Miller"'
Autor:
Mousumi Mandal, Ahmed Rakib, Md Abdullah Al Mamun, Santosh Kumar, Frank Park, Dong-Jin Hwang, Wei Li, Duane D. Miller, Udai P. Singh
Publikováno v:
Biomedicine & Pharmacotherapy, Vol 179, Iss , Pp 117379- (2024)
Scope: Inflammatory bowel disease (IBD) is a chronic intestinal inflammatory condition of unknown etiology, although recent evidence suggests that it is caused by an excessive immune response to mucosal antigens. We determined the anti-inflammatory p
Externí odkaz:
https://doaj.org/article/68627205b8b144398d54d7ad824ae8ff
Autor:
Sarah Asemota, Wendy Effah, Kirsten L. Young, Jeremiah Holt, Linnea Cripe, Suriyan Ponnusamy, Thirumagal Thiyagarajan, Dong-Jin Hwang, Yali He, Keely Mcnamara, Daniel Johnson, Yinan Wang, Brandy Grimes, Yekta Khosrosereshki, T.J. Hollingsworth, Martin D. Fleming, Frances E. Pritchard, Ashley Hendrix, Farhan Khan, Meiyun Fan, Liza Makowski, Zheng Yin, Hironobu Sasano, D. Neil Hayes, Lawrence M. Pfeffer, Duane D. Miller, Ramesh Narayanan
Publikováno v:
Cell Reports, Vol 42, Iss 12, Pp 113461- (2023)
Summary: Triple-negative breast cancer (TNBC) is an aggressive subtype with no targeted therapeutics. The luminal androgen receptor (LAR) subtype constitutes 15% of TNBC and is enriched for androgen receptor (AR) and AR target genes. Here, we show th
Externí odkaz:
https://doaj.org/article/ac241ea52bf347e5b56f2020cc95e398
Autor:
Vivek K. Kashyap, Qinghui Wang, Saini Setua, Prashanth K. B. Nagesh, Neeraj Chauhan, Sonam Kumari, Pallabita Chowdhury, Duane D. Miller, Murali M. Yallapu, Wei Li, Meena Jaggi, Bilal Bin Hafeez, Subhash C. Chauhan
Publikováno v:
Journal of Experimental & Clinical Cancer Research, Vol 38, Iss 1, Pp 1-14 (2019)
Abstract Background The management of pancreatic cancer (PanCa) is exceptionally difficult due to poor response to available therapeutic modalities. Tubulins play a major role in cell dynamics, thus are important molecular targets for cancer therapy.
Externí odkaz:
https://doaj.org/article/7d607ed9963c4751b96e411a70836440
Publikováno v:
Frontiers in Pharmacology, Vol 12 (2021)
Melanoma is one of the deadliest skin cancers having a five-year survival rate around 15–20%. An overactivated MAPK/AKT pathway is well-established in BRAF mutant melanoma. Vemurafenib (Vem) was the first FDA-approved BRAF inhibitor and gained grea
Externí odkaz:
https://doaj.org/article/6540032f3e5f49da9a6f0ad624f66370
Publikováno v:
Pharmaceuticals, Vol 14, Iss 9, p 904 (2021)
Glioblastoma (GBM) is a deadly and incurable brain cancer with limited therapeutic options. PFI-3 is a small-molecule bromodomain (BRD) inhibitor of the BRM/BRG1 subunits of the SWI/SNF chromatin remodeling complex. The objective of this study is to
Externí odkaz:
https://doaj.org/article/da5742221075436398f2df2505adaef4
Autor:
Souvik Banerjee, Jin Wang, Susan Pfeffer, Dejian Ma, Lawrence M. Pfeffer, Shivaputra A. Patil, Wei Li, Duane D. Miller
Publikováno v:
Molecules, Vol 20, Iss 9, Pp 17152-17165 (2015)
A novel series of 5H-chromenopyridines was identified as anticancer agents in our continuing effort to discover and develop new small molecule anti-proliferative agents. Based on our initial lead SP-6-27 compound, we designed and synthesized novel tr
Externí odkaz:
https://doaj.org/article/46a71670f24a4e93aca81a2b4ef0cadc
Publikováno v:
Molecules, Vol 22, Iss 8, p 1281 (2017)
Antibody-drug conjugates (ADCs) are a class of highly potent biopharmaceutical drugs generated by conjugating cytotoxic drugs with specific monoclonal antibodies through appropriate linkers. Specific antibodies used to guide potent warheads to tumor
Externí odkaz:
https://doaj.org/article/1cdf578c9a114ff491aa6e8ec185252e
Publikováno v:
Molecules, Vol 21, Iss 11, p 1468 (2016)
Extensive research over the last decade has resulted in a number of highly potent tubulin polymerization inhibitors acting either as microtubule stabilizing agents (MSAs) or microtubule destabilizing agents (MDAs). These inhibitors have potent cytoto
Externí odkaz:
https://doaj.org/article/7ed2392200b14ed8a91eefefb88d763f
Autor:
Satyanarayana Pochampally, Kelli L. Hartman, Rui Wang, Jiaxing Wang, Mi-Kyung Yun, Keyur Parmar, Hyunseo Park, Bernd Meibohm, Stephen W. White, Wei Li, Duane D. Miller
Publikováno v:
ACS Pharmacology & Translational Science. 6:526-545
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::af219ab03b3902ba8d41b80411cfde07
https://doi.org/10.1021/acsptsci.2c00108
https://doi.org/10.1021/acsptsci.2c00108
Autor:
Wei Li, Tiffany N. Seagroves, Duane D. Miller, Hao Chen, Hilaire C. Playa, Deanna N. Parke, Zongtao Lin, Qinghui Wang, Raisa I. Krutilina, Shanshan Deng
Figure S4 shows that FACS analysis profiles of MDA-MB-231 and MDA-MB-468 TNBC cells following treatment with vehicle (Control), colchicine or paclitaxel, showing VERU-111 induces G2/M checkpoint arrest and apoptosis in TNBC cells. (A) Representative
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::4abbf7e6fa32c353eb37d21ea549a635
https://doi.org/10.1158/1535-7163.22521088.v1
https://doi.org/10.1158/1535-7163.22521088.v1
