Zobrazeno 1 - 10
of 118
pro vyhledávání: '"Duan Ni"'
Publikováno v:
BMC Medicine, Vol 22, Iss 1, Pp 1-5 (2024)
Abstract Background Breastfeeding (BF) confers metabolic benefits to infants, including reducing risks of metabolic syndrome such as obesity and diabetes later in life. However, the underlying mechanism is not yet fully understood. Hence, we aim to i
Externí odkaz:
https://doaj.org/article/d69ea066da4b4b80b43b4d3cf799e1e5
Autor:
Jibran A. Wali, Duan Ni, Harrison J. W. Facey, Tim Dodgson, Tamara J. Pulpitel, Alistair M. Senior, David Raubenheimer, Laurence Macia, Stephen J. Simpson
Publikováno v:
Nature Communications, Vol 14, Iss 1, Pp 1-12 (2023)
Abstract The metabolic effects of sugars and fat lie at the heart of the “carbohydrate vs fat” debate on the global obesity epidemic. Here, we use nutritional geometry to systematically investigate the interaction between dietary fat and the majo
Externí odkaz:
https://doaj.org/article/f5a90d3a385d45ddb77b2968864670c5
Autor:
Alanna G. Spiteri, Claire L. Wishart, Duan Ni, Barney Viengkhou, Laurence Macia, Markus J. Hofer, Nicholas J. C. King
Publikováno v:
Acta Neuropathologica Communications, Vol 11, Iss 1, Pp 1-27 (2023)
Abstract As the resident parenchymal myeloid population in the central nervous system (CNS), microglia are strategically positioned to respond to neurotropic virus invasion and have been implicated in promoting both disease resolution and progression
Externí odkaz:
https://doaj.org/article/7a43bb50ad4e4929b9aa65ff14a72977
Autor:
Jian Tan, Duan Ni, Jemma Taitz, Gabriela Veronica Pinget, Mark Read, Alistair Senior, Jibran Abdul Wali, Reem Elnour, Erin Shanahan, Huiling Wu, Steven J. Chadban, Ralph Nanan, Nicholas Jonathan Cole King, Georges Emile Grau, Stephen J. Simpson, Laurence Macia
Publikováno v:
Nature Communications, Vol 13, Iss 1, Pp 1-15 (2022)
Secretory IgA plays vital roles interfacing between the host immune system and the resident microbiota at the mucosal surface. Here the authors explore the effect of dietary protein on the production of secretory IgA, driven by the production of extr
Externí odkaz:
https://doaj.org/article/1a558a672c5147d9bc844ff084a46355
Autor:
Qiufen Zhang, Yingyi Chen, Duan Ni, Zhimin Huang, Jiacheng Wei, Li Feng, Jun-Cheng Su, Yingqing Wei, Shaobo Ning, Xiuyan Yang, Mingzhu Zhao, Yuran Qiu, Kun Song, Zhengtian Yu, Jianrong Xu, Xinyi Li, Houwen Lin, Shaoyong Lu, Jian Zhang
Publikováno v:
Acta Pharmaceutica Sinica B, Vol 12, Iss 2, Pp 876-889 (2022)
SIRT6 belongs to the conserved NAD+-dependent deacetylase superfamily and mediates multiple biological and pathological processes. Targeting SIRT6 by allosteric modulators represents a novel direction for therapeutics, which can overcome the selectiv
Externí odkaz:
https://doaj.org/article/fd113152da8f4eababaf6fec04c0e6bb
Autor:
Haiming Zhuang, Xiaohua Fan, Dong Ji, Yuanhao Wang, Jigang Fan, Mingyu Li, Duan Ni, Shaoyong Lu, Xiaolong Li, Zongtao Chai
Publikováno v:
Computational and Structural Biotechnology Journal, Vol 20, Iss , Pp 1352-1365 (2022)
Argonaute (AGO) proteins, the core of RNA-induced silencing complex, are guided by microRNAs (miRNAs) to recognize target RNA for repression. The miRNA–target RNA recognition forms initially through pairing at the seed region while the additional s
Externí odkaz:
https://doaj.org/article/5306dacd299b49bbb2aed289bc3b215e
Autor:
Yuran Qiu, Yuanhao Wang, Zongtao Chai, Duan Ni, Xinyi Li, Jun Pu, Jie Chen, Jian Zhang, Shaoyong Lu, Chuan Lv, Mingfei Ji
Publikováno v:
Acta Pharmaceutica Sinica B, Vol 11, Iss 11, Pp 3433-3446 (2021)
RAS, a member of the small GTPase family, functions as a binary switch by shifting between inactive GDP-loaded and active GTP-loaded state. RAS gain-of-function mutations are one of the leading causes in human oncogenesis, accounting for ∼19% of th
Externí odkaz:
https://doaj.org/article/0f94c0b405394554beaf7fb7464520c3
Autor:
Shaoyong Lu, Xinheng He, Zhao Yang, Zongtao Chai, Shuhua Zhou, Junyan Wang, Ashfaq Ur Rehman, Duan Ni, Jun Pu, Jinpeng Sun, Jian Zhang
Publikováno v:
Nature Communications, Vol 12, Iss 1, Pp 1-15 (2021)
G protein-coupled receptors (GPCRs) are a critical target in modern drug development across a wide range of indications. Here the authors provide a comprehensive characterization of a typical GPCR, the angiotensin II (AngII) type 1 receptor (AT1R), a
Externí odkaz:
https://doaj.org/article/ac9008e70a2947a995418dd644c36965
Publikováno v:
Frontiers in Molecular Biosciences, Vol 9 (2022)
Glucocorticoid receptor (GR) regulates various cellular functions. Given its broad influence on metabolic activities, it has been the target of drug discovery for decades. However, how drugs induce conformational changes in GR has remained elusive. H
Externí odkaz:
https://doaj.org/article/c36445d2d1174a339512cdc8d371dfbe
Mechanism of allosteric activation of SIRT6 revealed by the action of rationally designed activators
Publikováno v:
Acta Pharmaceutica Sinica B, Vol 11, Iss 5, Pp 1355-1361 (2021)
The recent discovery of activator compounds binding to an allosteric site on the NAD+-dependent protein lysine deacetylase, sirtuin 6 (SIRT6) has attracted interest and presents a pharmaceutical target for aging-related and cancer diseases. However,
Externí odkaz:
https://doaj.org/article/3f959280a9c7483e80196bfd87bd5081