Zobrazeno 1 - 10
of 1 050
pro vyhledávání: '"Dual target"'
Publikováno v:
Cognitive Research, Vol 9, Iss 1, Pp 1-16 (2024)
Abstract Two experiments explored the search for pairs of faces in a disjunctive dual-target face search (DDTFS) task for unfamiliar face targets. The distinctiveness of the target was manipulated such that both faces were typical or distinctive or c
Externí odkaz:
https://doaj.org/article/ddaeaa22ca274225bc2b3f8731ed1145
Autor:
Linlin Sun, Bin Cao, Qingshuang Ma, Qiuzhi Gao, Jiahao Luo, Minglong Gong, Jing Bai, Huijun Li
Publikováno v:
Journal of Materials Research and Technology, Vol 29, Iss , Pp 656-667 (2024)
Developing materials with multiple desired characteristics is a tremendous challenge, particularly in an elaborate material system. Herein, a machine learning assisted material design strategy was applied to simultaneously optimize dual target attrib
Externí odkaz:
https://doaj.org/article/f9ac19a36d3f4ea08261b4d6136ca08b
Publikováno v:
Biomedicine & Pharmacotherapy, Vol 177, Iss , Pp 116839- (2024)
Dual-specificity tyrosine phosphorylation-regulated kinase 2 (DYRK2) and histone deacetylase 8 (HDAC8) have been shown to be associated with the development of several cancers. Here, we identified a dual-target DYRK2/HDAC8 inhibitor (DYC-1) through a
Externí odkaz:
https://doaj.org/article/58ff2c3710c44972a679df787b149ddb
Autor:
Thua-Phong Lam, Ngoc-Vi Nguyen Tran, Long-Hung Dinh Pham, Nghia Vo-Trong Lai, Bao-Tran Ngoc Dang, Ngoc-Lam Nguyen Truong, Song-Ky Nguyen-Vo, Thuy-Linh Hoang, Tan Thanh Mai, Thanh-Dao Tran
Publikováno v:
Natural Products and Bioprospecting, Vol 14, Iss 1, Pp 1-32 (2024)
Abstract Diabetes mellitus remains a major global health issue, and great attention is directed at natural therapeutics. This systematic review aimed to assess the potential of flavonoids as antidiabetic agents by investigating their inhibitory effec
Externí odkaz:
https://doaj.org/article/3b9558aff2034d50a9af071a38754195
Autor:
Chu Cong-Qiu
Publikováno v:
Medical Review, Vol 3, Iss 6, Pp 521-525 (2023)
The success and safety seen in treating complement-mediated hemolysis conditions has sparked the development of targeted therapies for rare autoimmune diseases, with expansion to more common autoimmune conditions. Various classes of drugs, including
Externí odkaz:
https://doaj.org/article/7321629956774e9c95097409ba06661d
Autor:
Ke Gong, Juyang Jiao, Zhihua Wu, Quan Wang, Jinghan Liao, Yi Duan, Jiangtao Lin, Jian Yu, Ying Sun, Yong Zhang, Yourong Duan
Publikováno v:
Advanced Science, Vol 11, Iss 20, Pp n/a-n/a (2024)
Abstract CD47 blockade has emerged as a promising immunotherapy against liver cancer. However, the optimization of its antitumor effectiveness using efficient drug delivery systems or combinations of therapeutic agents remains largely incomplete. Her
Externí odkaz:
https://doaj.org/article/e5ad4f15081c4e06a3db5447ac2fc45e
Autor:
Giuseppe Sberna, Roberta Gagliardini, Gabriella Rozera, Federica Forbici, Stefania Cicalini, Andrea Antinori, Fabrizio Maggi, Alessandra Amendola
Publikováno v:
Heliyon, Vol 10, Iss 9, Pp e29842- (2024)
In a restricted subset of people living with HIV-1 (PLWH) on antiretroviral therapy (ART) with persistent suppressed viral load (i.e., pol-based HIV-RNA repeatedly undetected), a dual-target (pol and LTR) diagnostic assay for HIV-RNA monitoring can m
Externí odkaz:
https://doaj.org/article/b1745a979d604dc6a53c77d297357c4f
Autor:
Lisa Sophie Pflüger, Dominik Nörz, Moritz Grunwald, Susanne Pfefferle, Katja Giersch, Martin Christner, Beatrice Weber, Martin Aepfelbacher, Holger Rohde, Marc Lütgehetmann
Publikováno v:
Microbiology Spectrum, Vol 12, Iss 3 (2024)
ABSTRACTFor effective infection control measures for Chlamydia trachomatis (CT) and Neisseria gonorrhoeae (NG), a reliable tool for screening and diagnosis is essential. Here, we aimed to establish and validate a multiplex PCR assay on an automated s
Externí odkaz:
https://doaj.org/article/33e557bf82084615bfbb9f584091eedb
Autor:
Guang Ma, Shuhui You, Yizhao Xie, Bingxin Gu, Cheng Liu, Xichun Hu, Shaoli Song, Biyun wang, Zhongyi Yang
Publikováno v:
Cancer Imaging, Vol 23, Iss 1, Pp 1-8 (2023)
Abstract Objective Intra-tumoral heterogeneity of 18F‐fluorodeoxyglucose (18F‐FDG) uptake has been proven to be a surrogate marker for predicting treatment outcome in various tumors. However, the value of intra-tumoral heterogeneity in metastatic
Externí odkaz:
https://doaj.org/article/e5a09c0e73834eac9ad0bdbae032ea73
Publikováno v:
Journal of Integrative Neuroscience, Vol 23, Iss 8, p 161 (2024)
Background: The clinical application of 10 Hz repetitive transcranil magnetic stimulation (rTMS) remains limited despite its demonstrated effectiveness in enhancing cortical excitability and improving cognitive function. The present study used a nove
Externí odkaz:
https://doaj.org/article/97aa52aa5adb46839504ab4d297a4f70