Detection of minority drug resistant mutations in Malawian HIV-1 subtype C-positive patients initiating and on first-line antiretroviral therapy

Autor: Zhiyong Zhou, Kevin Tang, Guoqing Zhang, Nellie Wadonda-Kabondo, Kundai Moyo, Lori A. Rowe, Joshua R. DeVos, Nick Wagar, Du-Ping Zheng, Hongxiong Guo, John Nkengasong, Mike Frace, Scott Sammons, Chunfu Yang

Publikováno v: African Journal of Laboratory Medicine, Vol 7, Iss 1, Pp e1-e9 (2018)

Background: Minority drug resistance mutations (DRMs) that are often missed by Sanger sequencing are clinically significant, as they can cause virologic failure in individuals treated with antiretroviral therapy (ART) drugs. Objective: This study ai

Externí odkaz: https://doaj.org/article/13d0f9c6ea3b4931821b0e95467225c9

Global Distribution of Rubella Virus Genotypes

Autor: Du-Ping Zheng, Teryl K. Frey, Joseph P. Icenogle, Shigetaka Katow, Emily S. Abernathy, Ki-Joon Song, Wen-Bo Xu, Vitaly Yarulin, R.G. Desjatskova, Yair Aboudy, Gisela Enders, Margaret Croxson

Publikováno v: Emerging Infectious Diseases, Vol 9, Iss 12, Pp 1523-1530 (2003)

Phylogenetic analysis of a collection of 103 E1 gene sequences from rubella viruses isolated from 17 countries from 1961 to 2000 confirmed the existence of at least two genotypes. Rubella genotype I (RGI) isolates, predominant in Europe, Japan, and t

Externí odkaz: https://doaj.org/article/10db8c20a27646a683bedac6d2b7495e

Molecular characterization of ambiguous mutations in HIV-1 polymerase gene: implications for monitoring HIV infection status and drug resistance.

Autor: Du-Ping Zheng, Margarida Rodrigues, Ebi Bile, Duc B Nguyen, Karidia Diallo, Joshua R DeVos, John N Nkengasong, Chunfu Yang

Publikováno v: PLoS ONE, Vol 8, Iss 10, p e77649 (2013)

Detection of recent HIV infections is a prerequisite for reliable estimations of transmitted HIV drug resistance (t-HIVDR) and incidence. However, accurately identifying recent HIV infection is challenging due partially to the limitations of current

Externí odkaz: https://doaj.org/article/dede984077b941eaa58794c2837e9418

Detection of minority drug resistant mutations in Malawian HIV-1 subtype C-positive patients initiating and on first-line antiretroviral therapy

Autor: Hongxiong Guo, Lori A. Rowe, John N. Nkengasong, Kevin Tang, Kundai Moyo, Nellie Wadonda-Kabondo, Joshua DeVos, Du-Ping Zheng, Guoqing Zhang, Zhiyong Zhou, Nick Wagar, Mike Frace, Chunfu Yang, Scott Sammons

Publikováno v: African Journal of Laboratory Medicine, Vol 7, Iss 1, Pp e1-e9 (2018)
African Journal of Laboratory Medicine
African Journal of Laboratory Medicine, Volume: 7, Issue: 1, Pages: 1-9, Published: 2018

Background: Minority drug resistance mutations (DRMs) that are often missed by Sanger sequencing are clinically significant, as they can cause virologic failure in individuals treated with antiretroviral therapy (ART) drugs. Objective: This study aim

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::dd68ed31369619c5905ac61c6dfd6171
https://doi.org/10.4102/ajlm.v7i1.708

Utilization of dried blood spot specimens can expedite nationwide surveillance of HIV drug resistance in resource-limited settings

Autor: Nicholas Wagar, Joshua DeVos, Lucy Ng’ang’a, Mary S. Kibona, Sandra Medina-Moreno, Du-Ping Zheng, R. Suzanne Beard, Karidia Diallo, Christine Mwachari, Chunfu Yang, Elliot Raizes, Guoqing Zhang, Boniface Jullu, Carolyn Riwa, Ngugi Evelyn Wangari

Publikováno v: PLoS ONE, Vol 13, Iss 9, p e0203296 (2018)
PLoS ONE

Introduction Surveillance of HIV drug resistance (HIVDR) is crucial to ensuring the continued success of antiretroviral therapy (ART) programs. With the concern of reduced genotyping sensitivity of HIV on dried blood spots (DBS), DBS for HIVDR survei

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::ec890dd500ce79440e9b3b349fb80674
https://doi.org/10.1371/journal.pone.0203296