Zobrazeno 1 - 10
of 52
pro vyhledávání: '"Du Hyung Choi"'
Autor:
Ji Yeon Kim, Du Hyung Choi
Publikováno v:
Pharmaceutics, Vol 14, Iss 11, p 2416 (2022)
Although various quality by design (QbD) approaches have been used to establish a design space to obtain robust drug formulation and process parameters, the effect of excipient variability on the design space and drug product quality is unclear. In t
Externí odkaz:
https://doaj.org/article/77c3338037b343a09313ccd132da9a58
Publikováno v:
Asian Journal of Pharmaceutical Sciences, Vol 14, Iss 3, Pp 287-304 (2019)
The current study was to understand how process variables of high shear wet granulations affect physical properties of granules and tablets. The knowledge gained was intended to be used for Quality-by-Design based process design and optimization. The
Externí odkaz:
https://doaj.org/article/be75cb1d79fd427eb50623ffaf46d50b
Publikováno v:
Pharmaceutics, Vol 13, Iss 9, p 1443 (2021)
Control strategy and quality by design (QbD) are widely used to develop pharmaceutical products and improve drug quality; however, studies on fixed-dose combination (FDC) bilayer tablets are limited. In this study, the bilayer tablet consisted of hig
Externí odkaz:
https://doaj.org/article/7694148c14714f46bb1380db600d1d20
Publikováno v:
Pharmaceutics, Vol 13, Iss 6, p 919 (2021)
Various frameworks and methods, such as quality by design (QbD), real time release test (RTRT), and continuous process verification (CPV), have been introduced to improve drug product quality in the pharmaceutical industry. The methods recognize that
Externí odkaz:
https://doaj.org/article/b490fe5bf1ce40b2ade2607f45e06926
Publikováno v:
Antioxidants, Vol 10, Iss 1, p 90 (2021)
In this study, we designed amorphous solid dispersions based on Eudragit E/HCl (neutralized Eudragit E using hydrochloric acid) to maximize the dissolution of trans-resveratrol. Solid-state characterization of amorphous solid dispersions of trans-res
Externí odkaz:
https://doaj.org/article/2d447f5d18474fb1ac4c614935c3dba0
Publikováno v:
Pharmaceutics, Vol 13, Iss 1, p 80 (2021)
In this study, we developed a control strategy for a drug product prepared by high-shear wet granulation and roller compaction using integrated quality by design (QbD). During the first and second stages, we optimized the process parameters through t
Externí odkaz:
https://doaj.org/article/eac885c292dc43ebb98de8a4f6446fbc
Publikováno v:
Pharmaceutics, Vol 12, Iss 5, p 453 (2020)
In the pharmaceutical industry, it is a major challenge to maintain consistent quality of drug products when the batch scale of a process is changed from a laboratory scale to a pilot or commercial scale. Generally, a pharmaceutical manufacturing pro
Externí odkaz:
https://doaj.org/article/0e92585d66d841df844326d5f5abfe9a
Autor:
Nam Ah Kim, Sungyoul Hong, Ki Hyun Kim, Du Hyung Choi, Joo Seok Kim, Kyung Eui Park, Jun Young Choi, Young Kee Shin, Seong Hoon Jeong
Publikováno v:
Pharmaceutics, Vol 12, Iss 2, p 121 (2020)
c-Met is a receptor tyrosine kinase with no commercially available product despite being a pivotal target in cancer progression. Unlike other c-Met inhibitors that fail clinically, ABN401 is a newly synthesized c-Met inhibitor that is not potentially
Externí odkaz:
https://doaj.org/article/d47a1325e7ed40efa896452cd874650d
Publikováno v:
Pharmaceutics, Vol 11, Iss 8, p 414 (2019)
Process simulation using mathematical modeling tools is becoming more common in the pharmaceutical industry. A mechanistic model is a mathematical modeling tool that can enhance process understanding, reduce experimentation cost and improve product q
Externí odkaz:
https://doaj.org/article/e6a514f3fc7045518f0ac5af023e8664
Publikováno v:
Pharmaceutics, Vol 11, Iss 6, p 252 (2019)
A robust manufacturing process and the relationship between intermediate quality attributes (IQAs), critical quality attributes (CQAs), and critical process parameters (CPPs) for high-shear wet granulation was determined in this study. Based on quali
Externí odkaz:
https://doaj.org/article/a253be8bcc5e4974a49c693321444121