Origin and Early Diversification of the Papain Family of Cysteine Peptidases

Autor: Dušan Kordiš, Vito Turk

Publikováno v: International Journal of Molecular Sciences, Vol 24, Iss 14, p 11761 (2023)

Peptidases of the papain family play a key role in protein degradation, regulated proteolysis, and the host–pathogen arms race. Although the papain family has been the subject of many studies, knowledge about its diversity, origin, and evolution in

Externí odkaz: https://doaj.org/article/02f7fccb90044d42acef9755ee55b3ed

Widespread Evolution of Molecular Resistance to Snake Venom α-Neurotoxins in Vertebrates

Autor: Muzaffar A. Khan, Daniel Dashevsky, Harald Kerkkamp, Dušan Kordiš, Merijn A. G. de Bakker, Roel Wouters, Jory van Thiel, Bianca op den Brouw, Freek J. Vonk, R. Manjunatha Kini, Jawad Nazir, Bryan G. Fry, Michael K. Richardson

Publikováno v: Toxins, Vol 12, Iss 10, p 638 (2020)

Venomous snakes are important subjects of study in evolution, ecology, and biomedicine. Many venomous snakes have alpha-neurotoxins (α-neurotoxins) in their venom. These toxins bind the alpha-1 nicotinic acetylcholine receptor (nAChR) at the neuromu

Externí odkaz: https://doaj.org/article/6e68fdb41bb641e5aa865d31fa79f023

Toward the massive genome of Proteus anguinus—illuminating longevity, regeneration, convergent evolution, and metabolic disorders

Autor: Dušan Kordiš, Nina Gunde-Cimerman, Rok Kostanjšek, Yonglun Luo, Cene Gostinčar, Hans Recknagel, Peter Trontelj, Børge Diderichsen, Guangyi Fan, Hui Jiang, Lars Bolund

Publikováno v: Annals of the New York Academy of Sciences
Kostanjšek, R, Diderichsen, B, Recknagel, H, Gunde-Cimerman, N, Gostinčar, C, Fan, G, Kordiš, D, Trontelj, P, Jiang, H, Bolund, L & Luo, Y 2022, ' Toward the massive genome of Proteus anguinus-illuminating longevity, regeneration, convergent evolution, and metabolic disorders ', Annals of the New York Academy of Sciences, vol. 1507, no. 1, pp. 5-11 . https://doi.org/10.1111/nyas.14686

Deciphering the genetic code of organisms with unusual phenotypes can help answer fundamental biological questions and provide insight into mechanisms relevant to human biomedical research. The cave salamander Proteus anguinus (Urodela: Proteidae), a

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::9a90c8ca0aeb7c1ca031945e1128996b

Widespread Evolution of Molecular Resistance to Snake Venom α-Neurotoxins in Vertebrates

Autor: Dušan Kordiš, Jawad Nazir, Roel Wouters, Michael K. Richardson, Bryan G. Fry, Bianca op den Brouw, R. Manjunatha Kini, Merijn A. G. de Bakker, Freek J. Vonk, Muzaffar Ali Khan, Harald M. I. Kerkkamp, Daniel Dashevsky, Jory van Thiel

Publikováno v: Toxins
Volume 12
Issue 10
Khan, M A, Dashevsky, D, Kerkkamp, H, Kordiš, D, de Bakker, M A G, Wouters, R, van Thiel, J, op den Brouw, B, Vonk, F, Manjunatha Kini, R, Nazir, J, Fry, B G & Richardson, M K 2020, ' Widespread evolution of molecular resistance to snake venom α-neurotoxins in vertebrates ', Toxins, vol. 12, no. 10, 638, pp. 1-20 . https://doi.org/10.3390/toxins12100638
Toxins, 12(10), 638. MDPI
Toxins, Vol 12, Iss 638, p 638 (2020)
Toxins, 12(10):638, 1-20. Multidisciplinary Digital Publishing Institute (MDPI)

Venomous snakes are important subjects of study in evolution, ecology, and biomedicine. Many venomous snakes have alpha-neurotoxins (&alpha
neurotoxins) in their venom. These toxins bind the alpha-1 nicotinic acetylcholine receptor (nAChR) at th

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::e02e1815136cd7ed10a179e0d8051b74
https://doi.org/10.3390/toxins12100638

The Life History of Domesticated Genes Illuminates the Evolution of Novel Mammalian Genes

Autor: Dušan Kordiš

Publikováno v: Evolutionary Biology: Self/Nonself Evolution, Species and Complex Traits Evolution, Methods and Concepts ISBN: 9783319615684

Molecular domestications of transposable elements have occurred repeatedly during the evolution of eukaryotes. Mammals possess numerous single copy domesticated genes that have originated from the intronless multicopy transposable elements. The genes

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_________::c66b4a1505fb97837610480a0412524e
https://doi.org/10.1007/978-3-319-61569-1_8