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An ex vivo human model system to evaluate specificity of replicating and non-replicating gene therapy agents

Autor: M. G. L. Elferink, WM Gommans, Geny M. M. Groothuis, Peter Olinga, Marianne G. Rots, Dorenda Oosterhuis, Jac Schalk, DT Curiel, Hidde J. Haisma

Publikováno v: Journal of gene medicine, 8(1), 35-41. Wiley

Background Inefficiency, aspecificity and toxicity of gene transfer vectors hamper gene therapy from showing its full potential. On this basis significant research currently focuses on developing vectors with improved infection and/or expression prof

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::b18f63925b37a0f937525cec970e8843
https://pubmed.ncbi.nlm.nih.gov/16044485

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Fiber knob modifications overcome low, heterogeneous expression of the coxsackievirus-adenovirus receptor that limits adenovirus gene transfer and oncolysis for human rhabdomyosarcoma cells

Autor: Tp, Cripe, Ej, Dunphy, Ad, Holub, Saini A, Nh, Vasi, Yy, Mahller, Mh, Collins, Jd, Snyder, Krasnykh V, Dt, Curiel, Tj, Wickham, James DeGregori, Jm, Bergelson, Ma, Currier

Publikováno v: Europe PubMed Central

Exploiting the lytic life cycle of viruses has gained recent attention as an anticancer strategy (oncolysis). To explore the utility of adenovirus (Ad)-mediated oncolysis for rhabdomyosarcoma (RMS), we tested RMS cell lines for Ad gene transduction a

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=pmid_dedup__::c274b7f8cac3557c28e5e28415a26183
https://pubmed.ncbi.nlm.nih.gov/11306473

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Fibroblast growth factor 2 retargeted adenovirus has redirected cellular tropism: evidence for reduced toxicity and enhanced antitumor activity in mice

Autor: Dl, Gu, Am, Gonzalez, Ma, Printz, Doukas J, Ying W, D'Andrea M, Dk, Hoganson, Dt, Curiel, Jt, Douglas, Ba, Sosnowski, Andrew Baird, Sl, Aukerman, Gf, Pierce

Publikováno v: Europe PubMed Central

Adenovirus (Ad) have been used as vectors to deliver genes to a wide variety of tissues. Despite achieving high expression levels in vivo, Ad vectors display normal tissue toxicity, transient expression, and antivector immune responses that limit the

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=pmid_dedup__::291ba106e8e0793bc5b9c32d4b122c7a
https://pubmed.ncbi.nlm.nih.gov/10363982

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Molecular conjugate vectors mediate efficient gene transfer into gastrointestinal epithelial cells

Autor: Raj K. Batra, Berschneider H, Dt, Curiel

Publikováno v: Europe PubMed Central

Transfer of genes to the gastrointestinal epithelium would be advantageous from investigational and therapeutic standpoints. Efficient transfer of DNA to the intestinal epithelial cells, however, has been problematic with conventional viral and nonvi

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=pmid_dedup__::f83b2e4c69e724fb8076329a06b5501a
https://pubmed.ncbi.nlm.nih.gov/7621250

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Receptor-mediated gene delivery employing lectin-binding specificity

Autor: Raj K. Batra, Wang-Johanning F, Wagner E, Ri, Garver, Dt, Curiel

Publikováno v: Europe PubMed Central

Selective targeting of malignant cells will be necessary to implement many of the gene therapy strategies being designed to combat cancer. Targeting can be achieved by transductional or transcriptional approaches. Transductional targeting can be acco

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=pmid_dedup__::6dbc26520af7c13c546acf7bac75efba
https://pubmed.ncbi.nlm.nih.gov/7584089

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Combined targeting of adenoviruses to integrins and epidermal growth factor receptors increases gene transfer into primary glioma cells and spheroids

Autor: Grill, J., Vw, Beusechem, Valk, P., Cmf, Dirven, Leonhart, A., Ds, Pherai, Hidde Haisma, Hm, Pinedo, Dt, Curiel, Wr, Gerritsen

Publikováno v: University of Groningen

Adenoviral-mediated gene transfer is suboptimal in human glioma and limits in vivo gene therapy approaches. There is a need for targeted vectors able to enhance gene transfer into the tumor as well as to lower the viral load in the surrounding normal

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=pmid_dedup__::2c3d5acc8fea2e5893e76d887c97b6bd
https://research.rug.nl/en/publications/6502706c-2af3-4158-abbc-cc4b5397f2b5

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Targeted gene delivery to Kaposi's sarcoma cells via the fibroblast growth factor receptor

Autor: Ck, Goldman, Be, Rogers, Jt, Douglas, Ba, Sosnowski, Ying W, Gp, Siegal, Andrew Baird, Ja, Campain, Dt, Curiel

Publikováno v: Europe PubMed Central

Kaposi's sarcoma (KS) is a major AIDS-related malignancy associated with significant morbidity and mortality. Current chemotherapeutic regimens are associated with a dismal prognosis. In an effort to develop a new approach to KS treatment, we devised

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=pmid_dedup__::72b80cc4bff6890bd0a79fdea3021b5f
http://europepmc.org/abstract/med/9108444

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Retraction Notice to: Inhibition of Multiple Protective Signaling Pathways and Ad.5/3 Delivery Enhances mda-7/IL-24 Therapy of Malignant Glioma.

Autor: Hamed HA, Yacoub A, Park MA, Eulitt PJ, Dash R, Sarkar D, Dmitriev IP, Lesniak MS, Shah K, Grant S, Curiel DT, Fisher PB, Dent P

Publikováno v: Molecular therapy : the journal of the American Society of Gene Therapy [Mol Ther] 2024 Dec 04; Vol. 32 (12), pp. 4524. Date of Electronic Publication: 2024 Aug 29.

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