An ex vivo human model system to evaluate specificity of replicating and non-replicating gene therapy agents

Autor: M. G. L. Elferink, WM Gommans, Geny M. M. Groothuis, Peter Olinga, Marianne G. Rots, Dorenda Oosterhuis, Jac Schalk, DT Curiel, Hidde J. Haisma

Publikováno v: Journal of gene medicine, 8(1), 35-41. Wiley

Background Inefficiency, aspecificity and toxicity of gene transfer vectors hamper gene therapy from showing its full potential. On this basis significant research currently focuses on developing vectors with improved infection and/or expression prof

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::b18f63925b37a0f937525cec970e8843
https://pubmed.ncbi.nlm.nih.gov/16044485

[HO (heme oxygenase)/CO (carbon monoxide) system]

Autor: Toshiro Seki, Dt, Curiel, Naruse M, Takano K

Publikováno v: Europe PubMed Central

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=pmid_dedup__::a94acc7f8fccd9d444504d6b6a7c2eb0
https://pubmed.ncbi.nlm.nih.gov/11026262

Molecular conjugate vectors mediate efficient gene transfer into gastrointestinal epithelial cells

Autor: Raj K. Batra, Berschneider H, Dt, Curiel

Publikováno v: Europe PubMed Central

Transfer of genes to the gastrointestinal epithelium would be advantageous from investigational and therapeutic standpoints. Efficient transfer of DNA to the intestinal epithelial cells, however, has been problematic with conventional viral and nonvi

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=pmid_dedup__::f83b2e4c69e724fb8076329a06b5501a
https://pubmed.ncbi.nlm.nih.gov/7621250

Combined targeting of adenoviruses to integrins and epidermal growth factor receptors increases gene transfer into primary glioma cells and spheroids

Autor: Grill, J., Vw, Beusechem, Valk, P., Cmf, Dirven, Leonhart, A., Ds, Pherai, Hidde Haisma, Hm, Pinedo, Dt, Curiel, Wr, Gerritsen

Publikováno v: University of Groningen

Adenoviral-mediated gene transfer is suboptimal in human glioma and limits in vivo gene therapy approaches. There is a need for targeted vectors able to enhance gene transfer into the tumor as well as to lower the viral load in the surrounding normal

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=pmid_dedup__::2c3d5acc8fea2e5893e76d887c97b6bd
https://research.rug.nl/en/publications/6502706c-2af3-4158-abbc-cc4b5397f2b5

Mucosal adenovirus vaccine boosting elicits IgA and durably prevents XBB.1.16 infection in nonhuman primates.

Autor: Gagne M; Vaccine Research Center, National Institute of Allergy and Infectious Diseases, National Institutes of Health, Bethesda, MD, USA., Flynn BJ; Vaccine Research Center, National Institute of Allergy and Infectious Diseases, National Institutes of Health, Bethesda, MD, USA., Andrew SF; Vaccine Research Center, National Institute of Allergy and Infectious Diseases, National Institutes of Health, Bethesda, MD, USA., Marquez J; Vaccine Research Center, National Institute of Allergy and Infectious Diseases, National Institutes of Health, Bethesda, MD, USA., Flebbe DR; Vaccine Research Center, National Institute of Allergy and Infectious Diseases, National Institutes of Health, Bethesda, MD, USA., Mychalowych A; Vaccine Research Center, National Institute of Allergy and Infectious Diseases, National Institutes of Health, Bethesda, MD, USA., Lamb E; Vaccine Research Center, National Institute of Allergy and Infectious Diseases, National Institutes of Health, Bethesda, MD, USA., Davis-Gardner ME; Department of Pediatrics, Center for Childhood Infections and Vaccines of Children's Healthcare of Atlanta, Emory University School of Medicine, Atlanta, GA, USA.; Emory Vaccine Center, Emory University, Atlanta, GA, USA.; Emory National Primate Research Center, Atlanta, GA, USA., Burnett MR; Vaccine Research Center, National Institute of Allergy and Infectious Diseases, National Institutes of Health, Bethesda, MD, USA., Serebryannyy LA; Vaccine Research Center, National Institute of Allergy and Infectious Diseases, National Institutes of Health, Bethesda, MD, USA., Lin BC; Vaccine Research Center, National Institute of Allergy and Infectious Diseases, National Institutes of Health, Bethesda, MD, USA., Ziff ZE; Vaccine Research Center, National Institute of Allergy and Infectious Diseases, National Institutes of Health, Bethesda, MD, USA., Maule E; Vaccine Research Center, National Institute of Allergy and Infectious Diseases, National Institutes of Health, Bethesda, MD, USA., Carroll R; Vaccine Research Center, National Institute of Allergy and Infectious Diseases, National Institutes of Health, Bethesda, MD, USA., Naisan M; Vaccine Research Center, National Institute of Allergy and Infectious Diseases, National Institutes of Health, Bethesda, MD, USA., Jethmalani Y; Vaccine Research Center, National Institute of Allergy and Infectious Diseases, National Institutes of Health, Bethesda, MD, USA., Pessaint L; Bioqual, Inc., Rockville, MD, USA., Todd JM; Vaccine Research Center, National Institute of Allergy and Infectious Diseases, National Institutes of Health, Bethesda, MD, USA., Doria-Rose NA; Vaccine Research Center, National Institute of Allergy and Infectious Diseases, National Institutes of Health, Bethesda, MD, USA., Case JB; Department of Medicine, Washington University School of Medicine, St. Louis, MO, USA., Dmitriev IP; Department of Radiation Oncology, Washington University School of Medicine, St. Louis, MO, USA., Kashentseva EA; Department of Radiation Oncology, Washington University School of Medicine, St. Louis, MO, USA., Ying B; Department of Medicine, Washington University School of Medicine, St. Louis, MO, USA., Dodson A; Bioqual, Inc., Rockville, MD, USA., Kouneski K; Bioqual, Inc., Rockville, MD, USA., O'Dell S; Vaccine Research Center, National Institute of Allergy and Infectious Diseases, National Institutes of Health, Bethesda, MD, USA., Wali B; Department of Pediatrics, Center for Childhood Infections and Vaccines of Children's Healthcare of Atlanta, Emory University School of Medicine, Atlanta, GA, USA.; Emory Vaccine Center, Emory University, Atlanta, GA, USA.; Emory National Primate Research Center, Atlanta, GA, USA., Ellis M; Department of Pediatrics, Center for Childhood Infections and Vaccines of Children's Healthcare of Atlanta, Emory University School of Medicine, Atlanta, GA, USA.; Emory Vaccine Center, Emory University, Atlanta, GA, USA.; Emory National Primate Research Center, Atlanta, GA, USA., Godbole S; Vaccine Research Center, National Institute of Allergy and Infectious Diseases, National Institutes of Health, Bethesda, MD, USA., Laboune F; Vaccine Research Center, National Institute of Allergy and Infectious Diseases, National Institutes of Health, Bethesda, MD, USA., Henry AR; Vaccine Research Center, National Institute of Allergy and Infectious Diseases, National Institutes of Health, Bethesda, MD, USA., Teng IT; Vaccine Research Center, National Institute of Allergy and Infectious Diseases, National Institutes of Health, Bethesda, MD, USA., Wang D; Vaccine Research Center, National Institute of Allergy and Infectious Diseases, National Institutes of Health, Bethesda, MD, USA., Wang L; Vaccine Research Center, National Institute of Allergy and Infectious Diseases, National Institutes of Health, Bethesda, MD, USA., Zhou Q; Vaccine Research Center, National Institute of Allergy and Infectious Diseases, National Institutes of Health, Bethesda, MD, USA., Zouantchangadou S; Bioqual, Inc., Rockville, MD, USA., Van Ry A; Bioqual, Inc., Rockville, MD, USA., Lewis MG; Bioqual, Inc., Rockville, MD, USA., Andersen H; Bioqual, Inc., Rockville, MD, USA., Kwong PD; Vaccine Research Center, National Institute of Allergy and Infectious Diseases, National Institutes of Health, Bethesda, MD, USA., Curiel DT; Department of Radiation Oncology, Washington University School of Medicine, St. Louis, MO, USA., Roederer M; Vaccine Research Center, National Institute of Allergy and Infectious Diseases, National Institutes of Health, Bethesda, MD, USA., Nason MC; Biostatistics Research Branch, Division of Clinical Research, National Institute of Allergy and Infectious Diseases, National Institutes of Health, Bethesda, MD, USA., Foulds KE; Vaccine Research Center, National Institute of Allergy and Infectious Diseases, National Institutes of Health, Bethesda, MD, USA., Suthar MS; Department of Pediatrics, Center for Childhood Infections and Vaccines of Children's Healthcare of Atlanta, Emory University School of Medicine, Atlanta, GA, USA.; Emory Vaccine Center, Emory University, Atlanta, GA, USA.; Emory National Primate Research Center, Atlanta, GA, USA., Diamond MS; Department of Medicine, Washington University School of Medicine, St. Louis, MO, USA.; Department of Pathology & Immunology, Washington University School of Medicine, St. Louis, MO, USA.; Department of Molecular Microbiology, Washington University School of Medicine, St. Louis, MO, USA.; The Andrew M. and Jane M. Bursky Center for Human Immunology & Immunotherapy Programs, Washington University School of Medicine, St. Louis, MO, USA.; Center for Vaccines & Immunity to Microbial Pathogens, Washington University School of Medicine, St. Louis, MO, USA., Douek DC; Vaccine Research Center, National Institute of Allergy and Infectious Diseases, National Institutes of Health, Bethesda, MD, USA. ddouek@mail.nih.gov., Seder RA; Vaccine Research Center, National Institute of Allergy and Infectious Diseases, National Institutes of Health, Bethesda, MD, USA. rseder@mail.nih.gov.

Publikováno v: Nature immunology [Nat Immunol] 2024 Oct; Vol. 25 (10), pp. 1913-1927. Date of Electronic Publication: 2024 Sep 03.