Výsledky vyhledávání - "Ds, Khodyrev"

[Methylation of promoter region of RAR-beta2 gene in renal cell, breast, and ovarian carcinomas]

Autor: Ds, Khodyrev, Vitaly Loginov, Iv, Pronina, Tp, Kazubskaia, Rf, Gar Kavtseva, Ea, Braga

Publikováno v: Europe PubMed Central

The protein encoded by RAR-beta (retinoic acid receptor) gene is a member of the superfamily, of nuclear receptors of retinoids which are involved in regulation of cell differentiation and proliferation. The level of RAR-beta2 mRNA is downregulated i

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=pmid_dedup__::a614b8bc812815f4b32169dc301f0eb7
https://pubmed.ncbi.nlm.nih.gov/18825962

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[Methylation of the putative tumor suppressor gene, RASSF1A, in primary cervical tumors]

Autor: Av, Maliukova, Vitaly Loginov, Ds, Khodyrev, El, Kadyrova, Iv, Pronina, Ta, Ivanova, Fl, Kiselev, Np, Zabarovskiĭ, Ea, Braga

Publikováno v: Europe PubMed Central

The methylation level of 13 CpG-dinucleotides in the promoter region of the putative tumor suppressor gene RASSF1A (3p21.31) was analyzed in HPV-positive squamous cell carcinomas of cervix using methyl-sensitive restriction endonuclease analysis foll

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=pmid_dedup__::35b2aed42e63a2b29525c49fdad81edf
https://pubmed.ncbi.nlm.nih.gov/15612586

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[Human chromosome 3P regions of putative tumor-suppressor genes in renal, breast, and ovarian carcinomas]

Autor: Vitaly Loginov, Iv, Bazov, Ds, Khodyrev, Iv, Pronina, Tp, Kazubskaia, Vd, Ermilova, Rf, Gar Kavtseva, Er, Zbarovskiĭ, Ea, Braga

Publikováno v: Europe PubMed Central

Allelic imbalances (AI) of polymorphic markers at the short arm of chromosome 3 (3p) were mapped using DNA samples of renal cell carcinoma (RCC, 80 cases), breast carcinoma (BC, 95 cases), and epithelial ovarian cancer (EOC, 50 cases) at the same den

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=pmid_dedup__::12ae7b92ab2c7c22e00c34c1106a62e0
http://europepmc.org/abstract/med/18619045

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[Two CpG-islands of SEMA3B gene: methylation in clear cell renal cell carcinoma]

Autor: Vitaly Loginov, Ds, Khodyrev, Iv, Pronina, Av, Maliukova, Tp, Kazubskaia, Vd, Ermilova, Rf, Gar Kavtseva, Er, Zabarovskiĭ, Ea, Braga

Publikováno v: Europe PubMed Central

Earlier in some small cell lung (SCLC) and non-small cell lung carcinoma (NSCLC) cell lines, methylation of CpG-island was found in the SEMA3B region, which belongs to the first intron according to the NCBI data base (Build 36). The aim of this work

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=pmid_dedup__::4ce8c2310ec88522b3ee691878d0bfd6
http://europepmc.org/abstract/med/20088387

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[Alteration of SEMA3B gene expression levels in epithelial tumors]

Autor: Iv, Pronina, Vitaly Loginov, Vs, Prasolov, Ea, Klimov, Ds, Khodyrev, Tp, Kazubskaia, Rf, Gar Kavtseva, Ge, Sulimova, Ea, Braga

Publikováno v: Europe PubMed Central

Gene expression decreasing in tumors permits to suggest tumor-suppressor activities for these genes. Thus, mRNA quantity decrease was found for SEMA3B gene in many cell lines of small cell (SCLC) and non-small cell lung carcinoma (NSCLC) and it is we

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=pmid_dedup__::4793e08f2064c4a7192f52036c124da2
http://europepmc.org/abstract/med/19548530

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[Methylation of promoter region of RASSF1A gene and frequencies of allelic imbalances in chromosome 3 critical regions are correlated with progression of clear cell renal cell carcinoma]

Autor: Vitaly Loginov, Ds, Khodyrev, Iv, Pronina, Tp, Kazubskaia, Vd, Ermilova, Rf, Gar Kavtseva, Ea, Braga

Publikováno v: Europe PubMed Central

The short arm of chromosome 3 (3p) contains several critical regions harboring the set of genes with tumor suppressor activities. The RASSF1A gene (LUCA region, 3p21.31) shows various functions which can be associated with tumorigenesis. Among 3p gen

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=pmid_dedup__::18123edd478b890733c01de95604adc2
http://europepmc.org/abstract/med/19548529

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[Methylation of the promoter region of the RASSF1A gene, a candidate tumor suppressor, in primary epithelial tumors]

Autor: Vitaly Loginov, Av, Maliukova, Seregin IuA, Ds, Khodyrev, Tp, Kazubskaia, Vd, Ermilova, Rf, Gar Kavtseva, Ll, Kiselev, Er, Zabarovskiĭ, Ea, Braga

Publikováno v: Europe PubMed Central

Methylation of the promoter CpG-islands of the candidate tumor suppressor gene RASSF1A (3p21.31) was studied in primary tumors of kidney, breast and ovary (172 cases). Methylation-specific PCR (MSP) and methyl-sensitive restriction endonuclease diges

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=pmid_dedup__::a80b86cb67a40c64f490b58daef45059
http://europepmc.org/abstract/med/15456137

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[Methylation in the Regulation of the Expression of Chromosome 3 and microRNA Genes in Clear-Cell Renal Cell Carcinomas]

Autor: Ea, Braga, Ds, Khodyrev, Vitaly Loginov, Iv, Pronina, Vn, Senchenko, Aa, Dmitriev, Aa, Kubatiev, Ne, Kushlinskii

Publikováno v: Europe PubMed Central

The methylation of CpG islands in promoter regions, together with the interaction of miRNAs with the mRNAs of their target genes on the posttranscriptional level, are complex epigenetic mechanisms that perform the delicate and dynamic regulation of g

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=pmid_dedup__::085be1fec921bd52a026d94cc7e9f1a3
http://europepmc.org/abstract/med/26310030

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[Activation of RHOA gene transcription in epithelial tumors may be caused by gene amplification and/or demethylation of its promotor region]

Autor: Ea, Braga, Vitaly Loginov, Ea, Klimov, Kilosanidze G, Ds, Khodyrev, Nl, Kaganova, Tp, Kazybskaia, Vd, Ermilova, Rf, Gar Kavtseva, Iv, Pronina, Oi, Rud Ko, Er, Zabarskiĭ, Ge, Sulimova, Ll, Kiselev

Publikováno v: Europe PubMed Central

RHOA protein, a member of small GTPases family, is implicated in cell morphogenesis, adhesion, and in cell cycle regulation. RHOA gene (3p21.31) exhibits cell transformation activity, and therefore gene is considered as a potential oncogene. The aim

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=pmid_dedup__::46847b20b2b03da167111551e50a9443
http://europepmc.org/abstract/med/17086988

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[Methylation of some miRNA genes is involved in the regulation of their target genes RAR-beta2 and NKIRAS1 expression in lung cancer]

Autor: Ds, Khodyrev, Iv, Pronina, Sv, Rykov, Ev, Beresneva, Mv, Fridman, Tp, Kazubskaia, Vitaly Loginov, Éa, Braga

Publikováno v: Europe PubMed Central

To date, there are more than two thousand human miRNAs, each of them may be involved in the regulation of hundreds of protein coding target genes. Methylation of CpG-islands, in turn, affects miRNAs gene expression. Our aim was to evaluate the role o

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=pmid_dedup__::191bd3a01aba03e77abc9c020bf341b7
http://europepmc.org/abstract/med/23156677

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