Zobrazeno 1 - 10
of 2 084
pro vyhledávání: '"Drysdale, P."'
The Hypothalamic-Pituitary-Adrenal (HPA) axis is a major neuroendocrine system, and its dysregulation is implicated in various diseases. This system also presents interesting mathematical challenges for modeling. We consider a nonlinear delay differe
Externí odkaz:
http://arxiv.org/abs/2408.00845
We introduce the Rigged Dynamic Mode Decomposition (Rigged DMD) algorithm, which computes generalized eigenfunction decompositions of Koopman operators. By considering the evolution of observables, Koopman operators transform complex nonlinear dynami
Externí odkaz:
http://arxiv.org/abs/2405.00782
Autor:
Xin Huang, Chris Fowler, Yihan Li, Qiao-Xin Li, Jiaqi Sun, Yijun Pan, Liang Jin, Keyla A. Perez, Céline Dubois, Yen Y. Lim, Candace Drysdale, Rebecca L. Rumble, Holly R. Chinnery, Christopher C. Rowe, Ralph N. Martins, Paul Maruff, James D. Doecke, Yong Lin, Abdel A. Belaidi, Kevin J. Barnham, Colin L. Masters, Ben J. Gu
Publikováno v:
Nature Communications, Vol 15, Iss 1, Pp 1-17 (2024)
Abstract Impaired clearance of amyloid β (Aβ) in late-onset Alzheimer’s disease (AD) affects disease progression. The role of peripheral monocytes in Aβ clearance from the central nervous system (CNS) is unclear. We use a flow cytometry assay to
Externí odkaz:
https://doaj.org/article/3d0335505eb94001ae1c6a1edbac7289
Autor:
Myriam Drysdale, Holly Tibble, Vishal Patel, Daniel C. Gibbons, Emily J. Lloyd, William Kerr, Calum Macdonald, Helen J. Birch, Aziz Sheikh
Publikováno v:
BMC Infectious Diseases, Vol 24, Iss 1, Pp 1-10 (2024)
Abstract Background The clinical benefit of coronavirus disease 2019 (COVID-19) treatments against new circulating variants remains unclear. We sought to describe characteristics and clinical outcomes of highest risk patients with COVID-19 receiving
Externí odkaz:
https://doaj.org/article/e6f97d2fec77487f82c4dc9b302868dd
Autor:
Drysdale, Erik
Post-selection inference (PoSI) is a statistical technique for obtaining valid confidence intervals and p-values when hypothesis generation and testing use the same source of data. PoSI can be used on a range of popular algorithms including the Lasso
Externí odkaz:
http://arxiv.org/abs/2305.12581
Autor:
Vishal Patel, Bethany Levick, Stephen Boult, Daniel C. Gibbons, Myriam Drysdale, Emily J. Lloyd, Moushmi Singh, Helen J. Birch
Publikováno v:
BMC Infectious Diseases, Vol 24, Iss 1, Pp 1-8 (2024)
Abstract Background The impact of the constantly evolving severe acute respiratory syndrome coronavirus 2 on the effectiveness of early coronavirus disease 2019 (COVID-19) treatments is unclear. Here, we report characteristics and acute clinical outc
Externí odkaz:
https://doaj.org/article/9ffce5c4ddc843bca1345684dccb61e5
Autor:
Andrew R. Pearson, Bethany R. S. Fox, John C. Hellstrom, Marcus J. Vandergoes, Sebastian F. M. Breitenbach, Russell N Drysdale, Sebastian N. Höpker, Christopher T. Wood, Martin Schiller, Adam Hartland
Publikováno v:
Nature Communications, Vol 15, Iss 1, Pp 1-15 (2024)
Abstract Despite decades of research, the influence of climate on the export of dissolved organic carbon (DOC) from soil remains poorly constrained, adding uncertainty to global carbon models. The limited temporal range of contemporary monitoring dat
Externí odkaz:
https://doaj.org/article/dc52331b16ea4285803ef554b3c83242
Publikováno v:
Health Expectations, Vol 27, Iss 4, Pp n/a-n/a (2024)
ABSTRACT Background We assessed experiences of human papillomavirus (HPV) vaginal self‐sampling and future screening preferences in an ethnically and socio‐economically diverse group of women overdue for cervical screening. Setting and Participan
Externí odkaz:
https://doaj.org/article/0b52a762efef488c9490511068d4ac33
Autor:
Ben Goldacre, Carl Heneghan, Henry Drysdale, Nicholas J DeVito, Jessica Morley, James Andrew Smith
Publikováno v:
BMJ Medicine, Vol 3, Iss 1 (2024)
Objective To identify the availability of results for trials registered on the European Union Clinical Trials Register (EUCTR) compared with other dissemination routes to understand its value as a results repository.Design Cross sectional audit study
Externí odkaz:
https://doaj.org/article/614b54dd1d6e4757b4d49a96e1a9117f
Autor:
Stephen J Brett, Vishal Patel, Sophie Young, Bethany Levick, Daniel C Gibbons, Tahereh Kamalati, Myriam Drysdale, Evgeniy R Galimov, Marcus James Yarwood, Jonathan D Watkins, Benjamin F Pierce, Emily J Lloyd, William Kerr, Helen J Birch
Publikováno v:
BMJ Open Respiratory Research, Vol 11, Iss 1 (2024)
Background We assessed the effectiveness of sotrovimab vs no early COVID-19 treatment in highest-risk COVID-19 patients during Omicron predominance.Methods Retrospective cohort study using the Discover dataset in North West London. Included patients
Externí odkaz:
https://doaj.org/article/63c9ad243a8c40aca8bd08c0e7ef1fac