Structure and rational engineering of the PglX methyltransferase and specificity factor for BREX phage defence.

Autor: Went SC; Department of Biosciences, Durham University, South Road, Durham, UK., Picton DM; Department of Biosciences, Durham University, South Road, Durham, UK., Morgan RD; New England Biolabs, 240 County Road, Ipswich, MA, USA., Nelson A; Faculty of Health and Life Sciences, Northumbria University, Newcastle Upon Tyne, UK., Brady A; Institute of Infection, Veterinary and Ecological Sciences, University of Liverpool, Liverpool, UK., Mariano G; Department of Microbial Sciences, Faculty of Health and Medical Sciences, University of Surrey, Guildford, UK., Dryden DTF; Department of Biosciences, Durham University, South Road, Durham, UK., Smith DL; Faculty of Health and Life Sciences, Northumbria University, Newcastle Upon Tyne, UK., Wenner N; Institute of Infection, Veterinary and Ecological Sciences, University of Liverpool, Liverpool, UK., Hinton JCD; Institute of Infection, Veterinary and Ecological Sciences, University of Liverpool, Liverpool, UK., Blower TR; Department of Biosciences, Durham University, South Road, Durham, UK. timothy.blower@durham.ac.uk.

Publikováno v: Nature communications [Nat Commun] 2024 Aug 22; Vol. 15 (1), pp. 7236. Date of Electronic Publication: 2024 Aug 22.

The phage defence island of a multidrug resistant plasmid uses both BREX and type IV restriction for complementary protection from viruses.

Autor: Picton DM; Department of Biosciences, Durham University, Stockton Road, Durham DH1 3LE, UK., Luyten YA; New England Biolabs, 240 County Road, Ipswich, MA 01938, USA., Morgan RD; New England Biolabs, 240 County Road, Ipswich, MA 01938, USA., Nelson A; Department of Applied Sciences, University of Northumbria, Newcastle Upon Tyne NE1 8ST, UK., Smith DL; Department of Applied Sciences, University of Northumbria, Newcastle Upon Tyne NE1 8ST, UK., Dryden DTF; Department of Biosciences, Durham University, Stockton Road, Durham DH1 3LE, UK., Hinton JCD; Institute of Infection, Veterinary and Ecological Sciences, University of Liverpool, Liverpool L69 7ZB, UK., Blower TR; Department of Biosciences, Durham University, Stockton Road, Durham DH1 3LE, UK.

Publikováno v: Nucleic acids research [Nucleic Acids Res] 2021 Nov 08; Vol. 49 (19), pp. 11257-11273.

A survey of generative AI for de novo drug design: new frontiers in molecule and protein generation.

Autor: Tang, Xiangru¹ (AUTHOR) mark@gersteinlab.org, Dai, Howard¹ (AUTHOR), Knight, Elizabeth² (AUTHOR), Wu, Fang³ (AUTHOR), Li, Yunyang¹ (AUTHOR), Li, Tianxiao⁴ (AUTHOR), Gerstein, Mark^1,4,5,6,7 (AUTHOR)

Publikováno v: Briefings in Bioinformatics. Jul2024, Vol. 25 Issue 4, p1-19. 19p.

A genome-wide cytotoxicity screen of cluster F1 mycobacteriophage Girr reveals novel inhibitors of Mycobacterium smegmatis growth.

Autor: Pollenz, Richard S¹ (AUTHOR) pollenz@usf.edu, Barnhill, Kaylee¹ (AUTHOR), Biggs, Abbigail¹ (AUTHOR), Bland, Jackson¹ (AUTHOR), Carter, Victoria¹ (AUTHOR), Chase, Michael¹ (AUTHOR), Clark, Hayley¹ (AUTHOR), Coleman, Caitlyn¹ (AUTHOR), Daffner, Marshall¹ (AUTHOR), Deam, Caitlyn¹ (AUTHOR), Finocchiaro, Alyssa¹ (AUTHOR), Franco, Vanessa¹ (AUTHOR), Fuller, Thomas¹ (AUTHOR), Pinera, Juan Gallardo¹ (AUTHOR), Horne, Mae¹ (AUTHOR), Howard, Zoe¹ (AUTHOR), Kanahan, Olivia¹ (AUTHOR), Miklaszewski, Christopher¹ (AUTHOR), Miller, Sydney¹ (AUTHOR), Morgan, Ryan¹ (AUTHOR)

Publikováno v: G3: Genes | Genomes | Genetics. May2024, Vol. 14 Issue 5, p1-10. 10p.

DNA target recognition domains in the Type I restriction and modification systems of Staphylococcus aureus.

Autor: Cooper LP; EaStCHEM School of Chemistry, University of Edinburgh, The King's Buildings, Edinburgh, EH9 3FJ, UK., Roberts GA; EaStCHEM School of Chemistry, University of Edinburgh, The King's Buildings, Edinburgh, EH9 3FJ, UK., White JH; EaStCHEM School of Chemistry, University of Edinburgh, The King's Buildings, Edinburgh, EH9 3FJ, UK., Luyten YA; New England Biolabs, 240 County Road, Ipswich, MA 01938-2723, USA., Bower EKM; EaStCHEM School of Chemistry, University of Edinburgh, The King's Buildings, Edinburgh, EH9 3FJ, UK., Morgan RD; New England Biolabs, 240 County Road, Ipswich, MA 01938-2723, USA., Roberts RJ; New England Biolabs, 240 County Road, Ipswich, MA 01938-2723, USA., Lindsay JA; Institute of Infection and Immunity, St George's, University of London, Cranmer Terrace, London, SW17 0RE, UK., Dryden DTF; Department of Biosciences, Durham University, Stockton Road, Durham, DH1 3LE, UK.

Publikováno v: Nucleic acids research [Nucleic Acids Res] 2017 Apr 07; Vol. 45 (6), pp. 3395-3406.